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Gene: Nlrp1b (NLR family, pyrin domain containing 1B) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Nlrp1b

Name:

NLR family, pyrin domain containing 1B

RGD ID:

1593294

Description:

Predicted to enable cysteine-type endopeptidase activator activity and pattern recognition receptor activity. Predicted to be involved in activation of innate immune response; inflammatory response; and intrinsic apoptotic signaling pathway. Predicted to be located in neuronal cell body. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1); PARTICIPATES IN NOD-like receptor signaling pathway; .

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

AABR07029890.1; LOC691998; NACHT, LRR and PYD domains-containing protein 1b allele 3-like; similar to NACHT, leucine rich repeat and PYD containing 1

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	NLRP1 (NLR family pyrin domain containing 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid
Alliance orthologs ³
Homo sapiens (human):	NLRP1 (NLR family pyrin domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NLRP1 (NLR family pyrin domain containing 1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Homo sapiens (human):	CARD8 (caspase recruitment domain family member 8)	Alliance	DIOPT (HGNC)
Mus musculus (house mouse):	Nlrp1b (NLR family, pyrin domain containing 1B)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Mus musculus (house mouse):	Nlrp1b (NLR family, pyrin domain containing 1B)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nlrb5 (NOD-like receptor family B, member 5)	Alliance	DIOPT (InParanoid\|OMA\|PhylomeDB)
Danio rerio (zebrafish):	nlrp1	Alliance	DIOPT (InParanoid\|OMA\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	LOC108644478	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100493406	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nlrp12	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100491706	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100486737	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100487218	Alliance	DIOPT (PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC116407562	Alliance	DIOPT (PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100493406	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC116407632	Alliance	DIOPT (PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	56,336,957 - 56,412,796 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	56,341,577 - 56,411,347 (-)	Ensembl				GRCr8
mRatBN7.2	10	55,838,381 - 55,904,374 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	55,843,001 - 55,912,774 (-)	Ensembl				mRatBN7.2
Rnor_6.0	10	57,755,957 - 57,847,867 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	57,836,931 - 57,837,602 (-)	NCBI			rn6	Rnor6.0
Rnor_5.0	10	57,500,498 - 57,596,098 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	58,027,087 - 58,108,465 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	54,987,574 - 55,051,227 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (IBA)

immune system process (IEA)

inflammatory response (IBA,IEA)

innate immune response (IEA)

intrinsic apoptotic signaling pathway (IBA)

negative regulation of cellular defense response (IEA)

positive regulation of pyroptotic inflammatory response (IEA)

programmed cell death (IEA)

proteolysis (IEA)

regulation of apoptotic process (IEA)

Cellular Component

canonical inflammasome complex (IEA)

neuronal cell body (IEA)

NLRP3 inflammasome complex (IBA)

nucleus (IBA,IEA)

protein-containing complex (IEA)

Molecular Function

ATP binding (IEA)

cysteine-type endopeptidase activator activity (IBA)

nucleotide binding (IEA)

pattern recognition receptor activity (IBA)

peptidase activity (IEA)

scaffold protein binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

NOD-like receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11551959	PMID:11821383	PMID:12067710	PMID:15030775	PMID:23818853

Genomics

Variants

Variants in Nlrp1b
559 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	122
Count of miRNA genes:	94
Interacting mature miRNAs:	100
Transcripts:	ENSRNOT00000075185
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35893451	64140567	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	51071897	96071897	Rat
152025229	Scl83	Serum cholesterol level QTL 83	4.33		blood cholesterol amount (VT:0000180)		10	36211556	69161158	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31796281	76796281	Rat
152025227	Bw195	Body weight QTL 195	5.73		body mass (VT:0001259)		10	47489017	69161158	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15776754	60776754	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	27443787	72443787	Rat
152025224	Bw193	Body weight QTL 193	6.47		body mass (VT:0001259)		10	52162433	75582749	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	35509383	91417879	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
1578762	Toxo1	Toxoplasma gondii resistance QTL 1			brain integrity trait (VT:0010579)	percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)	10	52699004	59876693	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	19939207	64939207	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	18035782	63035782	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	54296336	99451733	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41831278	86831278	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50464802	95464802	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45529164	96099749	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44939359	89939359	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21833758	61843633	Rat
10450493	Bp382	Blood pressure QTL 382		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50860288	95860288	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28950353	73950353	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35893263	64653589	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29800910	64653589	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	27443787	72443787	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42823274	87823274	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44939359	89939359	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42823274	87823274	Rat
2306787	Ean3	Experimental allergic neuritis QTL 3	3.1		nervous system integrity trait (VT:0010566)	body weight loss (CMO:0001399)	10	54296227	67476781	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	49495492	94495492	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
1354585	Eae18a	Experimental allergic encephalomyelitis QTL 18a	7.5	0.0004	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	54296227	58944345	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	14653541	59653541	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24662123	73695339	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	27023535	61843633	Rat
2298480	Eau7	Experimental allergic uveoretinitis QTL 7		0.0049	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	35509383	80509383	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	16175525	61175525	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	20110614	65110614	Rat
2289985	Bp305	Blood pressure QTL 305			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	29076978	74076978	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	55307972	93608131	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	18035782	63035782	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	43608793	88608793	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	27443787	72443787	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
7207811	Bmd90	Bone mineral density QTL 90	5.2		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	10	49943710	94943710	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31129113	76129113	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44939359	89939359	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47869129	92869129	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
2292436	Bp310	Blood pressure QTL 310			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50604677	95604677	Rat
12880050	Am10	Aortic mass QTL 10		0.016	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	39503487	84503487	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	35509383	88177745	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	20110614	65110614	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

D10Rat158

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	55,873,136 - 55,873,336 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	57,782,460 - 57,782,659	NCBI	Rnor6.0
Rnor_5.0	10	57,532,236 - 57,532,435	UniSTS	Rnor5.0
RGSC_v3.4	10	58,066,807 - 58,067,007	RGD	RGSC3.4
RGSC_v3.4	10	58,066,808 - 58,067,007	UniSTS	RGSC3.4
Celera	10	55,011,689 - 55,011,888	UniSTS
RGSC_v3.1	10	58,080,430 - 58,080,630	RGD
SHRSP x BN Map	10	46.5699	RGD
SHRSP x BN Map	10	46.5699	UniSTS
Cytogenetic Map	10	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	sensory system	visual system
7	24	12	21	12	24	2	16	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008775761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000075185 ⟹ ENSRNOP00000064378

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	56,341,577 - 56,411,347 (-)	Ensembl
mRatBN7.2 Ensembl	10	55,843,001 - 55,912,774 (-)	Ensembl

RefSeq Acc Id:

XM_063270033 ⟹ XP_063126103

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	56,336,957 - 56,412,796 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_063126103	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064378
	ENSRNOP00000064378.3

Ensembl Acc Id:

ENSRNOP00000064378 ⟸ ENSRNOT00000075185

RefSeq Acc Id:	XP_063126103 ⟸ XM_063270033
- UniProtKB:	M0R4T2 (UniProtKB/TrEMBL)

Protein Domains

CARD FIIND NACHT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0R4T2-F1-model_v2	AlphaFold	M0R4T2	1-224	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1593294	AgrOrtholog
BioCyc Gene	G2FUF-24409	BioCyc
Ensembl Genes	ENSRNOG00000048125	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000075185	ENTREZGENE
	ENSRNOT00000075185.4	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
InterPro	CARD	UniProtKB/TrEMBL
	CARD8/ASC/NALP1_CARD	UniProtKB/TrEMBL
	DEATH-like_dom_sf	UniProtKB/TrEMBL
	FIIND_dom	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
	NACHT_NTPase	UniProtKB/TrEMBL
	NLRP_HD2	UniProtKB/TrEMBL
	NLRP_Inflammasome	UniProtKB/TrEMBL
	NOD2_WH	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
NCBI Gene	691998	ENTREZGENE
PANTHER	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1B ALLELE 2	UniProtKB/TrEMBL
Pfam	CARD	UniProtKB/TrEMBL
	FIIND	UniProtKB/TrEMBL
	LRR_6	UniProtKB/TrEMBL
	NACHT	UniProtKB/TrEMBL
	NLRC4_HD2	UniProtKB/TrEMBL
	NOD2_WH	UniProtKB/TrEMBL
	UPA-FIIND	UniProtKB/TrEMBL
PhenoGen	Nlrp1b	PhenoGen
PRINTS	DISEASERSIST	UniProtKB/TrEMBL
PROSITE	CARD	UniProtKB/TrEMBL
	FIIND	UniProtKB/TrEMBL
	NACHT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000048125	RatGTEx
SMART	LRR_RI	UniProtKB/TrEMBL
Superfamily-SCOP	RNI-like	UniProtKB/TrEMBL
	SSF47986	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	M0R4T2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Nlrp1b	NLR family, pyrin domain containing 1B	AABR07029890.1		Data merged from RGD:15005441	737654	PROVISIONAL
2019-11-08	AABR07029890.1				Symbol and Name status set to provisional	45752	PROVISIONAL
2013-05-24	Nlrp1b	NLR family, pyrin domain containing 1B	LOC687768	similar to NACHT, leucine rich repeat and PYD containing 1	Data merged from RGD:1597517	1643240	APPROVED
2011-02-18	Nlrp1b	NLR family, pyrin domain containing 1B	LOC691998	similar to NACHT, leucine rich repeat and PYD containing 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC691998	similar to NACHT, leucine rich repeat and PYD containing 1			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-20	LOC687768	similar to NACHT, leucine rich repeat and PYD containing 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)