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Gene: Iqsec3 (IQ motif and Sec7 domain ArfGEF 3) Rattus norvegicus

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Symbol:

Iqsec3

Name:

IQ motif and Sec7 domain ArfGEF 3

RGD ID:

1593191

Description:

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in activation of GTPase activity; postsynapse organization; and regulation of small GTPase mediated signal transduction. Is active in GABA-ergic synapse. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; allethrin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

IQ motif and Sec7 domain 3; IQ motif and SEC7 domain-containing protein 3; potential synaptic guanine nucleotide exchange factor for Arf; sag; synArfGEF; synArfGEF-Po

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Iqsec3 (IQ motif and Sec7 domain 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GCDH (glutaryl-CoA dehydrogenase)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Iqsec3 (IQ motif and Sec7 domain 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	iqsec3a (IQ motif and Sec7 domain 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	iqsec3a (IQ motif and Sec7 domain 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	iqsec3b (IQ motif and Sec7 domain 3b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	bris-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	siz	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	siz	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SYT1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	iqsec3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	156,283,040 - 156,379,396 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	156,283,043 - 156,379,396 (-)	Ensembl				GRCr8
mRatBN7.2	4	154,610,933 - 154,707,310 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	154,610,934 - 154,707,310 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	160,877,071 - 160,973,796 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	156,660,548 - 156,757,257 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	155,283,989 - 155,380,498 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	153,948,052 - 154,044,493 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	153,948,055 - 154,044,493 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	221,035,992 - 221,132,460 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	157,807,767 - 157,904,039 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	143,449,428 - 143,544,902 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

allethrin (EXP)

amphetamine (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

CGP 52608 (ISO)

Cuprizon (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

dimethylselenide (ISO)

ethanol (ISO)

ethylparaben (ISO)

fenvalerate (EXP)

folic acid (ISO)

fulvestrant (ISO)

GSK-J4 (ISO)

lead(0) (ISO)

linsidomine (EXP)

maneb (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N,N-diethyl-m-toluamide (EXP)

niclosamide (ISO)

paracetamol (ISO)

paraquat (ISO)

PCB138 (ISO)

permethrin (EXP)

pyrethrins (EXP)

reactive oxygen species (ISO)

resveratrol (ISO)

silver atom (ISO)

silver(0) (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of GTPase activity (IDA)

postsynapse organization (IDA,IMP)

regulation of ARF protein signal transduction (IEA)

regulation of postsynaptic neurotransmitter receptor internalization (IBA)

regulation of small GTPase mediated signal transduction (IDA,IEA)

vesicle-mediated transport (IBA)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

GABA-ergic synapse (IDA,IEA,IMP,ISO)

glycinergic synapse (IEA,ISO)

inhibitory synapse (IEA,ISO)

postsynaptic density (IEA,ISO,ISS)

postsynaptic density membrane (IBA)

postsynaptic membrane (IEA,ISO)

postsynaptic specialization of symmetric synapse (IEA,ISO)

Molecular Function

guanyl-nucleotide exchange factor activity (IBA,IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses.	Fukaya M, etal., J Neurochem. 2011 Mar;116(6):1122-37. doi: 10.1111/j.1471-4159.2010.07167.x. Epub 2011 Jan 20.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation.	Um JW, etal., J Biol Chem. 2016 May 6;291(19):10119-30. doi: 10.1074/jbc.M115.712893. Epub 2016 Mar 21.

Additional References at PubMed

PMID:15189337	PMID:27609886	PMID:30053369	PMID:30142695

Genomics

Comparative Map Data

Iqsec3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	156,283,040 - 156,379,396 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	156,283,043 - 156,379,396 (-)	Ensembl				GRCr8
mRatBN7.2	4	154,610,933 - 154,707,310 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	154,610,934 - 154,707,310 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	160,877,071 - 160,973,796 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	156,660,548 - 156,757,257 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	155,283,989 - 155,380,498 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	153,948,052 - 154,044,493 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	153,948,055 - 154,044,493 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	221,035,992 - 221,132,460 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	157,807,767 - 157,904,039 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	143,449,428 - 143,544,902 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

IQSEC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	66,767 - 178,455 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	66,767 - 178,455 (+)	Ensembl			hg38	GRCh38
GRCh37	12	175,933 - 287,621 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	56,803 - 150,755 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	12	1,815,754 - 1,896,258 (+)	NCBI		Celera
Cytogenetic Map	12	p13.33	NCBI
HuRef	12	28,476 - 140,365 (+)	NCBI		HuRef
CHM1_1	12	174,887 - 286,602 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	58,888 - 174,477 (+)	NCBI		T2T-CHM13v2.0

Iqsec3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	121,349,886 - 121,450,697 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	121,349,892 - 121,450,637 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	121,372,927 - 121,473,738 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	121,372,933 - 121,473,678 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	121,322,951 - 121,423,696 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	121,338,552 - 121,439,297 (-)	NCBI		MGSCv36	mm8
Celera	6	123,209,117 - 123,309,961 (-)	NCBI		Celera
Cytogenetic Map	6	F1	NCBI
cM Map	6	57.28	NCBI

Iqsec3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	6,981,338 - 7,079,486 (-)	Ensembl
ChiLan1.0	NW_004955454	6,978,317 - 7,079,490 (-)	NCBI	ChiLan1.0	ChiLan1.0

IQSEC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	5,553,009 - 5,660,555 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	5,549,776 - 5,657,317 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	128,587 - 236,302 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	105,685 - 213,213 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	105,804 - 209,812 (+)	Ensembl			panPan2	panpan1.1

IQSEC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	42,149,006 - 42,259,881 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	42,148,956 - 42,256,790 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	4,424,441 - 4,534,976 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	42,507,444 - 42,618,070 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	42,507,349 - 42,618,065 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	42,448,683 - 42,559,183 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	42,418,597 - 42,529,299 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	3,784,423 - 3,895,047 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Iqsec3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	108,795,613 - 108,912,919 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936606	271,291 - 374,940 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936606	271,217 - 388,505 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IQSEC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	67,445,838 - 67,540,485 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	67,445,839 - 67,540,488 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	69,760,244 - 69,828,226 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IQSEC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	69,565 - 179,968 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	69,712 - 179,103 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666063	8,161,250 - 8,278,226 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Iqsec3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	8,333,613 - 8,434,127 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624735	8,333,560 - 8,437,208 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Iqsec3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	25,265,976 - 25,361,399 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Iqsec3
980 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	670
Count of miRNA genes:	296
Interacting mature miRNAs:	344
Transcripts:	ENSRNOT00000018902
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	134095016	179095016	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	149763204	169799698	Rat
61446	Coreg2	Compensatory renal growth QTL 2	3.5		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	4	150095743	159267220	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1358364	Sradr4	Stress Responsive Adrenal Weight QTL 4	4.92		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	131384565	176384565	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	123870974	168870974	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	111383604	156383604	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	127263297	172263297	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	126334185	171334185	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	111383604	156383604	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	124700988	169700988	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	134199006	168870974	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	148121375	176967367	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
12798525	Anxrr57	Anxiety related response QTL 57	3.21	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	148834094	168870974	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	11	55	155	64	63	32	58	32	6	237	143	8	128	43	74	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_207617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286403	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001837484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001837485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB057643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018902 ⟹ ENSRNOP00000018902

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	156,283,043 - 156,379,396 (-)	Ensembl
mRatBN7.2 Ensembl	4	154,610,934 - 154,707,310 (-)	Ensembl
Rnor_6.0 Ensembl	4	153,951,215 - 154,043,850 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076318 ⟹ ENSRNOP00000067900

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	153,948,055 - 154,044,493 (-)	Ensembl

RefSeq Acc Id:

NM_207617 ⟹ NP_997500

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	156,283,045 - 156,379,396 (-)	NCBI
mRatBN7.2	4	154,610,933 - 154,707,310 (-)	NCBI
Rnor_6.0	4	153,948,057 - 154,044,493 (-)	NCBI
Rnor_5.0	4	221,035,992 - 221,132,460 (-)	NCBI
RGSC_v3.4	4	157,807,767 - 157,904,039 (-)	RGD
Celera	4	143,449,428 - 143,544,902 (-)	RGD

Sequence:

show sequence

ACTAAGCAACAGACACACGCATTGTTTTCTAGAGTCTATTAACTGTTCACAGACACCCCACAAA
GCAAATTGTTGAGCATCAAAAAGGCAGGTATGTCCTCCTCAGAAGGTCTTAAAAATGGGCCCTG
CCTCCGAGTTAGATACAGGAAAATGTGATTGTGACCTTTTCGAGCTGGGTGCCTATATGCCTCT
CTTCGTCAGTGCCAGCTTCCCCCCTCCTTATTCTTCCTTTTTCTCAGAAGGCTTCCTTTTTGTC
TTCGTTCCCTAGCACTTTCCCAGCTCTTCTGCTCGGGTTGACCGGTAGAACTGATCTCCATCCT
GGAATCTCACAGAGTATCTTGCTCGACCGAACCTCTTCCTCTTTGCTCTCCCTTCGCCCCCGCC
TCCCCTACGCCCCCGCGGGAAGCAGAGTTCCTCACGAAGCCCAGAGGTGGGAGGTGGGCCCTGG
CGCCGGTCCGCCCCTTAGTGCGTGTGCGAATGCCTGTGTGGCGGTGACGCGCAGGCGACGGCGG
GAAGGGGAGGGAGAGAGAGAGAGGGAGGGAGGCCACCGACCGACAGAGCTGCTGGGCTGCTGGG
CTCCTGCGCGCTCACGCTCCCCGCCGCCCGCCTAGGCGCAGGCAGGGCGCAGGCGGCGGCGGGC
GGCATGGAGAGCCTGCTGGAGAACCCGGTGCGCGCCGTGCTCTACCTTAAGGAGCTCACGGCCA
TCGTGCAGAACCAGCAAAGCCTCATCCATACCCAGCGCCAGCGCATCGATGAGCTGGAGCGGCG
TCTAGACGAGCTGAGCGCGGAGAACCGCAGCCTGTGGGAACACCAGCAGCTGCTGCAAGCCCAG
CCTCCGCCTGGGCTGGTTCCCCCGCCGTCTGCCCCACTGCCGGCTCCTGCAGCCACTGCTCCGG
CCGCCACTGCGGCCCAGGAACCGCTTCAGGACCACGGACAGCTCATACCCGCCACGCCGGAGCC
GCCGCTTCAGCACCACGGACAGCTCCTGGCACAGCCACAGCCGGCCCCCAGCAGCAGGGTTCAG
ACTCCCCAGTCGCCCCACCAGCACCCGGTGGCACCCGGGGCCGTAGCTGACAAGGAGAAGGAGC
GTCCCTCGAGTTGTTGTGCTGCCGCGGGAGCCCTGCTTCAGCACGCATCCCCCGCCGCCCTCGG
CAAGGGCGTCCTGAGCAGGAGACCCAAGAATGAGACCGTGCTACACCAATTCTGCTGCCCCGCC
ACTGACACTGAGCAGAAGCCTGCTTGCTCTGACCTGGCTTCCCAAAGTGATGGCTCCTGTGCCC
AGGCCGGTGGGGGCATGGAGGACTCCGTGGTGGCAGCGGTGGCAGCCGGCAGACCCAGTGCCCA
TGCCCCGAAGGCTCAAGCCCCGGAGCTACAGCAGGAGGAGGAGCGGCCAGGGGCGGTGGGCTCC
CCACGGGCTGGCCCCCTCCGCGCGGCCTCCCCTGGCCAGCAGCAGCCTGCCCTGGCGACGGCGC
TCTGCTCCCACACTCCTGCTGCCTCCGAGTACGAACTCTCCCTTGACCTAAAGAATAAACAGAT
TGAAATGCTAGAACACAAATACGGGGGCCACCTGGTATCCCGACGCGCCGCGTGCACCATCCAA
ACCGCTTTTCGCCAGTACCAGCTCAGCAAGAACTTTGAGAAGATCCGTAACTCGCTCCTGGAGA
GCCGCCTGCCTCGGCGGATCTCGCTGCGCAAGGTGAGGGCGCCCACAGCGGAAAGCCTGGTGGC
AGAGAAGGCACTCCTGGAGAGCTGTGGGCTCCTGGGGCTCCCGCTGGGGCGCTCGCCCTCCCTA
CCACCCACCTTCGCAGGCTCTCTCACCGAGCTGGAGGACTCCTTTACCGAGCAGGTGCAGTCCC
TGGCCAAGTCCATAGACGACGCCCTCAGCACCTGGAGCCTCAAGACCATGTGCTCGCTGCAGGA
GAGTGGCGCGTACCAGCTCCACCAGGCGCTGCACCCTAGTGCCGGGCAGCCAGGTCTGGAGACC
GAGGCGGCGCGGGAGCCGGACAGCGGCCCAGGGTCAGGAGATGAGGCCGGTAGCCTGCCTCAGG
GTCACAGCGGTACCCTCATGATGGCTTTCCGGGACGTCACGGTGCAGATCGCTAACCAGAACAT
CTCTGTTTCCTCCTCCACCGCCCTGTCTGTGGCTAACTGTCTGGGCGCACAGACCGCTCAGGCC
ACAGCCGAGCCTGCAGCCGTTCAAACCGAACAAGGGGACGCTGCGACTCAGGAGGTCTCGGAAG
TCCCAGCCTCGGAACTGATGGACCCACCCGTTGAGGACTCAGAGGCGGCGGAGAGCGGCGCCCA
GAGCGCACACGAACCCACGGTGGCCGAGGCCGTGGTGGAGGAGGCAGTGGCTACAGAAGCAGAA
GAGGAAGAAGAAGGGGCCGGGCAGGCAGGGAAAGGGGCGGAGGCTGAGGTGGGCGACAACTCTG
AGCAGTTGAGCAGCAGCAGCGCATCCACCAAGTCCGCCAAATCTGGCTCAGAGGTCTCTGCCGC
TGCCTCCAAGGAGGCCCTGCAGGCGGTGATCCTGAGCTTGCCTCGCTACCACTGCGAGAACCCA
GCCAGCTGCAGGTCCCCCACGCTCTCCACAGACACCCTGCGCAAGCGGCTATACCGCATAGGCC
TCAACCTCTTCAATATAAATCCGGACAAGGGCATCCAGTTCCTGATCTCCCGTGGCTTCATCCC
CGACACCCCCATCGGTGTGGCCCACTTCCTCCTCCAGCGCAAAGGCCTCAGCCGCCAGATGATA
GGAGAGTTTCTGGGCAATAGCAAGAAGCAGTTCAACCGGGACGTGCTAGACTGCGTGGTGGATG
AGATGGACTTTTCCAACATGGAGCTGGATGAAGCCCTGAGGAAGTTTCAAGCGCACATCCGAGT
GCAAGGGGAAGCCCAGAAGGTAGAGCGACTCATAGAAGCTTTCAGCCAACGCTACTGCATGTGC
AATCCTGAGGTGGTGCAACAATTCCACAACCCAGACACTATCTTCATCCTGGCCTTCGCCATCA
TCCTCCTCAACACCGACATGTACAGCCCCAACATCAAGCCTGACCGGAAGATGATGCTGGAAGA
TTTTATCCGGAACCTCCGAGGTGTGGATGACGGCGCTGACATCCCCAGGGAGCTGGTGGTAGGC
ATCTATGAAAGGATCCAGCAGAAGGAGCTCAAGTCCAATGAGGACCATGTCACATATGTCACCA
AGGTGGAGAAGTCCATCGTGGGCATGAAGACGGTGCTGTCCATGCCACATCGCCGCCTGGTCTG
CTGTAGCCGGCTCTTCGAGGTGACCGATGTGAACAAGTTACAGAAACAAGCCGCCCACCAGAGA
GAAGTGTTCCTCTTCAACGATCTGCTGGTGATTCTCAAGCTGTGTCCAAAGAAGAAGAGCTCCT
TCACATACACCTTCTGCAAAGCGGTCGGCCTGTTAGGCATGCGATTCCACCTCTTTGAGAACGA
GTATTACTCTCATGGTATCACCCTGGCGACCCCGCTCTCGGGCTCCGAGAAGAAGCAGGTGCTG
CACTTCTGCGCCCTGGGCTCCGACGAGATGCAGAAGTTCGTGGAAGACCTGAAGGAGTCCATCG
CCGAGGTGACAGAGCTGGAGCAGATTCGGATAGAATGGGAACTGGAGAGGCAGCAGGGAACAAA
GACACTCTCTGCAAGGTCTGCTGGAGCCCAGGGGGACCCACAGTCAAAGCAAGGATCACCCACA
GCCAAGAGGGAAGCGATGGCAGGAGAGAAAGCGACGGAGAGCTCGGGGGAGGTGTCAATTCACA
ACAGGCTTCAAACGTTCCAGCACAGCCCCAAGTTGGGGGTCGAGAGGGGAGCGCCAGCACCATC
ACCACCAACATCACCACCACCACCGTTGCCACCAGACCCACAGCCTAGTCCCCTGAGGGAGCAG
CCCCCGCCACTGCCACTGCCACCACCCACACCCCCAGGCACCCTGGTACAGTGCCAGCAAATTG
TCAAGGTCATTGTCCTGGATAAACCCTGCTTGGCCCGCATGGAGCCCCTGCTGAGCCAGGCTCT
GTCCTGCTATGCCTCATCCTCCTCAGACTCCTGTGGCTCCACACCTTTGCGTGGTCCGGGCTCC
CCAGTTAAGGTCATCCACCAGCCTCCACTGCCCCCACCCCCACCCCCATACAACCACCCTCACC
AGTTCTGCCCACCAGGCTCTCTGCTACTCCGGCGCCGCTACTCCAGTGGCTCCAGGAGCCTGGT
GTAGACCCTTAGCACCCCGATGTTCCAGTGGGTTGTCCTTCAGGAATCTGGGCTGCTCCTTGGC
ACTCCTCACATCTTGGCATAATGCCTTCCTGGCCACTGGTCACTGTCGTGAAAAGAGAATGCCC
TGGCAAGATGGTTTGCTTGACCCAACCATCCTTCACTACGTGATTTGAGTACCTCACCACAAAC
ATACCACTTTCTCACTCTCTCCAGGGGTGCCACATGGCCAGATGGGCCTTCTCCTCTGTGTTCA
CCATGCTCCCCTAATTAGATTGTACATCGAAGGAGCCAAGGGGCCTGTGGGGCTGATGGGCTGA
CCATCTTGGTCTACTAGTGTCCATGTCTTGGGCCAGTGGACAAGAGCAAAAGGCTGGACCTGCC
AGCAGCACACCCTAGGACGGGGCAGGCTACCCCAGCATAAGGTGTATCTATGACCAAGCTGAAT
CAAGGAATGCTATCCCTGGCTCCCTGGAGAGGTCTAAACATAGTAGGAGAAGGGAGCTTTGTCT
GCTGTGTCCTGTTATCCAAACCTACAGTCAGGAAACTCGTTCTTAGCTCCCCAGGGACATTGGC
TCCCTTAACCATGTCTGCTCTCCTGCCTCCCCTAGACCCAGGAAAGATCCAAGAAAGAGAAGGA
ATTGGGGTATTCAGGTTTATCTGGGTCAGTTCAACATGGCCCTGAAACGGTGAGGTCATGTCTG
CAAAGTGCACTTTTTAAGAACATTTCTTGGTTCTCTAGCCTTAAACACTTGGCCAGTACTGAGT
GTACACAGGCAGTTATCCATAAACACATGTGAGAACCAGGTTGATGACTTCCTTGTGGAACCAG
AAGCAAAGGGAATGACATGCTGGTTTGGCCAACAGAGGTGTGACTGGGCCTGGAGCAGGACTTC
CTGGTGTACGACTCTGCGGCCTCTGTGTACACAGACAAGGCAAAGCAGTGGGGTTCCAGAGTCA
CTCTGCCACCCCTGTTGCCCTACCCTTGAAACATTTCCTCCCTGGAAAATGTACGCTGGCTTCC
AGCAGGGGTGGCCTAGACTTCCTGGACCTTCCAAACTGCAGACAGAGCTGAGCAGGGAGAGCTT
GTCGGCTTGCCAGGTCTGCTAGCACAGGTAGCCCTGGCCCTACAGAGCCCCAGACAGATGAGGC
AGCCCCAGAGTCAGACTTCAGGGGTGATATCATGGGCTGTCACCTTCATGCTGTTTTCAGGGAC
CACCTGTCACAAGCCAGGCCAGTCTCCTTTGTCCTGTGCCAACAGCAATCTCTGACCATCCTCA
AGATGTCCTCCTCCTCAAAGCCTGTTTTTAAAGTTTCCCAAGAGGCTACAGGCACAGTGAACGT
GGCCATAGTCAAAAGTAAATTGAGGGGCTGGGAATTTAGCTCAGTGGTAGAGCGCTTACCTAGG
AAGCGCAAGGCCCTGGGTTCGGTCCCCAGCTCCGAAAAAAAGAACCAAAAAAAAGAAAAAAATT
GACTTTTCCTGGTCCCTACTATCCACCCCGAGATTCAGTACCCTGAACCAGATAGGAGGCTTTT
AGAGGGGCCAAATGTCCCCATTTCACATGCATGCATGTATGTGCATGTATGTGAATGAATGTGT
ATGCGTGTGCGTTTTCATCCAGAGGTCATTATGACGACACCCAGGATGTTTCTGTCCTATTCCT
GTAACTCTTGGCCAATATAATATTTCCTCAGAGGCTCCCTGCCTGTATTTTTCTGAGTTGGCTG
CCTTGGGCCCTCCTGGAGCACCCATATTTCAGAAAATCATCAGAATCTGTCAGACTGGAACAGC
TGACAGATAGGTGCCGTGCTTAGACATCTCACCCATCTGGGCTGGAGAACAAAGGTTCGAGACT
AGGTAAAGCACAAAGCTTTGATTGTGATTGGAGGGCACTGAAATAGAGGGGAATTCATGGCTAA
TAAGGAGGACGTGGGGTATGAAGGAGTGTAAGTTATAGATGTGTCTAAGCATGTTTCTGGAGTA
GAGGCCGTGGTGTCAAGGGCTGATAAAAGGGACATAGCCCTGGATAGCCCAGTTCCCATTGCCA
AGCCCTGCTCCCTGCTCACACCTGGCTTCCTGCTAACAGTGCCCTCTGTCCCTCCCACCTCAGC
TGAAGCCCGACTTTTCAGATGAGCTCTCAGATGAGCTCCAGCATCAGCAGAGGTTTGGGGGCTG
GCCCACCTGTGCAGGCTCTGAGAACCCAGAGTCTCAGCACTGTGTACCTTTCCTCCAGGCAGAG
GCTTAGCTCGCTAGGGTTGCTACAGTAGTTCACCCACTCCCTGCTAGGCAGAGCAAAGTCCTGC
ACAGGAAGCCACGCTGCTTGGGGTCCTAGCATGGAGCAACCCTGAGCTGTCAGGGTTTTGAGCC
CCAATAGCCCAGAGCAGGAAGGAACTGGCCCACCTTACTGGTCAGGTGAACTTAGAGTCCCTGT
GTGTGTTGCATCAGCCAACCTTCAAATGGTGGAATTCACCTGTATCTTAGTCCCTAGAGACCTG
GGAGAAAAATCCTCCCACCCGCCGTGGCAGGGCCTCCATTTTTTGGTAGAGGCCCAGAAAGAGG
CTCTTGAGACTCCAGTTGTCTCAAAATTAAGGGAGCAGTGGAGTGCTAGCTAAGCTCCCAGATC
CAAGCTCCCTAAGATGCCCCGGTCTATCAGCTCTCTAGGCCTTATTTTGGGGAGCCTGGGCCCC
TCTTCCGGTTTGTCCATTTGGCCCCAACTCCAGGATCAAGAGGGAGGTGAAACCAGATTCCTTA
CCTCCTTTTAGGCAATCCCACCTAAAGTAGTCCTGTCTTGGCAGCCTTTCCCGGGAGCTGGCCT
GTCTGTCTTTTCGTCTGCAAAGATGTCTTGCTCCCACAAATATGTATTAGTCCTGGGTCTTTGA
TTCCCCCACCCCAATGTCCAAAGTGTGCCAGGATGTCTCTGTTACCCAGTAGAGGTTCCTGATG
TCATCCATCTGTCCGTCCCTGCATCAGCTGTCCATCTTCCAGAGGTACCTCTCCTCCCTGCTTA
CCCCTCACCAGATGGAGTGACAGCTCTCTGGGGACAGGCAGGGTGGCCGCACTCAGTAACTAAT
CCAAATGGCAAATATTTTGTAACAAAATAGCCCAGAGGTATTTTATCTGTTCAATTCCTAGAGT
TTTAGAGATTTTATTGAACTGTGTCACTTGACCGAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063286401 ⟹ XP_063142471

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	156,283,040 - 156,378,868 (-)	NCBI

RefSeq Acc Id:

XM_063286402 ⟹ XP_063142472

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	156,283,040 - 156,378,868 (-)	NCBI

RefSeq Acc Id:

XM_063286403 ⟹ XP_063142473

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	156,283,040 - 156,378,868 (-)	NCBI

RefSeq Acc Id:

XM_063286404 ⟹ XP_063142474

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	156,283,040 - 156,378,273 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_997500	(Get FASTA)	NCBI Sequence Viewer
	XP_063142471	(Get FASTA)	NCBI Sequence Viewer
	XP_063142472	(Get FASTA)	NCBI Sequence Viewer
	XP_063142473	(Get FASTA)	NCBI Sequence Viewer
	XP_063142474	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAD14305	(Get FASTA)	NCBI Sequence Viewer
	EDM02011	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018902
GenBank Protein	Q76M68	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_997500 ⟸ NM_207617

- UniProtKB:

Q76M68 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLLQAQP
PPGLVPPPSAPLPAPAATAPAATAAQEPLQDHGQLIPATPEPPLQHHGQLLAQPQPAPSSRVQT
PQSPHQHPVAPGAVADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPKNETVLHQFCCPAT
DTEQKPACSDLASQSDGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSP
RAGPLRAASPGQQQPALATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQT
AFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRAPTAESLVAEKALLESCGLLGLPLGRSPSLP
PTFAGSLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETE
AAREPDSGPGSGDEAGSLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQAT
AEPAAVQTEQGDAATQEVSEVPASELMDPPVEDSEAAESGAQSAHEPTVAEAVVEEAVATEAEE
EEEGAGQAGKGAEAEVGDNSEQLSSSSASTKSAKSGSEVSAAASKEALQAVILSLPRYHCENPA
SCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIG
EFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCN
PEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI
YERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQRE
VFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLH
FCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELERQQGTKTLSARSAGAQGDPQSKQGSPTA
KREAMAGEKATESSGEVSIHNRLQTFQHSPKLGVERGAPAPSPPTSPPPPLPPDPQPSPLREQP
PPLPLPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYASSSSDSCGSTPLRGPGSP
VKVIHQPPLPPPPPPYNHPHQFCPPGSLLLRRRYSSGSRSLV

hide sequence

Ensembl Acc Id:

ENSRNOP00000018902 ⟸ ENSRNOT00000018902

Ensembl Acc Id:

ENSRNOP00000067900 ⟸ ENSRNOT00000076318

RefSeq Acc Id:	XP_063142473 ⟸ XM_063286403
- Peptide Label:	isoform X3
- UniProtKB:	F1LPA3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142471 ⟸ XM_063286401
- Peptide Label:	isoform X1
- UniProtKB:	F1LPA3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142472 ⟸ XM_063286402
- Peptide Label:	isoform X2
- UniProtKB:	F1LPA3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142474 ⟸ XM_063286404
- Peptide Label:	isoform X4

Protein Domains

IQ PH SEC7

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q76M68-F1-model_v2	AlphaFold	Q76M68	1-1194	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1593191	AgrOrtholog
BioCyc Gene	G2FUF-43176	BioCyc
Ensembl Genes	ENSRNOG00000014083	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000018902	ENTREZGENE
Gene3D-CATH	1.10.1000.11	UniProtKB/Swiss-Prot
	1.10.220.20	UniProtKB/Swiss-Prot
	2.30.29.30	UniProtKB/Swiss-Prot
InterPro	IQSEC_PH	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	Sec7_C_sf	UniProtKB/Swiss-Prot
	Sec7_dom	UniProtKB/Swiss-Prot
	Sec7_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:404781	UniProtKB/Swiss-Prot
NCBI Gene	404781	ENTREZGENE
PANTHER	GUANYL-NUCLEOTIDE EXCHANGE FACTOR	UniProtKB/Swiss-Prot
	IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 3	UniProtKB/Swiss-Prot
Pfam	IQ_SEC7_PH	UniProtKB/Swiss-Prot
	Sec7	UniProtKB/Swiss-Prot
PhenoGen	Iqsec3	PhenoGen
PROSITE	PS50096	UniProtKB/Swiss-Prot
	SEC7	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000014083	RatGTEx
SMART	Sec7	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF48425	UniProtKB/Swiss-Prot
UniProt	A6ILC8_RAT	UniProtKB/TrEMBL
	F1LPA3	ENTREZGENE, UniProtKB/TrEMBL
	IQEC3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-13	Iqsec3	IQ motif and Sec7 domain ArfGEF 3	Iqsec3	IQ motif and Sec7 domain 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	Iqsec3	IQ motif and Sec7 domain 3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)