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Gene: Ap5z1 (adaptor related protein complex 5 subunit zeta 1) Rattus norvegicus

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Symbol:

Ap5z1 (Ensembl: AABR07035428.2)

Name:

adaptor related protein complex 5 subunit zeta 1

RGD ID:

1593125

Description:

Predicted to be involved in double-strand break repair via homologous recombination and endosomal transport. Predicted to act upstream of or within several processes, including late endosome to Golgi transport; lysosomal protein catabolic process; and vacuole organization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of AP-5 adaptor complex. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia and hereditary spastic paraplegia 48. Orthologous to human AP5Z1 (adaptor related protein complex 5 subunit zeta 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

adaptor-related protein complex 5, zeta 1 subunit; AP-5 complex subunit zeta-1; hypothetical protein LOC641386; KIAA0415

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	17,207,315 - 17,222,975 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	17,207,315 - 17,222,467 (-)	Ensembl				GRCr8
mRatBN7.2	12	12,093,834 - 12,109,043 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	12,093,834 - 12,108,511 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	12,896,069 - 12,910,699 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	13,519,300 - 13,533,930 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	12,550,426 - 12,565,056 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	14,161,998 - 14,175,997 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	12	16,190,603 - 16,204,666 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	12,490,951 - 12,505,621 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	13,876,298 - 13,890,974 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

fundus dystrophy (ISO)

genetic disease (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 48 (ISO,ISS)

High Myopia (ISO)

optic atrophy (ISO)

paraplegia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,4-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

DDE (ISO)

folic acid (ISO)

geraniol (ISO)

ivermectin (ISO)

Licochalcone B (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tetraphene (ISO)

thiram (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome assembly (ISO)

autophagy (ISO)

axon development (ISO)

biological_process (ND)

double-strand break repair via homologous recombination (ISO)

endosomal transport (ISO)

gene expression (ISO)

Golgi organization (ISO)

intracellular protein transport (ISO)

late endosome to Golgi transport (ISO)

lysosomal protein catabolic process (ISO)

lysosome organization (ISO)

Cellular Component

AP-5 adaptor complex (IEA)

cytoplasm (ISO)

lysosome (ISO)

nuclear speck (ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation
5.	A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.	Slabicki M, etal., PLoS Biol. 2010 Jun 29;8(6):e1000408. doi: 10.1371/journal.pbio.1000408.

Additional References at PubMed

PMID:8889548	PMID:15277470	PMID:22022230

Genomics

Comparative Map Data

Ap5z1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	17,207,315 - 17,222,975 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	17,207,315 - 17,222,467 (-)	Ensembl				GRCr8
mRatBN7.2	12	12,093,834 - 12,109,043 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	12,093,834 - 12,108,511 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	12,896,069 - 12,910,699 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	13,519,300 - 13,533,930 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	12,550,426 - 12,565,056 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	14,161,998 - 14,175,997 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	12	16,190,603 - 16,204,666 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	12,490,951 - 12,505,621 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	13,876,298 - 13,890,974 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

AP5Z1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	4,775,623 - 4,794,397 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	4,775,615 - 4,794,397 (+)	Ensembl			hg38	GRCh38
GRCh37	7	4,815,254 - 4,834,028 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	4,781,790 - 4,797,925 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	4,774,915 - 4,791,050 (+)	NCBI		Celera
Cytogenetic Map	7	p22.1	NCBI
HuRef	7	4,732,073 - 4,750,836 (+)	NCBI		HuRef
CHM1_1	7	4,815,007 - 4,833,771 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	4,892,837 - 4,911,604 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	4,861,617 - 4,880,381 (+)	NCBI

Ap5z1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	142,448,960 - 142,464,471 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	142,449,699 - 142,464,465 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	142,463,207 - 142,478,716 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	142,463,944 - 142,478,710 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	142,939,885 - 142,954,669 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	142,716,405 - 142,731,189 (+)	NCBI		MGSCv36	mm8
MGSCv36	5	141,388,952 - 141,403,736 (+)	NCBI		MGSCv36	mm8
Celera	5	139,518,977 - 139,533,398 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	81.53	NCBI

Ap5z1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	10,996,796 - 11,009,525 (-)	Ensembl
ChiLan1.0	NW_004955460	10,997,554 - 11,009,435 (-)	NCBI	ChiLan1.0	ChiLan1.0

AP5Z1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	9,741,028 - 9,757,768 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	58,066,193 - 58,082,473 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	5,027,987 - 5,044,215 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	5,068,846 - 5,085,087 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	5,068,846 - 5,085,087 (+)	Ensembl			panPan2	panpan1.1

AP5Z1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	12,847,699 - 12,858,769 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	12,847,713 - 12,858,681 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	14,318,559 - 14,329,556 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	12,984,045 - 12,995,047 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	12,984,048 - 12,994,608 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	12,794,723 - 12,805,737 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	12,727,748 - 12,738,752 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	13,003,941 - 13,014,944 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ap5z1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	141,121,273 - 141,132,243 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936765	1,111,882 - 1,123,316 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936765	1,112,333 - 1,123,244 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AP5Z1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	3,622,699 - 3,642,412 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	3,622,684 - 3,642,370 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	4,271,069 - 4,289,843 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AP5Z1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	16,852,314 - 16,868,408 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	16,851,998 - 16,868,395 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666090	5,051,852 - 5,068,163 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ap5z1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	28,509,230 - 28,527,519 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	28,509,979 - 28,527,813 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ap5z1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	10,666,678 - 10,679,894 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ap5z1
444 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

AW520453

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	17,223,671 - 17,223,882 (+)	Marker Load Pipeline
mRatBN7.2	12	12,110,191 - 12,110,402 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	14,177,678 - 14,177,888	NCBI	Rnor6.0
Rnor_5.0	12	16,206,283 - 16,206,493	UniSTS	Rnor5.0
RGSC_v3.4	12	12,507,302 - 12,507,512	UniSTS	RGSC3.4
Celera	12	13,892,655 - 13,892,865	UniSTS
RH 3.4 Map	12	164.2	UniSTS
Cytogenetic Map	12	p11	UniSTS

AI463295

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	12,110,372 - 12,110,502 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	14,177,859 - 14,177,988	NCBI	Rnor6.0
Rnor_5.0	12	16,206,464 - 16,206,593	UniSTS	Rnor5.0
RGSC_v3.4	12	12,507,483 - 12,507,612	UniSTS	RGSC3.4
Celera	12	13,892,836 - 13,892,965	UniSTS
Cytogenetic Map	12	p11	UniSTS

RH135250

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	12,097,711 - 12,097,895 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	14,165,876 - 14,166,059	NCBI	Rnor6.0
Rnor_5.0	12	16,194,481 - 16,194,664	UniSTS	Rnor5.0
RGSC_v3.4	12	12,494,823 - 12,495,006	UniSTS	RGSC3.4
Celera	12	13,880,176 - 13,880,359	UniSTS
Cytogenetic Map	12	p11	UniSTS

RH140098

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	12,093,935 - 12,094,139 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	14,162,100 - 14,162,303	NCBI	Rnor6.0
Rnor_5.0	12	16,190,705 - 16,190,908	UniSTS	Rnor5.0
RGSC_v3.4	12	12,491,047 - 12,491,250	UniSTS	RGSC3.4
Celera	12	13,876,400 - 13,876,603	UniSTS
RH 3.4 Map	12	162.6	UniSTS
Cytogenetic Map	12	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
7	1	18	50	67	138	95	11	49	36	32	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AI704812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI707081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AW251939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF285208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB745877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB745985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB804272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CF978310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK840769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR465116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV779741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ131235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000087860 ⟹ ENSRNOP00000070678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	17,207,315 - 17,221,991 (-)	Ensembl
mRatBN7.2 Ensembl	12	12,093,834 - 12,108,511 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000142375 ⟹ ENSRNOP00000108019

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	17,207,315 - 17,222,467 (-)	Ensembl

RefSeq Acc Id:

NM_001037220 ⟹ NP_001032297

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	17,207,315 - 17,221,991 (-)	NCBI
mRatBN7.2	12	12,093,834 - 12,108,511 (-)	NCBI
Rnor_6.0	12	14,161,998 - 14,175,997 (-)	NCBI
Rnor_5.0	12	16,190,603 - 16,204,666 (-)	NCBI
RGSC_v3.4	12	12,490,951 - 12,505,621 (-)	RGD
Celera	12	13,876,298 - 13,890,974 (-)	NCBI

Sequence:

show sequence

CGGAAGCCCGCGACAACATTTCGGTCGCCGGTGGGCTTGGGGCTGTGGCGGCATGTTCTCGGCG
GGCGCGGAGAGTCTGCTGCACCAGGCCAGGGAGATCCAGGATGAGGAGTTGCAGCGCTTCTGCT
CCAGGGTCACTAAGCTGCTGCAGGAAGCCCCAGGGCCGGCCACTGTGGATGCCTTACAGAGACT
CTTCCTCATAGTCTCATCCACCAAGTATCCCCGGAGGCTGGAGAAAGCGTGTGTGGACCTGTTG
CAGACCACTCTCTGCTTGCCCACAAGCCCTGAGCAGCTGCAGGTCCTTTGTGCTGCTATCTTGA
GAGAGATGTCGCCTTTTAATGACCTGACCCTGTCCTGTGATCACACCCAAAACACCCCGCAGCT
TAGCCTTGTGGCCTCTGTGCTCTTGGCCCAGGGAGACAGGAACGGAGAAATCAGACAAGTGAGC
CAACGCATCTTCAAGATCCTGGAGAACCGGCAGCCTGAGGGGCCCAGTGTCAGGCCCCTCCTCC
CCGTCCTGTCCAAGGTCATTGGCCTTGCCCCAGGCATCCTCGTGGAAGACCAGACCAACCTGCT
CAGCAAAAGGCTGGTAGACTGGCTCCGCTACGCCAGCATCCAGCAAGGGCTTCCGTATTCAGGG
GGCTTCTTTTCTACGCCCAGGACCCGGCAGCCAGGTCCCATCACCGAGGTGGATGGAGCAGTGG
CTTCTGACTTCTTCACGGTACTCTCCACGGGCCAGCACTTCACAGAGGACCAGTGGGTGAACAT
GCAGGCCTTCTCCATGCTGAGGAAATGGTTGCTGCACAGCGGCCCCGAGGACCCTGGCAGCCCA
GATGCAGATGACAAGTCAGAGCTGGAGGGCTCTATGCTGTCTGTGCTCTCCGCGGCCTCCACTG
CGAGCCGACTGCTGCCCCCTCGGGAGCGGCTGAGGGAGGTGGCCTTTGAATACTGCCAGCGCCT
GTTGGAGCAGAGTAACCGGAGAGCGCTGAGGAAGGGGGACTCGGACCTACAGAAAGCCTGCCTG
GTGGAAGCTGTGTTGGTGCTAGATGTGCTGTGCCGGCAGGACCCCTCCTTCCTTTATCGTACCC
TCTCCTGCCTGAAGCCACTGCACAGGAGGCTGGGCGAAGACCCTGGCAGCGAGCGGGCTCTGGT
GCCTCTTGCCCAGTTCTTCCTGAACCACGGGGAGGCGGCCGCCATGGATGCAGAAGCCATCTAC
GCACAGCTGCTAGGCAGTCTCCCTTCTGAGCGCTTCCACAGCCCGACTCTGGCCTTCGAGGTCA
TACACTTCTGCACGCACAACCTGGCTCTGTTCGACCCCCACTTTCTCAGCCTTCTCCGGCTGAG
CTTCCCAAATCTATTCAAGTTCCTGGCTTGGAACAGCCCTCCGCTCACAGCCGAGTTTGTGGTA
CTCCTCCCTGCTCTCGTGGATGCTGGAACTGCTGTGGAGATGTTGCATGCCCTGCTTGACCTGC
CCTGTCTGACTGCTGCCCTGGACCTACAGCTCAGGTCCACACAGACCCCGTCGGAAAGGCCGCT
TTGGGATGTCTCCCTCAGGGTCCCTAGCTGCCTGGAGGCCTTCCAGGACCCACAGTTCCAAGGA
CTCTTCCGGCACCTGCTTCGCACCAAGGCCAGCGGCTCCACCGAGAGACTGACGCCACTTCATC
AGGTGCTGAAGCCCATGGCCAGCTGTGCCCGGGTAGCCCAGTGTGTGGAGGCAATTCCTGTCTT
GCTCCANGCTTTCTTCTCAGCTGTGACCCAGACTGCCGACGGGCCCCTCATCAACCAGCTGGCA
CTGCTGCTCCTGGAGAGAAGTGACTCCCTCTACCCAGTCCCTCAGTATGAGGCCCGTGTGCACA
GGGTGCTGAGCTCCCAGCTCCTGGTGCTGTGTAAGCTGAAACCATCACTGGTGGTGGAACTGTC
CCGAGAGCTTCTGGAGTTCGTGGGGAGCGTGAGCAGCATCCGCAGCCGAGCCAGCATGTTCACC
TGTGTGGTGTGGGCCATTGGTGAGTATCTGTCGGTGACCTGCGACAAGAGGTGCACAGCAGAGC
AGATCAACAAGTTCTTTGAAGCCCTGGAAGCCCTGCTGTTTGAAGTCACCCAGTCCCGCCCCTC
AGCCGACTTGCCCTGCTGTCCCCCAGAGCTGGTCACTGCACTCATGACCACATTGACCAAGCTA
GCCTCCCGGAGCCAAGACCTGATCCCAAGGGTGTCACTGTTCCTGTCAAAAATGCGGACCCTGG
CCCAGAACCCAGCCACCAGCTCTATGCACAGTGAGGAGGATACAGAATCCATCCGGATCCGGGC
TACAGAGCTGCTAACCCTACTGAAGATGCCCAGTGTGGCCCAGTTTGTGTTCACACCCACCGTG
GGCGTGTGCCAGCCCCGCTACCACCAAGACACCAACGTGGCCCTGCCTCTGGCTCTGCGTACGG
TCAGCCGACTGGTGGAGAAGGAGGCTGGCCTCTTGCCAGGTTGAAGGGACAGTCACCACCTAAA
CAGTGGCTTCAGCTGAAGAGCCTGGGCAGTCGATGATAATAGAGCTCAGCTGCAGGCTCAGGTA
GCTCGTGAGGAGCAGGAGGGAGGCGGACATGGCTGTGAGGTTGGGGTCACCAGCCCCTGGGTAT
GAGTCATCCCTCCTTGTCTCTGTGGCTGGCTGTAGTCAGCCTTGACAGCTGATAAGTGACTGAG
TGTTAACTTCCTAGGCCGAGCACAAATGGCCTGGTCTGCTTCTGCTGTTACTCATTTCTGAACT
TGGGGGCAGGGAGCAGTGTAGGAAAAATAAACTGTAAAAAATGATGTATGCTGGGCAATGGGGG
CACATGCCTTTCATCCCAGTACTCAGGAGAAACAGAGACAGGCAGATCTGAGTTTGAGGCCAGC
CTGGTTTACAGAGTGAGCTCCATGACAGCCAGGGTTACACAGAGAATCCCTGTCTCAAAAAATT
AAAAAGAAAAAAGAAAAAAAAAAGAAAGAATTACTTAATATTTATGTGTAGGTGTTTGCACACA
CCACAGCGCACACGGGGAAATCAGGAGACAACTTCGGTGATCAGTTCTCTCCTTCAGCCATGTG
GGTCCTGGCTGATTGCCTGACTCAGTGACAAGTGCCTTTACTTACAGAGCCATTTTACCTGCCC
CCAAGTAAACTTTCCAATGCTGTGTACAGCCCAGACCTCTGCCTTCCTCAGGCTGGGAGATCAC
CAGGGAGCCTGACCATGGTCTGCTGCCCTTCCCACACTGCCCTCTGTGGAGGGGGGTCCCTGGG
TCTCCTGTTTGCTTCCTGTGTTCTTGATGTGACAGAAATAACATGCTCTGGAGCTGAAGCTTTG
CCACTAAGCCCTACATTTAATCCCCAGTGTAACATGGTGATGCATACTGTAATCCCAGAAGGTA
GAGGCAGGAAGGTCAGAAGTTCAAGGTCAGCCTAGGCTACAGAAGAAATTGGGCTGGGAAGACT
TCTCAGCACATAAAAGCCCTTGCCCTGATGACACAGGGTTGTCCCCTAGATCACATGTGTGAAG
CCACAGACCATGGTGTGTGTGTGCACCTGTGGAGACAGCATCAAAGCTCAAAGGCTTGCTAGAG
CAGTGGAAGGACGAAATGGAAGGCAAGAACTAACTCTCAACGCATGCTGTGCCTTGGTCACACG
AGACATTTTAATCTAAATAAAGCTCAAGGTGTATTCATGAGGG

hide sequence

RefSeq Acc Id:

XM_039089719 ⟹ XP_038945647

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	17,207,321 - 17,219,676 (-)	NCBI
mRatBN7.2	12	12,093,837 - 12,108,497 (-)	NCBI

RefSeq Acc Id:

XM_039089720 ⟹ XP_038945648

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	17,207,321 - 17,221,369 (-)	NCBI
mRatBN7.2	12	12,093,837 - 12,107,889 (-)	NCBI

RefSeq Acc Id:

XR_005491669

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	17,209,199 - 17,222,975 (-)	NCBI
mRatBN7.2	12	12,095,718 - 12,109,043 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001032297	(Get FASTA)	NCBI Sequence Viewer
	XP_038945647	(Get FASTA)	NCBI Sequence Viewer
	XP_038945648	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070678
	ENSRNOP00000070678.2
	ENSRNOP00000108019.1

RefSeq Acc Id:

NP_001032297 ⟸ NM_001037220

- UniProtKB:

A0A0G2JYJ5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFSAGAESLLHQAREIQDEELQRFCSRVTKLLQEAPGPATVDALQRLFLIVSSTKYPRRLEKAC
VDLLQTTLCLPTSPEQLQVLCAAILREMSPFNDLTLSCDHTQNTPQLSLVASVLLAQGDRNGEI
RQVSQRIFKILENRQPEGPSVRPLLPVLSKVIGLAPGILVEDQTNLLSKRLVDWLRYASIQQGL
PYSGGFFSTPRTRQPGPITEVDGAVASDFFTVLSTGQHFTEDQWVNMQAFSMLRKWLLHSGPED
PGSPDADDKSELEGSMLSVLSAASTASRLLPPRERLREVAFEYCQRLLEQSNRRALRKGDSDLQ
KACLVEAVLVLDVLCRQDPSFLYRTLSCLKPLHRRLGEDPGSERALVPLAQFFLNHGEAAAMDA
EAIYAQLLGSLPSERFHSPTLAFEVIHFCTHNLALFDPHFLSLLRLSFPNLFKFLAWNSPPLTA
EFVVLLPALVDAGTAVEMLHALLDLPCLTAALDLQLRSTQTPSERPLWDVSLRVPSCLEAFQDP
QFQGLFRHLLRTKASGSTERLTPLHQVLKPMASCARVAQCVEAIPVLLXAFFSAVTQTADGPLI
NQLALLLLERSDSLYPVPQYEARVHRVLSSQLLVLCKLKPSLVVELSRELLEFVGSVSSIRSRA
SMFTCVVWAIGEYLSVTCDKRCTAEQINKFFEALEALLFEVTQSRPSADLPCCPPELVTALMTT
LTKLASRSQDLIPRVSLFLSKMRTLAQNPATSSMHSEEDTESIRIRATELLTLLKMPSVAQFVF
TPTVGVCQPRYHQDTNVALPLALRTVSRLVEKEAGLLPG

hide sequence

RefSeq Acc Id:	XP_038945647 ⟸ XM_039089719
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038945648 ⟸ XM_039089720
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000070678 ⟸ ENSRNOT00000087860

Ensembl Acc Id:

ENSRNOP00000108019 ⟸ ENSRNOT00000142375

Protein Domains

AP-5 complex subunit zeta-1 ARM repeats AP-5 complex subunit zeta-1 C-terminal TPR AP-5 complex subunit zeta-1 N-terminal TPR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JYJ5-F1-model_v2	AlphaFold	A0A0G2JYJ5	1-545	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1593125	AgrOrtholog
BioCyc Gene	G2FUF-19968	BioCyc
Ensembl Genes	ENSRNOG00000056768	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000087860	ENTREZGENE
	ENSRNOT00000087860.3	UniProtKB/TrEMBL
	ENSRNOT00000142375.1	UniProtKB/TrEMBL
Gene3D-CATH	Leucine-rich Repeat Variant	UniProtKB/TrEMBL
InterPro	AP5Z1	UniProtKB/TrEMBL
	AP5Z1_ARM	UniProtKB/TrEMBL
	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	TPR_AP5Z1_C	UniProtKB/TrEMBL
	TPR_AP5Z1_N	UniProtKB/TrEMBL
NCBI Gene	641386	ENTREZGENE
PANTHER	AP-5 COMPLEX SUBUNIT ZETA-1	UniProtKB/TrEMBL
	PTHR46488	UniProtKB/TrEMBL
Pfam	SPG48	UniProtKB/TrEMBL
	TPR_AP5Z1	UniProtKB/TrEMBL
	TPR_AP5Z1_C	UniProtKB/TrEMBL
PhenoGen	Ap5z1	PhenoGen
RatGTEx	ENSRNOG00000056768	RatGTEx
Superfamily-SCOP	SSF48371	UniProtKB/TrEMBL
UniProt	A0A0G2JYJ5	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LWU2_RAT	UniProtKB/TrEMBL
	A6K1Q4_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-03	Ap5z1	adaptor related protein complex 5 subunit zeta 1	Ap5z1	adaptor-related protein complex 5, zeta 1 subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-01	Ap5z1	adaptor-related protein complex 5, zeta 1 subunit	Kiaa0415	KIAA0415 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	Kiaa0415	KIAA0415 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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