Igsf7 (immunoglobulin superfamily, member 7) - Rat Genome Database

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Gene: Igsf7 (immunoglobulin superfamily, member 7) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Igsf7 (Ensembl: Igsf7l1)
Name: immunoglobulin superfamily, member 7 (Ensembl:immunoglobulin superfamily, member 7 like 1)
RGD ID: 1592119
Description: Predicted to be involved in immune system process. Predicted to be located in plasma membrane; INTERACTS WITH 3,4-methylenedioxymethamphetamine; amphetamine; methylmercury chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CMRF-35-like molecule 4; CMRF35-like molecule; Mair-II
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810100,652,768 - 100,660,499 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10100,655,705 - 100,682,549 (+)EnsemblGRCr8
mRatBN7.210100,153,767 - 100,161,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,156,238 - 100,182,647 (+)EnsemblmRatBN7.2
Rnor_6.010104,975,782 - 104,980,853 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010103,304,960 - 103,309,914 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1098,737,897 - 98,741,144 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12874256  


Genomics

Variants

.
Variants in Igsf7
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000073646
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 15 41 67 131 92 11 35 32 32 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000074003   ⟹   ENSRNOP00000065726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,177,948 - 100,182,644 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083683   ⟹   ENSRNOP00000072284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,156,753 - 100,182,647 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085222   ⟹   ENSRNOP00000074560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,156,753 - 100,161,442 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105421   ⟹   ENSRNOP00000092746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,156,238 - 100,161,442 (+)Ensembl
RefSeq Acc Id: XM_006247739   ⟹   XP_006247801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,655,542 - 100,660,499 (+)NCBI
mRatBN7.210100,156,536 - 100,161,589 (+)NCBI
Rnor_6.010104,975,782 - 104,980,853 (+)NCBI
Rnor_5.010103,304,960 - 103,309,914 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087794   ⟹   XP_038943722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,652,768 - 100,660,499 (+)NCBI
mRatBN7.210100,153,767 - 100,161,540 (+)NCBI
RefSeq Acc Id: XM_039087795   ⟹   XP_038943723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,655,541 - 100,660,499 (+)NCBI
mRatBN7.210100,156,531 - 100,161,589 (+)NCBI
RefSeq Acc Id: XM_340957   ⟹   XP_340958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,655,539 - 100,660,499 (+)NCBI
mRatBN7.210100,156,526 - 100,161,589 (+)NCBI
Rnor_6.010104,975,782 - 104,980,853 (+)NCBI
Rnor_5.010103,304,960 - 103,309,914 (-)NCBI
Sequence:
RefSeq Acc Id: XP_340958   ⟸   XM_340957
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006247801   ⟸   XM_006247739
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038943722   ⟸   XM_039087794
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K8D0 (UniProtKB/TrEMBL),   A0A0G2K2K9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943723   ⟸   XM_039087795
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000065726   ⟸   ENSRNOT00000074003
Ensembl Acc Id: ENSRNOP00000072284   ⟸   ENSRNOT00000083683
Ensembl Acc Id: ENSRNOP00000074560   ⟸   ENSRNOT00000085222
Ensembl Acc Id: ENSRNOP00000092746   ⟸   ENSRNOT00000105421
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8D0-F1-model_v2 AlphaFold A0A0G2K8D0 1-213 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592119 AgrOrtholog
BioCyc Gene G2FUF-22713 BioCyc
Ensembl Genes ENSRNOG00000046216 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000050974 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077158.3 UniProtKB/TrEMBL
  ENSRNOT00000083683.3 UniProtKB/TrEMBL
  ENSRNOT00000085222.3 UniProtKB/TrEMBL
  ENSRNOT00000085850 ENTREZGENE
  ENSRNOT00000085850.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CD300_family_receptors UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
NCBI Gene 287813 ENTREZGENE
PANTHER POLYMERIC-IMMUNOGLOBULIN RECEPTOR UniProtKB/TrEMBL
  PROTEIN CD300H UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Igsf7 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046216 RatGTEx
  ENSRNOG00000050974 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K2K9 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K5H9_RAT UniProtKB/TrEMBL
  A0A0G2K8D0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDH3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-11-20 Igsf7  immunoglobulin superfamily, member 7      Symbol and Name status set to provisional 70820 PROVISIONAL