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Gene: Sh3bgrl2 (SH3 domain binding glutamate-rich protein like 2) Rattus norvegicus

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Symbol:

Sh3bgrl2

Name:

SH3 domain binding glutamate-rich protein like 2

RGD ID:

1591931

Description:

Predicted to enable SH3 domain binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human SH3BGRL2 (SH3 domain binding glutamate rich protein like 2); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; benzo[a]pyrene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC102554622; LOC501026; SH3 domain binding glutamic acid-rich protein like 2; SH3 domain-binding glutamic acid-rich-like protein 2; SH3 domain-binding glutamic acid-rich-like protein 2-like; similar to SH3 domain binding glutamic acid-rich protein like 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	93,341,104 - 93,433,143 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	93,341,149 - 93,433,143 (+)	Ensembl				GRCr8
mRatBN7.2	8	84,461,019 - 84,553,124 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	84,461,121 - 84,551,564 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	90,072,458 - 90,164,419 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	88,294,734 - 88,386,622 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	86,164,659 - 86,256,652 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	91,069,925 - 91,162,537 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	91,070,073 - 91,160,258 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	90,589,261 - 90,681,749 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	88,608,712 - 88,700,719 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	84,117,164 - 84,208,916 (+)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

juvenile rheumatoid arthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

benzene (ISO)

benzo[a]pyrene (EXP,ISO)

Benzo[k]fluoranthene (ISO)

benzoates (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diethylstilbestrol (ISO)

diuron (EXP)

ethanol (ISO)

fenofibrate (ISO)

indole-3-methanol (EXP)

inulin (ISO)

leflunomide (ISO)

manganese(II) chloride (EXP)

methoxychlor (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nitrates (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

nucleoplasm (ISO)

nucleus (IBA,IEA)

Molecular Function

protein binding (ISO)

protein-macromolecule adaptor activity (IBA)

SH3 domain binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:23376485

Genomics

Comparative Map Data

Sh3bgrl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	93,341,104 - 93,433,143 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	93,341,149 - 93,433,143 (+)	Ensembl				GRCr8
mRatBN7.2	8	84,461,019 - 84,553,124 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	84,461,121 - 84,551,564 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	90,072,458 - 90,164,419 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	88,294,734 - 88,386,622 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	86,164,659 - 86,256,652 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	91,069,925 - 91,162,537 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	91,070,073 - 91,160,258 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	90,589,261 - 90,681,749 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	88,608,712 - 88,700,719 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	84,117,164 - 84,208,916 (+)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

SH3BGRL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	79,537,633 - 79,703,655 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	79,537,185 - 79,703,655 (+)	Ensembl			hg38	GRCh38
GRCh37	6	80,247,350 - 80,413,372 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	80,397,719 - 80,470,088 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	80,397,718 - 80,470,088	NCBI
Celera	6	80,756,102 - 80,828,496 (+)	NCBI		Celera
Cytogenetic Map	6	q14.1	NCBI
HuRef	6	77,561,602 - 77,633,903 (+)	NCBI		HuRef
CHM1_1	6	80,438,515 - 80,510,892 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	80,743,141 - 80,909,216 (+)	NCBI		T2T-CHM13v2.0

Sh3bgrl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	83,430,391 - 83,482,345 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	83,430,380 - 83,520,854 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	83,548,338 - 83,600,292 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	83,548,327 - 83,638,801 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	83,441,945 - 83,493,899 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	83,344,974 - 83,397,010 (+)	NCBI		MGSCv36	mm8
Celera	9	80,637,109 - 80,689,836 (+)	NCBI		Celera
Cytogenetic Map	9	E2	NCBI
cM Map	9	45.49	NCBI

Sh3bgrl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955502	7,517,461 - 7,575,951 (+)	Ensembl
ChiLan1.0	NW_004955502	7,517,466 - 7,575,560 (+)	NCBI	ChiLan1.0	ChiLan1.0

SH3BGRL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	99,623,023 - 99,789,036 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	97,502,301 - 97,668,304 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	77,303,334 - 77,584,938 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	80,760,201 - 80,854,236 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	80,782,103 - 80,850,087 (+)	Ensembl			panPan2	panpan1.1

SH3BGRL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	40,579,997 - 40,656,376 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	40,597,149 - 40,654,005 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	40,452,836 - 40,530,468 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	41,343,158 - 41,421,585 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	41,360,146 - 41,421,585 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	40,664,309 - 40,742,633 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	40,650,980 - 40,717,492 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	40,799,225 - 40,860,262 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

SH3BGRL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	86,358,483 - 86,481,776 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	86,416,281 - 86,481,805 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	97,115,948 - 97,200,580 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SH3BGRL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	4,342,588 - 4,416,054 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	4,363,387 - 4,413,063 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	180,591,523 - 180,660,979 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sh3bgrl2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	77,686,012 - 77,738,024 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sh3bgrl2
763 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	166
Count of miRNA genes:	130
Interacting mature miRNAs:	134
Transcripts:	ENSRNOT00000012904
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

D8Arb13

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	84,531,276 - 84,531,599 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	91,140,233 - 91,140,553	NCBI	Rnor6.0
Rnor_5.0	8	90,659,569 - 90,659,889	UniSTS	Rnor5.0
RGSC_v3.4	8	88,679,073 - 88,679,394	RGD	RGSC3.4
RGSC_v3.4	8	88,679,074 - 88,679,394	UniSTS	RGSC3.4
Celera	8	84,187,239 - 84,187,559	UniSTS
RGSC_v3.1	8	88,698,529 - 88,698,849	RGD
RH 3.4 Map	8	970.5	UniSTS
RH 3.4 Map	8	970.5	RGD
RH 2.0 Map	8	774.9	RGD
SHRSP x BN Map	8	48.8	RGD
FHH x ACI Map	8	59.1299	RGD
Cytogenetic Map	8	q31	UniSTS

D8Got132

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	93,347,742 - 93,347,967 (+)	Marker Load Pipeline
mRatBN7.2	8	84,467,716 - 84,467,941 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	91,076,519 - 91,076,749	NCBI	Rnor6.0
Rnor_5.0	8	90,595,855 - 90,596,085	UniSTS	Rnor5.0
RGSC_v3.4	8	88,615,305 - 88,615,536	RGD	RGSC3.4
RGSC_v3.4	8	88,615,306 - 88,615,536	UniSTS	RGSC3.4
Celera	8	84,123,756 - 84,123,986	UniSTS
RGSC_v3.1	8	88,634,761 - 88,634,991	RGD
RH 3.4 Map	8	974.7	RGD
RH 3.4 Map	8	974.7	UniSTS
RH 2.0 Map	8	772.4	RGD
Cytogenetic Map	8	q31	UniSTS

RH130635

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	84,514,439 - 84,514,636 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	91,123,421 - 91,123,617	NCBI	Rnor6.0
Rnor_5.0	8	90,642,757 - 90,642,953	UniSTS	Rnor5.0
RGSC_v3.4	8	88,661,946 - 88,662,142	UniSTS	RGSC3.4
Celera	8	84,170,269 - 84,170,465	UniSTS
RH 3.4 Map	8	976.8	UniSTS
Cytogenetic Map	8	q31	UniSTS

RH132007

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	84,480,496 - 84,480,714 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	91,089,305 - 91,089,522	NCBI	Rnor6.0
Rnor_5.0	8	90,608,641 - 90,608,858	UniSTS	Rnor5.0
RGSC_v3.4	8	88,628,092 - 88,628,309	UniSTS	RGSC3.4
Celera	8	84,136,327 - 84,136,544	UniSTS
RH 3.4 Map	8	976.2	UniSTS
Cytogenetic Map	8	q31	UniSTS

RH134543

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	84,513,121 - 84,513,310 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	91,122,103 - 91,122,291	NCBI	Rnor6.0
Rnor_5.0	8	90,641,439 - 90,641,627	UniSTS	Rnor5.0
RGSC_v3.4	8	88,660,628 - 88,660,816	UniSTS	RGSC3.4
Celera	8	84,168,951 - 84,169,139	UniSTS
RH 3.4 Map	8	976.2	UniSTS
Cytogenetic Map	8	q31	UniSTS

RH126548

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	84,513,462 - 84,513,647 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	91,122,444 - 91,122,628	NCBI	Rnor6.0
Rnor_5.0	8	90,641,780 - 90,641,964	UniSTS	Rnor5.0
RGSC_v3.4	8	88,660,969 - 88,661,153	UniSTS	RGSC3.4
Celera	8	84,169,292 - 84,169,476	UniSTS
Cytogenetic Map	8	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	67	165	91	90	59	92	59	6	355	191	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001137647	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001389250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001389251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010054016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012904 ⟹ ENSRNOP00000012904

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	91,070,073 - 91,160,258 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084852 ⟹ ENSRNOP00000074616

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	93,341,149 - 93,430,382 (+)	Ensembl
mRatBN7.2 Ensembl	8	84,461,121 - 84,550,363 (+)	Ensembl
Rnor_6.0 Ensembl	8	91,099,491 - 91,115,366 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095246 ⟹ ENSRNOP00000087955

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	93,341,149 - 93,408,519 (+)	Ensembl
mRatBN7.2 Ensembl	8	84,461,121 - 84,551,564 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096648 ⟹ ENSRNOP00000088668

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	93,341,149 - 93,433,143 (+)	Ensembl
mRatBN7.2 Ensembl	8	84,461,121 - 84,551,564 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000125535 ⟹ ENSRNOP00000109142

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	93,341,149 - 93,408,742 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000156765 ⟹ ENSRNOP00000109586

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	93,341,188 - 93,394,786 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000165238 ⟹ ENSRNOP00000102151

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	93,341,149 - 93,423,313 (+)	Ensembl

RefSeq Acc Id:

NM_001389250 ⟹ NP_001376179

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	93,341,149 - 93,394,814 (+)	NCBI
mRatBN7.2	8	84,461,121 - 84,514,789 (+)	NCBI

RefSeq Acc Id:

NM_001389251 ⟹ NP_001376180

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	93,341,149 - 93,433,143 (+)	NCBI
mRatBN7.2	8	84,461,121 - 84,553,124 (+)	NCBI

RefSeq Acc Id:

XM_039081966 ⟹ XP_038937894

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	93,341,104 - 93,394,814 (+)	NCBI
mRatBN7.2	8	84,461,069 - 84,514,789 (+)	NCBI

RefSeq Acc Id:

XR_010054016

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	93,341,115 - 93,394,814 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001376179	(Get FASTA)	NCBI Sequence Viewer
	NP_001376180	(Get FASTA)	NCBI Sequence Viewer
	XP_038937894	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL77661	(Get FASTA)	NCBI Sequence Viewer
	EDL77662	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074616.2
	ENSRNOP00000087955.2
	ENSRNOP00000088668
	ENSRNOP00000088668.1
	ENSRNOP00000102151.1
	ENSRNOP00000109142.1
	ENSRNOP00000109586
	ENSRNOP00000109586.1

Ensembl Acc Id:

ENSRNOP00000074616 ⟸ ENSRNOT00000084852

Ensembl Acc Id:

ENSRNOP00000012904 ⟸ ENSRNOT00000012904

RefSeq Acc Id:	XP_038937894 ⟸ XM_039081966
- Peptide Label:	isoform X1

RefSeq Acc Id:	NP_001376180 ⟸ NM_001389251
- Peptide Label:	isoform 2
- UniProtKB:	A0A8I6GGG5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001376179 ⟸ NM_001389250
- Peptide Label:	isoform 1
- UniProtKB:	A0A0G2K8I0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000088668 ⟸ ENSRNOT00000096648

Ensembl Acc Id:

ENSRNOP00000087955 ⟸ ENSRNOT00000095246

Ensembl Acc Id:

ENSRNOP00000109586 ⟸ ENSRNOT00000156765

Ensembl Acc Id:

ENSRNOP00000109142 ⟸ ENSRNOT00000125535

Ensembl Acc Id:

ENSRNOP00000102151 ⟸ ENSRNOT00000165238

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K8I0-F1-model_v2	AlphaFold	A0A0G2K8I0	1-92	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1591931	AgrOrtholog
BioCyc Gene	G2FUF-29689	BioCyc
Ensembl Genes	ENSRNOG00000009613	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000068670	Ensembl
Ensembl Transcript	ENSRNOT00000084852.3	UniProtKB/TrEMBL
	ENSRNOT00000095246.2	UniProtKB/TrEMBL
	ENSRNOT00000096648	ENTREZGENE
	ENSRNOT00000096648.2	UniProtKB/TrEMBL
	ENSRNOT00000125535.1	UniProtKB/TrEMBL
	ENSRNOT00000156765	ENTREZGENE
	ENSRNOT00000156765.1	UniProtKB/TrEMBL
	ENSRNOT00000165238.1	UniProtKB/TrEMBL
Gene3D-CATH	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Glut_rich_SH3-bd	UniProtKB/TrEMBL
	SH3BGR	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
NCBI Gene	501026	ENTREZGENE
PANTHER	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN	UniProtKB/TrEMBL
	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2	UniProtKB/TrEMBL
Pfam	SH3BGR	UniProtKB/TrEMBL
PhenoGen	Sh3bgrl2	PhenoGen
PIRSF	SH3-bind_E-rich_L	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009613	RatGTEx
	ENSRNOG00000068670	RatGTEx
Superfamily-SCOP	SSF52833	UniProtKB/TrEMBL
UniProt	A0A0G2K8I0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GGG5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GGK0_RAT	UniProtKB/TrEMBL
	A0ABK0LD27_RAT	UniProtKB/TrEMBL
	A0ABK0LU28_RAT	UniProtKB/TrEMBL
	A0ABK0LV52_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Sh3bgrl2	SH3 domain binding glutamate-rich protein like 2	LOC102554622	SH3 domain-binding glutamic acid-rich-like protein 2-like	Data merged from RGD:7633245	737654	PROVISIONAL
2014-03-13	Sh3bgrl2	SH3 domain binding glutamate-rich protein like 2	Sh3bgrl2	SH3 domain binding glutamic acid-rich protein like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-12-18	LOC102554622	SH3 domain-binding glutamic acid-rich-like protein 2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-05	Sh3bgrl2	SH3 domain binding glutamic acid-rich protein like 2	LOC501026	similar to SH3 domain binding glutamic acid-rich protein like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC501026	similar to SH3 domain binding glutamic acid-rich protein like 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD