Cmtm7 (CKLF-like MARVEL transmembrane domain containing 7) - Rat Genome Database

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Gene: Cmtm7 (CKLF-like MARVEL transmembrane domain containing 7) Rattus norvegicus
Analyze
Symbol: Cmtm7
Name: CKLF-like MARVEL transmembrane domain containing 7
RGD ID: 1591926
Description: Predicted to act upstream of or within B-1a B cell differentiation. Predicted to be located in membrane. Orthologous to human CMTM7 (CKLF like MARVEL transmembrane domain containing 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chemokine-like factor super family 7; CKLF-like MARVEL transmembrane domain-containing protein 7; Cklfsf7; LOC501065; similar to chemokine-like factor super family 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88123,326,233 - 123,353,148 (-)NCBIGRCr8
mRatBN7.28114,448,037 - 114,474,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,448,042 - 114,474,621 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8120,065,256 - 120,092,224 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08118,264,493 - 118,291,459 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08116,107,340 - 116,134,310 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08122,814,563 - 122,841,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,812,459 - 122,841,477 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08122,126,648 - 122,153,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48119,175,165 - 119,202,081 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8113,694,951 - 113,721,844 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888   PMID:24080084  


Genomics

Comparative Map Data
Cmtm7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88123,326,233 - 123,353,148 (-)NCBIGRCr8
mRatBN7.28114,448,037 - 114,474,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,448,042 - 114,474,621 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8120,065,256 - 120,092,224 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08118,264,493 - 118,291,459 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08116,107,340 - 116,134,310 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08122,814,563 - 122,841,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,812,459 - 122,841,477 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08122,126,648 - 122,153,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48119,175,165 - 119,202,081 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8113,694,951 - 113,721,844 (-)NCBICelera
Cytogenetic Map8q32NCBI
CMTM7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38332,391,853 - 32,455,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl332,391,698 - 32,483,067 (+)EnsemblGRCh38hg38GRCh38
GRCh37332,433,345 - 32,497,020 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36332,408,167 - 32,471,337 (+)NCBINCBI36Build 36hg18NCBI36
Build 34332,408,166 - 32,471,337NCBI
Celera332,370,594 - 32,433,419 (+)NCBICelera
Cytogenetic Map3p22.3NCBI
HuRef332,368,696 - 32,431,820 (+)NCBIHuRef
CHM1_1332,383,146 - 32,446,330 (+)NCBICHM1_1
T2T-CHM13v2.0332,388,830 - 32,452,466 (+)NCBIT2T-CHM13v2.0
Cmtm7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399114,585,904 - 114,611,061 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9114,585,904 - 114,610,924 (-)EnsemblGRCm39 Ensembl
GRCm389114,756,836 - 114,781,993 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9114,756,836 - 114,781,856 (-)EnsemblGRCm38mm10GRCm38
MGSCv379114,665,954 - 114,690,947 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369114,605,534 - 114,630,527 (-)NCBIMGSCv36mm8
Celera9115,232,130 - 115,257,424 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map965.13NCBI
Cmtm7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543023,752,919 - 23,807,141 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543023,752,910 - 23,803,754 (+)NCBIChiLan1.0ChiLan1.0
CMTM7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2232,366,245 - 32,432,252 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1332,373,547 - 32,437,019 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0332,308,975 - 32,372,711 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1332,624,258 - 32,687,245 (+)NCBIpanpan1.1PanPan1.1panPan2
CMTM7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12312,317,636 - 12,382,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2312,328,303 - 12,382,837 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2312,292,218 - 12,357,621 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02312,608,527 - 12,674,013 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2312,619,421 - 12,674,012 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12312,409,876 - 12,475,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02312,551,996 - 12,617,616 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02312,557,185 - 12,630,035 (-)NCBIUU_Cfam_GSD_1.0
Cmtm7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118189,798,491 - 189,808,681 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647322,937,056 - 22,947,381 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647322,932,965 - 22,947,309 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CMTM7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1318,412,215 - 18,424,122 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11318,371,327 - 18,424,132 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21320,399,737 - 20,411,233 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CMTM7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11576,896,216 - 76,960,117 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604150,250,298 - 50,314,312 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cmtm7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478810,477,355 - 10,523,596 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478810,477,476 - 10,523,506 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cmtm7
195 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:69
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000014861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
1599689Iddm24Insulin dependent diabetes mellitus QTL 244.720.001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)8112834440118649220Rat

Markers in Region
RH129264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28114,448,123 - 114,448,305 (+)MAPPERmRatBN7.2
Rnor_6.08122,814,650 - 122,814,831NCBIRnor6.0
Rnor_5.08122,126,735 - 122,126,916UniSTSRnor5.0
RGSC_v3.48119,175,252 - 119,175,433UniSTSRGSC3.4
Celera8113,695,038 - 113,695,219UniSTS
Cytogenetic Map8q32UniSTS
RH129273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28114,448,098 - 114,448,260 (+)MAPPERmRatBN7.2
Rnor_6.08122,814,625 - 122,814,786NCBIRnor6.0
Rnor_5.08122,126,710 - 122,126,871UniSTSRnor5.0
RGSC_v3.48119,175,227 - 119,175,388UniSTSRGSC3.4
Celera8113,695,013 - 113,695,174UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 12 14 6 18 6 8 18 32 3
Low 1 31 43 35 1 35 8 11 66 17 9 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000014861   ⟹   ENSRNOP00000014861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8122,812,459 - 122,841,477 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095439   ⟹   ENSRNOP00000094536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8114,448,042 - 114,456,861 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107716   ⟹   ENSRNOP00000085390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8114,448,046 - 114,474,621 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110225   ⟹   ENSRNOP00000087278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8114,448,046 - 114,474,464 (-)Ensembl
RefSeq Acc Id: NM_001109300   ⟹   NP_001102770
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88123,326,233 - 123,353,148 (-)NCBI
mRatBN7.28114,448,037 - 114,474,958 (-)NCBI
Rnor_6.08122,814,563 - 122,841,479 (-)NCBI
Rnor_5.08122,126,648 - 122,153,564 (-)NCBI
RGSC_v3.48119,175,165 - 119,202,081 (-)RGD
Celera8113,694,951 - 113,721,844 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266011   ⟹   XP_063122081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88123,326,960 - 123,352,874 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102770 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122081 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76979 (Get FASTA)   NCBI Sequence Viewer  
  EDL76980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085390
  ENSRNOP00000085390.1
  ENSRNOP00000087278.1
  ENSRNOP00000094536.1
RefSeq Acc Id: NP_001102770   ⟸   NM_001109300
- UniProtKB: A6I3P7 (UniProtKB/TrEMBL),   A0A8I6A023 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014861   ⟸   ENSRNOT00000014861
RefSeq Acc Id: ENSRNOP00000085390   ⟸   ENSRNOT00000107716
RefSeq Acc Id: ENSRNOP00000087278   ⟸   ENSRNOT00000110225
RefSeq Acc Id: ENSRNOP00000094536   ⟸   ENSRNOT00000095439
RefSeq Acc Id: XP_063122081   ⟸   XM_063266011
- Peptide Label: isoform X1
Protein Domains
MARVEL

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A768-F1-model_v2 AlphaFold D4A768 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696356
Promoter ID:EPDNEW_R6881
Type:initiation region
Name:Cmtm7_1
Description:CKLF-like MARVEL transmembrane domain containing 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08122,841,003 - 122,841,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591926 AgrOrtholog
BioCyc Gene G2FUF-28911 BioCyc
Ensembl Genes ENSRNOG00000010986 Ensembl
  ENSRNOG00000067317 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095439.1 UniProtKB/TrEMBL
  ENSRNOT00000107716 ENTREZGENE
  ENSRNOT00000107716.1 UniProtKB/TrEMBL
  ENSRNOT00000110225.1 UniProtKB/TrEMBL
InterPro Marvel UniProtKB/TrEMBL
KEGG Report rno:501065 UniProtKB/TrEMBL
NCBI Gene 501065 ENTREZGENE
PANTHER CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 7 UniProtKB/TrEMBL
  MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN UniProtKB/TrEMBL
Pfam MARVEL UniProtKB/TrEMBL
PhenoGen Cmtm7 PhenoGen
PROSITE MARVEL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010986 RatGTEx
  ENSRNOG00000067317 RatGTEx
UniProt A0A8I6A023 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7G4_RAT UniProtKB/TrEMBL
  A0A8I6ANH0_RAT UniProtKB/TrEMBL
  A6I3P7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Cmtm7  CKLF-like MARVEL transmembrane domain containing 7  LOC501065  similar to chemokine-like factor super family 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC501065  similar to chemokine-like factor super family 7      Symbol and Name status set to provisional 70820 PROVISIONAL