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Gene: Smim12 (small integral membrane protein 12) Rattus norvegicus

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Symbol:

Smim12

Name:

small integral membrane protein 12

RGD ID:

1591379

Description:

Predicted to be located in mitochondrion. Orthologous to human SMIM12 (small integral membrane protein 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical protein LOC685634; LOC685634

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SMIM12 (small integral membrane protein 12)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Smim12 (small integral membrane protein 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Smim12 (small integral membrane protein 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SMIM12 (small integral membrane protein 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SMIM12 (small integral membrane protein 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Smim12 (small integral membrane protein 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SMIM12 (small integral membrane protein 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SMIM12 (small integral membrane protein 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Smim12 (small integral membrane protein 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	KLHL25 (kelch like family member 25)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SMIM12 (small integral membrane protein 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Smim12 (small integral membrane protein 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	smim12 (small integral membrane protein 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG34228	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	smim12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Related Pseudogenes:

Smim12-ps1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	144,853,887 - 144,857,746 (+)	NCBI		GRCr8
mRatBN7.2	5	139,569,367 - 139,573,276 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	139,569,391 - 139,574,320 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	142,264,872 - 142,268,683 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	144,034,870 - 144,038,681 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	144,035,643 - 144,039,454 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	145,311,317 - 145,315,185 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	145,311,375 - 145,315,185 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	149,080,643 - 149,084,601 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	146,692,300 - 146,696,110 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	138,063,425 - 138,067,235 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smim12	Rat	Charcot-Marie-Tooth disease dominant intermediate C		ISO	SMIM12 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate C	ClinVar	PMID:28492532

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smim12	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	Smim12 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SMIM12 mRNA	CTD	PMID:36331819
Smim12	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	Smim12 (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SMIM12 mRNA	CTD	PMID:22206623
Smim12	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Smim12 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of SMIM12 mRNA	CTD	PMID:24680724
Smim12	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of SMIM12 mRNA	CTD	PMID:33387578
Smim12	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of SMIM12 mRNA	CTD	PMID:36041667
Smim12	Rat	arsenite(3-)	multiple interactions	ISO	SMIM12 (Homo sapiens)	6480464	arsenite promotes the reaction [G3BP1 protein binds to SMIM12 mRNA]	CTD	PMID:32406909
Smim12	Rat	benzo[a]pyrene	increases methylation	ISO	SMIM12 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of SMIM12 promoter	CTD	PMID:27901495
Smim12	Rat	beta-lapachone	increases expression	ISO	SMIM12 (Homo sapiens)	6480464	beta-lapachone results in increased expression of SMIM12 mRNA	CTD	PMID:38218311
Smim12	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of SMIM12 mRNA	CTD	PMID:25181051
Smim12	Rat	bisphenol A	increases expression	ISO	Smim12 (Mus musculus)	6480464	bisphenol A results in increased expression of SMIM12 mRNA	CTD	PMID:32156529
Smim12	Rat	bisphenol A	decreases expression	ISO	Smim12 (Mus musculus)	6480464	bisphenol A results in decreased expression of SMIM12 mRNA	CTD	PMID:35598803
Smim12	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of SMIM12 mRNA	CTD	PMID:36041667
Smim12	Rat	bisphenol A	multiple interactions	ISO	SMIM12 (Homo sapiens)	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of SMIM12 gene	CTD	PMID:31601247
Smim12	Rat	bisphenol A	decreases expression	ISO	SMIM12 (Homo sapiens)	6480464	bisphenol A results in decreased expression of SMIM12 mRNA	CTD	PMID:29275510
Smim12	Rat	bisphenol F	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of SMIM12 mRNA	CTD	PMID:36041667
Smim12	Rat	chlorpyrifos	increases expression	ISO	Smim12 (Mus musculus)	6480464	Chlorpyrifos results in increased expression of SMIM12 mRNA	CTD	PMID:37019170
Smim12	Rat	copper(II) sulfate	decreases expression	ISO	SMIM12 (Homo sapiens)	6480464	Copper Sulfate results in decreased expression of SMIM12 mRNA	CTD	PMID:19549813
Smim12	Rat	cypermethrin	increases expression	ISO	Smim12 (Mus musculus)	6480464	cypermethrin results in increased expression of SMIM12 mRNA	CTD	PMID:29020013
Smim12	Rat	dexamethasone	increases expression	ISO	SMIM12 (Homo sapiens)	6480464	Dexamethasone results in increased expression of SMIM12 mRNA	CTD	PMID:25047013
Smim12	Rat	Dibutyl phosphate	affects expression	ISO	SMIM12 (Homo sapiens)	6480464	di-n-butylphosphoric acid affects the expression of SMIM12 mRNA	CTD	PMID:37042841
Smim12	Rat	ethanol	affects expression	ISO	Smim12 (Mus musculus)	6480464	Ethanol affects the expression of SMIM12 mRNA	CTD	PMID:30319688
Smim12	Rat	fenthion	increases expression	ISO	Smim12 (Mus musculus)	6480464	Fenthion results in increased expression of SMIM12 mRNA	CTD	PMID:34813904
Smim12	Rat	folic acid	multiple interactions	ISO	Smim12 (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SMIM12 mRNA	CTD	PMID:22206623
Smim12	Rat	fulvestrant	multiple interactions	ISO	SMIM12 (Homo sapiens)	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of SMIM12 gene	CTD	PMID:31601247
Smim12	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of SMIM12 mRNA	CTD	PMID:33387578
Smim12	Rat	lead(0)	affects expression	ISO	SMIM12 (Homo sapiens)	6480464	Lead affects the expression of SMIM12 mRNA	CTD	PMID:28903495
Smim12	Rat	methidathion	increases expression	ISO	Smim12 (Mus musculus)	6480464	methidathion results in increased expression of SMIM12 mRNA	CTD	PMID:34813904
Smim12	Rat	methotrexate	decreases expression	ISO	SMIM12 (Homo sapiens)	6480464	Methotrexate results in decreased expression of SMIM12 mRNA	CTD	PMID:24449571
Smim12	Rat	methyl methanesulfonate	decreases expression	ISO	SMIM12 (Homo sapiens)	6480464	Methyl Methanesulfonate results in decreased expression of SMIM12 mRNA	CTD	PMID:23649840
Smim12	Rat	nitrates	multiple interactions	ISO	Smim12 (Mus musculus)	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of SMIM12 mRNA	CTD	PMID:35964746
Smim12	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	Smim12 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SMIM12 mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of SMIM12 mRNA	CTD	PMID:36331819
Smim12	Rat	silver atom	decreases expression	ISO	SMIM12 (Homo sapiens)	6480464	Silver results in decreased expression of SMIM12 mRNA	CTD	PMID:26014281
Smim12	Rat	silver(0)	decreases expression	ISO	SMIM12 (Homo sapiens)	6480464	Silver results in decreased expression of SMIM12 mRNA	CTD	PMID:26014281
Smim12	Rat	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of SMIM12 mRNA	CTD	PMID:33387578
Smim12	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of SMIM12 mRNA	CTD	PMID:34492290
Smim12	Rat	thiram	decreases expression	ISO	SMIM12 (Homo sapiens)	6480464	Thiram results in decreased expression of SMIM12 mRNA	CTD	PMID:38568856
Smim12	Rat	trichloroethene	decreases expression	EXP		6480464	Trichloroethylene results in decreased expression of SMIM12 mRNA	CTD	PMID:33387578
Smim12	Rat	valproic acid	increases expression	ISO	SMIM12 (Homo sapiens)	6480464	Valproic Acid results in increased expression of SMIM12 mRNA	CTD	PMID:23179753
Smim12	Rat	valproic acid	affects expression	ISO	SMIM12 (Homo sapiens)	6480464	Valproic Acid affects the expression of SMIM12 mRNA	CTD	PMID:25979313
Smim12	Rat	vinclozolin	decreases expression	EXP		6480464	vinclozolin results in decreased expression of SMIM12 mRNA	CTD	PMID:23034163

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smim12	Rat	membrane	located_in	IEA	UniProtKB-SubCell:SL-0162	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Smim12	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Smim12	Rat	mitochondrion	located_in	ISO	SMIM12 (Homo sapiens)	9068941	PMID:34800366	FlyBase	PMID:34800366

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smim12	Rat	protein binding	enables	ISO	SMIM12 (Homo sapiens)	1624291	UniProtKB:O75400-2 more ...	RGD	PMID:32814053

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:15326124	PMID:34800366

Smim12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	144,853,887 - 144,857,746 (+)	NCBI		GRCr8
mRatBN7.2	5	139,569,367 - 139,573,276 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	139,569,391 - 139,574,320 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	142,264,872 - 142,268,683 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	144,034,870 - 144,038,681 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	144,035,643 - 144,039,454 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	145,311,317 - 145,315,185 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	145,311,375 - 145,315,185 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	149,080,643 - 149,084,601 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	146,692,300 - 146,696,110 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	138,063,425 - 138,067,235 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

SMIM12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	34,850,362 - 34,859,749 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	34,712,737 - 34,859,755 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	35,315,963 - 35,325,350 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	35,091,711 - 35,097,934 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	33,589,547 - 33,599,002 (-)	NCBI		Celera
Cytogenetic Map	1	p34.3	NCBI
HuRef	1	33,433,527 - 33,442,967 (-)	NCBI		HuRef
CHM1_1	1	35,431,467 - 35,440,901 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	34,712,985 - 34,722,442 (-)	NCBI		T2T-CHM13v2.0

Smim12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	127,137,577 - 127,141,602 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	127,137,577 - 127,141,602 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	127,243,784 - 127,247,809 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	127,243,784 - 127,247,809 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	126,921,028 - 126,925,053 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	126,746,145 - 126,750,113 (+)	NCBI		MGSCv36	mm8
Celera	4	125,578,251 - 125,582,269 (+)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	61.41	NCBI

Smim12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	12,972,797 - 12,976,962 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	12,972,797 - 12,976,963 (-)	NCBI	ChiLan1.0	ChiLan1.0

SMIM12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	191,986,403 - 191,991,175 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	191,107,515 - 191,113,869 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	34,121,669 - 34,126,465 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1 Ensembl	1	35,303,890 - 35,304,168 (-)	Ensembl	panpan1.1		panPan2

SMIM12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	7,121,532 - 7,126,450 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	7,121,189 - 7,126,450 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	7,360,099 - 7,364,782 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	7,266,656 - 7,271,543 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	7,270,619 - 7,271,543 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	7,129,342 - 7,134,017 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	7,177,167 - 7,182,038 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	7,191,291 - 7,196,173 (+)	NCBI		UU_Cfam_GSD_1.0

Smim12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	51,662,093 - 51,667,022 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	17,486,894 - 17,487,982 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	17,486,883 - 17,491,222 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SMIM12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	91,109,698 - 91,109,976 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	91,109,044 - 91,113,686 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SMIM12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	98,028,144 - 98,032,620 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	98,028,144 - 98,032,290 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666256	42,915 - 47,683 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Smim12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	17,894,153 - 17,897,758 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	17,894,154 - 17,897,796 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Smim12
14 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	64
Count of miRNA genes:	60
Interacting mature miRNAs:	64
Transcripts:	ENSRNOT00000019224
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1300122	Wbc1	White blood cell count QTL 1	2.75		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	5	125392826	139989768	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	94858972	143070159	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	129132447	151006154	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	129132428	143070159	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	120740824	143608494	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	120740824	151018848	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001276483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006238907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BP485002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DV214253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019224 ⟹ ENSRNOP00000019224

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	139,569,993 - 139,573,277 (+)	Ensembl
Rnor_6.0 Ensembl	5	145,311,375 - 145,315,185 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094142 ⟹ ENSRNOP00000096325

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	139,569,391 - 139,574,320 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101473 ⟹ ENSRNOP00000084740

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	139,570,636 - 139,573,277 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102125 ⟹ ENSRNOP00000087108

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	139,570,636 - 139,573,277 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102383 ⟹ ENSRNOP00000081715

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	139,569,391 - 139,574,320 (+)	Ensembl

RefSeq Acc Id:

NM_001276483 ⟹ NP_001263412

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	144,853,936 - 144,857,746 (+)	NCBI
mRatBN7.2	5	139,569,464 - 139,573,274 (+)	NCBI
Rnor_6.0	5	145,311,375 - 145,315,185 (+)	NCBI
Rnor_5.0	5	149,080,643 - 149,084,601 (+)	NCBI
Celera	5	138,063,425 - 138,067,235 (+)	NCBI

Sequence:

show sequence

GGGAACCCCGACGTTCGTGTTGCTCCCGGCTAGCGGGCGCAGCGCGGGGCCGGTCCGGGTTGTTCGGGCTGGGCCGCAGATGTCATGTGGCCTGTGCTTTGGACCGTGGTGCGTACCTATGCCCCCTA
TGTCACCTTCCCTGTGGCCTTTGTGGTCGGGGCTGTGGGCTACCACCTGGAATGGTTCATCAGGGGAAAGGATCCCCAGCCTGTGGAGGAGGAGAAGAGTATCTTGGAGCGCCGAGAGGACCGAAAGC
TGGATGAGATGCTAGGCAAGGACCACACTCAGGTGGTGAGCCTTAAGGACAAGCTAGAATTTGCCCCTAAGGCAGTCCTGAACAGAAACCGCCCAGAGAAGAATTGATGGAGGGCCCAGGTCCCTGTG
GTGCACAGGGAGATGCCATGTCCTGCCTCCACACCACCCAGCTTCAGAACATGCATCTGATTTGCTTTGCTGCTCACTCCGGCCCCTGTGCACTCACAGCCACACCTGTACTGCCTGGTCCTTTATGG
CTGTACACCTGCCGTAGTAGGGGCCAGCAAAGAGGAAGACGCATCTGCTCAGCGGGCTCTCTCCATGGCTGGGCAGGCTGCTGATCTTTCCTGGGAGCACTGCAGGGAGGAGCCCTGGGGCATGAACC
CTGGTCTCAGGCTCCCTGGGGAAGGGCTTGGCCTCAGCTGGGAATGATTGGGGTTTATCATTGCCATTAGGAGGGACACCTCCAGGTCAACTAGTCTTTGCACTGGAAAAATTTCAGAAATGCCCCTG
GCTCCCTTGATGAGCTTCTCTTATTTTTCTGTGCACATCCTTCCCTGTGTTGGCTCAGGCATGGGATTCTCAGGGGAAGGAAGGCATGTTTCTACTGTGGGGAGCGAGGTTGGTTACCTCAGGGCCGA
TGGGGCTTAGCCTGGAAGCAATCACTGTCTTCCACCCTTCCTCACTGTGGTGAGGACTCAATTAAAGTGGCACCTGGCACACGTT

hide sequence

RefSeq Acc Id:

XM_006238907 ⟹ XP_006238969

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	144,853,887 - 144,857,746 (+)	NCBI
mRatBN7.2	5	139,569,367 - 139,573,276 (+)	NCBI
Rnor_6.0	5	145,311,317 - 145,315,185 (+)	NCBI
Rnor_5.0	5	149,080,643 - 149,084,601 (+)	NCBI

Sequence:

show sequence

CCCCGAGAGAGCCTGGACGCTAGTAGGCGGGGCCTTGGGCGGCGCCCCGCGGGCTACTGGGAACCCCGACGTTCGTGTTGCTCCCGGCTAGCGGGCGCAGCGCGGGGCCGGTCCGGGTTGTTCGGGCT
GGGCCGCAGAGTATTTCGGGGACCCAACTGTTGCACAAAGCACAGTGGCTGCTTGCTGCTCTGCGGGGTGGCTGCTCAATTATTAGGTGCCAGGCTGCCTGATGTCATGTGGCCTGTGCTTTGGACCG
TGGTGCGTACCTATGCCCCCTATGTCACCTTCCCTGTGGCCTTTGTGGTCGGGGCTGTGGGCTACCACCTGGAATGGTTCATCAGGGGAAAGGATCCCCAGCCTGTGGAGGAGGAGAAGAGTATCTTG
GAGCGCCGAGAGGACCGAAAGCTGGATGAGATGCTAGGCAAGGACCACACTCAGGTGGTGAGCCTTAAGGACAAGCTAGAATTTGCCCCTAAGGCAGTCCTGAACAGAAACCGCCCAGAGAAGAATTG
ATGGAGGGCCCAGGTCCCTGTGGTGCACAGGGAGATGCCATGTCCTGCCTCCACACCACCCAGCTTCAGAACATGCATCTGATTTGCTTTGCTGCTCACTCCGGCCCCTGTGCACTCACAGCCACACC
TGTACTGCCTGGTCCTTTATGGCTGTACACCTGCCGTAGTAGGGGCCAGCAAAGAGGAAGACGCATCTGCTCAGCGGGCTCTCTCCATGGCTGGGCAGGCTGCTGATCTTTCCTGGGAGCACTGCAGG
GAGGAGCCCTGGGGCATGAACCCTGGTCTCAGGCTCCCTGGGGAAGGGCTTGGCCTCAGCTGGGAATGATTGGGGTTTATCATTGCCATTAGGAGGGACACCTCCAGGTCAACTAGTCTTTGCACTGG
AAAAATTTCAGAAATGCCCCTGGCTCCCTTGATGAGCTTCTCTTATTTTTCTGTGCACATCCTTCCCTGTGTTGGCTCAGGCATGGGATTCTCAGGGGAAGGAAGGCATGTTTCTACTGTGGGGAGCG
AGGTTGGTTACCTCAGGGCCGATGGGGCTTAGCCTGGAAGCAATCACTGTCTTCCACCCTTCCTCACTGTGGTGAGGACTCAATTAAAGTGGCACCTGGCACACGTT

hide sequence


Protein RefSeqs	NP_001263412	(Get FASTA)	NCBI Sequence Viewer
	XP_006238969	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D4ACP2	(Get FASTA)	NCBI Sequence Viewer
	EDL80479	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019224
	ENSRNOP00000019224.2
	ENSRNOP00000081715.1
	ENSRNOP00000084740
	ENSRNOP00000084740.1
	ENSRNOP00000087108.1
	ENSRNOP00000096325.1

RefSeq Acc Id:	NP_001263412 ⟸ NM_001276483
- UniProtKB:	D4ACP2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MWPVLWTVVRTYAPYVTFPVAFVVGAVGYHLEWFIRGKDPQPVEEEKSILERREDRKLDEMLGKDHTQVVSLKDKLEFAPKAVLNRNRPEKN hide sequence

RefSeq Acc Id:	XP_006238969 ⟸ XM_006238907
- Peptide Label:	isoform X1
- UniProtKB:	D4ACP2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MWPVLWTVVRTYAPYVTFPVAFVVGAVGYHLEWFIRGKDPQPVEEEKSILERREDRKLDEMLGKDHTQVVSLKDKLEFAPKAVLNRNRPEKN hide sequence

Ensembl Acc Id:

ENSRNOP00000019224 ⟸ ENSRNOT00000019224

Ensembl Acc Id:

ENSRNOP00000087108 ⟸ ENSRNOT00000102125

Ensembl Acc Id:

ENSRNOP00000081715 ⟸ ENSRNOT00000102383

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ACP2-F1-model_v2	AlphaFold	D4ACP2	1-92	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13694048

Promoter ID:

EPDNEW_R4573

Type:

initiation region

Name:

Smim12_1

Description:

small integral membrane protein 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	145,311,367 - 145,311,427	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-39856	BioCyc
Ensembl Genes	ENSRNOG00000014352	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000019224	ENTREZGENE
	ENSRNOT00000019224.6	UniProtKB/Swiss-Prot
	ENSRNOT00000094142.1	UniProtKB/Swiss-Prot
	ENSRNOT00000101473	ENTREZGENE
	ENSRNOT00000101473.1	UniProtKB/Swiss-Prot
	ENSRNOT00000102125.1	UniProtKB/Swiss-Prot
	ENSRNOT00000102383.1	UniProtKB/Swiss-Prot
InterPro	UPF0767	UniProtKB/Swiss-Prot
KEGG Report	rno:685634	UniProtKB/Swiss-Prot
NCBI Gene	685634	ENTREZGENE
PANTHER	PTHR28599	UniProtKB/Swiss-Prot
	SMALL INTEGRAL MEMBRANE PROTEIN 12	UniProtKB/Swiss-Prot
Pfam	UPF0767	UniProtKB/Swiss-Prot
PhenoGen	Smim12	PhenoGen
RatGTEx	ENSRNOG00000014352	RatGTEx
UniProt	D4ACP2	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-12-18	Smim12	small integral membrane protein 12	LOC685634	hypothetical protein LOC685634	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC685634	hypothetical protein LOC685634	LOC681972	hypothetical protein LOC681972	Data merged from RGD:1589307	1643240	APPROVED
2006-11-20	LOC685634	hypothetical protein LOC685634			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC681972	hypothetical protein LOC681972			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - ClinVar