Tha1 (threonine aldolase 1) - Rat Genome Database

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Gene: Tha1 (threonine aldolase 1) Rattus norvegicus
Analyze
Symbol: Tha1
Name: threonine aldolase 1
RGD ID: 1591140
Description: Predicted to enable L-allo-threonine aldolase activity. Predicted to be involved in L-threonine catabolic process and glycine biosynthetic process. Predicted to be active in cytosol. Orthologous to human THA1P (threonine aldolase 1, pseudogene); INTERACTS WITH eugenol; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC688286; probable low-specificity L-threonine aldolase 1; probable low-specificity L-threonine aldolase 2; similar to threonine aldolase 1; uncharacterized protein Tha1
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,593,363 - 103,598,851 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10103,593,098 - 103,604,792 (-)EnsemblGRCr8
mRatBN7.210103,094,681 - 103,100,169 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,094,681 - 103,100,519 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd10106,737,205 - 106,742,636 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive10107,465,250 - 107,470,681 (-)NCBILyon_Normotensive
Lyon_Hypertensive10108,906,810 - 108,912,253 (-)NCBILyon_Hypertensive
F344_StmMcwi10109,026,408 - 109,031,839 (-)NCBIF344_StmMcwi
Rnor_6.010106,877,585 - 106,883,706 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,878,085 - 106,883,423 (-)Ensemblrn6Rnor6.0
Rnor_5.010106,516,263 - 106,521,770 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera10101,654,626 - 101,660,806 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline

Genomics

Comparative Map Data
Tha1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,593,363 - 103,598,851 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10103,593,098 - 103,604,792 (-)EnsemblGRCr8
mRatBN7.210103,094,681 - 103,100,169 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,094,681 - 103,100,519 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd10106,737,205 - 106,742,636 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive10107,465,250 - 107,470,681 (-)NCBILyon_Normotensive
Lyon_Hypertensive10108,906,810 - 108,912,253 (-)NCBILyon_Hypertensive
F344_StmMcwi10109,026,408 - 109,031,839 (-)NCBIF344_StmMcwi
Rnor_6.010106,877,585 - 106,883,706 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,878,085 - 106,883,423 (-)Ensemblrn6Rnor6.0
Rnor_5.010106,516,263 - 106,521,770 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera10101,654,626 - 101,660,806 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
THA1P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,248,590 - 78,256,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,248,493 - 78,254,416 (-)Ensemblhg38GRCh38
GRCh371776,244,671 - 76,252,266 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,756,169 - 73,762,092 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1772,840,698 - 72,848,293 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,668,791 - 71,676,394 (-)NCBIHuRef
CHM1_11776,309,208 - 76,316,803 (-)NCBICHM1_1
T2T-CHM13v2.01779,142,679 - 79,150,294 (-)NCBIT2T-CHM13v2.0
Tha1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,758,775 - 117,764,352 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,758,778 - 117,764,307 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811117,867,949 - 117,873,526 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,867,952 - 117,873,481 (-)Ensemblmm10GRCm38
MGSCv3711117,729,263 - 117,734,840 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611117,684,041 - 117,689,571 (-)NCBIMGSCv36mm8
Celera11129,613,184 - 129,618,761 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI

Variants

.
Variants in Tha1
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:55
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000071406
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 90 59 6 354 190 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071406   ⟹   ENSRNOP00000065022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,593,098 - 103,599,201 (-)Ensembl
mRatBN7.2 Ensembl10103,094,681 - 103,100,519 (-)Ensembl
Rnor_6.0 Ensembl10106,878,085 - 106,883,423 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094579   ⟹   ENSRNOP00000095538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,593,369 - 103,604,792 (-)Ensembl
mRatBN7.2 Ensembl10103,094,681 - 103,100,156 (-)Ensembl
RefSeq Acc Id: NM_001430275   ⟹   NP_001417204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Dahl_SR_JrHsd10106,737,205 - 106,742,636 (-)NCBI
Lyon_Normotensive10107,465,250 - 107,470,681 (-)NCBI
Lyon_Hypertensive10108,906,810 - 108,912,253 (-)NCBI
F344_StmMcwi10109,026,408 - 109,031,839 (-)NCBI
RefSeq Acc Id: XM_006247853   ⟹   XP_006247915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,593,363 - 103,598,808 (-)NCBI
mRatBN7.210103,094,681 - 103,099,983 (-)NCBI
Rnor_6.010106,877,585 - 106,882,835 (-)NCBI
Rnor_5.010106,516,263 - 106,521,770 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247854   ⟹   XP_006247916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,593,363 - 103,598,851 (-)NCBI
mRatBN7.210103,094,681 - 103,100,169 (-)NCBI
Rnor_6.010106,877,585 - 106,883,706 (-)NCBI
Rnor_5.010106,516,263 - 106,521,770 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087505   ⟹   XP_038943433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,593,363 - 103,598,841 (-)NCBI
mRatBN7.210103,094,681 - 103,100,014 (-)NCBI
RefSeq Acc Id: XM_039087506   ⟹   XP_038943434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,593,363 - 103,598,687 (-)NCBI
mRatBN7.210103,094,681 - 103,100,014 (-)NCBI
RefSeq Acc Id: XP_006247916   ⟸   XM_006247854
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006247915   ⟸   XM_006247853
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000065022   ⟸   ENSRNOT00000071406
RefSeq Acc Id: XP_038943434   ⟸   XM_039087506
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038943433   ⟸   XM_039087505
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000095538   ⟸   ENSRNOT00000094579
RefSeq Acc Id: NP_001417204   ⟸   NM_001430275
Protein Domains
Aromatic amino acid beta-eliminating lyase/threonine

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R6H1-F1-model_v2 AlphaFold M0R6H1 1-399 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591140 AgrOrtholog
BioCyc Gene G2FUF-22532 BioCyc
Ensembl Genes ENSRNOG00000045615 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071406.4 UniProtKB/TrEMBL
  ENSRNOT00000094579 ENTREZGENE
  ENSRNOT00000094579.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro ArAA_b-elim_lyase/Thr_aldolase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub1 UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub2 UniProtKB/TrEMBL
  Threonine_aldolase UniProtKB/TrEMBL
NCBI Gene 688286 ENTREZGENE
PANTHER L-THREONINE ALDOLASE-RELATED UniProtKB/TrEMBL
  PTHR48097:SF9 UniProtKB/TrEMBL
Pfam Beta_elim_lyase UniProtKB/TrEMBL
PhenoGen Tha1 PhenoGen
PIRSF Thr_aldolase UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045615 RatGTEx
Superfamily-SCOP PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
UniProt A0A8I6GL69 ENTREZGENE, UniProtKB/TrEMBL
  A6HL38 ENTREZGENE, UniProtKB/TrEMBL
  M0R6H1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-09-30 Tha1  threonine aldolase 1  LOC688286  similar to threonine aldolase 1  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC688286  similar to threonine aldolase 1      Symbol and Name status set to provisional 70820 PROVISIONAL