Zar1l (zygote arrest 1-like) - Rat Genome Database

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Gene: Zar1l (zygote arrest 1-like) Rattus norvegicus
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Symbol: Zar1l
Name: zygote arrest 1-like
RGD ID: 1591034
Description: Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in negative regulation of translation; oocyte maturation; and translation. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cytoplasm. Orthologous to human ZAR1L (zygote arrest 1 like); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07034923.1; LOC689594; similar to Zygote arrest 1 (Oocyte-specific maternal effect factor)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,882,162 - 4,892,064 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl124,881,161 - 4,892,214 (-)EnsemblGRCr8
mRatBN7.21246,534 - 56,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,534 - 56,425 (-)EnsemblmRatBN7.2
Rnor_6.012491,043 - 500,372 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12491,007 - 499,601 (-)NCBIrn6Rnor6.0
RGSC_v3.4124,323,628 - 4,337,022 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera121,756,183 - 1,766,124 (-)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20014101  


Genomics

Comparative Map Data
Zar1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,882,162 - 4,892,064 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl124,881,161 - 4,892,214 (-)EnsemblGRCr8
mRatBN7.21246,534 - 56,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,534 - 56,425 (-)EnsemblmRatBN7.2
Rnor_6.012491,043 - 500,372 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12491,007 - 499,601 (-)NCBIrn6Rnor6.0
RGSC_v3.4124,323,628 - 4,337,022 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera121,756,183 - 1,766,124 (-)NCBICelera
Cytogenetic Map12p12NCBI
ZAR1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381332,303,699 - 32,315,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1332,303,699 - 32,315,363 (-)Ensemblhg38GRCh38
GRCh371332,877,836 - 32,889,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361331,775,837 - 31,784,062 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1313,944,739 - 13,952,921 (-)NCBICelera
Cytogenetic Map13q13.1NCBI
HuRef1313,689,477 - 13,697,879 (-)NCBIHuRef
CHM1_11332,845,455 - 32,853,638 (-)NCBICHM1_1
T2T-CHM13v2.01331,520,944 - 31,532,608 (-)NCBIT2T-CHM13v2.0
Zar1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395150,430,520 - 150,441,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5150,430,520 - 150,441,629 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385150,507,055 - 150,518,194 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,507,055 - 150,518,164 (-)Ensemblmm10GRCm38
MGSCv375151,309,644 - 151,320,734 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365150,775,434 - 150,786,376 (-)NCBIMGSCv36mm8
Celera5148,511,597 - 148,522,685 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.51NCBI
Zar1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543113,532,795 - 13,541,682 (+)Ensembl
ChiLan1.0NW_00495543113,532,795 - 13,541,771 (+)NCBIChiLan1.0ChiLan1.0
ZAR1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21431,869,708 - 31,878,687 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11322,976,223 - 22,985,180 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01313,562,691 - 13,571,395 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11331,997,411 - 32,005,724 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1331,997,411 - 32,005,724 (-)EnsemblpanPan2panpan1.1
ZAR1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,799,130 - 7,807,653 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,799,615 - 7,856,230 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha257,827,909 - 7,917,527 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0257,895,358 - 7,932,137 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,895,804 - 7,905,469 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,794,791 - 7,883,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,792,167 - 7,881,786 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,850,128 - 7,939,890 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Zar1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945169,009,032 - 169,017,629 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647226,934,701 - 26,942,483 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647226,934,689 - 26,942,483 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZAR1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl118,795,487 - 8,805,881 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1118,795,478 - 8,805,876 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZAR1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1311,058,794 - 11,069,865 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl311,059,156 - 11,067,146 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605733,285,409 - 33,293,985 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zar1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247765,576,656 - 5,586,907 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247765,575,367 - 5,586,098 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Zar1l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11667,253 - 79,117 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zar1l
61 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat


Expression

RNA-SEQ Expression

reproductive system
2

Sequence


Ensembl Acc Id: ENSRNOT00000076716   ⟹   ENSRNOP00000068055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl124,881,161 - 4,892,214 (-)Ensembl
mRatBN7.2 Ensembl1246,534 - 56,425 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130391   ⟹   ENSRNOP00000107510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl124,881,161 - 4,892,214 (-)Ensembl
RefSeq Acc Id: XM_039089886   ⟹   XP_038945814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,882,162 - 4,892,064 (-)NCBI
mRatBN7.21246,534 - 56,434 (-)NCBI
RefSeq Acc Id: XM_063271918   ⟹   XP_063127988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,882,162 - 4,892,064 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038945814 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127988 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068055
  ENSRNOP00000068055.2
  ENSRNOP00000107510.1
RefSeq Acc Id: XP_038945814   ⟸   XM_039089886
- Peptide Label: isoform X2
- UniProtKB: A0A096MJA5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000068055   ⟸   ENSRNOT00000076716
RefSeq Acc Id: XP_063127988   ⟸   XM_063271918
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000107510   ⟸   ENSRNOT00000130391
Protein Domains
3CxxC-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591034 AgrOrtholog
BioCyc Gene G2FUF-20528 BioCyc
Ensembl Genes ENSRNOG00000051294 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076716 ENTREZGENE
  ENSRNOT00000076716.3 UniProtKB/TrEMBL
  ENSRNOT00000130391.1 UniProtKB/TrEMBL
InterPro Zar1 UniProtKB/TrEMBL
  Znf-3CxxC UniProtKB/TrEMBL
NCBI Gene 689594 ENTREZGENE
PANTHER PTHR31054 UniProtKB/TrEMBL
  ZAR1-LIKE PROTEIN UniProtKB/TrEMBL
Pfam zf-3CxxC UniProtKB/TrEMBL
PhenoGen Zar1l PhenoGen
RatGTEx ENSRNOG00000051294 RatGTEx
SMART zf-3CxxC UniProtKB/TrEMBL
UniProt A0A096MJA5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LZU3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Zar1l  zygote arrest 1-like  AABR07034923.1    Data merged from RGD:15006298 737654 PROVISIONAL
2019-11-08 AABR07034923.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-05-24 Zar1l  zygote arrest 1-like  LOC682680  similar to Zygote arrest 1 (Oocyte-specific maternal effect factor)  Data merged from RGD:1596613 1643240 APPROVED
2010-04-23 Zar1l  zygote arrest 1-like  LOC689594  similar to Zygote arrest 1 (Oocyte-specific maternal effect factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC689594  similar to Zygote arrest 1 (Oocyte-specific maternal effect factor)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682680  similar to Zygote arrest 1 (Oocyte-specific maternal effect factor)      Symbol and Name status set to provisional 70820 PROVISIONAL