Fam131c (family with sequence similarity 131, member C) - Rat Genome Database

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Pathways
Gene: Fam131c (family with sequence similarity 131, member C) Rattus norvegicus
Analyze
Symbol: Fam131c
Name: family with sequence similarity 131, member C
RGD ID: 1590955
Description: Orthologous to human FAM131C (family with sequence similarity 131 member C); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC690880; LOC100911582; LOC690880; protein FAM131C-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,957,444 - 158,973,773 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5158,957,451 - 158,974,019 (+)EnsemblGRCr8
mRatBN7.25153,674,459 - 153,690,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,671,772 - 153,690,800 (+)EnsemblmRatBN7.2
Rnor_6.05159,914,931 - 159,931,089 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,914,931 - 159,931,090 (+)Ensemblrn6Rnor6.0
Rnor_5.05163,642,663 - 163,647,669 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,268,665 - 160,273,424 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,046,363 - 152,054,951 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fam131c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,957,444 - 158,973,773 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5158,957,451 - 158,974,019 (+)EnsemblGRCr8
mRatBN7.25153,674,459 - 153,690,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,671,772 - 153,690,800 (+)EnsemblmRatBN7.2
Rnor_6.05159,914,931 - 159,931,089 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,914,931 - 159,931,090 (+)Ensemblrn6Rnor6.0
Rnor_5.05163,642,663 - 163,647,669 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,268,665 - 160,273,424 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,046,363 - 152,054,951 (+)NCBICelera
Cytogenetic Map5q36NCBI
FAM131C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,057,769 - 16,073,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,057,769 - 16,073,651 (-)Ensemblhg38GRCh38
GRCh37116,384,264 - 16,400,146 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,256,851 - 16,272,714 (-)NCBIBuild 36Build 36hg18NCBI36
Celera114,864,163 - 14,877,593 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef114,902,743 - 14,918,526 (-)NCBIHuRef
CHM1_1116,182,877 - 16,198,717 (-)NCBICHM1_1
T2T-CHM13v2.0115,499,150 - 15,515,031 (-)NCBIT2T-CHM13v2.0
Fam131c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,095,503 - 141,111,485 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,095,531 - 141,111,486 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384141,368,192 - 141,384,174 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,368,220 - 141,384,175 (+)Ensemblmm10GRCm38
MGSCv374140,924,135 - 140,940,090 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364140,640,329 - 140,656,250 (+)NCBIMGSCv36mm8
Celera4143,185,056 - 143,201,002 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.88NCBI
Fam131c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,182,570 - 2,207,068 (+)Ensembl
ChiLan1.0NW_0049555272,182,624 - 2,203,063 (+)NCBIChiLan1.0ChiLan1.0
FAM131C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,847,450 - 210,863,352 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,096,061 - 210,111,951 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0115,195,111 - 15,211,000 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,188,630 - 16,199,722 (-)NCBIPanPan1.1PanPan1.1panPan2
FAM131C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,595,383 - 81,611,739 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,595,276 - 81,611,112 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha278,114,619 - 78,147,174 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0282,224,690 - 82,257,357 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,240,352 - 82,257,578 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,977,767 - 79,010,545 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,994,895 - 80,027,712 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,062,856 - 81,095,406 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fam131c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,777,546 - 37,782,672 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364743,602,881 - 3,607,452 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364743,602,330 - 3,607,462 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM131C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,193,399 - 75,212,154 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1675,193,397 - 75,213,081 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,529,608 - 69,545,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM131C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,223,237 - 116,241,144 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,235,177 - 116,241,379 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605419,719,909 - 19,767,949 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam131c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,212,404 - 2,233,574 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247642,212,511 - 2,234,012 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fam131c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1116,760,483 - 16,776,180 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fam131c
25 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:54
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000037202
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
D18Chm13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,685,212 - 153,685,449 (+)MAPPERmRatBN7.2
mRatBN7.2185,663,669 - 5,663,898 (+)MAPPERmRatBN7.2
Rnor_6.0185,904,726 - 5,904,950NCBIRnor6.0
Rnor_6.05159,925,513 - 159,925,749NCBIRnor6.0
Rnor_5.0185,873,175 - 5,873,399UniSTSRnor5.0
RGSC_v3.4185,761,653 - 5,761,877UniSTSRGSC3.4
RGSC_v3.45160,268,100 - 160,268,336UniSTSRGSC3.4
Celera185,696,822 - 5,697,046UniSTS
Celera5152,049,381 - 152,049,617UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 64 137 80 81 55 55 55 6 301 146 7 116 77 92 26 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000037202   ⟹   ENSRNOP00000038610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5158,957,451 - 158,974,019 (+)Ensembl
mRatBN7.2 Ensembl5153,671,772 - 153,690,800 (+)Ensembl
Rnor_6.0 Ensembl5159,914,931 - 159,931,090 (+)Ensembl
RefSeq Acc Id: XM_008764303   ⟹   XP_008762525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,957,444 - 158,973,773 (+)NCBI
mRatBN7.25153,674,459 - 153,690,791 (+)NCBI
Rnor_6.05159,914,931 - 159,931,089 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001418208 (Get FASTA)   NCBI Sequence Viewer  
  XP_008762525 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038610.6
RefSeq Acc Id: XP_008762525   ⟸   XM_008764303
- Sequence:
Ensembl Acc Id: ENSRNOP00000038610   ⟸   ENSRNOT00000037202

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M473-F1-model_v2 AlphaFold F1M473 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590955 AgrOrtholog
BioCyc Gene G2FUF-39352 BioCyc
Ensembl Genes ENSRNOG00000023008 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037202.8 UniProtKB/TrEMBL
InterPro FAM131 UniProtKB/TrEMBL
KEGG Report rno:690880 UniProtKB/TrEMBL
NCBI Gene 690880 ENTREZGENE
PANTHER PROTEIN FAM131C UniProtKB/TrEMBL
  PTHR15736 UniProtKB/TrEMBL
Pfam FAM131 UniProtKB/TrEMBL
PhenoGen Fam131c PhenoGen
RatGTEx ENSRNOG00000023008 RatGTEx
UniProt A6ITS9 ENTREZGENE, UniProtKB/TrEMBL
  F1M473 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Fam131c  family with sequence similarity 131, member C  LOC100911582  protein FAM131C-like  Data merged from RGD:6491937 737654 PROVISIONAL
2013-05-24 Fam131c  family with sequence similarity 131, member C  LOC100364461  hypothetical protein LOC100364461  Data merged from RGD:2320999 1643240 APPROVED
2012-07-05 LOC100911582  protein FAM131C-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-05 LOC100364461  hypothetical protein LOC100364461      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Fam131c  family with sequence similarity 131, member C  LOC690880  hypothetical protein LOC690880  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC690880  hypothetical protein LOC690880  LOC686156  hypothetical protein LOC686156  Data merged from RGD:1585443 1643240 APPROVED
2006-11-20 LOC690880  hypothetical protein LOC690880      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC686156  hypothetical protein LOC686156      Symbol and Name status set to provisional 70820 PROVISIONAL