Zik1 (zinc finger protein interacting with K protein 1) - Rat Genome Database

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Gene: Zik1 (zinc finger protein interacting with K protein 1) Rattus norvegicus
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Symbol: Zik1
Name: zinc finger protein interacting with K protein 1
RGD ID: 1590949
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZIK1 (zinc finger protein interacting with K protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC102554457; LOC690887; similar to zinc finger protein interacting with K protein 1; uncharacterized LOC102554457; zinc finger protein interacting with K protein 1 homolog; zinc finger protein interacting with K protein 1 homolog (mouse); zinc finger protein interacting with ribonucleoprotein K
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,831,766 - 73,878,538 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl173,833,313 - 73,840,976 (-)EnsemblGRCr8
mRatBN7.2164,916,831 - 64,963,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl164,916,836 - 64,925,897 (-)EnsemblmRatBN7.2
Rnor_6.0163,297,063 - 63,331,224 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl163,286,802 - 63,293,635 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl168,262,389 - 68,269,117 (-)Ensemblrn6Rnor6.0
Rnor_5.0169,603,034 - 69,618,067 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4163,239,962 - 63,249,114 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera162,683,321 - 62,719,003 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zik1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,831,766 - 73,878,538 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl173,833,313 - 73,840,976 (-)EnsemblGRCr8
mRatBN7.2164,916,831 - 64,963,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl164,916,836 - 64,925,897 (-)EnsemblmRatBN7.2
Rnor_6.0163,297,063 - 63,331,224 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl163,286,802 - 63,293,635 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl168,262,389 - 68,269,117 (-)Ensemblrn6Rnor6.0
Rnor_5.0169,603,034 - 69,618,067 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4163,239,962 - 63,249,114 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera162,683,321 - 62,719,003 (-)NCBICelera
Cytogenetic Map1q12NCBI
ZIK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381957,584,145 - 57,593,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1957,578,456 - 57,593,890 (+)Ensemblhg38GRCh38
GRCh371958,095,513 - 58,105,258 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361962,787,440 - 62,795,570 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1955,139,206 - 55,147,336 (+)NCBICelera
Cytogenetic Map19q13.43NCBI
HuRef1954,407,930 - 54,416,185 (+)NCBIHuRef
CHM1_11958,089,575 - 58,097,706 (+)NCBICHM1_1
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBIT2T-CHM13v2.0
Zik1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39710,221,151 - 10,229,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl710,221,156 - 10,229,321 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38710,487,224 - 10,495,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl710,487,229 - 10,495,394 (-)Ensemblmm10GRCm38
MGSCv37711,072,573 - 11,080,730 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3679,362,117 - 9,370,232 (-)NCBIMGSCv36mm8
Celera77,521,746 - 7,529,904 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map76.47NCBI
ZIK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22063,862,228 - 63,873,799 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11965,647,775 - 65,662,174 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01954,593,169 - 54,605,771 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11963,424,943 - 63,435,202 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1963,426,256 - 63,432,584 (+)EnsemblpanPan2panpan1.1
ZIK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1649,952,238 - 49,964,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl649,956,496 - 49,966,124 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660453,044,201 - 3,052,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zik1
100 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
D1Got427  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0169,599,993 - 69,600,164NCBIRnor5.0
Rnor_5.0169,044,626 - 69,044,797NCBIRnor5.0
Rnor_5.0168,975,937 - 68,976,075NCBIRnor5.0
Rnor_5.0169,532,089 - 69,532,227NCBIRnor5.0
RGSC_v3.4163,234,374 - 63,234,544UniSTSRGSC3.4
RGSC_v3.4163,165,685 - 63,165,822UniSTSRGSC3.4
Celera162,669,221 - 62,669,391UniSTS
Celera162,601,198 - 62,601,335UniSTS
Cytogenetic Map1 RGD
RH129943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2164,916,856 - 64,917,052 (+)MAPPERmRatBN7.2
Rnor_6.0168,260,069 - 68,260,264NCBIRnor6.0
Rnor_6.0163,284,477 - 63,284,672NCBIRnor6.0
Rnor_5.0169,603,063 - 69,603,258UniSTSRnor5.0
Rnor_5.0169,047,696 - 69,047,891UniSTSRnor5.0
RGSC_v3.4163,237,443 - 63,237,638UniSTSRGSC3.4
Celera162,672,290 - 62,672,485UniSTS
RH 3.4 Map1713.4UniSTS
Cytogenetic Map1q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 1 30 94 44 36 12 77 12 12 204 141 11 69 32 54 24 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000072367   ⟹   ENSRNOP00000066382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl173,833,313 - 73,840,976 (-)Ensembl
mRatBN7.2 Ensembl164,916,836 - 64,925,897 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090337   ⟹   ENSRNOP00000075004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl163,286,802 - 63,293,635 (-)Ensembl
RefSeq Acc Id: XM_039100336   ⟹   XP_038956264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,831,766 - 73,878,538 (-)NCBI
mRatBN7.2164,916,831 - 64,963,590 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038956264 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066382
  ENSRNOP00000066382.3
Ensembl Acc Id: ENSRNOP00000075004   ⟸   ENSRNOT00000090337
RefSeq Acc Id: XP_038956264   ⟸   XM_039100336
Ensembl Acc Id: ENSRNOP00000066382   ⟸   ENSRNOT00000072367
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RA43-F1-model_v2 AlphaFold M0RA43 1-460 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590949 AgrOrtholog
Ensembl Genes ENSRNOG00000046455 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000055843 Ensembl
Ensembl Transcript ENSRNOT00000072367 ENTREZGENE
  ENSRNOT00000072367.4 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Snail/Krueppel_Znf UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene Zik1 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 281-RELATED UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Zik1 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046455 RatGTEx
  ENSRNOG00000055843 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt M0RA43_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Zik1  zinc finger protein interacting with K protein 1  LOC102554457  uncharacterized LOC102554457  Data merged from RGD:7631102 737654 PROVISIONAL
2015-06-26 Zik1  zinc finger protein interacting with K protein 1  Zik1  zinc finger protein interacting with K protein 1 homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102554457  uncharacterized LOC102554457      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-02 Zik1  zinc finger protein interacting with K protein 1 homolog (mouse)  LOC100359821  hypothetical LOC100359821  Data merged from RGD:2323320 1643240 APPROVED
2010-05-06 LOC100359821  hypothetical LOC100359821      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-25 Zik1  zinc finger protein interacting with K protein 1 homolog (mouse)  Zik1  zinc finger protein interacting with K protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Zik1  zinc finger protein interacting with K protein 1  LOC683321  similar to zinc finger protein interacting with K protein 1  Data merged from RGD:1588048 1643240 APPROVED
2008-03-06 Zik1  zinc finger protein interacting with K protein 1  LOC690887  similar to zinc finger protein interacting with K protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC690887  similar to zinc finger protein interacting with K protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683321  similar to zinc finger protein interacting with K protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL