ZIK1 (zinc finger protein interacting with K protein 1) - Rat Genome Database

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Gene: ZIK1 (zinc finger protein interacting with K protein 1) Homo sapiens
Analyze
Symbol: ZIK1
Name: zinc finger protein interacting with K protein 1
RGD ID: 1604492
HGNC Page HGNC:33104
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC119699; MGC119700; MGC119701; zinc finger protein 762; zinc finger protein interacting with K protein 1 homolog; zinc finger protein interacting with ribonucleoprotein K; ZNF762
RGD Orthologs
Mouse
Rat
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: ZIK1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381957,584,145 - 57,593,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1957,578,456 - 57,593,890 (+)EnsemblGRCh38hg38GRCh38
GRCh371958,095,513 - 58,105,258 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361962,787,440 - 62,795,570 (+)NCBINCBI36Build 36hg18NCBI36
Celera1955,139,206 - 55,147,336 (+)NCBICelera
Cytogenetic Map19q13.43NCBI
HuRef1954,407,930 - 54,416,185 (+)NCBIHuRef
CHM1_11958,089,575 - 58,097,706 (+)NCBICHM1_1
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8910362   PMID:12477932   PMID:14702039   PMID:16344560   PMID:21873635   PMID:30021884   PMID:32814053  


Genomics

Comparative Map Data
ZIK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381957,584,145 - 57,593,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1957,578,456 - 57,593,890 (+)EnsemblGRCh38hg38GRCh38
GRCh371958,095,513 - 58,105,258 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361962,787,440 - 62,795,570 (+)NCBINCBI36Build 36hg18NCBI36
Celera1955,139,206 - 55,147,336 (+)NCBICelera
Cytogenetic Map19q13.43NCBI
HuRef1954,407,930 - 54,416,185 (+)NCBIHuRef
CHM1_11958,089,575 - 58,097,706 (+)NCBICHM1_1
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBIT2T-CHM13v2.0
Zik1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39710,221,151 - 10,229,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl710,221,156 - 10,229,321 (-)EnsemblGRCm39 Ensembl
GRCm38710,487,224 - 10,495,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl710,487,229 - 10,495,394 (-)EnsemblGRCm38mm10GRCm38
MGSCv37711,072,573 - 11,080,730 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3679,362,117 - 9,370,232 (-)NCBIMGSCv36mm8
Celera77,521,746 - 7,529,904 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map76.47NCBI
Zik1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,831,766 - 73,878,538 (-)NCBIGRCr8
mRatBN7.2164,916,831 - 64,963,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl164,916,836 - 64,925,897 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0163,297,063 - 63,331,224 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,262,389 - 68,269,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl163,286,802 - 63,293,635 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,603,034 - 69,618,067 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,239,962 - 63,249,114 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera162,683,321 - 62,719,003 (-)NCBICelera
Cytogenetic Map1q12NCBI
ZIK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22063,862,228 - 63,873,799 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11965,647,775 - 65,662,174 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01954,593,169 - 54,605,771 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11963,424,943 - 63,435,202 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1963,426,256 - 63,432,584 (+)Ensemblpanpan1.1panPan2
ZIK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1649,952,238 - 49,964,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl649,956,496 - 49,966,124 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660453,044,201 - 3,052,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ZIK1
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:51141518-58539965)x3 copy number gain See cases [RCV000052926] Chr19:51141518..58539965 [GRCh38]
Chr19:51644775..59051332 [GRCh37]
Chr19:56336587..63743144 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.43(chr19:56363208-58581203)x3 copy number gain See cases [RCV000052927] Chr19:56363208..58581203 [GRCh38]
Chr19:56874577..59092570 [GRCh37]
Chr19:61566389..63784382 [NCBI36]
Chr19:19q13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
NM_001010879.2(ZIK1):c.1244C>T (p.Ser415Phe) single nucleotide variant Malignant melanoma [RCV000063655] Chr19:57591055 [GRCh38]
Chr19:58102423 [GRCh37]
Chr19:62794235 [NCBI36]
Chr19:19q13.43		 not provided
GRCh38/hg38 19q13.41-13.43(chr19:52612432-58581203)x3 copy number gain See cases [RCV000134174] Chr19:52612432..58581203 [GRCh38]
Chr19:53115685..59092570 [GRCh37]
Chr19:57807497..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52955056-58581203)x3 copy number gain See cases [RCV000134139] Chr19:52955056..58581203 [GRCh38]
Chr19:53458309..59092570 [GRCh37]
Chr19:58150121..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.43(chr19:57546443-57889946)x3 copy number gain See cases [RCV000141360] Chr19:57546443..57889946 [GRCh38]
Chr19:58057811..58401314 [GRCh37]
Chr19:62749623..63093126 [NCBI36]
Chr19:19q13.43		 uncertain significance
GRCh38/hg38 19q13.41-13.43(chr19:52143873-58445521)x3 copy number gain See cases [RCV000142008] Chr19:52143873..58445521 [GRCh38]
Chr19:52647126..58956888 [GRCh37]
Chr19:57338938..63648700 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.43(chr19:56353449-58445521)x3 copy number gain See cases [RCV000141900] Chr19:56353449..58445521 [GRCh38]
Chr19:56864818..58956888 [GRCh37]
Chr19:61556630..63648700 [NCBI36]
Chr19:19q13.43		 uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:50489390-59095359)x3 copy number gain See cases [RCV000445925] Chr19:50489390..59095359 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.43(chr19:58026984-58246176)x1 copy number loss See cases [RCV000512135] Chr19:58026984..58246176 [GRCh37]
Chr19:19q13.43		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.43(chr19:56706500-58956888)x3 copy number gain See cases [RCV000512396] Chr19:56706500..58956888 [GRCh37]
Chr19:19q13.43		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
Single allele duplication not provided [RCV000677936] Chr19:57953199..58196644 [GRCh37]
Chr19:19q13.43		 uncertain significance
GRCh37/hg19 19q13.43(chr19:57891243-58536930)x3 copy number gain not provided [RCV000684084] Chr19:57891243..58536930 [GRCh37]
Chr19:19q13.43		 likely benign
GRCh37/hg19 19q13.42-13.43(chr19:54196216-58759679)x3 copy number gain not provided [RCV000684095] Chr19:54196216..58759679 [GRCh37]
Chr19:19q13.42-13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.43(chr19:58092045-58686148)x3 copy number gain not provided [RCV000849080] Chr19:58092045..58686148 [GRCh37]
Chr19:19q13.43		 uncertain significance
GRCh37/hg19 19q13.43(chr19:58054819-58410552)x3 copy number gain not provided [RCV000848932] Chr19:58054819..58410552 [GRCh37]
Chr19:19q13.43		 uncertain significance
GRCh37/hg19 19q13.43(chr19:57952073-58661581)x3 copy number gain not provided [RCV000846105] Chr19:57952073..58661581 [GRCh37]
Chr19:19q13.43		 uncertain significance
GRCh37/hg19 19q13.43(chr19:58026985-58255427)x3 copy number gain not provided [RCV001832942] Chr19:58026985..58255427 [GRCh37]
Chr19:19q13.43		 likely benign
NM_001010879.4(ZIK1):c.514G>T (p.Val172Phe) single nucleotide variant not specified [RCV004145300] Chr19:57590325 [GRCh38]
Chr19:58101693 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.229A>C (p.Thr77Pro) single nucleotide variant not specified [RCV004236789] Chr19:57590040 [GRCh38]
Chr19:58101408 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.791A>G (p.Glu264Gly) single nucleotide variant not specified [RCV004140498] Chr19:57590602 [GRCh38]
Chr19:58101970 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.694G>T (p.Val232Phe) single nucleotide variant not specified [RCV004155965] Chr19:57590505 [GRCh38]
Chr19:58101873 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.871G>A (p.Gly291Arg) single nucleotide variant not specified [RCV004195456] Chr19:57590682 [GRCh38]
Chr19:58102050 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.503G>A (p.Arg168His) single nucleotide variant not specified [RCV004225027] Chr19:57590314 [GRCh38]
Chr19:58101682 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.740C>T (p.Ala247Val) single nucleotide variant not specified [RCV004117027] Chr19:57590551 [GRCh38]
Chr19:58101919 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.1277G>A (p.Arg426Gln) single nucleotide variant not specified [RCV004188636] Chr19:57591088 [GRCh38]
Chr19:58102456 [GRCh37]
Chr19:19q13.43		 likely benign
NM_001010879.4(ZIK1):c.97G>A (p.Ala33Thr) single nucleotide variant not specified [RCV004181362] Chr19:57588563 [GRCh38]
Chr19:58099931 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.476T>C (p.Leu159Pro) single nucleotide variant not specified [RCV004249484] Chr19:57590287 [GRCh38]
Chr19:58101655 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.796C>G (p.Pro266Ala) single nucleotide variant not specified [RCV004328339] Chr19:57590607 [GRCh38]
Chr19:58101975 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.1088G>A (p.Ser363Asn) single nucleotide variant not specified [RCV004354500] Chr19:57590899 [GRCh38]
Chr19:58102267 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.13G>A (p.Ala5Thr) single nucleotide variant not specified [RCV004353316] Chr19:57584369 [GRCh38]
Chr19:58095737 [GRCh37]
Chr19:19q13.43		 uncertain significance
GRCh37/hg19 19q13.43(chr19:58034484-58421498)x3 copy number gain not provided [RCV003485203] Chr19:58034484..58421498 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.1144G>A (p.Gly382Ser) single nucleotide variant not specified [RCV004488883] Chr19:57590955 [GRCh38]
Chr19:58102323 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.1276C>T (p.Arg426Trp) single nucleotide variant not specified [RCV004488884] Chr19:57591087 [GRCh38]
Chr19:58102455 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.541C>T (p.Arg181Trp) single nucleotide variant not specified [RCV004488890] Chr19:57590352 [GRCh38]
Chr19:58101720 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.742T>G (p.Phe248Val) single nucleotide variant not specified [RCV004488893] Chr19:57590553 [GRCh38]
Chr19:58101921 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.927C>G (p.Ser309Arg) single nucleotide variant not specified [RCV004488894] Chr19:57590738 [GRCh38]
Chr19:58102106 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.210T>A (p.His70Gln) single nucleotide variant not specified [RCV004488886] Chr19:57590021 [GRCh38]
Chr19:58101389 [GRCh37]
Chr19:19q13.43		 uncertain significance
GRCh37/hg19 19q13.42-13.43(chr19:54344821-58956888)x3 copy number gain See cases [RCV000448186] Chr19:54344821..58956888 [GRCh37]
Chr19:19q13.42-13.43		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50740074-59097160)x3 copy number gain not provided [RCV000740208] Chr19:50740074..59097160 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
NM_001010879.4(ZIK1):c.581C>G (p.Pro194Arg) single nucleotide variant not specified [RCV004359947] Chr19:57590392 [GRCh38]
Chr19:58101760 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.309G>C (p.Glu103Asp) single nucleotide variant not specified [RCV004358104] Chr19:57590120 [GRCh38]
Chr19:58101488 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.242A>G (p.Gln81Arg) single nucleotide variant not specified [RCV004488887] Chr19:57590053 [GRCh38]
Chr19:58101421 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.304T>G (p.Cys102Gly) single nucleotide variant not specified [RCV004488888] Chr19:57590115 [GRCh38]
Chr19:58101483 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.611T>A (p.Ile204Asn) single nucleotide variant not specified [RCV004488891] Chr19:57590422 [GRCh38]
Chr19:58101790 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.721T>C (p.Cys241Arg) single nucleotide variant not specified [RCV004488892] Chr19:57590532 [GRCh38]
Chr19:58101900 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_001010879.4(ZIK1):c.185T>C (p.Leu62Pro) single nucleotide variant not specified [RCV004488885] Chr19:57588651 [GRCh38]
Chr19:58100019 [GRCh37]
Chr19:19q13.43		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3989
Count of miRNA genes:945
Interacting mature miRNAs:1100
Transcripts:ENST00000307468, ENST00000536878, ENST00000597219, ENST00000597850, ENST00000598689, ENST00000598726, ENST00000599456, ENST00000600053
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH91313  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371958,104,819 - 58,104,941UniSTSGRCh37
Build 361962,796,631 - 62,796,753RGDNCBI36
Celera1955,148,397 - 55,148,519RGD
Cytogenetic Map19q13.43UniSTS
HuRef1954,417,246 - 54,417,368UniSTS
GeneMap99-GB4 RH Map19288.26UniSTS
STS-N64074  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371958,104,977 - 58,105,160UniSTSGRCh37
Build 361962,796,789 - 62,796,972RGDNCBI36
Celera1955,148,555 - 55,148,738RGD
Cytogenetic Map19q13.43UniSTS
HuRef1954,417,404 - 54,417,587UniSTS
GeneMap99-GB4 RH Map19287.74UniSTS
NCBI RH Map19600.5UniSTS
SHGC-37565  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371958,105,133 - 58,105,233UniSTSGRCh37
Build 361962,796,945 - 62,797,045RGDNCBI36
Celera1955,148,711 - 55,148,811RGD
Cytogenetic Map19q13.43UniSTS
HuRef1954,417,560 - 54,417,660UniSTS
GeneMap99-G3 RH Map192912.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2 9 19 4 137 4 191 10 135 24 109 99
Low 2176 2410 1337 262 1268 103 4004 1963 3502 357 1247 1421 164 1 1199 2652 4 2
Below cutoff 181 572 360 351 499 350 150 218 97 23 69 58 9 5 136

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001010879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC003682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA101277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB277510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB480028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN993640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000307468   ⟹   ENSP00000303820
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1957,584,260 - 57,592,390 (+)Ensembl
RefSeq Acc Id: ENST00000536878   ⟹   ENSP00000438487
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1957,584,140 - 57,593,777 (+)Ensembl
RefSeq Acc Id: ENST00000597219   ⟹   ENSP00000470019
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1957,584,145 - 57,588,615 (+)Ensembl
RefSeq Acc Id: ENST00000597850   ⟹   ENSP00000472867
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1957,584,145 - 57,593,890 (+)Ensembl
RefSeq Acc Id: ENST00000598689   ⟹   ENSP00000469971
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1957,584,145 - 57,590,214 (+)Ensembl
RefSeq Acc Id: ENST00000598726
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1957,578,456 - 57,588,625 (+)Ensembl
RefSeq Acc Id: ENST00000599456   ⟹   ENSP00000468937
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1957,584,260 - 57,592,390 (+)Ensembl
RefSeq Acc Id: ENST00000600053   ⟹   ENSP00000472088
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1957,583,610 - 57,590,198 (+)Ensembl
RefSeq Acc Id: NM_001010879   ⟹   NP_001010879
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,584,145 - 57,593,890 (+)NCBI
GRCh371958,095,508 - 58,105,256 (+)NCBI
Build 361962,787,440 - 62,795,570 (+)NCBI Archive
Celera1955,139,206 - 55,147,336 (+)RGD
HuRef1954,407,930 - 54,416,185 (+)ENTREZGENE
CHM1_11958,089,291 - 58,099,206 (+)NCBI
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001321145   ⟹   NP_001308074
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,584,145 - 57,593,890 (+)NCBI
CHM1_11958,089,291 - 58,099,206 (+)NCBI
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001321146   ⟹   NP_001308075
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,584,145 - 57,593,890 (+)NCBI
CHM1_11958,089,291 - 58,099,206 (+)NCBI
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001321147   ⟹   NP_001308076
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,584,145 - 57,593,890 (+)NCBI
CHM1_11958,089,291 - 58,099,206 (+)NCBI
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526761   ⟹   XP_011525063
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,584,145 - 57,593,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526762   ⟹   XP_011525064
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,584,145 - 57,593,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526765   ⟹   XP_011525067
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,584,145 - 57,593,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526766   ⟹   XP_011525068
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,584,145 - 57,593,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526767   ⟹   XP_011525069
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,588,851 - 57,593,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054320584   ⟹   XP_054176559
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBI
RefSeq Acc Id: XM_054320585   ⟹   XP_054176560
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBI
RefSeq Acc Id: XM_054320586   ⟹   XP_054176561
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBI
RefSeq Acc Id: XM_054320587   ⟹   XP_054176562
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01960,681,073 - 60,690,819 (+)NCBI
RefSeq Acc Id: XM_054320588   ⟹   XP_054176563
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01960,685,780 - 60,690,819 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001010879 (Get FASTA)   NCBI Sequence Viewer  
  NP_001308074 (Get FASTA)   NCBI Sequence Viewer  
  NP_001308075 (Get FASTA)   NCBI Sequence Viewer  
  NP_001308076 (Get FASTA)   NCBI Sequence Viewer  
  XP_011525063 (Get FASTA)   NCBI Sequence Viewer  
  XP_011525064 (Get FASTA)   NCBI Sequence Viewer  
  XP_011525067 (Get FASTA)   NCBI Sequence Viewer  
  XP_011525068 (Get FASTA)   NCBI Sequence Viewer  
  XP_011525069 (Get FASTA)   NCBI Sequence Viewer  
  XP_054176559 (Get FASTA)   NCBI Sequence Viewer  
  XP_054176560 (Get FASTA)   NCBI Sequence Viewer  
  XP_054176561 (Get FASTA)   NCBI Sequence Viewer  
  XP_054176562 (Get FASTA)   NCBI Sequence Viewer  
  XP_054176563 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC24608 (Get FASTA)   NCBI Sequence Viewer  
  AAI03958 (Get FASTA)   NCBI Sequence Viewer  
  AAI03959 (Get FASTA)   NCBI Sequence Viewer  
  AAI03960 (Get FASTA)   NCBI Sequence Viewer  
  BAG52570 (Get FASTA)   NCBI Sequence Viewer  
  BAG54663 (Get FASTA)   NCBI Sequence Viewer  
  EAW72516 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000303820.4
  ENSP00000438487
  ENSP00000438487.1
  ENSP00000468937
  ENSP00000468937.1
  ENSP00000469971.1
  ENSP00000470019.1
  ENSP00000472088.1
  ENSP00000472867
  ENSP00000472867.1
GenBank Protein Q3SY52 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001010879   ⟸   NM_001010879
- Peptide Label: isoform 1
- UniProtKB: Q3SY51 (UniProtKB/Swiss-Prot),   O43339 (UniProtKB/Swiss-Prot),   Q3SY53 (UniProtKB/Swiss-Prot),   Q3SY52 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011525064   ⟸   XM_011526762
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011525063   ⟸   XM_011526761
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011525067   ⟸   XM_011526765
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011525068   ⟸   XM_011526766
- Peptide Label: isoform X4
- UniProtKB: Q3SY52 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011525069   ⟸   XM_011526767
- Peptide Label: isoform X5
- UniProtKB: Q3SY52 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001308075   ⟸   NM_001321146
- Peptide Label: isoform 3
- UniProtKB: Q3SY52 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001308074   ⟸   NM_001321145
- Peptide Label: isoform 2
- UniProtKB: F5H435 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001308076   ⟸   NM_001321147
- Peptide Label: isoform 4
- UniProtKB: Q3SY52 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000303820   ⟸   ENST00000307468
RefSeq Acc Id: ENSP00000472867   ⟸   ENST00000597850
RefSeq Acc Id: ENSP00000470019   ⟸   ENST00000597219
RefSeq Acc Id: ENSP00000469971   ⟸   ENST00000598689
RefSeq Acc Id: ENSP00000468937   ⟸   ENST00000599456
RefSeq Acc Id: ENSP00000472088   ⟸   ENST00000600053
RefSeq Acc Id: ENSP00000438487   ⟸   ENST00000536878
RefSeq Acc Id: XP_054176560   ⟸   XM_054320585
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054176562   ⟸   XM_054320587
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054176561   ⟸   XM_054320586
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054176559   ⟸   XM_054320584
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054176563   ⟸   XM_054320588
- Peptide Label: isoform X5
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3SY52-F1-model_v2 AlphaFold Q3SY52 1-487 view protein structure

Promoters
RGD ID:13205909
Promoter ID:EPDNEW_H26535
Type:initiation region
Name:ZIK1_1
Description:zinc finger protein interacting with K protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381957,584,145 - 57,584,205EPDNEW
RGD ID:6795463
Promoter ID:HG_KWN:31173
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Lymphoblastoid
Transcripts:ENST00000356724,   NM_001010879,   UC002QPH.1,   UC002QPI.1,   UC002QPJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361962,787,019 - 62,787,519 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33104 AgrOrtholog
COSMIC ZIK1 COSMIC
Ensembl Genes ENSG00000171649 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000307468.4 UniProtKB/TrEMBL
  ENST00000536878 ENTREZGENE
  ENST00000536878.6 UniProtKB/TrEMBL
  ENST00000597219.1 UniProtKB/TrEMBL
  ENST00000597850 ENTREZGENE
  ENST00000597850.2 UniProtKB/Swiss-Prot
  ENST00000598689.1 UniProtKB/TrEMBL
  ENST00000599456 ENTREZGENE
  ENST00000599456.1 UniProtKB/Swiss-Prot
  ENST00000600053.5 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000171649 GTEx
HGNC ID HGNC:33104 ENTREZGENE
Human Proteome Map ZIK1 Human Proteome Map
InterPro KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:284307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 284307 ENTREZGENE
PANTHER IP01201P-RELATED UniProtKB/Swiss-Prot
  KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 132 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 383-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 747 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 879 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162409747 PharmGKB
PROSITE KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART KRAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3KS08_HUMAN UniProtKB/TrEMBL
  B3KY01_HUMAN UniProtKB/TrEMBL
  F5H435 ENTREZGENE, UniProtKB/TrEMBL
  M0QYP0_HUMAN UniProtKB/TrEMBL
  M0QYQ8_HUMAN UniProtKB/TrEMBL
  M0R1S7_HUMAN UniProtKB/TrEMBL
  O43339 ENTREZGENE
  Q3SY51 ENTREZGENE
  Q3SY52 ENTREZGENE
  Q3SY53 ENTREZGENE
  X6R413_HUMAN UniProtKB/TrEMBL
  ZIK1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary O43339 UniProtKB/Swiss-Prot
  Q3SY51 UniProtKB/Swiss-Prot
  Q3SY53 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 ZIK1  zinc finger protein interacting with K protein 1    zinc finger protein interacting with K protein 1 homolog (mouse)  Symbol and/or name change 5135510 APPROVED