Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Vsir | Rat | 1,1-dichloroethene | increases expression | ISO | Vsir (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of VSIR mRNA | CTD | PMID:26682919 | Vsir | Rat | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of VSIR mRNA | CTD | PMID:25380136 | Vsir | Rat | 17beta-estradiol | multiple interactions | ISO | VSIR (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of VSIR mRNA | CTD | PMID:30165855 | Vsir | Rat | 17beta-estradiol | decreases expression | ISO | Vsir (Mus musculus) | 6480464 | Estradiol results in decreased expression of VSIR mRNA | CTD | PMID:39298647 | Vsir | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of VSIR protein | CTD | PMID:32145629 | Vsir | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of VSIR mRNA | CTD | PMID:34747641 | Vsir | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of VSIR mRNA | CTD | PMID:33387578 | Vsir | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | EXP | | 6480464 | tetrabromobisphenol A results in decreased expression of VSIR mRNA | CTD | PMID:28300664 | Vsir | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | VSIR (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Vsir | Rat | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of VSIR mRNA | CTD | PMID:25380136 | Vsir | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Vsir (Mus musculus) | 6480464 | Fenretinide results in decreased expression of VSIR mRNA | CTD | PMID:28973697 | Vsir | Rat | 5-aza-2'-deoxycytidine | decreases methylation | ISO | Vsir (Mus musculus) | 6480464 | Decitabine results in decreased methylation of VSIR gene | CTD | PMID:27923600 | Vsir | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of VSIR mRNA | CTD | PMID:31881176 | Vsir | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of VSIR mRNA | CTD | PMID:28959563 | Vsir | Rat | all-trans-retinoic acid | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Tretinoin results in increased expression of VSIR mRNA | CTD | PMID:21934132|PMID:23830798|PMID:33167477 | Vsir | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of VSIR mRNA | CTD | PMID:38685447 | Vsir | Rat | antirheumatic drug | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of VSIR mRNA | CTD | PMID:24449571 | Vsir | Rat | aristolochic acid A | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of VSIR mRNA | CTD | PMID:33212167 | Vsir | Rat | benzo[a]pyrene | multiple interactions | ISO | Vsir (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Vsir | Rat | benzo[a]pyrene | decreases methylation | ISO | VSIR (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of VSIR promoter | CTD | PMID:27901495 | Vsir | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of VSIR mRNA | CTD | PMID:20382639 | Vsir | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Vsir (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Vsir | Rat | benzo[e]pyrene | increases methylation | ISO | VSIR (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of VSIR intron | CTD | PMID:30157460 | Vsir | Rat | benzo[e]pyrene | decreases methylation | ISO | VSIR (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of VSIR 3' UTR | CTD | PMID:30157460 | Vsir | Rat | beta-lapachone | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of VSIR mRNA | CTD | PMID:38218311 | Vsir | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of VSIR mRNA | CTD | PMID:25181051|PMID:30816183|PMID:32528016|PMID:34947998 | Vsir | Rat | bisphenol A | increases expression | ISO | Vsir (Mus musculus) | 6480464 | bisphenol A results in increased expression of VSIR mRNA | CTD | PMID:32156529 | Vsir | Rat | bisphenol A | multiple interactions | ISO | VSIR (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Vsir | Rat | bisphenol F | multiple interactions | ISO | VSIR (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Vsir | Rat | cadmium dichloride | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of VSIR mRNA | CTD | PMID:38174414 | Vsir | Rat | chlordecone | increases expression | ISO | Vsir (Mus musculus) | 6480464 | Chlordecone results in increased expression of VSIR mRNA | CTD | PMID:33711761 | Vsir | Rat | chrysene | multiple interactions | ISO | Vsir (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Vsir | Rat | cisplatin | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Cisplatin results in increased expression of VSIR mRNA | CTD | PMID:27392435|PMID:27594783 | Vsir | Rat | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of VSIR mRNA | CTD | PMID:30556269 | Vsir | Rat | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of VSIR mRNA | CTD | PMID:30556269 | Vsir | Rat | copper(II) chloride | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | cupric chloride results in decreased expression of VSIR mRNA | CTD | PMID:38568856 | Vsir | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of VSIR mRNA | CTD | PMID:27523638 | Vsir | Rat | cyclosporin A | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of VSIR mRNA | CTD | PMID:25562108 | Vsir | Rat | dexamethasone | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Dexamethasone results in increased expression of VSIR mRNA | CTD | PMID:25047013 | Vsir | Rat | dexamethasone | multiple interactions | ISO | VSIR (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Vsir | Rat | diallyl trisulfide | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | diallyl trisulfide results in decreased expression of VSIR mRNA | CTD | PMID:34995734 | Vsir | Rat | Dibutyl phosphate | affects expression | ISO | VSIR (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of VSIR mRNA | CTD | PMID:37042841 | Vsir | Rat | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression more ... | CTD | PMID:33729688 | Vsir | Rat | doxorubicin | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of VSIR mRNA | CTD | PMID:29803840 | Vsir | Rat | doxorubicin | decreases expression | ISO | Vsir (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of VSIR mRNA | CTD | PMID:39631538 | Vsir | Rat | ethanol | increases expression | ISO | Vsir (Mus musculus) | 6480464 | Ethanol results in increased expression of VSIR mRNA | CTD | PMID:30319688 | Vsir | Rat | fenofibrate | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | Fenofibrate results in decreased expression of VSIR mRNA | CTD | PMID:25572481 | Vsir | Rat | fragrance | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Perfume results in increased expression of VSIR mRNA | CTD | PMID:24768652 | Vsir | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of VSIR mRNA | CTD | PMID:33387578 | Vsir | Rat | GSK-J4 | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | GSK-J4 results in decreased expression of VSIR mRNA | CTD | PMID:29301935 | Vsir | Rat | indometacin | multiple interactions | ISO | VSIR (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Vsir | Rat | lipopolysaccharide | multiple interactions | ISO | VSIR (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of VSIR mRNA; [S-(1,2-dichlorovinyl)cysteine more ... | CTD | PMID:35811015 | Vsir | Rat | lipopolysaccharide | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | Lipopolysaccharides results in decreased expression of VSIR mRNA | CTD | PMID:35811015 | Vsir | Rat | methapyrilene | increases methylation | ISO | VSIR (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of VSIR intron | CTD | PMID:30157460 | Vsir | Rat | methapyrilene | decreases methylation | ISO | VSIR (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of VSIR 3' UTR | CTD | PMID:30157460 | Vsir | Rat | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of VSIR mRNA | CTD | PMID:19013360 | Vsir | Rat | N-nitrosodimethylamine | increases expression | EXP | | 6480464 | Dimethylnitrosamine results in increased expression of VSIR mRNA | CTD | PMID:25380136 | Vsir | Rat | paracetamol | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of VSIR mRNA | CTD | PMID:22230336 | Vsir | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of VSIR mRNA | CTD | PMID:33387578 | Vsir | Rat | paracetamol | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of VSIR mRNA | CTD | PMID:29067470 | Vsir | Rat | perfluorooctanoic acid | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of VSIR mRNA | CTD | PMID:36326898 | Vsir | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | VSIR (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of VSIR mRNA; [S-(1,2-dichlorovinyl)cysteine more ... | CTD | PMID:35811015 | Vsir | Rat | silver atom | increases expression | ISO | Vsir (Mus musculus) | 6480464 | Silver results in increased expression of VSIR mRNA | CTD | PMID:27131904 | Vsir | Rat | silver(0) | increases expression | ISO | Vsir (Mus musculus) | 6480464 | Silver results in increased expression of VSIR mRNA | CTD | PMID:27131904 | Vsir | Rat | sodium arsenite | decreases expression | ISO | Vsir (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of VSIR mRNA | CTD | PMID:39515575 | Vsir | Rat | sodium arsenite | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of VSIR mRNA | CTD | PMID:39719251 | Vsir | Rat | sodium arsenite | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of VSIR mRNA | CTD | PMID:38568856 | Vsir | Rat | sulforaphane | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of VSIR mRNA | CTD | PMID:31838189 | Vsir | Rat | sunitinib | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Sunitinib results in increased expression of VSIR mRNA | CTD | PMID:31533062 | Vsir | Rat | tetraphene | multiple interactions | ISO | Vsir (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Vsir | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of VSIR mRNA | CTD | PMID:34492290 | Vsir | Rat | thiram | decreases expression | ISO | VSIR (Homo sapiens) | 6480464 | Thiram results in decreased expression of VSIR mRNA | CTD | PMID:38568856 | Vsir | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of VSIR mRNA | CTD | PMID:33387578 | Vsir | Rat | triphenyl phosphate | affects expression | ISO | VSIR (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of VSIR mRNA | CTD | PMID:37042841 | Vsir | Rat | tris(2-butoxyethyl) phosphate | affects expression | ISO | VSIR (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of VSIR mRNA | CTD | PMID:29024780 | Vsir | Rat | triticonazole | increases expression | EXP | | 6480464 | triticonazole results in increased expression of VSIR mRNA | CTD | PMID:36084822 | Vsir | Rat | urethane | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Urethane results in increased expression of VSIR mRNA | CTD | PMID:28818685 | Vsir | Rat | valproic acid | increases expression | ISO | VSIR (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of VSIR mRNA | CTD | PMID:23179753|PMID:28001369|PMID:29154799 | | 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