VSIR (V-set immunoregulatory receptor)

Gene: VSIR (V-set immunoregulatory receptor) Chlorocebus sabaeus

Analyze

Symbol:

VSIR

Name:

V-set immunoregulatory receptor

RGD ID:

18574583

Description:

ENCODES a protein that exhibits endopeptidase activator activity (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN BMP signaling pathway (ortholog); negative regulation of CD4-positive, alpha-beta T cell proliferation (ortholog); negative regulation of CD8-positive, alpha-beta T cell proliferation (ortholog); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 12 (ortholog); combined saposin deficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN external side of plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C9H10orf54; platelet receptor Gi24; V-type immunoglobulin domain-containing suppressor of T-cell activation

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	59,516,012 - 59,538,628 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	59,516,073 - 59,542,242 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	20,159,695 - 20,182,168 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness 12 (ISO)

combined saposin deficiency (ISO)

Experimental Liver Cirrhosis (ISO)

pituitary adenoma 5 (ISO)

retinitis pigmentosa-deafness syndrome (ISO)

Usher syndrome type 1D (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

BMP signaling pathway (ISO)

negative regulation of alpha-beta T cell activation (IEA)

negative regulation of CD4-positive, alpha-beta T cell proliferation (ISO)

negative regulation of CD8-positive, alpha-beta T cell proliferation (ISO)

negative regulation of interleukin-10 production (ISO)

negative regulation of interleukin-17 production (ISO)

negative regulation of T cell cytokine production (ISO)

negative regulation of tumor necrosis factor production (ISO)

negative regulation of type II interferon production (ISO)

positive regulation of BMP signaling pathway (ISO)

positive regulation of cell migration (ISO)

positive regulation of collagen catabolic process (ISO)

positive regulation of gene expression (ISO)

positive regulation of regulatory T cell differentiation (ISO)

positive regulation of stem cell differentiation (ISO)

regulation of immune response (IEA)

stem cell differentiation (ISO)

zymogen activation (ISO)

Cellular Component

external side of plasma membrane (ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

endopeptidase activator activity (ISO)

enzyme binding (ISO)

identical protein binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

VSIR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	59,516,012 - 59,538,628 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	59,516,073 - 59,542,242 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	20,159,695 - 20,182,168 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

VSIR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	71,747,556 - 71,773,520 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	71,747,556 - 71,773,520 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	73,507,313 - 73,533,277 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	73,177,319 - 73,203,343 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	66,789,752 - 66,815,911 (-)	NCBI		Celera
Cytogenetic Map	10	q22.1	NCBI
HuRef	10	67,501,145 - 67,527,120 (-)	NCBI		HuRef
CHM1_1	10	73,789,445 - 73,815,328 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	72,618,370 - 72,644,252 (-)	NCBI		T2T-CHM13v2.0

Vsir
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	60,182,630 - 60,266,073 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	60,182,630 - 60,208,463 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	60,346,851 - 60,430,294 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	60,346,851 - 60,372,684 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	59,809,599 - 59,835,432 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	59,742,261 - 59,768,041 (+)	NCBI		MGSCv36	mm8
Celera	10	61,443,716 - 61,469,794 (+)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	30.26	NCBI

Vsir
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	28,824,493 - 28,850,175 (+)	NCBI		GRCr8
mRatBN7.2	20	28,281,582 - 28,307,262 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	28,281,596 - 28,303,878 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	29,296,385 - 29,322,002 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	28,682,693 - 28,708,310 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	29,425,156 - 29,450,774 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	29,897,543 - 29,923,381 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	29,897,594 - 29,919,998 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	31,709,023 - 31,734,846 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	27,662,633 - 27,684,891 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	29,719,788 - 29,742,034 (+)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

Vsir
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955437	19,716,466 - 19,743,428 (+)	NCBI	ChiLan1.0	ChiLan1.0

VSIR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	83,898,498 - 83,924,301 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	83,900,069 - 83,929,613 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	68,218,230 - 68,243,687 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	70,742,062 - 70,767,613 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	70,742,062 - 70,767,613 (-)	Ensembl	panpan1.1		panPan2

VSIR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	22,504,888 - 22,530,702 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	22,459,363 - 22,530,687 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	22,640,897 - 22,668,397 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	22,779,509 - 22,807,057 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	22,783,285 - 22,805,226 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	22,685,865 - 22,713,397 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	22,884,409 - 22,911,939 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	23,238,917 - 23,266,458 (-)	NCBI		UU_Cfam_GSD_1.0

VSIR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	74,666,624 - 74,693,281 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	74,667,081 - 74,693,347 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	80,558,168 - 80,584,424 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Vsir
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	5,665,445 - 5,686,692 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	5,664,899 - 5,686,675 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	1	20	15
Low	35		45
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007963136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000006496 ⟹ ENSCSAP00000004700

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	9	59,516,073 - 59,542,242 (+)	Ensembl

RefSeq Acc Id:

XM_007963136 ⟹ XP_007961327

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	9	59,516,012 - 59,538,628 (+)	NCBI
Vero_WHO_p1.0	NW_023666048	20,159,695 - 20,182,168 (+)	NCBI

Sequence:

show sequence

GGGGCGGGTGCCTGGAGCGCGGCGCTGGGGCCGCCCGCTGCGCTCACTCGCTCGCACTCGCTCG
CACTCACTCGCGGGAGGCTTCCCCGCGCCGGCGGCGTTCCTCCCGCTCCCCGGCACCAGAAGTT
CCTCTGCGCGTCTAAAGGCGACATGGGCGTCCGCACGGCCCCGGAGGCCGGCTGCTGGCGCTGG
GGATCCCTGCTCTTCGCCCTCTTCCTGGCTGCGTCCCTAGGTCCAGTGGCAGCCTTCAAGGTCG
CCACGCTGTATTCCCTGTACGTCTGTCCCGAGGGGCAGAACGTCACCCTCACCTGCAGGCTCTT
CGGCCCTGTCGACAAAGGGCATGATGTGACCTTCTACAAGACGTGGTACCGCAGCTCGAGGGGC
GAGGTGCAGACCTGCTCAGAGCGCCGGCCCATCCGCAACCTCACGTTCCAGGACCTTCACCTGC
ACCATGGAGGCCACCAGGCTGCCAACACCAGCCACGACCTGGCCCAGCGCCACGGGCTGGAGTC
GGCCTCCGACCACCATGGCAACTTCTCCATCACCATGCGCAACCTGACCCTGCTGGACAGCGGC
CTCTACTGCTGCCTTGTGGTGGAGATCAAGCACCACCACTCGGAGCACAGGGTCCATGGTGCCA
TGGAGCTGCAGGTGCAGACAGGCAAAGATGCACCATCCAACTGCGTGGCATACCCATCCTCCTC
CCAGGAGAGTGAAAACATCACGGCTGCAGCCCTGGCTACCGGTGCCTGCATCGTAGGAATCCTC
TGCCTCCCCCTCATCCTGCTCCTGGTCTACAAGCAAAGGCAGGCGGCCTCCAACCGTCGTGCCC
AGGAGCTGGTGCGGATGGACAGCAACACTCAAGGGATTGAAAACCCTGGCTTTGAGGCCTCATC
ACCTGCCCAGGGGATACTGGAGGCCAAAGTCAGGCACCCCCTGTCCTATGTGGCCCAGCGGCAG
CCTTCTGAGTCTGGGCGGCATCTGCTTTCGGAGCCCGGCACCCCCCTATCTCCTCCAGGCCCCG
GAGACGTCTTCTTCCCATCCCTGGACCCTGTTCCTGACTCTCCAAACTTTGAGGTCATCTAGAC
CAGCTGGGGGACAGTGGGCCGTTGTGGCTGGGTTTGGGGCAGGTGCATTTGAGCCAGGGCTGGC
TCTGTGAGTGGCCTCCTTGGCCTCGGCCCTGGTTCCCTCCCTCCTGCTCTGGGTTCAGATGCTG
CGACATCCCAGAAGCCCAGACCCTCAACCCCTCTGGATGCTACATGGGGACGCTGGATGGCTAA
GCCCCTGTTCCAAGGATTTTGGGGTGCTGAGATTCTCCCCTAGAGACCTGAACTTCACCAGCCA
CAGATTCAAATGACTTAATGTTAAGAAGTCTCAGAATGTCCAGCCCGTCAGCAGTTCTAATTCT
GAGACATGAGCCTTGGGATGTGGCAGCATCAGTGGGACAAGATGGACACTGGGCCACCCTCCCA
GACATGAGACACACGGCACTGTGGAGAGACTTCTCCCCCATGGCTGCCTGGGCTCCCCCATCTC
GCCTGAGGCTGCTCTTCTGTCAGACTTCCTCTTTGTACCACAGTGGCTCTGGGGCCAGGCCTGC
CTGCCCACTGGCCATCGCCACCTTCCCCAGCTGCCTCCTACCAGCAGTTTCTCTGATGATCTGT
CAACAGGTTCAGTCAATCTGGGGCTTCCAGTGCCTGCATTCCAGTCCCCAGAGCCTGGTGGTCC
CGAAACGGGAAGTACGTACTGGGGCCTAGTGGCCACTGTGAGCAAATGGTGTCTTGGGCAATCT
GAGGCCAGGCCAGATGTTGCACCACCCACTGAGATGGTGGTGAGGGAGGTGGGTGGGGCCTTCT
GGGAAGGTAAGTGGGGCCCCCCACCCTCCCCATCCTCTACTCCCACTGCTCAGCCTGGGCCATT
GCAAGGGTGCCACACAATGTCTTGTCCACTCTGGGCCACTTCTGAGTGTGAAGCGGGATGCTAT
TAAAAACTACGTGGGGAAACAGGTGCAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007961327	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004700
	ENSCSAP00000004700.1

RefSeq Acc Id:	XP_007961327 ⟸ XM_007963136
- UniProtKB:	A0A0D9R7W1 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000004700 ⟸ ENSCSAT00000006496

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000008444	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000006496.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
	VISTA	UniProtKB/TrEMBL
KEGG Report	csab:103216038	UniProtKB/TrEMBL
NCBI Gene	VSIR	ENTREZGENE
PANTHER	PTHR44819	UniProtKB/TrEMBL
	V-TYPE IMMUNOGLOBULIN DOMAIN-CONTAINING SUPPRESSOR OF T-CELL ACTIVATION	UniProtKB/TrEMBL
Pfam	V-set	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
SMART	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A0D9R7W1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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