Itsn2 (intersectin 2) - Rat Genome Database

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Gene: Itsn2 (intersectin 2) Rattus norvegicus
Analyze
Symbol: Itsn2
Name: intersectin 2
RGD ID: 1590890
Description: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in clathrin-dependent synaptic vesicle endocytosis and positive regulation of dendrite extension. Predicted to act upstream of or within cell-cell signaling and endocytosis. Predicted to be located in centrosome. Predicted to be active in cytosol; intracellular vesicle; and presynaptic membrane. Orthologous to human ITSN2 (intersectin 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: intersectin-2; LOC313934; similar to Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8633,336,086 - 33,446,818 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl633,336,441 - 33,446,818 (+)EnsemblGRCr8
mRatBN7.2627,616,645 - 27,727,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,600,406 - 27,727,124 (+)EnsemblmRatBN7.2
Rnor_6.0630,098,378 - 30,208,694 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl630,098,380 - 30,187,337 (-)Ensemblrn6Rnor6.0
Rnor_5.0639,701,659 - 39,790,623 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera627,085,036 - 27,196,783 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centrosome  (IEA,ISO)
cytoplasm  (IBA,IEA)
cytosol  (ISO)
intracellular vesicle  (IBA)
plasma membrane  (IBA)
presynapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16903783   PMID:19056867   PMID:20448150   PMID:20479469   PMID:23999003  


Genomics

Comparative Map Data
Itsn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8633,336,086 - 33,446,818 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl633,336,441 - 33,446,818 (+)EnsemblGRCr8
mRatBN7.2627,616,645 - 27,727,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,600,406 - 27,727,124 (+)EnsemblmRatBN7.2
Rnor_6.0630,098,378 - 30,208,694 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl630,098,380 - 30,187,337 (-)Ensemblrn6Rnor6.0
Rnor_5.0639,701,659 - 39,790,623 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera627,085,036 - 27,196,783 (+)NCBICelera
Cytogenetic Map6q14NCBI
ITSN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38224,202,864 - 24,361,368 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl224,202,864 - 24,360,807 (-)Ensemblhg38GRCh38
GRCh37224,425,733 - 24,583,405 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,279,239 - 24,436,881 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34224,354,843 - 24,495,028NCBI
Celera224,266,029 - 24,423,608 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef224,164,460 - 24,322,301 (-)NCBIHuRef
CHM1_1224,355,106 - 24,512,765 (-)NCBICHM1_1
T2T-CHM13v2.0224,237,561 - 24,395,986 (-)NCBIT2T-CHM13v2.0
Itsn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,642,792 - 4,763,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,642,638 - 4,763,962 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38124,592,643 - 4,713,952 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,592,638 - 4,713,962 (+)Ensemblmm10GRCm38
MGSCv37124,599,814 - 4,720,758 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36124,606,965 - 4,727,848 (+)NCBIMGSCv36mm8
Celera124,524,713 - 4,645,575 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map122.09NCBI
Itsn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554696,358,131 - 6,493,956 (-)Ensembl
ChiLan1.0NW_0049554696,358,131 - 6,493,956 (-)NCBIChiLan1.0ChiLan1.0
ITSN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212102,161,744 - 102,316,713 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A102,165,886 - 102,320,676 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A24,199,600 - 24,354,314 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A24,296,617 - 24,451,013 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A24,297,373 - 24,419,593 (-)EnsemblpanPan2panpan1.1
ITSN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11718,627,543 - 18,756,669 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1718,627,935 - 18,756,114 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1718,525,190 - 18,654,045 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01718,901,627 - 19,030,962 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1718,901,631 - 19,030,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11718,638,301 - 18,766,826 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01718,647,161 - 18,776,232 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01718,687,565 - 18,789,791 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itsn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629262,996,753 - 63,123,155 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,738,630 - 7,842,814 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,716,424 - 7,842,818 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITSN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3114,363,529 - 114,508,444 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13114,363,319 - 114,508,447 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23121,628,711 - 121,773,090 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITSN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11483,297,061 - 83,452,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1483,297,259 - 83,453,335 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604528,716,121 - 28,869,191 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itsn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247386,480,257 - 6,637,722 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247386,480,203 - 6,637,713 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Itsn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1725,263,153 - 25,371,844 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itsn2
812 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:79
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000073870, ENSRNOT00000074150
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
D6Got197  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,653,295 - 27,653,421 (-)MAPPERmRatBN7.2
Rnor_6.0630,172,059 - 30,172,184NCBIRnor6.0
Rnor_5.0639,716,817 - 39,716,942UniSTSRnor5.0
Celera627,122,727 - 27,122,870UniSTS
RH 3.4 Map6115.4RGD
RH 3.4 Map6115.4UniSTS
RH 2.0 Map6229.6RGD
Cytogenetic Map6q12UniSTS
RH128822  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,727,166 - 27,727,346 (-)MAPPERmRatBN7.2
Rnor_6.0630,098,405 - 30,098,584NCBIRnor6.0
Rnor_5.0639,790,417 - 39,790,596UniSTSRnor5.0
Celera627,196,577 - 27,196,756UniSTS
RH 3.4 Map6117.3UniSTS
Cytogenetic Map6q12UniSTS
AA850325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,695,109 - 27,695,290 (-)MAPPERmRatBN7.2
Rnor_6.0630,129,456 - 30,129,636NCBIRnor6.0
Rnor_5.0639,759,365 - 39,759,545UniSTSRnor5.0
Celera627,164,556 - 27,164,736UniSTS
RH 3.4 Map6117.6UniSTS
Cytogenetic Map6q12UniSTS
RH138620  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,663,272 - 27,663,472 (-)MAPPERmRatBN7.2
Rnor_6.0630,161,693 - 30,161,892NCBIRnor6.0
Rnor_5.0639,727,109 - 39,727,308UniSTSRnor5.0
Celera627,132,720 - 27,132,919UniSTS
RH 3.4 Map6116.49UniSTS
Cytogenetic Map6q12UniSTS
BM386909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,692,922 - 27,693,125 (-)MAPPERmRatBN7.2
Rnor_6.0630,131,621 - 30,131,823NCBIRnor6.0
Rnor_5.0639,757,178 - 39,757,380UniSTSRnor5.0
Celera627,162,369 - 27,162,571UniSTS
RH 3.4 Map6116.49UniSTS
Cytogenetic Map6q12UniSTS
AL033711  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21125,255,754 - 25,255,877 (+)MAPPERmRatBN7.2
mRatBN7.2627,673,081 - 27,673,204 (-)MAPPERmRatBN7.2
Rnor_6.0630,151,960 - 30,152,082NCBIRnor6.0
Rnor_6.01125,674,523 - 25,674,645NCBIRnor6.0
Rnor_5.0639,736,919 - 39,737,041UniSTSRnor5.0
Rnor_5.01129,298,025 - 29,298,147UniSTSRnor5.0
RGSC_v3.41125,761,857 - 25,761,979UniSTSRGSC3.4
Celera1125,055,477 - 25,055,599UniSTS
Celera627,142,530 - 27,142,652UniSTS
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001067254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003750126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003754161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_233945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000074150   ⟹   ENSRNOP00000065329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl633,363,402 - 33,446,818 (+)Ensembl
mRatBN7.2 Ensembl627,643,958 - 27,727,124 (+)Ensembl
Rnor_6.0 Ensembl630,098,380 - 30,187,337 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099866   ⟹   ENSRNOP00000089614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl633,336,446 - 33,446,818 (+)Ensembl
mRatBN7.2 Ensembl627,600,406 - 27,727,124 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100901   ⟹   ENSRNOP00000094789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl633,336,446 - 33,446,818 (+)Ensembl
mRatBN7.2 Ensembl627,600,406 - 27,727,124 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119587   ⟹   ENSRNOP00000096723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl633,336,441 - 33,446,816 (+)Ensembl
mRatBN7.2 Ensembl627,600,406 - 27,727,124 (+)Ensembl
RefSeq Acc Id: NM_001427104   ⟹   NP_001414033
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,446 - 33,446,818 (+)NCBI
RefSeq Acc Id: XM_039113102   ⟹   XP_038969030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,220 - 33,446,818 (+)NCBI
mRatBN7.2627,616,812 - 27,727,373 (+)NCBI
RefSeq Acc Id: XM_039113103   ⟹   XP_038969031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,086 - 33,446,818 (+)NCBI
mRatBN7.2627,616,645 - 27,727,373 (+)NCBI
RefSeq Acc Id: XM_039113104   ⟹   XP_038969032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,706 - 33,446,818 (+)NCBI
mRatBN7.2627,617,258 - 27,727,373 (+)NCBI
RefSeq Acc Id: XM_039113105   ⟹   XP_038969033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,255 - 33,446,818 (+)NCBI
mRatBN7.2627,616,812 - 27,727,373 (+)NCBI
RefSeq Acc Id: XM_039113106   ⟹   XP_038969034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,255 - 33,446,818 (+)NCBI
mRatBN7.2627,616,812 - 27,727,373 (+)NCBI
RefSeq Acc Id: XM_039113108   ⟹   XP_038969036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,211 - 33,446,818 (+)NCBI
mRatBN7.2627,616,812 - 27,727,373 (+)NCBI
RefSeq Acc Id: XM_039113109   ⟹   XP_038969037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,255 - 33,444,890 (+)NCBI
mRatBN7.2627,616,812 - 27,723,699 (+)NCBI
RefSeq Acc Id: XM_039113110   ⟹   XP_038969038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,255 - 33,414,944 (+)NCBI
mRatBN7.2627,616,812 - 27,695,503 (+)NCBI
RefSeq Acc Id: XM_063261877   ⟹   XP_063117947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,255 - 33,446,818 (+)NCBI
RefSeq Acc Id: XM_063261878   ⟹   XP_063117948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,255 - 33,414,944 (+)NCBI
RefSeq Acc Id: XM_063261879   ⟹   XP_063117949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,336,211 - 33,414,944 (+)NCBI
Ensembl Acc Id: ENSRNOP00000065329   ⟸   ENSRNOT00000074150
RefSeq Acc Id: XP_038969031   ⟸   XM_039113103
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8K6 (UniProtKB/TrEMBL),   M0R7A6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969030   ⟸   XM_039113102
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8K6 (UniProtKB/TrEMBL),   M0R7A6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969033   ⟸   XM_039113105
- Peptide Label: isoform X2
- UniProtKB: M0R7A6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969036   ⟸   XM_039113108
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AMD2 (UniProtKB/TrEMBL),   A6HAI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969034   ⟸   XM_039113106
- Peptide Label: isoform X3
- UniProtKB: M0R7A6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969037   ⟸   XM_039113109
- Peptide Label: isoform X6
- UniProtKB: M0R7A6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969038   ⟸   XM_039113110
- Peptide Label: isoform X7
- UniProtKB: A6HAI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969032   ⟸   XM_039113104
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8K6 (UniProtKB/TrEMBL),   M0R7A6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096723   ⟸   ENSRNOT00000119587
Ensembl Acc Id: ENSRNOP00000094789   ⟸   ENSRNOT00000100901
Ensembl Acc Id: ENSRNOP00000089614   ⟸   ENSRNOT00000099866
RefSeq Acc Id: XP_063117949   ⟸   XM_063261879
- Peptide Label: isoform X9
- UniProtKB: A6HAI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117947   ⟸   XM_063261877
- Peptide Label: isoform X5
- UniProtKB: A6HAI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117948   ⟸   XM_063261878
- Peptide Label: isoform X8
- UniProtKB: A6HAI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414033   ⟸   NM_001427104
- UniProtKB: A0A8I6ASA9 (UniProtKB/TrEMBL),   A6HAI3 (UniProtKB/TrEMBL)
Protein Domains
C2   DH   EF-hand   EH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7A6-F1-model_v2 AlphaFold M0R7A6 1-1716 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590890 AgrOrtholog
BioCyc Gene G2FUF-38270 BioCyc
Ensembl Genes ENSRNOG00000046741 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074150 ENTREZGENE
  ENSRNOT00000074150.5 UniProtKB/TrEMBL
  ENSRNOT00000099866 ENTREZGENE
  ENSRNOT00000099866.2 UniProtKB/TrEMBL
  ENSRNOT00000100901 ENTREZGENE
  ENSRNOT00000100901.2 UniProtKB/TrEMBL
  ENSRNOT00000119587 ENTREZGENE
  ENSRNOT00000119587.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  EF-hand-like_dom UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Endocytic_GEF_Adapter UniProtKB/TrEMBL
  EPS15_homology UniProtKB/TrEMBL
  Intersectin-2_SH3_1 UniProtKB/TrEMBL
  Intersectin-2_SH3_2 UniProtKB/TrEMBL
  Intersectin-2_SH3_3 UniProtKB/TrEMBL
  Intersectin-2_SH3_4 UniProtKB/TrEMBL
  Intersectin-2_SH3_5 UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene 313934 ENTREZGENE
PANTHER EH DOMAIN UniProtKB/TrEMBL
  INTERSECTIN-2 UniProtKB/TrEMBL
  INTERSECTIN-2 ISOFORM X1 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A UniProtKB/TrEMBL
Pfam EF-hand_4 UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PH_13 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PhenoGen Itsn2 PhenoGen
PRINTS P67PHOX UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  PS50031 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046741 RatGTEx
SMART EFh UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00027 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
UniProt A0A8I6A8K6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASA9 ENTREZGENE, UniProtKB/TrEMBL
  A6HAI3 ENTREZGENE, UniProtKB/TrEMBL
  A6HAI6 ENTREZGENE, UniProtKB/TrEMBL
  M0R7A6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Itsn2  intersectin 2  LOC313934  similar to Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC313934  similar to Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)      Symbol and Name status set to provisional 70820 PROVISIONAL