Ticam1 (TIR domain containing adaptor molecule 1) - Rat Genome Database

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Gene: Ticam1 (TIR domain containing adaptor molecule 1) Rattus norvegicus
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Symbol: Ticam1
Name: TIR domain containing adaptor molecule 1
RGD ID: 1590868
Description: Predicted to enable protein kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; pattern recognition receptor signaling pathway; and positive regulation of cytokine production. Predicted to act upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of lymphocyte activation; and positive regulation of metabolic process. Predicted to be located in cytosol and mitochondrion. Predicted to be part of ripoptosome. Predicted to be active in early endosome and endosome membrane. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (TIR domain containing adaptor molecule 1); PARTICIPATES IN Toll-like receptor signaling pathway; INTERACTS WITH alpha-D-galactose; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363328; similar to TICAM-1; TIR domain-containing adapter molecule 1; toll-like receptor adaptor molecule 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,189,717 - 1,197,730 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,172,963 - 1,196,892 (-)EnsemblGRCr8
mRatBN7.291,102,559 - 1,111,023 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,102,366 - 1,123,147 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd91,897,780 - 1,904,410 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive91,688,583 - 1,695,205 (-)NCBILyon_Normotensive
Lyon_Hypertensive91,497,791 - 1,504,413 (-)NCBILyon_Hypertensive
Rnor_6.0910,780,185 - 10,790,280 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.099,774,816 - 9,781,948 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera97,397,373 - 7,407,468 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
apoptotic signaling pathway  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
defense response to virus  (IEA,ISO)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
lipopolysaccharide-mediated signaling pathway  (ISO)
macrophage activation involved in immune response  (ISO)
MyD88-independent toll-like receptor signaling pathway  (ISO)
obsolete positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IBA,ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of myeloid dendritic cell cytokine production  (ISO)
positive regulation of natural killer cell activation  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (IBA,ISO)
regulation of protein-containing complex assembly  (ISO)
response to exogenous dsRNA  (IEA,ISO)
response to lipopolysaccharide  (ISO)
signal transduction  (IEA)
toll-like receptor 3 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
toll-like receptor signaling pathway  (ISO)
TRIF-dependent toll-like receptor signaling pathway  (IBA,IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12761501   PMID:12855817   PMID:12872135   PMID:14530355   PMID:14982987   PMID:17658277   PMID:19734906   PMID:20037584   PMID:21059856   PMID:21266579   PMID:21703541   PMID:21737330  
PMID:25636800  


Genomics

Comparative Map Data
Ticam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,189,717 - 1,197,730 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,172,963 - 1,196,892 (-)EnsemblGRCr8
mRatBN7.291,102,559 - 1,111,023 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,102,366 - 1,123,147 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd91,897,780 - 1,904,410 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive91,688,583 - 1,695,205 (-)NCBILyon_Normotensive
Lyon_Hypertensive91,497,791 - 1,504,413 (-)NCBILyon_Hypertensive
Rnor_6.0910,780,185 - 10,790,280 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.099,774,816 - 9,781,948 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera97,397,373 - 7,407,468 (+)NCBICelera
Cytogenetic Map9q11NCBI
TICAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,815,932 - 4,831,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,815,932 - 4,831,712 (-)Ensemblhg38GRCh38
GRCh37194,815,944 - 4,831,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,766,992 - 4,769,451 (-)NCBIBuild 36Build 36hg18NCBI36
Celera194,753,860 - 4,769,659 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,577,650 - 4,593,372 (-)NCBIHuRef
CHM1_1194,815,534 - 4,831,367 (-)NCBICHM1_1
T2T-CHM13v2.0194,801,397 - 4,817,189 (-)NCBIT2T-CHM13v2.0
Ticam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,576,462 - 56,583,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,576,319 - 56,583,786 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381756,269,462 - 56,276,767 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,269,319 - 56,276,786 (-)Ensemblmm10GRCm38
MGSCv371756,408,885 - 56,416,190 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361755,328,736 - 55,335,977 (-)NCBIMGSCv36mm8
MGSCv361755,903,171 - 55,910,412 (-)NCBIMGSCv36mm8
Cytogenetic Map17DNCBI
cM Map1729.24NCBI
Ticam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,202,372 - 4,204,513 (+)Ensembl
ChiLan1.0NW_0049554954,197,083 - 4,204,999 (+)NCBIChiLan1.0ChiLan1.0
TICAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2209,211,162 - 9,227,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,440,455 - 8,456,977 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,836,100 - 3,852,017 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,787,244 - 4,803,727 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,787,557 - 4,790,206 (-)EnsemblpanPan2panpan1.1
TICAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,948,237 - 54,961,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,959,525 - 54,961,780 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2054,672,888 - 54,686,637 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02055,602,634 - 55,616,374 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,614,210 - 55,616,158 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,664,010 - 54,677,669 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,144,587 - 55,158,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,342,534 - 55,356,281 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ticam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,005,381 - 215,015,878 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365882,818,909 - 2,827,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TICAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,004,308 - 74,021,873 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1274,004,566 - 74,021,100 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TICAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,526,719 - 4,543,251 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,527,033 - 4,529,168 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660813,618,262 - 3,633,550 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ticam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,971,093 - 4,973,198 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248284,964,199 - 4,973,465 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ticam1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1487,661,536 - 87,664,438 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ticam1
10 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat

Markers in Region
RH134483  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,111,285 - 1,111,482 (-)MAPPERmRatBN7.2
mRatBN7.22022,132,543 - 22,132,740 (+)MAPPERmRatBN7.2
Rnor_6.02023,566,923 - 23,567,119NCBIRnor6.0
Rnor_6.0910,781,357 - 10,781,553NCBIRnor6.0
Rnor_5.099,773,025 - 9,773,221UniSTSRnor5.0
Rnor_5.02025,646,916 - 25,647,112UniSTSRnor5.0
RGSC_v3.42023,019,069 - 23,019,265UniSTSRGSC3.4
Celera2023,484,940 - 23,485,136UniSTS
Celera97,398,545 - 7,398,741UniSTS
Cytogenetic Map20p11UniSTS
Cytogenetic Map9q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 66 137 94 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000070978   ⟹   ENSRNOP00000066344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,189,717 - 1,193,954 (-)Ensembl
mRatBN7.2 Ensembl91,102,941 - 1,123,147 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000072501   ⟹   ENSRNOP00000076995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,189,719 - 1,194,098 (-)Ensembl
mRatBN7.2 Ensembl91,102,366 - 1,109,331 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111500   ⟹   ENSRNOP00000085855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,110,592 - 1,118,597 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122650   ⟹   ENSRNOP00000100176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,189,678 - 1,195,512 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128154   ⟹   ENSRNOP00000102710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,177,565 - 1,192,666 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143167   ⟹   ENSRNOP00000103335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,172,963 - 1,196,892 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149903   ⟹   ENSRNOP00000103639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,174,559 - 1,192,666 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150365   ⟹   ENSRNOP00000107104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,189,609 - 1,194,651 (-)Ensembl
RefSeq Acc Id: NM_001431327   ⟹   NP_001418256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Dahl_SR_JrHsd91,897,780 - 1,904,410 (-)NCBI
Lyon_Normotensive91,688,583 - 1,695,205 (-)NCBI
Lyon_Hypertensive91,497,791 - 1,504,413 (-)NCBI
RefSeq Acc Id: XM_017596709   ⟹   XP_017452198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,189,717 - 1,197,730 (-)NCBI
mRatBN7.291,102,559 - 1,111,023 (-)NCBI
Rnor_6.0910,783,149 - 10,790,280 (+)NCBI
Sequence:
RefSeq Acc Id: XP_017452198   ⟸   XM_017596709
- Sequence:
Ensembl Acc Id: ENSRNOP00000076995   ⟸   ENSRNOT00000072501
Ensembl Acc Id: ENSRNOP00000085855   ⟸   ENSRNOT00000111500
Ensembl Acc Id: ENSRNOP00000066344   ⟸   ENSRNOT00000070978
Ensembl Acc Id: ENSRNOP00000103335   ⟸   ENSRNOT00000143167
Ensembl Acc Id: ENSRNOP00000103639   ⟸   ENSRNOT00000149903
Ensembl Acc Id: ENSRNOP00000107104   ⟸   ENSRNOT00000150365
Ensembl Acc Id: ENSRNOP00000100176   ⟸   ENSRNOT00000122650
Ensembl Acc Id: ENSRNOP00000102710   ⟸   ENSRNOT00000128154
RefSeq Acc Id: NP_001418256   ⟸   NM_001431327

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590868 AgrOrtholog
BioCyc Gene G2FUF-28538 BioCyc
Ensembl Genes ENSRNOG00000048462 Ensembl
  ENSRNOG00000080915 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070978.4 UniProtKB/TrEMBL
  ENSRNOT00000072501 ENTREZGENE
  ENSRNOT00000072501.3 UniProtKB/TrEMBL
  ENSRNOT00000122650.1 UniProtKB/TrEMBL
  ENSRNOT00000128154.1 UniProtKB/TrEMBL
  ENSRNOT00000143167.1 UniProtKB/TrEMBL
  ENSRNOT00000149903.1 UniProtKB/TrEMBL
  ENSRNOT00000150365.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.780 UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/TrEMBL
InterPro RHIM_dom UniProtKB/TrEMBL
  TCAM1/2 UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
  TRIF_N UniProtKB/TrEMBL
KEGG Report rno:363328 UniProtKB/TrEMBL
NCBI Gene 363328 ENTREZGENE
PANTHER PTHR47230 UniProtKB/TrEMBL
  TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 UniProtKB/TrEMBL
Pfam RHIM UniProtKB/TrEMBL
  TRIF-NTD UniProtKB/TrEMBL
PhenoGen Ticam1 PhenoGen
PROSITE TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048462 RatGTEx
  ENSRNOG00000080915 RatGTEx
Superfamily-SCOP SSF52200 UniProtKB/TrEMBL
UniProt A0A8I5Y6Z3 ENTREZGENE
  A0ABK0LPU7_RAT UniProtKB/TrEMBL
  M0RA08 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8I5Y6Z3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Ticam1  TIR domain containing adaptor molecule 1  Ticam1  toll-like receptor adaptor molecule 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-09 Ticam1  toll-like receptor adaptor molecule 1  LOC363328  similar to TICAM-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC363328  similar to TICAM-1      Symbol and Name status set to provisional 70820 PROVISIONAL