Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ak5 | Rat | (S)-nicotine | increases expression | ISO | Ak5 (Mus musculus) | 6480464 | Nicotine results in increased expression of AK5 mRNA | CTD | PMID:21955143 | Ak5 | Rat | 17beta-estradiol | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of AK5 mRNA | CTD | PMID:20823114 | Ak5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ak5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of AK5 mRNA | CTD | PMID:21570461 | Ak5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AK5 mRNA | CTD | PMID:32109520 | Ak5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | AK5 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of AK5 mRNA | CTD | PMID:22574217 | Ak5 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of AK5 mRNA | CTD | PMID:32109520 | Ak5 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | AK5 (Homo sapiens) | 6480464 | 2,2',4,4',5-brominated diphenyl ether results in increased expression of AK5 mRNA | CTD | PMID:26705709 | Ak5 | Rat | 2-palmitoylglycerol | increases expression | ISO | AK5 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of AK5 mRNA | CTD | PMID:37199045 | Ak5 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Ak5 (Mus musculus) | 6480464 | bisphenol S results in increased expression of AK5 mRNA | CTD | PMID:30951980 | Ak5 | Rat | 5-azacytidine | increases expression | ISO | AK5 (Homo sapiens) | 6480464 | Azacitidine results in increased expression of AK5 mRNA | CTD | PMID:20823114 | Ak5 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of AK5 mRNA | CTD | PMID:24780913 | Ak5 | Rat | afimoxifene | decreases response to substance | ISO | AK5 (Homo sapiens) | 6480464 | AK5 results in decreased susceptibility to afimoxifene | CTD | PMID:21233418 | Ak5 | Rat | aflatoxin B1 | affects methylation | ISO | AK5 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of AK5 intron | CTD | PMID:30157460 | Ak5 | Rat | all-trans-retinoic acid | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of AK5 mRNA | CTD | PMID:23724009 | Ak5 | Rat | antirheumatic drug | increases expression | ISO | AK5 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of AK5 mRNA | CTD | PMID:24449571 | Ak5 | Rat | benzo[a]pyrene | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of AK5 mRNA | CTD | PMID:20064835 | Ak5 | Rat | benzo[a]pyrene | increases methylation | ISO | AK5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of AK5 exon | CTD | PMID:27901495 | Ak5 | Rat | benzo[a]pyrene | increases methylation | ISO | Ak5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of AK5 exon; Benzo(a)pyrene results in increased methylation of AK5 more ... | CTD | PMID:27901495 | Ak5 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of AK5 mRNA | CTD | PMID:31163220 | Ak5 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Ak5 | Rat | bisphenol A | increases expression | ISO | Ak5 (Mus musculus) | 6480464 | bisphenol A results in increased expression of AK5 mRNA | CTD | PMID:30245210 | Ak5 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of AK5 mRNA | CTD | PMID:41034487 | Ak5 | Rat | bisphenol A | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of AK5 gene | CTD | PMID:31601247 | Ak5 | Rat | bisphenol A | increases methylation | ISO | AK5 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of AK5 gene | CTD | PMID:31601247 | Ak5 | Rat | bisphenol F | increases expression | ISO | Ak5 (Mus musculus) | 6480464 | bisphenol F results in increased expression of AK5 mRNA | CTD | PMID:30951980 | Ak5 | Rat | bucladesine | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of AK5 mRNA | CTD | PMID:20823114 | Ak5 | Rat | Butylbenzyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Ak5 | Rat | calcitriol | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of AK5 mRNA | CTD | PMID:26485663 | Ak5 | Rat | CGP 52608 | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to AK5 gene] | CTD | PMID:28238834 | Ak5 | Rat | clobetasol | decreases expression | ISO | Ak5 (Mus musculus) | 6480464 | Clobetasol results in decreased expression of AK5 mRNA | CTD | PMID:27462272 | Ak5 | Rat | copper atom | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of AK5 mRNA | CTD | PMID:20971185 | Ak5 | Rat | copper(0) | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of AK5 mRNA | CTD | PMID:20971185 | Ak5 | Rat | copper(II) sulfate | affects expression | ISO | AK5 (Homo sapiens) | 6480464 | Copper Sulfate affects the expression of AK5 mRNA | CTD | PMID:19549813 | Ak5 | Rat | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Ak5 | Rat | diethyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Ak5 | Rat | diisobutyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Ak5 | Rat | diisononyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Ak5 | Rat | diquat | decreases expression | ISO | Ak5 (Mus musculus) | 6480464 | Diquat results in decreased expression of AK5 mRNA | CTD | PMID:36851058 | Ak5 | Rat | doramapimod | increases expression | EXP | | 6480464 | doramapimod results in increased expression of AK5 mRNA | CTD | PMID:24303162 | Ak5 | Rat | dorsomorphin | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Ak5 | Rat | ethanol | decreases expression | ISO | Ak5 (Mus musculus) | 6480464 | Ethanol results in decreased expression of AK5 mRNA | CTD | PMID:21955143 | Ak5 | Rat | ethanol | affects splicing | ISO | Ak5 (Mus musculus) | 6480464 | Ethanol affects the splicing of AK5 mRNA | CTD | PMID:30319688 | Ak5 | Rat | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of AK5 mRNA | CTD | PMID:30307764 | Ak5 | Rat | fonofos | increases methylation | ISO | AK5 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of AK5 promoter | CTD | PMID:22847954 | Ak5 | Rat | fulvestrant | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of AK5 gene | CTD | PMID:31601247 | Ak5 | Rat | genistein | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | Genistein results in decreased expression of AK5 mRNA | CTD | PMID:22228119 | Ak5 | Rat | ivermectin | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of AK5 protein | CTD | PMID:32959892 | Ak5 | Rat | lead(0) | affects expression | ISO | AK5 (Homo sapiens) | 6480464 | Lead affects the expression of AK5 mRNA | CTD | PMID:28903495 | Ak5 | Rat | lipopolysaccharide | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of AK5 mRNA | CTD | PMID:35811015 | Ak5 | Rat | maneb | multiple interactions | ISO | Ak5 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of AK5 mRNA | CTD | PMID:36117858 | Ak5 | Rat | medroxyprogesterone acetate | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of AK5 mRNA | CTD | PMID:20823114 | Ak5 | Rat | methamphetamine | affects response to substance | ISO | AK5 (Homo sapiens) | 6480464 | AK5 gene SNP affects the susceptibility to Methamphetamine | CTD | PMID:18316681 | Ak5 | Rat | methylmercury chloride | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of AK5 mRNA | CTD | PMID:28001369 | Ak5 | Rat | mono(2-ethylhexyl) phthalate | increases expression | ISO | AK5 (Homo sapiens) | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of AK5 mRNA | CTD | PMID:36695872 | Ak5 | Rat | morphine | decreases expression | ISO | Ak5 (Mus musculus) | 6480464 | Morphine results in decreased expression of AK5 mRNA | CTD | PMID:21955143 | Ak5 | Rat | nicotine | increases expression | ISO | Ak5 (Mus musculus) | 6480464 | Nicotine results in increased expression of AK5 mRNA | CTD | PMID:21955143 | Ak5 | Rat | okadaic acid | increases expression | ISO | AK5 (Homo sapiens) | 6480464 | Okadaic Acid results in increased expression of AK5 mRNA | CTD | PMID:38832940 | Ak5 | Rat | paracetamol | multiple interactions | ISO | Ak5 (Mus musculus) | 6480464 | MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of AK5 mRNA] | CTD | PMID:18700144 | Ak5 | Rat | paraquat | multiple interactions | ISO | Ak5 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of AK5 mRNA | CTD | PMID:36117858 | Ak5 | Rat | parathion | increases methylation | ISO | AK5 (Homo sapiens) | 6480464 | Parathion results in increased methylation of AK5 promoter | CTD | PMID:22847954 | Ak5 | Rat | PCB138 | increases expression | EXP | | 6480464 | 2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of AK5 mRNA | CTD | PMID:23829299 | Ak5 | Rat | phenylmercury acetate | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of AK5 mRNA | CTD | PMID:26272509 | Ak5 | Rat | phenylmercury acetate | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Ak5 | Rat | pirinixic acid | increases expression | ISO | Ak5 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of AK5 mRNA | CTD | PMID:20813756 | Ak5 | Rat | potassium chromate | increases expression | ISO | AK5 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of AK5 mRNA | CTD | PMID:22714537 | Ak5 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | S-(1,2-dichlorovinyl)cysteine results in decreased expression of AK5 mRNA | CTD | PMID:35811015 | Ak5 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of AK5 mRNA | CTD | PMID:35811015 | Ak5 | Rat | SB 431542 | multiple interactions | ISO | AK5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Ak5 | Rat | silicon dioxide | increases expression | ISO | AK5 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of AK5 mRNA | CTD | PMID:25895662 | Ak5 | Rat | terbufos | increases methylation | ISO | AK5 (Homo sapiens) | 6480464 | terbufos results in increased methylation of AK5 promoter | CTD | PMID:22847954 | Ak5 | Rat | trichostatin A | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of AK5 mRNA | CTD | PMID:24935251 | Ak5 | Rat | triptonide | decreases expression | ISO | Ak5 (Mus musculus) | 6480464 | triptonide results in decreased expression of AK5 mRNA | CTD | PMID:33045310 | Ak5 | Rat | tunicamycin | increases expression | ISO | Ak5 (Mus musculus) | 6480464 | Tunicamycin results in increased expression of AK5 mRNA | CTD | PMID:17127020 | Ak5 | Rat | valproic acid | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of AK5 mRNA | CTD | PMID:23179753 | Ak5 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of AK5 gene | CTD | PMID:31682807 | Ak5 | Rat | zoledronic acid | decreases expression | ISO | AK5 (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of AK5 mRNA | CTD | PMID:24714768 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















