Mcu (mitochondrial calcium uniporter) - Rat Genome Database

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Gene: Mcu (mitochondrial calcium uniporter) Rattus norvegicus
Analyze
Symbol: Mcu
Name: mitochondrial calcium uniporter
RGD ID: 1589771
Description: Enables uniporter activity. Involved in mitochondrial calcium ion transmembrane transport and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane. Orthologous to human MCU (mitochondrial calcium uniporter); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; aconitine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium uniporter protein, mitochondrial; Ccdc109a; coiled-coil domain containing 109A; coiled-coil domain-containing protein 109A; LOC294560; similar to CG18769-PB, isoform B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,960,520 - 28,123,103 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2027,961,327 - 28,123,103 (-)EnsemblGRCr8
mRatBN7.22027,417,529 - 27,580,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,417,526 - 27,580,110 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2028,428,977 - 28,592,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02027,815,235 - 27,978,481 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02028,559,862 - 28,721,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,037,452 - 29,199,224 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,038,480 - 29,199,224 (-)Ensemblrn6Rnor6.0
Rnor_5.02030,840,963 - 31,003,860 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera2028,862,404 - 29,023,532 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
choline  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
homocysteine  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lead(II) chloride  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
ruthenium red  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spermine  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Ca2+ -dependent inactivation of the mitochondrial Ca2+ uniporter involves proton flux through the ATP synthase. Moreau B and Parekh AB, Curr Biol. 2008 Jun 3;18(11):855-9.
3. Biphasic regulation of mitochondrial Ca2+ uptake by cytosolic Ca2+ concentration. Moreau B, etal., Curr Biol. 2006 Aug 22;16(16):1672-7.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Mitochondria as sensors and regulators of calcium signalling. Rizzuto R, etal., Nat Rev Mol Cell Biol. 2012 Sep;13(9):566-78. doi: 10.1038/nrm3412. Epub 2012 Aug 1.
6. NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter. Thu VT, etal., Cardiovasc Res. 2012 May 1;94(2):342-50. Epub 2012 Mar 16.
Additional References at PubMed
PMID:18614015   PMID:21162222   PMID:21186615   PMID:21671492   PMID:21685886   PMID:21685888   PMID:22829870   PMID:22925203   PMID:23409044   PMID:23426506   PMID:23755363   PMID:23900286  
PMID:24034353   PMID:24231807   PMID:24510075   PMID:24560927   PMID:24628066   PMID:25529443   PMID:25911325   PMID:26350567   PMID:27099988   PMID:27627464   PMID:27637331   PMID:28388446  
PMID:28916471   PMID:29995857   PMID:34415186  


Genomics

Comparative Map Data
Mcu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,960,520 - 28,123,103 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2027,961,327 - 28,123,103 (-)EnsemblGRCr8
mRatBN7.22027,417,529 - 27,580,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,417,526 - 27,580,110 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2028,428,977 - 28,592,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02027,815,235 - 27,978,481 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02028,559,862 - 28,721,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,037,452 - 29,199,224 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,038,480 - 29,199,224 (-)Ensemblrn6Rnor6.0
Rnor_5.02030,840,963 - 31,003,860 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera2028,862,404 - 29,023,532 (-)NCBICelera
Cytogenetic Map20q11NCBI
MCU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,692,143 - 72,887,694 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,692,110 - 72,887,694 (+)Ensemblhg38GRCh38
GRCh371074,451,901 - 74,647,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,121,895 - 74,317,458 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341074,121,894 - 74,317,456NCBI
Celera1067,737,028 - 67,932,591 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,445,749 - 68,641,292 (+)NCBIHuRef
CHM1_11074,733,636 - 74,929,181 (+)NCBICHM1_1
T2T-CHM13v2.01073,563,507 - 73,759,075 (+)NCBIT2T-CHM13v2.0
Mcu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,282,806 - 59,453,231 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,282,806 - 59,452,514 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381059,446,984 - 59,617,409 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,446,984 - 59,616,692 (-)Ensemblmm10GRCm38
MGSCv371058,911,181 - 59,079,440 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361058,843,954 - 58,853,517 (-)NCBIMGSCv36mm8
Celera1060,548,700 - 60,716,418 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.55NCBI
Mcu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,752,584 - 18,936,507 (-)Ensembl
ChiLan1.0NW_00495543718,750,779 - 18,800,149 (-)NCBIChiLan1.0ChiLan1.0
MCU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2884,870,738 - 85,063,141 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11084,876,077 - 85,068,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,243,282 - 69,435,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11071,707,819 - 71,898,545 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,845,335 - 71,898,545 (+)EnsemblpanPan2panpan1.1
MCU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,309,376 - 23,508,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,309,391 - 23,506,586 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha423,429,107 - 23,646,906 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0423,576,055 - 23,794,462 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,594,897 - 23,794,509 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,475,570 - 23,693,680 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,674,337 - 23,892,420 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,029,405 - 24,247,491 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mcu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,636,667 - 57,698,310 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,131,216 - 6,313,830 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,129,392 - 6,191,035 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,678,393 - 75,721,500 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11475,518,533 - 75,721,502 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,585,088 - 81,788,094 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,383,650 - 58,594,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,383,235 - 58,571,480 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604818,983,576 - 19,197,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247546,445,741 - 6,618,806 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mcu
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11825,296,843 - 25,462,814 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mcu
1109 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:156
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000071477
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071477   ⟹   ENSRNOP00000067686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2027,961,974 - 28,088,963 (-)Ensembl
mRatBN7.2 Ensembl2027,418,983 - 27,460,500 (-)Ensembl
Rnor_6.0 Ensembl2029,038,906 - 29,199,224 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090771   ⟹   ENSRNOP00000071314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2027,961,327 - 28,123,103 (-)Ensembl
mRatBN7.2 Ensembl2027,417,526 - 27,580,110 (-)Ensembl
Rnor_6.0 Ensembl2029,038,480 - 29,184,185 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102262   ⟹   ENSRNOP00000086023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,418,983 - 27,566,710 (-)Ensembl
RefSeq Acc Id: NM_001106398   ⟹   NP_001099868
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,961,974 - 28,123,103 (-)NCBI
mRatBN7.22027,418,983 - 27,580,110 (-)NCBI
Rnor_6.02029,038,906 - 29,199,224 (-)NCBI
Rnor_5.02030,840,963 - 31,003,860 (-)NCBI
Celera2028,862,404 - 29,023,532 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098623   ⟹   XP_038954551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,960,520 - 28,123,083 (-)NCBI
mRatBN7.22027,417,529 - 27,580,091 (-)NCBI
RefSeq Acc Id: XM_039098624   ⟹   XP_038954552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,960,520 - 28,111,674 (-)NCBI
mRatBN7.22027,417,529 - 27,567,058 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099868 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954551 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954552 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93070 (Get FASTA)   NCBI Sequence Viewer  
  EDL93071 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067686.3
  ENSRNOP00000071314
  ENSRNOP00000071314.2
RefSeq Acc Id: NP_001099868   ⟸   NM_001106398
- Peptide Label: precursor
- UniProtKB: A6K3V1 (UniProtKB/TrEMBL),   A0A0G2K059 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071314   ⟸   ENSRNOT00000090771
Ensembl Acc Id: ENSRNOP00000067686   ⟸   ENSRNOT00000071477
RefSeq Acc Id: XP_038954551   ⟸   XM_039098623
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2V9 (UniProtKB/TrEMBL),   M0RDI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954552   ⟸   XM_039098624
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2V9 (UniProtKB/TrEMBL),   M0RDI5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086023   ⟸   ENSRNOT00000102262
Protein Domains
Calcium uniporter protein C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RDI5-F1-model_v2 AlphaFold M0RDI5 1-350 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701590
Promoter ID:EPDNEW_R12114
Type:single initiation site
Name:Mcu_1
Description:mitochondrial calcium uniporter
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02029,199,223 - 29,199,283EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589771 AgrOrtholog
BioCyc Gene G2FUF-3764 BioCyc
Ensembl Genes ENSRNOG00000045920 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071477.3 UniProtKB/TrEMBL
  ENSRNOT00000090771 ENTREZGENE
  ENSRNOT00000090771.3 UniProtKB/TrEMBL
InterPro Coiled-coil-dom_prot_109_C UniProtKB/TrEMBL
  MCU_fam UniProtKB/TrEMBL
KEGG Report rno:294560 UniProtKB/TrEMBL
NCBI Gene 294560 ENTREZGENE
PANTHER CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR13462 UniProtKB/TrEMBL
Pfam DUF607 UniProtKB/TrEMBL
PhenoGen Mcu PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045920 RatGTEx
UniProt A0A0G2K059 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A2V9 ENTREZGENE
  A6K3V1 ENTREZGENE, UniProtKB/TrEMBL
  M0RDI5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-29 Mcu  mitochondrial calcium uniporter  Ccdc109a  coiled-coil domain containing 109A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Ccdc109a  coiled-coil domain containing 109A  LOC294560  similar to CG18769-PB, isoform B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC294560  similar to CG18769-PB, isoform B      Symbol and Name status set to provisional 70820 PROVISIONAL