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Gene: Marco (macrophage receptor with collagenous structure) Rattus norvegicus

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Symbol:

Marco

Name:

macrophage receptor with collagenous structure

RGD ID:

1589662

Description:

Enables G protein-coupled receptor binding activity; amyloid-beta binding activity; and cargo receptor activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; endocytosis; and positive regulation of ERK1 and ERK2 cascade. Located in cytoplasm and plasma membrane. Used to study silicosis. Biomarker of meningococcal meningitis. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH 17beta-estradiol; acetamide; aflatoxin B1.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC367391; macrophage receptor MARCO; similar to Macrophage receptor MARCO (Macrophage receptor with collagenous structure)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	34,169,011 - 34,210,340 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	34,169,011 - 34,201,255 (-)	Ensembl				GRCr8
mRatBN7.2	13	31,616,278 - 31,648,521 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	31,616,278 - 31,648,521 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	34,183,224 - 34,215,428 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	35,471,075 - 35,503,279 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	32,745,488 - 32,777,692 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	85,115,199 - 85,147,683 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	85,115,201 - 85,135,859 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	84,555,641 - 84,587,281 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	13	31,497,203 - 31,529,354 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bacterial Lung Diseases (ISO)

Clostridium Infections (ISO)

COVID-19 (ISO)

cryptococcosis (ISO)

diabetes mellitus (ISO)

hepatocellular carcinoma (ISO)

influenza A (ISO)

meningococcal meningitis (IEP)

Pneumococcal Meningitis (IEP)

pulmonary tuberculosis (ISO)

silicosis (IMP)

Streptococcus pneumonia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

butanal (ISO)

cadmium dichloride (EXP)

calcium atom (ISO)

calcium(0) (ISO)

carbon nanotube (EXP,ISO)

CGP 52608 (ISO)

cholesterol (ISO)

chrysene (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

diclofenac (ISO)

doxorubicin (ISO)

fumonisin B1 (ISO)

gardiquimod (ISO)

lipopolysaccharide (ISO)

LLY-507 (ISO)

magnesium atom (ISO)

medroxyprogesterone acetate (ISO)

methapyrilene (ISO)

mono(2-ethylhexyl) phthalate (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

poly(guanylic acid) (EXP,ISO)

protein kinase inhibitor (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (IDA)

amyloid-beta clearance (IMP)

apoptotic cell clearance (ISO)

endocytosis (IEA,ISO)

extracellular matrix organization (IBA)

phagocytosis, engulfment (IMP)

positive regulation of ERK1 and ERK2 cascade (IDA)

receptor-mediated endocytosis (IMP)

Cellular Component

cytoplasm (IDA)

membrane (IEA)

plasma membrane (IDA)

Molecular Function

amyloid-beta binding (IMP)

cargo receptor activity (IMP)

G protein-coupled receptor binding (IEA,IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

phagocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid.	Alarcón R, etal., J Biol Chem. 2005 Aug 26;280(34):30406-15. Epub 2005 Jun 29.
2.	The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles.	Arredouani M, etal., J Exp Med. 2004 Jul 19;200(2):267-72. doi: 10.1084/jem.20040731.
3.	Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population.	Bowdish DM, etal., BMC Med Genet. 2013 Apr 23;14:47. doi: 10.1186/1471-2350-14-47.
4.	Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells.	Brandenburg LO, etal., J Neurochem. 2010 May;113(3):749-60. doi: 10.1111/j.1471-4159.2010.06637.x. Epub 2010 Feb 5.
5.	The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis.	Braun BJ, etal., J Neuroinflammation. 2011 Feb 7;8(1):11. doi: 10.1186/1742-2094-8-11.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome.	Ghosh S, etal., Am J Respir Cell Mol Biol. 2011 Nov;45(5):1036-44. doi: 10.1165/rcmb.2010-0349OC. Epub 2011 May 11.
8.	Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population.	Lao W, etal., BMC Infect Dis. 2017 Jul 11;17(1):488. doi: 10.1186/s12879-017-2595-2.
9.	Impaired Recognition of Mycobacterium tuberculosis by Alveolar Macrophages From Diabetic Mice.	Martinez N, etal., J Infect Dis. 2016 Dec 1;214(11):1629-1637. doi: 10.1093/infdis/jiw436. Epub 2016 Sep 13.
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.	Thelen T, etal., J Immunol. 2010 Oct 1;185(7):4328-35. doi: 10.4049/jimmunol.1000989. Epub 2010 Sep 1.
15.	MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage.	Thuong NT, etal., Genes Immun. 2016 Dec;17(7):419-425. doi: 10.1038/gene.2016.43. Epub 2016 Nov 17.
16.	Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection.	Xu J, etal., J Immunol. 2017 May 1;198(9):3548-3557. doi: 10.4049/jimmunol.1700057. Epub 2017 Mar 15.
17.	Inhibition of MARCO ameliorates silica-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition.	Yang M, etal., Toxicol Lett. 2019 Feb;301:64-72. doi: 10.1016/j.toxlet.2018.10.031. Epub 2018 Nov 2.

Additional References at PubMed

PMID:19201851	PMID:31344978

Genomics

Comparative Map Data

Marco
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	34,169,011 - 34,210,340 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	34,169,011 - 34,201,255 (-)	Ensembl				GRCr8
mRatBN7.2	13	31,616,278 - 31,648,521 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	31,616,278 - 31,648,521 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	34,183,224 - 34,215,428 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	35,471,075 - 35,503,279 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	32,745,488 - 32,777,692 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	85,115,199 - 85,147,683 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	85,115,201 - 85,135,859 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	84,555,641 - 84,587,281 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	13	31,497,203 - 31,529,354 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

MARCO
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	118,942,194 - 118,994,660 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	118,942,172 - 118,994,664 (+)	Ensembl			hg38	GRCh38
GRCh37	2	119,699,770 - 119,752,236 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	119,416,215 - 119,468,706 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	119,415,974 - 119,468,467	NCBI
Celera	2	113,024,535 - 113,078,253 (+)	NCBI		Celera
Cytogenetic Map	2	q14.2	NCBI
HuRef	2	112,024,650 - 112,076,879 (+)	NCBI		HuRef
CHM1_1	2	119,703,356 - 119,755,847 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	119,375,479 - 119,427,929 (+)	NCBI		T2T-CHM13v2.0

Marco
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	120,402,267 - 120,432,753 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	120,402,267 - 120,432,753 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	120,474,538 - 120,505,024 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	120,474,538 - 120,505,024 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	122,371,115 - 122,401,661 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	122,302,084 - 122,332,630 (-)	NCBI		MGSCv36	mm8
Celera	1	123,137,568 - 123,168,212 (-)	NCBI		Celera
Cytogenetic Map	1	E2.3	NCBI
cM Map	1	52.71	NCBI

Marco
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	10,698,294 - 10,739,131 (-)	Ensembl
ChiLan1.0	NW_004955459	10,700,645 - 10,739,222 (-)	NCBI	ChiLan1.0	ChiLan1.0

MARCO
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	20,962,321 - 21,006,160 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	20,977,294 - 21,021,133 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	5,896,433 - 5,940,284 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	119,475,704 - 119,519,918 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	119,475,677 - 119,520,385 (+)	Ensembl			panPan2	panpan1.1

MARCO
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	30,996,209 - 31,034,520 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	30,996,347 - 31,034,487 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	31,260,569 - 31,305,455 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	32,381,105 - 32,426,221 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	32,381,113 - 32,419,679 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	31,067,312 - 31,112,187 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	31,233,786 - 31,278,688 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	32,420,649 - 32,465,527 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Marco
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	90,251,204 - 90,294,071 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936469	51,323,746 - 51,366,551 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MARCO
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	24,503,108 - 24,541,283 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	24,502,935 - 24,541,286 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	28,139,421 - 28,177,787 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MARCO
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	11,329,036 - 11,389,428 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	11,329,026 - 11,388,999 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666061	11,291,422 - 11,352,136 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Marco
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	26,203,219 - 26,236,057 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624732	26,203,345 - 26,236,001 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Marco
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	13,070,930 - 13,104,621 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Marco
344 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	39
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000075773
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34785618	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12285517	34884386	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	43736554	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	12285517	34884386	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	6002008	37088115	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	34785618	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Markers in Region

D13Rat15

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	31,623,770 - 31,623,898 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	85,122,693 - 85,122,820	NCBI	Rnor6.0
Rnor_5.0	16	84,563,135 - 84,563,262	UniSTS	Rnor5.0
Celera	13	31,504,697 - 31,504,824	UniSTS
RH 2.0 Map	13	60.2	RGD
SHRSP x BN Map	13	3.4599	RGD

D13Got222

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	31,636,565 - 31,636,701 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	85,135,488 - 85,135,624	NCBI	Rnor6.0
Rnor_5.0	16	84,575,930 - 84,576,066	UniSTS	Rnor5.0
Celera	13	31,517,492 - 31,517,623	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
2	4	9	35	75	80	55	21	55	4	130	39	1	23	30	44	25	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000075773 ⟹ ENSRNOP00000066125

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	34,169,011 - 34,201,255 (-)	Ensembl
mRatBN7.2 Ensembl	13	31,616,278 - 31,648,521 (-)	Ensembl
Rnor_6.0 Ensembl	16	85,115,201 - 85,135,859 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106911 ⟹ ENSRNOP00000077144

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	34,169,011 - 34,201,255 (-)	Ensembl
mRatBN7.2 Ensembl	13	31,616,278 - 31,648,521 (-)	Ensembl

RefSeq Acc Id:

NM_001109011 ⟹ NP_001102481

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	34,169,011 - 34,201,255 (-)	NCBI
mRatBN7.2	13	31,616,278 - 31,648,521 (-)	NCBI
Rnor_6.0	16	85,115,199 - 85,147,683 (-)	NCBI
Rnor_5.0	16	84,555,641 - 84,587,281 (-)	NCBI
Celera	13	31,497,203 - 31,529,354 (-)	NCBI

Sequence:

show sequence

GAGTGTCACCGAGGGGCTTGGGGACATGGAGGGTCTTTTCCAAACTTCTTCAATTATCCTTAAC
AGGCAGCTTCCCCACACAACAGCTCCACTGTGAACAGCCTGATTTTTAGCAAACTCTACATTAA
GGAACAGCCCGGTCCCCATAGTCAGGAAACATTGTGCAAATTGAGGATTCCTTGCCAAAGGGAA
GTCCTGAGGTCTCCAGCTAGCTGCCGCCGCTAAATGGGAGCCCCGCTTCCCCCTGGGGGAGCAT
TTCTGCTGGCTCCAGGGCTTTGACCACCTATAAAGCTTAGCAATGGGAAGTAAAGAAACCCTCA
AGGAGGAAGCCTTCTTGGGCAGCACAGAAGACGGAGCCGACTTTGACCAAGACATGCTCCCTGT
GATGGAGACCTTTGAAATCAATGATCCGGTGCCCAAGAAGAGAAATGGAAGGACCTTGTGCATG
GCAGTCATGGCCATCCACCTGATTCTGCTCACAGCAGGTACTGCCCTGCTGCTGATTCAAGTTC
TCAATCTGCAGGAGCAGTTCCAGAGCCTAGAGATGTGTTGTGACAATGGAACACTAGCTGCTGA
GGACAAGCCATTCTTCTCTCTGCAGTGGGCACGTCCCAAAACACACATAGTATCAGGAGCACAG
GGGCTGCAAGCCTTGCAGGCCCAGCTTAGCTGGGTCCACACCAGCCAGGAGCAACTGCGTCAGC
AAGTTGACAACCTCACTCAAAATCCAGAGTTGTTCCGGATTAAAGGTGAACGAGGCTCTCCAGG
TCCAAAAGGGGCCCCGGGCGCACCGGGAATCCCAGGCCTGCCTGGGCCATCTGCTGCGAAGGGA
GAAAAGGGGGCTGCGGGTCGTGACGGAACTCCAGGTGTCCGAGGACCCCAGGGCCCACCAGGCA
CCAAGGGAGAGGCAGGCCTCCAGGGATTCACGGGTGCACCAGGGAAGCAAGGAGCAGATGGTGC
TCCAGGGCCTCAAGGAGAAAAGGGCAGCAAAGGTGACAAAGGTCTCACTGGCCCCAAGGGGGAA
CACGGCACCAAGGGGGACAAAGGGGACCTAGGCCTTCCAGGAAGCAAAGGGGACACGGGCATGA
AGGGAGACAGGGGGGTCACGGGGTCCCCTGGAGCCCAGGGAAATAAAGGCGATGCTGGAAAACC
AGGCCTACCAGGTTTGGCTGGATCTCCTGGAGCCAAAGGTGATCAAGGAAAACTTGGAGTGCAG
GGTCCTCCAGGCCCTCCTGGTGCACCAGGACAATCAGGTGCCAAGGGTGAGCCGGGGCGCACTG
GTCCTCCTGGGCCAACAGGACCCCCAGGGATTGCCGGTAATCCAGGGGCTGCAGGTTTGAAAGG
AAGCAAGGGGGACATAGGAATTCAAGGACAGAAAGGCACAAAAGGAGAATCAGGAGTCCCAGGT
CTTGTAGGCAGAAAGGGAGACACTGGAAGCCCTGGGCTGGCAGGCCCCAAAGGAGAACCTGGAC
GAGCCGGTCTGAAGGGAGAACCTGGGATGAAAGGGTCTTCTGGCCAGCAAGGACAAAAGGGAGA
AAAAGGTCAAAAAGGCGATTTCAACCTGGTTGTCCGGATCGTGGGCGGCACCAGCAGAGGCCGA
GCTGAAGTTTACTATAACAATGTCTGGGGGACAATTTGCGATGATGGTTGGGATAATAACGATG
CCACTGTCTTCTGCCGCATGCTCGGTTACTCCAGCGGGAGGGGACTTGGCAGCTTTGGAGGTGG
CACTGGGAAGATCTGGCTGGATGATGTGAGTTGTCTGGGGACAGAGGCCACTTTGTGGGACTGC
AGGAAGAGCTCCTGGGGCTCTCACAATTGCAACCATAATGAAGATGCAGGAGTGGAATGCCGCT
GACCTGGGAGCCTGAGAAGTCATCCGTGTGTTCCCAGGTGTCTTTGGGCACCACCCACATGGAG
ATCTGTGGGCTTGCTGACTCTGTTGAGGGGAAACCAATAAAGCTCAACTAGGGATATGC

hide sequence

RefSeq Acc Id:

XM_063272524 ⟹ XP_063128594

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	34,169,014 - 34,210,340 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102481	(Get FASTA)	NCBI Sequence Viewer
	XP_063128594	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL87944	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000066125
	ENSRNOP00000066125.3
	ENSRNOP00000077144.2

RefSeq Acc Id:

NP_001102481 ⟸ NM_001109011

- UniProtKB:

M0R9F7 (UniProtKB/TrEMBL), A6K7Z9 (UniProtKB/TrEMBL), A0A8I5Y779 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSKETLKEEAFLGSTEDGADFDQDMLPVMETFEINDPVPKKRNGRTLCMAVMAIHLILLTAGT
ALLLIQVLNLQEQFQSLEMCCDNGTLAAEDKPFFSLQWARPKTHIVSGAQGLQALQAQLSWVHT
SQEQLRQQVDNLTQNPELFRIKGERGSPGPKGAPGAPGIPGLPGPSAAKGEKGAAGRDGTPGVR
GPQGPPGTKGEAGLQGFTGAPGKQGADGAPGPQGEKGSKGDKGLTGPKGEHGTKGDKGDLGLPG
SKGDTGMKGDRGVTGSPGAQGNKGDAGKPGLPGLAGSPGAKGDQGKLGVQGPPGPPGAPGQSGA
KGEPGRTGPPGPTGPPGIAGNPGAAGLKGSKGDIGIQGQKGTKGESGVPGLVGRKGDTGSPGLA
GPKGEPGRAGLKGEPGMKGSSGQQGQKGEKGQKGDFNLVVRIVGGTSRGRAEVYYNNVWGTICD
DGWDNNDATVFCRMLGYSSGRGLGSFGGGTGKIWLDDVSCLGTEATLWDCRKSSWGSHNCNHNE
DAGVECR

hide sequence

Ensembl Acc Id:

ENSRNOP00000066125 ⟸ ENSRNOT00000075773

Ensembl Acc Id:

ENSRNOP00000077144 ⟸ ENSRNOT00000106911

RefSeq Acc Id:	XP_063128594 ⟸ XM_063272524
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5Y779 (UniProtKB/TrEMBL)

Protein Domains

SRCR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0R9F7-F1-model_v2	AlphaFold	M0R9F7	1-470	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1589662	AgrOrtholog
BioCyc Gene	G2FUF-18504	BioCyc
Ensembl Genes	ENSRNOG00000049303	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000075773	ENTREZGENE
	ENSRNOT00000075773.4	UniProtKB/TrEMBL
	ENSRNOT00000106911.2	UniProtKB/TrEMBL
Gene3D-CATH	3.10.250.10	UniProtKB/TrEMBL
InterPro	Collagen	UniProtKB/TrEMBL
	Collagen_superfamily	UniProtKB/TrEMBL
	SRCR-like_dom_sf	UniProtKB/TrEMBL
	Srcr_rcpt	UniProtKB/TrEMBL
KEGG Report	rno:367391	UniProtKB/TrEMBL
NCBI Gene	367391	ENTREZGENE
PANTHER	COLLAGEN ALPHA	UniProtKB/TrEMBL
	MACROPHAGE RECEPTOR MARCO	UniProtKB/TrEMBL
Pfam	Collagen	UniProtKB/TrEMBL
	SRCR	UniProtKB/TrEMBL
PhenoGen	Marco	PhenoGen
PRINTS	SPERACTRCPTR	UniProtKB/TrEMBL
PROSITE	SRCR_1	UniProtKB/TrEMBL
	SRCR_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000049303	RatGTEx
SMART	SM00202	UniProtKB/TrEMBL
Superfamily-SCOP	Srcr_receptor	UniProtKB/TrEMBL
UniProt	A0A8I5Y779	ENTREZGENE, UniProtKB/TrEMBL
	A6K7Z9	ENTREZGENE, UniProtKB/TrEMBL
	M0R9F7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-05	Marco	macrophage receptor with collagenous structure	LOC367391	similar to Macrophage receptor MARCO (Macrophage receptor with collagenous structure)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC367391	similar to Macrophage receptor MARCO (Macrophage receptor with collagenous structure)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)