Marco (macrophage receptor with collagenous structure) - Rat Genome Database

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Gene: Marco (macrophage receptor with collagenous structure) Rattus norvegicus
Analyze
Symbol: Marco
Name: macrophage receptor with collagenous structure
RGD ID: 1589662
Description: Enables amyloid-beta binding activity and cargo receptor activity. Involved in amyloid-beta clearance; phagocytosis, engulfment; and receptor-mediated endocytosis. Located in cytoplasm and plasma membrane. Used to study silicosis. Biomarker of meningococcal meningitis. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH 17beta-estradiol; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC367391; macrophage receptor MARCO; similar to Macrophage receptor MARCO (Macrophage receptor with collagenous structure)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81334,169,011 - 34,210,340 (-)NCBIGRCr8
mRatBN7.21331,616,278 - 31,648,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,616,278 - 31,648,521 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1334,183,224 - 34,215,428 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,471,075 - 35,503,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,745,488 - 32,777,692 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01685,115,199 - 85,147,683 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1685,115,201 - 85,135,859 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01684,555,641 - 84,587,281 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,497,203 - 31,529,354 (-)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid. Alarcón R, etal., J Biol Chem. 2005 Aug 26;280(34):30406-15. Epub 2005 Jun 29.
2. The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. Arredouani M, etal., J Exp Med. 2004 Jul 19;200(2):267-72. doi: 10.1084/jem.20040731.
3. Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population. Bowdish DM, etal., BMC Med Genet. 2013 Apr 23;14:47. doi: 10.1186/1471-2350-14-47.
4. Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells. Brandenburg LO, etal., J Neurochem. 2010 May;113(3):749-60. doi: 10.1111/j.1471-4159.2010.06637.x. Epub 2010 Feb 5.
5. The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis. Braun BJ, etal., J Neuroinflammation. 2011 Feb 7;8(1):11. doi: 10.1186/1742-2094-8-11.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome. Ghosh S, etal., Am J Respir Cell Mol Biol. 2011 Nov;45(5):1036-44. doi: 10.1165/rcmb.2010-0349OC. Epub 2011 May 11.
8. Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population. Lao W, etal., BMC Infect Dis. 2017 Jul 11;17(1):488. doi: 10.1186/s12879-017-2595-2.
9. Impaired Recognition of Mycobacterium tuberculosis by Alveolar Macrophages From Diabetic Mice. Martinez N, etal., J Infect Dis. 2016 Dec 1;214(11):1629-1637. doi: 10.1093/infdis/jiw436. Epub 2016 Sep 13.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages. Thelen T, etal., J Immunol. 2010 Oct 1;185(7):4328-35. doi: 10.4049/jimmunol.1000989. Epub 2010 Sep 1.
15. MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage. Thuong NT, etal., Genes Immun. 2016 Dec;17(7):419-425. doi: 10.1038/gene.2016.43. Epub 2016 Nov 17.
16. Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection. Xu J, etal., J Immunol. 2017 May 1;198(9):3548-3557. doi: 10.4049/jimmunol.1700057. Epub 2017 Mar 15.
17. Inhibition of MARCO ameliorates silica-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition. Yang M, etal., Toxicol Lett. 2019 Feb;301:64-72. doi: 10.1016/j.toxlet.2018.10.031. Epub 2018 Nov 2.
Additional References at PubMed
PMID:19201851   PMID:31344978  


Genomics

Comparative Map Data
Marco
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81334,169,011 - 34,210,340 (-)NCBIGRCr8
mRatBN7.21331,616,278 - 31,648,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,616,278 - 31,648,521 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1334,183,224 - 34,215,428 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,471,075 - 35,503,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,745,488 - 32,777,692 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01685,115,199 - 85,147,683 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1685,115,201 - 85,135,859 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01684,555,641 - 84,587,281 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,497,203 - 31,529,354 (-)NCBICelera
Cytogenetic Map13q11NCBI
MARCO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382118,942,194 - 118,994,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2118,942,194 - 118,994,660 (+)EnsemblGRCh38hg38GRCh38
GRCh372119,699,770 - 119,752,236 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,416,215 - 119,468,706 (+)NCBINCBI36Build 36hg18NCBI36
Build 342119,415,974 - 119,468,467NCBI
Celera2113,024,535 - 113,078,253 (+)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2112,024,650 - 112,076,879 (+)NCBIHuRef
CHM1_12119,703,356 - 119,755,847 (+)NCBICHM1_1
T2T-CHM13v2.02119,375,479 - 119,427,929 (+)NCBIT2T-CHM13v2.0
Marco
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,402,267 - 120,432,753 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,402,267 - 120,432,753 (-)EnsemblGRCm39 Ensembl
GRCm381120,474,538 - 120,505,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,474,538 - 120,505,024 (-)EnsemblGRCm38mm10GRCm38
MGSCv371122,371,115 - 122,401,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,302,084 - 122,332,630 (-)NCBIMGSCv36mm8
Celera1123,137,568 - 123,168,212 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.71NCBI
Marco
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545910,698,294 - 10,739,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545910,700,645 - 10,739,222 (-)NCBIChiLan1.0ChiLan1.0
MARCO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21320,962,321 - 21,006,160 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B20,977,294 - 21,021,133 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B5,896,433 - 5,940,284 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B119,475,704 - 119,519,918 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B119,475,677 - 119,520,385 (+)Ensemblpanpan1.1panPan2
MARCO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11930,996,209 - 31,034,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1930,996,347 - 31,034,487 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,260,569 - 31,305,455 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01932,381,105 - 32,426,221 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1932,381,113 - 32,419,679 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11931,067,312 - 31,112,187 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01931,233,786 - 31,278,688 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01932,420,649 - 32,465,527 (-)NCBIUU_Cfam_GSD_1.0
Marco
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,251,204 - 90,294,071 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493646951,323,746 - 51,366,551 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARCO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,503,108 - 24,541,283 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11524,502,935 - 24,541,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,139,421 - 28,177,787 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MARCO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11011,329,036 - 11,389,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1011,329,026 - 11,388,999 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606111,291,422 - 11,352,136 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Marco
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473226,203,219 - 26,236,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473226,203,345 - 26,236,001 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Marco
295 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:39
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000075773
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat

Markers in Region
D13Rat15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,623,770 - 31,623,898 (+)MAPPERmRatBN7.2
Rnor_6.01685,122,693 - 85,122,820NCBIRnor6.0
Rnor_5.01684,563,135 - 84,563,262UniSTSRnor5.0
Celera1331,504,697 - 31,504,824UniSTS
RH 2.0 Map1360.2RGD
SHRSP x BN Map133.4599RGD
D13Got222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,636,565 - 31,636,701 (+)MAPPERmRatBN7.2
Rnor_6.01685,135,488 - 85,135,624NCBIRnor6.0
Rnor_5.01684,575,930 - 84,576,066UniSTSRnor5.0
Celera1331,517,492 - 31,517,623UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 36 35 1 35 1
Low 9 2 10 2 5 4
Below cutoff 7 7 7 4 4 12 8 21 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075773   ⟹   ENSRNOP00000066125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1331,616,278 - 31,648,521 (-)Ensembl
Rnor_6.0 Ensembl1685,115,201 - 85,135,859 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106911   ⟹   ENSRNOP00000077144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1331,616,278 - 31,648,521 (-)Ensembl
RefSeq Acc Id: NM_001109011   ⟹   NP_001102481
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81334,169,011 - 34,201,255 (-)NCBI
mRatBN7.21331,616,278 - 31,648,521 (-)NCBI
Rnor_6.01685,115,199 - 85,147,683 (-)NCBI
Rnor_5.01684,555,641 - 84,587,281 (-)NCBI
Celera1331,497,203 - 31,529,354 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272524   ⟹   XP_063128594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81334,169,014 - 34,210,340 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102481 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128594 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87944 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066125
  ENSRNOP00000066125.3
  ENSRNOP00000077144.1
Reference Protein Sequences
RefSeq Acc Id: NP_001102481   ⟸   NM_001109011
- UniProtKB: M0R9F7 (UniProtKB/TrEMBL),   A6K7Z9 (UniProtKB/TrEMBL),   A0A8I5Y779 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066125   ⟸   ENSRNOT00000075773
RefSeq Acc Id: ENSRNOP00000077144   ⟸   ENSRNOT00000106911
RefSeq Acc Id: XP_063128594   ⟸   XM_063272524
- Peptide Label: isoform X1
Protein Domains
SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R9F7-F1-model_v2 AlphaFold M0R9F7 1-470 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589662 AgrOrtholog
BioCyc Gene G2FUF-18504 BioCyc
Ensembl Genes ENSRNOG00000049303 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075773 ENTREZGENE
  ENSRNOT00000075773.3 UniProtKB/TrEMBL
  ENSRNOT00000106911.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.250.10 UniProtKB/TrEMBL
InterPro Collagen UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/TrEMBL
  Srcr_rcpt UniProtKB/TrEMBL
  Srcr_rcpt-rel UniProtKB/TrEMBL
KEGG Report rno:367391 UniProtKB/TrEMBL
NCBI Gene 367391 ENTREZGENE
PANTHER COLLAGEN ALPHA UniProtKB/TrEMBL
  COLLAGEN ALPHA-1(X) CHAIN UniProtKB/TrEMBL
  MACROPHAGE RECEPTOR MARCO UniProtKB/TrEMBL
Pfam Collagen UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
PhenoGen Marco PhenoGen
PRINTS SPERACTRCPTR UniProtKB/TrEMBL
PROSITE SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049303 RatGTEx
SMART SM00202 UniProtKB/TrEMBL
Superfamily-SCOP Srcr_receptor UniProtKB/TrEMBL
UniProt A0A8I5Y779 ENTREZGENE, UniProtKB/TrEMBL
  A6K7Z9 ENTREZGENE, UniProtKB/TrEMBL
  M0R9F7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Marco  macrophage receptor with collagenous structure  LOC367391  similar to Macrophage receptor MARCO (Macrophage receptor with collagenous structure)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC367391  similar to Macrophage receptor MARCO (Macrophage receptor with collagenous structure)      Symbol and Name status set to provisional 70820 PROVISIONAL