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Gene: Napb (NSF attachment protein beta) Rattus norvegicus

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Symbol:

Napb

Name:

NSF attachment protein beta

RGD ID:

1589649

Description:

Enables syntaxin binding activity. Involved in protein-containing complex disassembly; regulation of ATP-dependent activity; and regulation of receptor internalization. Located in dendrite. Is active in postsynapse and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 107. Orthologous to human NAPB (NSF attachment protein beta); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamiprid.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Beta-soluble NSF attachment protein; LOC499903; N-ethylmaleimide sensitive fusion protein attachment protein beta; N-ethylmaleimide-sensitive factor attachment protein beta; N-ethylmaleimide-sensitive factor attachment protein, beta; similar to N-ethylmaleimide sensitive fusion protein attachment protein beta; SNAP-beta; Snapb

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NAPB (NSF attachment protein beta)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Napb (N-ethylmaleimide sensitive fusion protein attachment protein beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Napb (NSF attachment protein beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NAPB (NSF attachment protein beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NAPB (NSF attachment protein beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Napb (NSF attachment protein beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NAPB (NSF attachment protein beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NAPB (NSF attachment protein beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Napb (NSF attachment protein beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Napb (NSF attachment protein beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NAPA (NSF attachment protein alpha)	HGNC	OrthoDB
Homo sapiens (human):	PIEZO2 (piezo type mechanosensitive ion channel component 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	NAPB (NSF attachment protein beta)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Napb (N-ethylmaleimide sensitive fusion protein attachment protein beta)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	napba (N-ethylmaleimide-sensitive factor attachment protein, beta a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	snap-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	snap-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SEC17	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SEC17	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alphaSnap	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alphaSnap	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	napbb	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	napb	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	napb	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Napb^{Tn(sb-T2/Bart3)2.162Mcwi}

Genetic Models:

F344-Napb^{Tn(sb-T2/Bart3)2.162Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	156,585,394 - 156,632,418 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	156,585,394 - 156,632,418 (-)	Ensembl				GRCr8
mRatBN7.2	3	136,132,248 - 136,179,280 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	136,133,428 - 136,179,345 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	140,088,084 - 140,131,334 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	148,672,232 - 148,715,485 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	146,361,580 - 146,404,830 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	143,017,571 - 143,063,904 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	143,020,454 - 143,063,983 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	149,431,212 - 149,473,190 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	137,447,072 - 137,490,500 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	134,978,251 - 135,020,908 (-)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

developmental and epileptic encephalopathy 1 (ISO)

developmental and epileptic encephalopathy 107 (ISO)

Down syndrome (ISO)

genetic disease (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

acetamiprid (EXP)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlordecone (ISO)

clofibrate (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

endosulfan (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenamidone (ISO)

formaldehyde (ISO)

gamma-tocopherol (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

hydrogen sulfide (ISO)

ivermectin (ISO)

lead(0) (ISO)

methyl methanesulfonate (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nickel sulfate (ISO)

paracetamol (EXP,ISO)

poly(I:C) (EXP)

quercetin (ISO)

rotenone (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

Soman (EXP)

sunitinib (ISO)

titanium dioxide (ISO)

tocopherol (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

intracellular protein transport (IBA,IEA)

protein transport (IEA)

protein-containing complex disassembly (IDA,IEA)

regulation of ATP-dependent activity (IDA)

regulation of receptor internalization (IDA)

regulation of synaptic vesicle priming (IBA,IEA,ISO)

SNARE complex disassembly (IBA,ISO)

synaptic transmission, glutamatergic (IBA,ISO)

vesicle-mediated transport (IEA)

Cellular Component

dendrite (IDA)

glutamatergic synapse (IEA,ISO)

membrane (IEA)

neuronal cell body (IDA)

postsynapse (IDA,IEP)

postsynaptic density (IDA)

presynapse (IDA,IEP)

presynaptic active zone membrane (IDA)

presynaptic membrane (IDA)

synapse (IDA)

synaptobrevin 2-SNAP-25-syntaxin-1a complex (IBA,IEA,ISO)

terminal bouton (IBA,IDA)

Molecular Function

protein binding (ISO)

SNARE binding (IPI)

soluble NSF attachment protein activity (IBA)

syntaxin binding (IBA,IDA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.	Hanley JG, etal., Neuron 2002 Mar 28;34(1):53-67.
3.	Distribution of soluble N-ethylmaleimide fusion protein attachment proteins (SNAPs) in the rat nervous system.	Nishiki T, etal., Neuroscience. 2001;107(3):363-71.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs.	Osten P, etal., Neuron. 1998 Jul;21(1):99-110. doi: 10.1016/s0896-6273(00)80518-8.
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	Synaptosomal proteins, beta-soluble N-ethylmaleimide-sensitive factor attachment protein (beta-SNAP), gamma-SNAP and synaptotagmin I in brain of patients with Down syndrome and Alzheimer's disease.	Yoo BC, etal., Dement Geriatr Cogn Disord. 2001 May-Jun;12(3):219-25.

Additional References at PubMed

PMID:14755058	PMID:15057822	PMID:16795052	PMID:17634366	PMID:21040848	PMID:21700703	PMID:23533145	PMID:29476059

Genomics

Comparative Map Data

Napb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	156,585,394 - 156,632,418 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	156,585,394 - 156,632,418 (-)	Ensembl				GRCr8
mRatBN7.2	3	136,132,248 - 136,179,280 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	136,133,428 - 136,179,345 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	140,088,084 - 140,131,334 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	148,672,232 - 148,715,485 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	146,361,580 - 146,404,830 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	143,017,571 - 143,063,904 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	143,020,454 - 143,063,983 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	149,431,212 - 149,473,190 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	137,447,072 - 137,490,500 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	134,978,251 - 135,020,908 (-)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

NAPB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	23,374,522 - 23,421,488 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	23,374,519 - 23,421,519 (-)	Ensembl			hg38	GRCh38
GRCh37	20	23,355,159 - 23,402,125 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	23,303,165 - 23,350,081 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	20	23,303,165 - 23,350,081	NCBI
Celera	20	23,428,529 - 23,475,530 (-)	NCBI		Celera
Cytogenetic Map	20	p11.21	NCBI
HuRef	20	23,316,796 - 23,363,800 (-)	NCBI		HuRef
CHM1_1	20	23,355,618 - 23,402,617 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	23,434,062 - 23,481,033 (-)	NCBI		T2T-CHM13v2.0

Napb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	148,535,905 - 148,574,396 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	148,535,905 - 148,574,387 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	148,693,985 - 148,732,425 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	148,693,985 - 148,732,467 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	148,520,393 - 148,558,156 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	148,386,098 - 148,423,861 (-)	NCBI		MGSCv36	mm8
Celera	2	149,962,927 - 150,000,652 (-)	NCBI		Celera
Cytogenetic Map	2	G3	NCBI
cM Map	2	73.53	NCBI

Napb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	30,392,165 - 30,427,773 (-)	Ensembl
ChiLan1.0	NW_004955415	30,392,692 - 30,427,773 (-)	NCBI	ChiLan1.0	ChiLan1.0

NAPB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	24,247,686 - 24,294,702 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	24,244,519 - 24,291,535 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	23,316,153 - 23,363,142 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	23,667,464 - 23,713,935 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	23,667,469 - 23,713,935 (-)	Ensembl			panPan2	panpan1.1

NAPB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	217,287 - 258,278 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	217,381 - 255,752 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	239,058 - 280,048 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	609,668 - 650,674 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	609,687 - 650,669 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	211,965 - 252,952 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	311,328 - 352,320 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	595,207 - 636,199 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Napb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	148,737,781 - 148,785,166 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936620	2,157,528 - 2,205,586 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936620	2,158,246 - 2,205,624 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NAPB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	30,359,420 - 30,396,083 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	30,361,439 - 30,396,105 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	34,450,374 - 34,485,114 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NAPB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	52,379,633 - 52,395,274 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666078	7,195,587 - 7,248,043 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Napb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	23,046,779 - 23,085,229 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624741	23,046,856 - 23,085,234 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Napb
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	128,228,331 - 128,267,552 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Napb
225 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	37
Count of miRNA genes:	33
Interacting mature miRNAs:	36
Transcripts:	ENSRNOT00000006329
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1582213	Insul6	Insulin level QTL 6	3.7	0.0009	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	141508991	166376254	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	152055202	189428310	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
1582256	Insul9	Insulin level QTL 9	4.4	0.0016	blood insulin amount (VT:0001560)	absolute change in serum insulin level (CMO:0002038)	3	155759447	189428310	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	141508991	177728348	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
1582248	Insul7	Insulin level QTL 7	3.9	0.0041	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Markers in Region

BE113916

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	136,142,093 - 136,142,260 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	143,026,777 - 143,026,943	NCBI	Rnor6.0
Rnor_5.0	3	149,437,337 - 149,437,503	UniSTS	Rnor5.0
RGSC_v3.4	3	137,453,197 - 137,453,363	UniSTS	RGSC3.4
Celera	3	134,984,376 - 134,984,542	UniSTS
Cytogenetic Map	3	q41	UniSTS

RH135049

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	136,175,530 - 136,175,746 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	143,060,210 - 143,060,425	NCBI	Rnor6.0
Rnor_5.0	3	149,469,496 - 149,469,711	UniSTS	Rnor5.0
RGSC_v3.4	3	137,486,806 - 137,487,021	UniSTS	RGSC3.4
Celera	3	135,017,214 - 135,017,429	UniSTS
RH 3.4 Map	3	1291.2	UniSTS
Cytogenetic Map	3	q41	UniSTS

Genetic Models

This gene Napb is modified in the following models/strains:

F344-Napb^{Tn(sb-T2/Bart3)2.162Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	90	59	6	354	190	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC110699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006329 ⟹ ENSRNOP00000006329

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	156,585,394 - 156,632,418 (-)	Ensembl
mRatBN7.2 Ensembl	3	136,133,428 - 136,179,345 (-)	Ensembl
Rnor_6.0 Ensembl	3	143,020,454 - 143,063,983 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100069 ⟹ ENSRNOP00000083784

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	136,133,428 - 136,179,345 (-)	Ensembl

RefSeq Acc Id:

NM_001191966 ⟹ NP_001178895

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	156,585,394 - 156,632,418 (-)	NCBI
mRatBN7.2	3	136,132,248 - 136,179,280 (-)	NCBI
Rnor_6.0	3	143,020,652 - 143,063,904 (-)	NCBI
Rnor_5.0	3	149,431,212 - 149,473,190 (-)	NCBI
Celera	3	134,978,251 - 135,020,908 (-)	NCBI

Sequence:

show sequence

ATGGACAACGCAGGGAAAGAACGAGAAGCGGTCCAGCTTATGGCGGAGGCCGAGAAGCGAGTGA
AGGCTTCCCACTCCTTCCTCCGAGGGTTGTTCGGAGGAAACACAAGAATAGAAGAGGCATGTGA
AATGTATACCAGAGCTGCAAATATGTTCAAGATGGCCAAGAACTGGAGTGCTGCAGGAAATGCA
TTTTGTCAAGCCGCCAAGCTCCACATGCAGCTTCAGAGCAAGCATGACTCTGCTACGAGCTTTG
TGGATGCTGGAAATGCTTACAAGAAAGCAGACCCTCAAGAGGCTATCAACTGCTTAAATGCAGC
CATCGACATTTACACAGACATGGGAAGATTCACAATCGCAGCCAAGCACCATATCACCATTGCT
GAGATCTATGAGACTGAGCTCGTGGACATTGAGAAGGCTATTGCACATTATGAACAATCTGCTG
ATTATTACAAAGGAGAAGAATCTAACAGCTCTGCTAACAAGTGTCTGCTGAAGGTGGCAGCCTA
TGCTGCACAGCTGGAGCAGTACCAGAAAGCCATCGAGATCTATGAGCAGGTGGGAGCAAACACT
ATGGATAACCCCTTGCTGAAGTACAGCGCAAAGGATTACTTCTTCAAGGCAGCACTCTGTCACT
TCATAGTGGATGAGCTGAATGCAAAGCTTGCTCTTGAGAAATACGAGGAAATGTTTCCAGCATT
TACTGACTCCAGAGAATGTAAATTATTGAAAAAACTTCTAGAAGCTCATGAAGAACAGAACAGT
GAAGCTTACACTGAAGCAGTGAAGGAGTTTGACTCAATATCACGTTTGGATCAGTGGCTGACTA
CCATGTTGCTTCGTATCAAGAAGTCCATTCAAGGGGATGGAGAAGGAGATGGAGACCTCAAGTG
A

hide sequence

RefSeq Acc Id:

XM_039105702 ⟹ XP_038961630

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	156,585,394 - 156,604,722 (-)	NCBI
mRatBN7.2	3	136,132,248 - 136,151,587 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178895	(Get FASTA)	NCBI Sequence Viewer
	XP_038961630	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95093	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006329
GenBank Protein	P85969	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001178895 ⟸ NM_001191966

- UniProtKB:

P85969 (UniProtKB/Swiss-Prot), A6K7C6 (UniProtKB/Swiss-Prot), F8WFM2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEMYTRAANMFKMAKNWSAAGNA
FCQAAKLHMQLQSKHDSATSFVDAGNAYKKADPQEAINCLNAAIDIYTDMGRFTIAAKHHITIA
EIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANT
MDNPLLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNS
EAYTEAVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK

hide sequence

Ensembl Acc Id:

ENSRNOP00000006329 ⟸ ENSRNOT00000006329

RefSeq Acc Id:	XP_038961630 ⟸ XM_039105702
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000083784 ⟸ ENSRNOT00000100069

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P85969-F1-model_v2	AlphaFold	P85969	1-297	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692498

Promoter ID:

EPDNEW_R3023

Type:

initiation region

Name:

Napb_1

Description:

NSF attachment protein beta

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	143,063,935 - 143,063,995	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1589649	AgrOrtholog
BioCyc Gene	G2FUF-47496	BioCyc
Ensembl Genes	ENSRNOG00000004753	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000006329	ENTREZGENE
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot
InterPro	NSF_attach	UniProtKB/Swiss-Prot
	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot
NCBI Gene	499903	ENTREZGENE
PANTHER	BETA-SOLUBLE NSF ATTACHMENT PROTEIN	UniProtKB/Swiss-Prot
	PTHR13768	UniProtKB/Swiss-Prot
Pfam	SNAP	UniProtKB/Swiss-Prot
PhenoGen	Napb	PhenoGen
PRINTS	NSFATTACHMNT	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004753	RatGTEx
Superfamily-SCOP	SSF48452	UniProtKB/Swiss-Prot
UniProt	A6K7C6	ENTREZGENE
	F8WFM2	ENTREZGENE, UniProtKB/TrEMBL
	P85969	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	A6K7C6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-05	Napb	N-ethylmaleimide sensitive fusion protein attachment protein beta	LOC499903	similar to N-ethylmaleimide sensitive fusion protein attachment protein beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC499903	similar to N-ethylmaleimide sensitive fusion protein attachment protein beta			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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