Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Maml2 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAML2 mRNA | CTD | PMID:22079256 | Maml2 | Rat | 17beta-estradiol | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of MAML2 mRNA | CTD | PMID:30165855 | Maml2 | Rat | 17beta-estradiol | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of MAML2 mRNA | CTD | PMID:31614463 | Maml2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MAML2 mRNA | CTD | PMID:20106945|PMID:21632981 | Maml2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MAML2 mRNA | CTD | PMID:33387578 | Maml2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MAML2 mRNA | CTD | PMID:32109520 | Maml2 | Rat | 3-chloropropane-1,2-diol | decreases expression | EXP | | 6480464 | alpha-Chlorohydrin results in decreased expression of MAML2 mRNA | CTD | PMID:28522335 | Maml2 | Rat | 5-fluorouracil | increases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Fluorouracil results in increased expression of MAML2 mRNA | CTD | PMID:16510598 | Maml2 | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of MAML2 mRNA | CTD | PMID:35163327 | Maml2 | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of MAML2 mRNA | CTD | PMID:30779732 | Maml2 | Rat | aristolochic acid A | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of MAML2 mRNA | CTD | PMID:33212167 | Maml2 | Rat | arsane | affects methylation | ISO | MAML2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of MAML2 gene | CTD | PMID:25304211 | Maml2 | Rat | arsane | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Maml2 | Rat | arsenic atom | affects methylation | ISO | MAML2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of MAML2 gene | CTD | PMID:25304211 | Maml2 | Rat | arsenic atom | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Maml2 | Rat | benzo[a]pyrene | decreases expression | ISO | Maml2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of MAML2 mRNA | CTD | PMID:21569818 | Maml2 | Rat | benzo[a]pyrene | decreases methylation | ISO | MAML2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of MAML2 5' UTR | CTD | PMID:27901495 | Maml2 | Rat | benzo[a]pyrene | increases methylation | ISO | MAML2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of MAML2 promoter | CTD | PMID:27901495 | Maml2 | Rat | benzo[a]pyrene | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of MAML2 mRNA | CTD | PMID:20106945|PMID:21632981|PMID:30453624 | Maml2 | Rat | benzo[a]pyrene diol epoxide I | affects expression | ISO | MAML2 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of MAML2 mRNA | CTD | PMID:20382639 | Maml2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAML2 mRNA | CTD | PMID:19150397|PMID:20018196 | Maml2 | Rat | beta-lapachone | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of MAML2 mRNA | CTD | PMID:38218311 | Maml2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of MAML2 mRNA | CTD | PMID:25181051|PMID:30816183|PMID:34947998 | Maml2 | Rat | bisphenol A | increases expression | ISO | Maml2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of MAML2 mRNA | CTD | PMID:35598803 | Maml2 | Rat | bisphenol A | affects methylation | ISO | MAML2 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of MAML2 gene | CTD | PMID:31601247 | Maml2 | Rat | cadmium atom | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MAML2 more ... | CTD | PMID:35301059 | Maml2 | Rat | cadmium dichloride | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MAML2 more ... | CTD | PMID:35301059 | Maml2 | Rat | caffeine | decreases phosphorylation | ISO | MAML2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of MAML2 protein | CTD | PMID:35688186 | Maml2 | Rat | carbon nanotube | decreases expression | ISO | Maml2 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of MAML2 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Maml2 | Rat | cisplatin | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of MAML2 mRNA | CTD | PMID:21603599|PMID:27392435 | Maml2 | Rat | cisplatin | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of MAML2 mRNA | CTD | PMID:27392435 | Maml2 | Rat | cobalt dichloride | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of MAML2 mRNA | CTD | PMID:19320972 | Maml2 | Rat | copper atom | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of MAML2 mRNA | CTD | PMID:20971185 | Maml2 | Rat | copper(0) | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of MAML2 mRNA | CTD | PMID:20971185 | Maml2 | Rat | crocidolite asbestos | affects expression | ISO | MAML2 (Homo sapiens) | 6480464 | Asbestos, Crocidolite affects the expression of MAML2 mRNA | CTD | PMID:17331233 | Maml2 | Rat | cyclosporin A | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of MAML2 mRNA | CTD | PMID:25562108 | Maml2 | Rat | Dibutyl phosphate | affects expression | ISO | MAML2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of MAML2 mRNA | CTD | PMID:37042841 | Maml2 | Rat | dorsomorphin | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Maml2 | Rat | doxorubicin | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of MAML2 mRNA | CTD | PMID:29803840 | Maml2 | Rat | entinostat | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | entinostat results in decreased expression of MAML2 mRNA | CTD | PMID:26272509 | Maml2 | Rat | entinostat | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Maml2 | Rat | ethanol | increases expression | ISO | Maml2 (Mus musculus) | 6480464 | Ethanol results in increased expression of MAML2 mRNA | CTD | PMID:30319688 | Maml2 | Rat | formaldehyde | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of MAML2 mRNA | CTD | PMID:20655997 | Maml2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of MAML2 mRNA | CTD | PMID:33387578 | Maml2 | Rat | leflunomide | increases expression | ISO | MAML2 (Homo sapiens) | 6480464 | leflunomide results in increased expression of MAML2 mRNA | CTD | PMID:28988120 | Maml2 | Rat | Licochalcone B | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | licochalcone B results in decreased expression of MAML2 mRNA | CTD | PMID:33647349 | Maml2 | Rat | manganese atom | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Maml2 | Rat | manganese(0) | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Maml2 | Rat | manganese(II) chloride | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Maml2 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of MAML2 gene | CTD | PMID:35440735 | Maml2 | Rat | methyl methanesulfonate | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of MAML2 mRNA | CTD | PMID:23649840 | Maml2 | Rat | methylisothiazolinone | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in decreased expression of MAML2 mRNA | CTD | PMID:31629900 | Maml2 | Rat | methylmercury chloride | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of MAML2 mRNA | CTD | PMID:28001369 | Maml2 | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] affects the methylation of MAML2 gene | CTD | PMID:33148267 | Maml2 | Rat | nickel atom | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Nickel results in decreased expression of MAML2 mRNA | CTD | PMID:25583101 | Maml2 | Rat | nitrates | multiple interactions | ISO | Maml2 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of MAML2 more ... | CTD | PMID:35964746 | Maml2 | Rat | ozone | multiple interactions | ISO | Maml2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Maml2 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of MAML2 mRNA | CTD | PMID:33387578 | Maml2 | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of MAML2 mRNA | CTD | PMID:35163327 | Maml2 | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] affects the methylation of MAML2 gene | CTD | PMID:33148267 | Maml2 | Rat | phenylmercury acetate | increases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of MAML2 mRNA | CTD | PMID:26272509 | Maml2 | Rat | phenylmercury acetate | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Maml2 | Rat | pirinixic acid | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Maml2 | Rat | potassium chromate | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of MAML2 mRNA | CTD | PMID:22079256 | Maml2 | Rat | potassium chromate | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAML2 mRNA | CTD | PMID:22079256 | Maml2 | Rat | SB 431542 | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Maml2 | Rat | sodium arsenate | decreases expression | ISO | Maml2 (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of MAML2 mRNA | CTD | PMID:39847705 | Maml2 | Rat | sodium arsenite | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Maml2 | Rat | sodium arsenite | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of MAML2 mRNA | CTD | PMID:39719251 | Maml2 | Rat | sunitinib | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of MAML2 mRNA | CTD | PMID:31533062 | Maml2 | Rat | testosterone | increases expression | ISO | Maml2 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of MAML2 mRNA | CTD | PMID:33848595 | Maml2 | Rat | testosterone | multiple interactions | ISO | Maml2 (Mus musculus) | 6480464 | 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane inhibits the reaction [Testosterone deficiency results in increased expression of MAML2 mRNA] | CTD | PMID:33848595 | Maml2 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of MAML2 mRNA | CTD | PMID:33387578 | Maml2 | Rat | trichostatin A | increases expression | ISO | MAML2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of MAML2 mRNA | CTD | PMID:26272509 | Maml2 | Rat | trichostatin A | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Maml2 | Rat | tris(2-butoxyethyl) phosphate | affects expression | ISO | MAML2 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of MAML2 mRNA | CTD | PMID:29024780 | Maml2 | Rat | valproic acid | increases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of MAML2 mRNA | CTD | PMID:24935251 | Maml2 | Rat | valproic acid | decreases expression | ISO | MAML2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of MAML2 mRNA | CTD | PMID:28001369 | Maml2 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of MAML2 gene | CTD | PMID:31079544 | Maml2 | Rat | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of MAML2 gene | CTD | PMID:31079544 | Maml2 | Rat | vorinostat | multiple interactions | ISO | MAML2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















