Awat1 (acyl-CoA wax alcohol acyltransferase 1) - Rat Genome Database

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Gene: Awat1 (acyl-CoA wax alcohol acyltransferase 1) Rattus norvegicus
Analyze
Symbol: Awat1
Name: acyl-CoA wax alcohol acyltransferase 1
RGD ID: 1587163
Description: Predicted to enable long-chain-alcohol O-fatty-acyltransferase activity. Predicted to be involved in lipid metabolic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AWAT1 (acyl-CoA wax alcohol acyltransferase 1); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Dgat2l3; diacylglycerol O-acyltransferase 2-like 3; LOC679520; similar to diacylglycerol O-acyltransferase 2-like 3; wax synthase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,708,286 - 69,714,531 (+)NCBIGRCr8
mRatBN7.2X65,668,205 - 65,674,450 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,668,205 - 65,674,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,151,614 - 67,157,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,652,006 - 70,658,251 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,212,905 - 68,219,150 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,408,124 - 70,414,369 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,408,064 - 70,414,368 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,279,694 - 71,285,939 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,570,707 - 88,576,952 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX66,027,072 - 66,033,317 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15671038  


Genomics

Comparative Map Data
Awat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,708,286 - 69,714,531 (+)NCBIGRCr8
mRatBN7.2X65,668,205 - 65,674,450 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,668,205 - 65,674,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,151,614 - 67,157,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,652,006 - 70,658,251 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,212,905 - 68,219,150 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,408,124 - 70,414,369 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,408,064 - 70,414,368 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,279,694 - 71,285,939 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,570,707 - 88,576,952 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX66,027,072 - 66,033,317 (+)NCBICelera
Cytogenetic MapXq22NCBI
AWAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,234,655 - 70,240,659 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,234,655 - 70,240,659 (+)EnsemblGRCh38hg38GRCh38
GRCh37X69,454,505 - 69,460,509 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,371,271 - 69,376,865 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX69,807,845 - 69,813,851 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,275,596 - 63,281,709 (+)NCBIHuRef
CHM1_1X69,348,486 - 69,354,491 (+)NCBICHM1_1
T2T-CHM13v2.0X68,667,982 - 68,673,985 (+)NCBIT2T-CHM13v2.0
Awat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,615,853 - 99,621,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,615,857 - 99,621,811 (+)EnsemblGRCm39 Ensembl
GRCm38X100,572,247 - 100,578,206 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,572,251 - 100,578,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X97,767,586 - 97,773,545 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X96,774,966 - 96,780,925 (+)NCBIMGSCv36mm8
CeleraX87,498,297 - 87,504,256 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.72NCBI
Awat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,780,080 - 9,789,448 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,780,080 - 9,785,675 (+)NCBIChiLan1.0ChiLan1.0
AWAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X69,911,653 - 69,917,948 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X69,915,381 - 69,921,550 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X59,502,965 - 59,509,092 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X69,562,111 - 69,568,244 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,562,111 - 69,568,244 (+)Ensemblpanpan1.1panPan2
AWAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,678,459 - 54,684,666 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX54,622,317 - 54,684,231 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX45,504,680 - 45,511,082 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X55,645,037 - 55,651,439 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX55,588,452 - 55,651,935 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X53,614,019 - 53,620,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X54,944,818 - 54,951,220 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X54,871,995 - 54,878,397 (+)NCBIUU_Cfam_GSD_1.0
Awat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,475,829 - 47,482,162 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367621,238,473 - 1,244,330 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367621,238,239 - 1,244,330 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AWAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X56,263,082 - 56,273,169 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,457,862 - 63,467,957 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AWAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,076,303 - 60,082,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,076,817 - 60,082,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660651,922,962 - 1,929,092 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Awat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624903198,012 - 204,067 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624903198,012 - 204,697 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Awat1
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000038924
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000038924   ⟹   ENSRNOP00000032529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,668,205 - 65,674,450 (+)Ensembl
Rnor_6.0 EnsemblX70,408,064 - 70,414,368 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,408,074 - 70,410,722 (+)Ensembl
RefSeq Acc Id: NM_001109371   ⟹   NP_001102841
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,708,286 - 69,714,531 (+)NCBI
mRatBN7.2X65,668,205 - 65,674,450 (+)NCBI
Rnor_6.0X70,408,124 - 70,414,369 (+)NCBI
Rnor_5.0X71,279,694 - 71,285,939 (+)NCBI
RGSC_v3.4X88,570,707 - 88,576,952 (+)RGD
CeleraX66,027,072 - 66,033,317 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102841 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95936 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032529
  ENSRNOP00000032529.3
RefSeq Acc Id: NP_001102841   ⟸   NM_001109371
- UniProtKB: D3ZVA9 (UniProtKB/TrEMBL),   A6IQ77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032529   ⟸   ENSRNOT00000038924

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVA9-F1-model_v2 AlphaFold D3ZVA9 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587163 AgrOrtholog
BioCyc Gene G2FUF-2131 BioCyc
Ensembl Genes ENSRNOG00000026231 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038924 ENTREZGENE
  ENSRNOT00000038924.5 UniProtKB/TrEMBL
InterPro DAGAT UniProtKB/TrEMBL
KEGG Report rno:679520 UniProtKB/TrEMBL
NCBI Gene 679520 ENTREZGENE
PANTHER ACYL-COA WAX ALCOHOL ACYLTRANSFERASE 1 UniProtKB/TrEMBL
  DIACYLGLYCEROL O-ACYLTRANSFERASE UniProtKB/TrEMBL
Pfam DAGAT UniProtKB/TrEMBL
PhenoGen Awat1 PhenoGen
RatGTEx ENSRNOG00000026231 RatGTEx
UniProt A6IQ77 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVA9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-03-24 Awat1  acyl-CoA wax alcohol acyltransferase 1  Dgat2l3  diacylglycerol O-acyltransferase 2-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Dgat2l3  diacylglycerol O-acyltransferase 2-like 3  LOC679520  similar to diacylglycerol O-acyltransferase 2-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC679520  similar to diacylglycerol O-acyltransferase 2-like 3  LOC684251  similar to diacylglycerol O-acyltransferase 2-like 3  Data merged from RGD:1592696 1643240 APPROVED
2006-11-20 LOC684251  similar to diacylglycerol O-acyltransferase 2-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679520  similar to diacylglycerol O-acyltransferase 2-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL