Ldlrad4 (low density lipoprotein receptor class A domain containing 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ldlrad4 (low density lipoprotein receptor class A domain containing 4) Rattus norvegicus
Analyze
Symbol: Ldlrad4
Name: low density lipoprotein receptor class A domain containing 4
RGD ID: 1587105
Description: Predicted to enable R-SMAD binding activity. Predicted to be involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in endosome and membrane. Predicted to be active in Golgi membrane and early endosome membrane. Orthologous to human LDLRAD4 (low density lipoprotein receptor class A domain containing 4); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC679578; low-density lipoprotein receptor class A domain-containing protein 4; similar to Protein C18orf1; uncharacterized protein LOC679578
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,789,089 - 64,118,166 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1863,790,440 - 64,113,064 (+)EnsemblGRCr8
mRatBN7.21861,519,253 - 61,848,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1861,521,428 - 61,843,238 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1863,722,243 - 63,918,315 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01864,427,017 - 64,623,184 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01862,272,000 - 62,467,935 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01863,717,423 - 64,045,224 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1863,882,610 - 64,044,023 (+)Ensemblrn6Rnor6.0
Rnor_5.01863,020,278 - 63,219,634 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41864,755,404 - 64,788,816 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1859,750,235 - 59,946,262 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlordecone  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
protein binding  (ISO)
R-SMAD binding  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24627487  


Genomics

Comparative Map Data
Ldlrad4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,789,089 - 64,118,166 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1863,790,440 - 64,113,064 (+)EnsemblGRCr8
mRatBN7.21861,519,253 - 61,848,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1861,521,428 - 61,843,238 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1863,722,243 - 63,918,315 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01864,427,017 - 64,623,184 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01862,272,000 - 62,467,935 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01863,717,423 - 64,045,224 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1863,882,610 - 64,044,023 (+)Ensemblrn6Rnor6.0
Rnor_5.01863,020,278 - 63,219,634 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41864,755,404 - 64,788,816 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1859,750,235 - 59,946,262 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
LDLRAD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381813,217,682 - 13,652,754 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1813,216,173 - 13,652,755 (+)Ensemblhg38GRCh38
GRCh371813,217,681 - 13,652,753 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361813,208,795 - 13,642,753 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341813,610,866 - 13,642,753NCBI
Celera1813,101,030 - 13,535,088 (+)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1813,172,315 - 13,607,009 (+)NCBIHuRef
CHM1_11813,218,367 - 13,652,114 (+)NCBICHM1_1
T2T-CHM13v2.01813,380,438 - 13,815,606 (+)NCBIT2T-CHM13v2.0
Ldlrad4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391868,065,345 - 68,393,621 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1868,066,328 - 68,401,701 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381867,932,274 - 68,260,550 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1867,933,257 - 68,268,630 (+)Ensemblmm10GRCm38
MGSCv371868,092,911 - 68,415,203 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361868,058,626 - 68,380,918 (+)NCBIMGSCv36mm8
Celera1869,232,373 - 69,563,908 (+)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1840.14NCBI
Ldlrad4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955402384,177 - 508,876 (-)NCBIChiLan1.0ChiLan1.0
LDLRAD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21724,390,591 - 24,829,455 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11810,083,187 - 10,522,217 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v018669,862 - 1,110,558 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1182,838,111 - 2,879,363 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl182,845,198 - 2,879,363 (-)EnsemblpanPan2panpan1.1
LDLRAD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,541,702 - 24,927,435 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl124,541,811 - 24,925,464 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha125,527,314 - 25,913,839 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0124,448,554 - 24,835,999 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,448,556 - 24,835,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,498,406 - 24,884,117 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,385,328 - 24,772,177 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,658,465 - 25,044,530 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ldlrad4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049443,502,377 - 3,860,211 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366262,865,352 - 3,081,703 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366262,730,689 - 3,088,527 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDLRAD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl696,401,654 - 96,577,643 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1696,401,650 - 96,578,162 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,708,022 - 89,884,466 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LDLRAD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11871,705,206 - 72,132,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1872,094,321 - 72,125,592 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605046,759,534 - 47,199,124 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ldlrad4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477020,137,979 - 20,269,714 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ldlrad4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11563,008,373 - 63,211,604 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ldlrad4
3208 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:89
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000022717
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186289225779484461Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186289225779484461Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Mit16  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81863,968,158 - 63,968,306 (+)Marker Load Pipeline
mRatBN7.21861,698,317 - 61,698,465 (+)MAPPERmRatBN7.2
Rnor_6.01863,897,474 - 63,897,621NCBIRnor6.0
Rnor_5.01863,072,266 - 63,072,413UniSTSRnor5.0
RGSC_v3.41864,900,053 - 64,900,201RGDRGSC3.4
RGSC_v3.41864,900,054 - 64,900,201UniSTSRGSC3.4
Celera1859,801,840 - 59,801,987UniSTS
RGSC_v3.11864,973,255 - 64,973,402RGD
RH 3.4 Map18630.2UniSTS
RH 3.4 Map18630.2RGD
Cytogenetic Map18q12.1UniSTS
RH131736  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21861,846,585 - 61,846,776 (+)MAPPERmRatBN7.2
Rnor_6.01864,045,162 - 64,045,352NCBIRnor6.0
Rnor_5.01863,201,239 - 63,201,429UniSTSRnor5.0
RGSC_v3.41864,751,868 - 64,752,058UniSTSRGSC3.4
Celera1859,949,374 - 59,949,564UniSTS
RH 3.4 Map18628.4UniSTS
Cytogenetic Map18q12.1UniSTS
BF386607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21861,694,106 - 61,694,256 (+)MAPPERmRatBN7.2
Rnor_6.01863,893,259 - 63,893,408NCBIRnor6.0
Rnor_5.01863,067,690 - 63,067,839UniSTSRnor5.0
RGSC_v3.41864,904,274 - 64,904,423UniSTSRGSC3.4
Celera1859,797,680 - 59,797,829UniSTS
RH 3.4 Map18628.4UniSTS
Cytogenetic Map18q12.1UniSTS
RH138542  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21861,842,278 - 61,842,402 (+)MAPPERmRatBN7.2
Rnor_6.01864,040,857 - 64,040,980NCBIRnor6.0
Rnor_5.01863,218,675 - 63,218,798UniSTSRnor5.0
RGSC_v3.41864,756,240 - 64,756,363UniSTSRGSC3.4
Celera1859,945,303 - 59,945,426UniSTS
RH 3.4 Map18628.4UniSTS
Cytogenetic Map18q12.1UniSTS
RH128670  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21861,848,032 - 61,848,250 (+)MAPPERmRatBN7.2
Rnor_6.01864,046,609 - 64,046,826NCBIRnor6.0
Rnor_5.01863,220,997 - 63,221,214UniSTSRnor5.0
Rnor_5.01863,202,686 - 63,202,903UniSTSRnor5.0
RGSC_v3.41864,750,394 - 64,750,611UniSTSRGSC3.4
Celera1859,950,823 - 59,951,040UniSTS
RH 3.4 Map18628.4UniSTS
Cytogenetic Map18q12.1UniSTS
BF399308  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21861,755,149 - 61,755,397 (+)MAPPERmRatBN7.2
Rnor_6.01863,953,774 - 63,954,021NCBIRnor6.0
Rnor_5.01863,128,605 - 63,128,852UniSTSRnor5.0
RGSC_v3.41864,843,205 - 64,843,452UniSTSRGSC3.4
Celera1859,858,626 - 59,858,873UniSTS
RH 3.4 Map18628.4UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022717   ⟹   ENSRNOP00000022717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1861,809,333 - 61,843,238 (+)Ensembl
Rnor_6.0 Ensembl1863,882,610 - 64,041,816 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083414   ⟹   ENSRNOP00000074865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1864,008,048 - 64,044,023 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113866   ⟹   ENSRNOP00000082880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1863,790,440 - 64,113,064 (+)Ensembl
mRatBN7.2 Ensembl1861,521,428 - 61,843,155 (+)Ensembl
RefSeq Acc Id: NM_001271365   ⟹   NP_001258294
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,916,552 - 64,113,065 (+)NCBI
mRatBN7.21861,646,711 - 61,843,238 (+)NCBI
Rnor_6.01863,843,999 - 64,041,816 (+)NCBI
Rnor_5.01863,020,278 - 63,219,634 (+)NCBI
Celera1859,750,235 - 59,946,262 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097098   ⟹   XP_038953026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,791,157 - 64,118,166 (+)NCBI
mRatBN7.21861,521,318 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097100   ⟹   XP_038953028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,790,518 - 64,118,166 (+)NCBI
mRatBN7.21861,520,502 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097101   ⟹   XP_038953029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,790,753 - 64,118,166 (+)NCBI
mRatBN7.21861,520,923 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097102   ⟹   XP_038953030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,789,089 - 64,118,166 (+)NCBI
mRatBN7.21861,519,253 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097103   ⟹   XP_038953031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,791,157 - 64,118,166 (+)NCBI
mRatBN7.21861,521,318 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097104   ⟹   XP_038953032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,790,518 - 64,118,166 (+)NCBI
mRatBN7.21861,520,670 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097105   ⟹   XP_038953033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,790,817 - 64,118,166 (+)NCBI
mRatBN7.21861,520,956 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097106   ⟹   XP_038953034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,789,133 - 64,118,166 (+)NCBI
mRatBN7.21861,519,277 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097107   ⟹   XP_038953035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,791,157 - 64,118,166 (+)NCBI
mRatBN7.21861,520,966 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097108   ⟹   XP_038953036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,911,707 - 64,118,166 (+)NCBI
mRatBN7.21861,641,866 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097109   ⟹   XP_038953037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,790,522 - 64,118,166 (+)NCBI
mRatBN7.21861,520,682 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097110   ⟹   XP_038953038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,910,456 - 64,118,166 (+)NCBI
mRatBN7.21861,641,354 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097111   ⟹   XP_038953039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,857,976 - 64,118,166 (+)NCBI
mRatBN7.21861,588,127 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097112   ⟹   XP_038953040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,791,157 - 64,118,166 (+)NCBI
mRatBN7.21861,521,067 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097113   ⟹   XP_038953041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81864,079,053 - 64,118,166 (+)NCBI
mRatBN7.21861,809,205 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097116   ⟹   XP_038953044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81864,079,015 - 64,118,166 (+)NCBI
mRatBN7.21861,809,174 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_039097117   ⟹   XP_038953045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,953,989 - 64,118,166 (+)NCBI
mRatBN7.21861,684,177 - 61,848,403 (+)NCBI
RefSeq Acc Id: XM_063277573   ⟹   XP_063133643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,790,811 - 64,118,166 (+)NCBI
RefSeq Acc Id: XM_063277574   ⟹   XP_063133644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,790,518 - 64,118,166 (+)NCBI
RefSeq Acc Id: XM_063277575   ⟹   XP_063133645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,790,522 - 64,118,166 (+)NCBI
RefSeq Acc Id: XM_063277576   ⟹   XP_063133646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81864,109,889 - 64,118,166 (+)NCBI
RefSeq Acc Id: NP_001258294   ⟸   NM_001271365
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074865   ⟸   ENSRNOT00000083414
Ensembl Acc Id: ENSRNOP00000022717   ⟸   ENSRNOT00000022717
RefSeq Acc Id: XP_038953030   ⟸   XM_039097102
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953034   ⟸   XM_039097106
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953028   ⟸   XM_039097100
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953032   ⟸   XM_039097104
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953037   ⟸   XM_039097109
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953029   ⟸   XM_039097101
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953033   ⟸   XM_039097105
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953035   ⟸   XM_039097107
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953040   ⟸   XM_039097112
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038953031   ⟸   XM_039097103
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953026   ⟸   XM_039097098
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953039   ⟸   XM_039097111
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953038   ⟸   XM_039097110
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953036   ⟸   XM_039097108
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953045   ⟸   XM_039097117
- Peptide Label: isoform X6
- UniProtKB: A6IXW9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953044   ⟸   XM_039097116
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038953041   ⟸   XM_039097113
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K955 (UniProtKB/TrEMBL),   F1LZA8 (UniProtKB/TrEMBL),   A6IXW8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082880   ⟸   ENSRNOT00000113866
RefSeq Acc Id: XP_063133644   ⟸   XM_063277574
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063133645   ⟸   XM_063277575
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063133643   ⟸   XM_063277573
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUC8 (UniProtKB/TrEMBL),   A6IXW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133646   ⟸   XM_063277576
- Peptide Label: isoform X7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZA8-F1-model_v2 AlphaFold F1LZA8 1-289 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587105 AgrOrtholog
BioCyc Gene G2FUF-7108 BioCyc
Ensembl Genes ENSRNOG00000016879 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000113866 ENTREZGENE
  ENSRNOT00000113866.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.400.10 UniProtKB/TrEMBL
InterPro LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  TMEPAI/LRAD4 UniProtKB/TrEMBL
KEGG Report rno:679578 UniProtKB/TrEMBL
NCBI Gene 679578 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  PTHR16514 UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/TrEMBL
PhenoGen Ldlrad4 PhenoGen
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016879 RatGTEx
SMART LDLa UniProtKB/TrEMBL
Superfamily-SCOP SSF57424 UniProtKB/TrEMBL
UniProt A0A0G2K955 ENTREZGENE
  A0A8I5ZUC8 ENTREZGENE, UniProtKB/TrEMBL
  A6IXW6 ENTREZGENE, UniProtKB/TrEMBL
  A6IXW8 ENTREZGENE, UniProtKB/TrEMBL
  A6IXW9 ENTREZGENE, UniProtKB/TrEMBL
  F1LZA8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-07 Ldlrad4  low density lipoprotein receptor class A domain containing 4  LOC679578  similar to Protein C18orf1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC679578  similar to Protein C18orf1      Symbol and Name status set to provisional 70820 PROVISIONAL