LDLRAD4 (low density lipoprotein receptor class A domain containing 4)

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General
Array IDs

Gene: LDLRAD4 (low density lipoprotein receptor class A domain containing 4) Homo sapiens

Symbol:

LDLRAD4

Name:

low density lipoprotein receptor class A domain containing 4

Description:

FOUND IN plasma membrane (inferred); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

C18orf1; clone 22; hypothetical protein LOC753; low-density lipoprotein receptor class A domain-containing protein 4; uncharacterized protein C18orf1

Orthologs:

Mus musculus : Ldlrad4 (low density lipoprotein receptor class A domain containing 4) MGI
Rattus norvegicus : Ldlrad4 (low density lipoprotein receptor class A domain containing 4)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	18	13,206,717 - 13,640,930	+	NCBI
Human Genome Assembly HuRef	18	13,172,372 - 13,607,009	+	NCBI
Human Genome Assembly GRCh37	18	13,218,786 - 13,652,753	+	NCBI
Human Celera Assembly	18	13,101,030 - 13,535,088	+	NCBI
Human Genome Assembly Build 36	18	13,208,795 - 13,642,753	+	NCBI
Human Cytogenetic Map	18	p11.21		NCBI
Human Genome Assembly	18	13,610,866 - 13,642,753		NCBI

Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation (Toggle Detail/Summary View)

Gene-Chemical Interaction Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of C18ORF1 mRNA; more ...	CTD	PMID:19619570
17beta-estradiol	multiple interactions	EXP		6480464	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of C18ORF1 mRNA; more ...	CTD	PMID:19619570
2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	EXP		6480464	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of C18ORF1 mRNA; more ...	CTD	PMID:19619570
2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of C18ORF1 mRNA; more ...	CTD	PMID:21632981
2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of C18ORF1 mRNA; more ...	CTD	PMID:19619570 PMID:20106945
2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of C18ORF1 mRNA	CTD	PMID:20106945 PMID:19619570
3,4-methylenedioxymethamphetamine	increases expression	ISO	RGD:1313100	6480464	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of D18ERTD653E mRNA; more ...	CTD	PMID:20188158
aflatoxin B1	affects expression	EXP		6480464	Aflatoxin B1 affects the expression of C18ORF1 protein; more ...	CTD	PMID:20106945
benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of C18ORF1 mRNA	CTD	PMID:20064835 PMID:20106945
benzo[a]pyrene	affects expression	EXP		6480464	Benzo(a)pyrene affects the expression of C18ORF1 mRNA; more ...	CTD	PMID:21714911
benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of C18ORF1 mRNA; more ...	CTD	PMID:20064835 more ...
benzo[a]pyrene	decreases expression	ISO	RGD:1313100	6480464	Benzo(a)pyrene results in decreased expression of D18ERTD653E mRNA; more ...	CTD	PMID:19770486
benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of C18ORF1 mRNA	CTD	PMID:20106945 PMID:20064835
biochanin A	decreases expression	EXP		6480464	biochanin A results in decreased expression of C18ORF1 mRNA; more ...	CTD	PMID:12111696
copper(2+) sulfate	decreases expression	EXP		6480464	Copper Sulfate results in decreased expression of C18ORF1 mRNA; more ...	CTD	PMID:19549813
cyclosporin A	decreases expression	EXP		6480464	Cyclosporine results in decreased expression of C18ORF1 mRNA; more ...	CTD	PMID:20106945
elemental selenium	increases expression	EXP		6480464	Selenium results in increased expression of C18ORF1 mRNA; more ...	CTD	PMID:19244175
lead diacetate	increases expression	ISO	RGD:1313100	6480464	lead acetate results in increased expression of LDLRAD4 mRNA	CTD	PMID:22609695
phenobarbital	affects expression	ISO	RGD:1313100	6480464	Phenobarbital affects the expression of LDLRAD4 mRNA	CTD	PMID:23091169
progesterone	increases expression	EXP		6480464	Progesterone results in increased expression of C18ORF1 mRNA; more ...	CTD	PMID:17404688
raloxifene	multiple interactions	EXP		6480464	[Raloxifene co-treated with ESR2 protein] results in increased expression of C18ORF1 mRNA; more ...	CTD	PMID:19059307
rosiglitazone	increases expression	EXP		6480464	rosiglitazone results in increased expression of C18ORF1 mRNA; more ...	CTD	PMID:16982809
selenium atom	increases expression	EXP		6480464	Selenium results in increased expression of C18ORF1 mRNA; more ...	CTD	PMID:19244175
tamoxifen	affects expression	EXP		6480464	Tamoxifen affects the expression of C18ORF1 mRNA; more ...	CTD	PMID:14699072
tamoxifen	multiple interactions	EXP		6480464	[Tamoxifen co-treated with ESR2 protein] results in increased expression of C18ORF1 mRNA; more ...	CTD	PMID:19059307

Gene Ontology Annotations

Biological Process

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
biological_process		ND		2290271	GO_REF:0000015	UniProtKB	GO_REF:0000015

Cellular Component

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
integral to membrane		NAS		2290271	PMID:9479497	UniProtKB	PMID:9479497
plasma membrane		IEA	UniProtKB-SubCell:SL-0039	2290271	GO_REF:0000039	UniProtKB	GO_REF:0000039

Molecular Function

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
molecular_function		ND		2290271	GO_REF:0000015	UniProtKB	GO_REF:0000015

Gene-Chemical Interaction Annotations

	17beta-estradiol (EXP)
	2,3,7,8-tetrachlorodibenzodioxine (EXP)
	3,4-methylenedioxymethamphetamine (ISO)
	aflatoxin B1 (EXP)
	benzo[a]pyrene (EXP,ISO)
	biochanin A (EXP)

	copper(2+) sulfate (EXP)
	cyclosporin A (EXP)
	elemental selenium (EXP)
	lead diacetate (ISO)
	phenobarbital (ISO)
	progesterone (EXP)

	raloxifene (EXP)
	rosiglitazone (EXP)
	selenium atom (EXP)
	tamoxifen (EXP)

Gene Ontology Annotations

Biological Process

biological_process (ND)

Cellular Component

integral to membrane (NAS)

plasma membrane (IEA)

Molecular Function

molecular_function (ND)

References - curated

1.	RGD automated import pipeline for gene-chemical interactions

References - uncurated

PubMed	12477932
	14702039
	15074360
	15489334
	16344560
	17207965
	19430479
	19461657
	19834535
	20379614
	22505724
	7566098
	8889548
	9129712
	9399696
	9479497

Genomics

Comparative Map Data

LDLRAD4 (Homo sapiens)

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	18	13,206,717 - 13,640,930	+	NCBI
Human Genome Assembly HuRef	18	13,172,372 - 13,607,009	+	NCBI
Human Genome Assembly GRCh37	18	13,218,786 - 13,652,753	+	NCBI
Human Celera Assembly	18	13,101,030 - 13,535,088	+	NCBI
Human Genome Assembly Build 36	18	13,208,795 - 13,642,753	+	NCBI
Human Cytogenetic Map	18	p11.21		NCBI
Human Genome Assembly	18	13,610,866 - 13,642,753		NCBI

Ldlrad4 (Mus musculus)

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	18	67,933,257 - 68,255,549	+	NCBI
Mouse cM Map	18	40.14		NCBI
Mouse Celera Assembly	18	69,232,373 - 69,563,908	+	NCBI
Mouse Genome Assembly Build 37	18	68,092,911 - 68,415,203	+	NCBI
Mouse Genome Assembly Build 36.1	18	68,092,911 - 68,415,203	+	NCBI
Mouse Cytogenetic Map	18	E2		NCBI

Ldlrad4 (Rattus norvegicus)

Map	Chr	Position	Strand	Source
Rat Cytogenetic Map	18	q12.1		NCBI
RGSC Genome Assembly v5.0	18	63,182,742 - 63,218,766	+	NCBI
RGSC Genome Assembly v3.4	18	64,755,404 - 64,788,816	-	NCBI
Rat Celera Assembly	18	59,750,235 - 59,946,262	+	NCBI

Position Markers

RH70515

Map	Chr	Position	Source
Human NCBI RH Map	18	185.7	UniSTS
Human GeneMap99-GB4 RH Map	18	113.73	UniSTS
Human Genome Assembly HuRef	18	13,599,872 - 13,599,999	UniSTS
Human Genome Assembly GRCh37	18	13,645,616 - 13,645,743	UniSTS
Human Celera Assembly	18	13,527,951 - 13,528,078	RGD
Human Genome Assembly Build 36	18	13,635,616 - 13,635,743	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

RH16027

Map	Chr	Position	Source
Human GeneMap99-GB4 RH Map	18	111.04	UniSTS
Human Genome Assembly HuRef	18	13,432,888 - 13,433,071	UniSTS
Human Genome Assembly GRCh37	18	13,478,848 - 13,479,031	UniSTS
Human Celera Assembly	18	13,360,880 - 13,361,063	RGD
Human Genome Assembly Build 36	18	13,468,848 - 13,469,031	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

STS-AA001607

Map	Chr	Position	Source
Human NCBI RH Map	18	184.6	UniSTS
Human GeneMap99-GB4 RH Map	18	109.36	UniSTS
Human Genome Assembly HuRef	18	13,590,322 - 13,590,595	UniSTS
Human Genome Assembly GRCh37	18	13,636,034 - 13,636,307	UniSTS
Human Celera Assembly	18	13,518,203 - 13,518,476	RGD
Human Genome Assembly Build 36	18	13,626,034 - 13,626,307	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

D18S852

Map	Chr	Position	Source
Human NCBI RH Map	18	189.9	UniSTS
Human Whitehead-YAC Contig Map	18		UniSTS
Human Whitehead-RH Map	18	100.9	UniSTS
Human Stanford-G3 RH Map	18	533.0	UniSTS
Human Genome Assembly HuRef	18	13,604,449 - 13,604,565	UniSTS
Human Genome Assembly GRCh37	18	13,650,193 - 13,650,309	UniSTS
Human Celera Assembly	18	13,532,528 - 13,532,644	RGD
Human Genome Assembly Build 36	18	13,640,193 - 13,640,309	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

WI-15670

Map	Chr	Position	Source
Human Whitehead-RH Map	18	115.5	UniSTS
Human Genome Assembly HuRef	18	13,604,985 - 13,605,084	UniSTS
Human Genome Assembly GRCh37	18	13,650,729 - 13,650,828	UniSTS
Human Celera Assembly	18	13,533,064 - 13,533,163	RGD
Human Genome Assembly Build 36	18	13,640,729 - 13,640,828	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

RH16149

Map	Chr	Position	Source
Human Genome Assembly HuRef	18	13,590,523 - 13,590,681	UniSTS
Human Genome Assembly GRCh37	18	13,636,235 - 13,636,393	UniSTS
Human Celera Assembly	18	13,518,404 - 13,518,562	RGD
Human Genome Assembly Build 36	18	13,626,235 - 13,626,393	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

RH92128

Map	Chr	Position	Source
Human Genome Assembly GRCh37	18	13,501,181 - 13,501,287	UniSTS
Human Genome Assembly Build 36	18	13,491,181 - 13,491,287	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

RH75211

Map	Chr	Position	Source
Human Genome Assembly HuRef	18	13,497,553 - 13,497,774	UniSTS
Human Genome Assembly GRCh37	18	13,543,354 - 13,543,575	UniSTS
Human Celera Assembly	18	13,425,526 - 13,425,747	RGD
Human Genome Assembly Build 36	18	13,533,354 - 13,533,575	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

RH79722

Map	Chr	Position	Source
Human GeneMap99-GB4 RH Map	18	101.82	UniSTS
Human Genome Assembly HuRef	18	13,485,853 - 13,486,142	UniSTS
Human Genome Assembly GRCh37	18	13,531,653 - 13,531,942	UniSTS
Human Celera Assembly	18	13,413,826 - 13,414,115	RGD
Human Genome Assembly Build 36	18	13,521,653 - 13,521,942	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

SHGC-81577

Map	Chr	Position	Source
Human TNG Radiation Hybrid Map	18	6353.0	UniSTS
Human Genome Assembly HuRef	18	13,383,590 - 13,383,902	UniSTS
Human Genome Assembly GRCh37	18	13,429,545 - 13,429,857	UniSTS
Human Celera Assembly	18	13,311,568 - 13,311,880	RGD
Human Genome Assembly Build 36	18	13,419,545 - 13,419,857	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

G59896

Map	Chr	Position	Source
Human TNG Radiation Hybrid Map	18	6320.0	UniSTS
Human Genome Assembly HuRef	18	13,291,545 - 13,291,656	UniSTS
Human Genome Assembly GRCh37	18	13,337,481 - 13,337,592	UniSTS
Human Celera Assembly	18	13,219,506 - 13,219,617	RGD
Human Genome Assembly Build 36	18	13,327,481 - 13,327,592	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

D18S1074

Map	Chr	Position	Source
Human Genome Assembly HuRef	18	13,280,206 - 13,280,307	UniSTS
Human Genome Assembly GRCh37	18	13,326,141 - 13,326,242	UniSTS
Human Celera Assembly	18	13,208,166 - 13,208,267	RGD
Human Genome Assembly Build 36	18	13,316,141 - 13,316,242	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

SHGC-146549

Map	Chr	Position	Source
Human TNG Radiation Hybrid Map	18	6297.0	UniSTS
Human Genome Assembly HuRef	18	13,193,561 - 13,193,850	UniSTS
Human Genome Assembly GRCh37	18	13,239,977 - 13,240,266	UniSTS
Human Celera Assembly	18	13,122,240 - 13,122,529	RGD
Human Genome Assembly Build 36	18	13,229,977 - 13,230,266	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

SHGC-149303

Map	Chr	Position	Source
Human TNG Radiation Hybrid Map	18	6334.0	UniSTS
Human Genome Assembly HuRef	18	13,331,296 - 13,331,637	UniSTS
Human Genome Assembly GRCh37	18	13,377,223 - 13,377,564	UniSTS
Human Celera Assembly	18	13,259,256 - 13,259,597	RGD
Human Genome Assembly Build 36	18	13,367,223 - 13,367,564	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

RH65178

Map	Chr	Position	Source
Human NCBI RH Map	18	189.9	UniSTS
Human GeneMap99-GB4 RH Map	18	111.35	UniSTS
Human Genome Assembly HuRef	18	13,600,711 - 13,600,887	UniSTS
Human Genome Assembly GRCh37	18	13,646,455 - 13,646,631	UniSTS
Human Celera Assembly	18	13,528,790 - 13,528,966	RGD
Human Genome Assembly Build 36	18	13,636,455 - 13,636,631	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

G20539

Map	Chr	Position	Source
Human Genome Assembly HuRef	18	13,606,782 - 13,606,930	UniSTS
Human Genome Assembly GRCh37	18	13,652,526 - 13,652,674	UniSTS
Human Celera Assembly	18	13,534,861 - 13,535,009	RGD
Human Genome Assembly Build 36	18	13,642,526 - 13,642,674	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

A005V34

Map	Chr	Position	Source
Human NCBI RH Map	18	186.7	UniSTS
Human GeneMap99-GB4 RH Map	18	112.66	UniSTS
Human Genome Assembly HuRef	18	13,606,782 - 13,606,930	UniSTS
Human Genome Assembly GRCh37	18	13,652,526 - 13,652,674	UniSTS
Human Celera Assembly	18	13,534,861 - 13,535,009	RGD
Human Genome Assembly Build 36	18	13,642,526 - 13,642,674	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

SHGC-58439

Map	Chr	Position	Source
Human TNG Radiation Hybrid Map	18	6320.0	UniSTS
Human Genome Assembly HuRef	18	13,285,254 - 13,285,350	UniSTS
Human Genome Assembly GRCh37	18	13,331,189 - 13,331,285	UniSTS
Human Celera Assembly	18	13,213,214 - 13,213,310	RGD
Human Genome Assembly Build 36	18	13,321,189 - 13,321,285	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

RH48512

Map	Chr	Position	Source
Human GeneMap99-GB4 RH Map	18	110.4	UniSTS
Human Genome Assembly HuRef	18	13,173,523 - 13,173,679	UniSTS
Human Genome Assembly GRCh37	18	13,219,936 - 13,220,092	UniSTS
Human Celera Assembly	18	13,102,181 - 13,102,337	RGD
Human Genome Assembly Build 36	18	13,209,936 - 13,210,092	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

SHGC-56441

Map	Chr	Position	Source
Human Genome Assembly HuRef	18	13,600,163 - 13,600,352	UniSTS
Human Genome Assembly GRCh37	18	13,645,907 - 13,646,096	UniSTS
Human Celera Assembly	18	13,528,242 - 13,528,431	RGD
Human Genome Assembly Build 36	18	13,635,907 - 13,636,096	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

RH15947

Map	Chr	Position	Source
Human NCBI RH Map	18	189.9	UniSTS
Human GeneMap99-GB4 RH Map	18	111.35	UniSTS
Human Genome Assembly HuRef	18	13,606,813 - 13,606,978	UniSTS
Human Genome Assembly GRCh37	18	13,652,557 - 13,652,722	UniSTS
Human Celera Assembly	18	13,534,892 - 13,535,057	RGD
Human Genome Assembly Build 36	18	13,642,557 - 13,642,722	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

WIAF-2137

Map	Chr	Position	Source
Human GeneMap99-GB4 RH Map	18	115.5	UniSTS
Human Genome Assembly HuRef	18	13,291,531 - 13,291,796	UniSTS
Human Genome Assembly GRCh37	18	13,337,467 - 13,337,732	UniSTS
Human Celera Assembly	18	13,219,492 - 13,219,757	RGD
Human Genome Assembly Build 36	18	13,327,467 - 13,327,732	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

G29169

Map	Chr	Position	Source
Human Genome Assembly HuRef	18	13,497,591 - 13,497,731	UniSTS
Human Genome Assembly GRCh37	18	13,543,392 - 13,543,532	UniSTS
Human Celera Assembly	18	13,425,564 - 13,425,704	RGD
Human Genome Assembly Build 36	18	13,533,392 - 13,533,532	RGD
Human Cytogenetic Map	18	p11.21	UniSTS

QTLs in Region (Human Genome Assembly GRCh37)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2315065	GLUCO139_H	Glucose level QTL 139 (human)	2.361		Glucose level		18	1	13646540	Human
2314755	GLUCO89_H	Glucose level QTL 89 (human)	2.3	.005	Glucose level	non-insulin dependent	18	1	16438648	Human
2314813	INSUL28_H	Insulin level QTL 28 (human)	2.18	.0094	Insulin level		18	1	18249033	Human
1358842	MULTSCL11_H	Multiple sclerosis susceptibility QTL 11 (human)			Multiple sclerosis susceptibility		18	1	18781314	Human
1331658	COPD27_H	Chronic obstructive pulmonary disease QTL 27 (human)	2.31		Chronic airflow obstruction	FEV1	18	1	21613861	Human
1358831	MULTSCL12_H	Multiple sclerosis susceptibility QTL 12 (human)			Multiple sclerosis susceptibility		18	1	21613861	Human
1643369	BW317_H	Body weight QTL 317 (human)	2.22	.0011	Body fat amount		18	1	21613861	Human
2289528	BW424_H	Body weight QTL 424 (human)	2.3		Body weight	BMI	18	1	21613861	Human
2315440	INSUL43_H	Insulin level QTL 43 (human)	3.1	.007	Insulin level		18	1	22961410	Human
1358840	MULTSCL23_H	Multiple sclerosis susceptibility QTL 23 (human)			Multiple sclerosis susceptibility		18	1	24492826	Human
2315797	GLUCO175_H	Glucose level QTL 175 (human)	3.07	.000085	Glucose level		18	646461	26646461	Human
1643458	BW75_H	Body weight QTL 75 (human)	2.3	.028	Body weight	body mass index	18	2869699	47356732	Human
1643084	BW114_H	Body Weight QTL 114 (human)	3.94	.00001	Body weight		18	5248944	54897291	Human
1559119	SCL29_H	Serum cholesterol level QTL 29 (human)	1.9	.045	Lipid level	HDL cholesterol adjusted for LDL particle size	18	5941014	48694945	Human
1559117	SCL30_H	Serum cholesterol level QTL 30 (human)	2.02	.029	Lipid level	HDL adjusted for triglyceride, LDL particle size	18	7472548	47356473	Human
2289169	BW268_H	Body Weight QTL 268 (human)	3.44	.00003	Body weight		18	8613770	38148934	Human
1559366	BW85_H	Body weight QTL 85 (human)	2.31	.002	Body weight	body mass index	18	9961263	47356732	Human
1643583	ACTIV1_H	Activity level QTL 1 (human)	4.07	.00000000000004	Activity level		18	11492737	61537981	Human
2316723	GLUCO286_H	Glucose level QTL 286 (human)	1.75	.00401	Glucose level		18	12147383	38147383	Human

Sequence

Nucleotide Sequences

Nucleotide RefSeqs	NM_001003674	(Get FASTA)	Search GEO for Microarray Profiles
	NM_001003675	(Get FASTA)	Search GEO for Microarray Profiles
	NM_001276249	(Get FASTA)	Search GEO for Microarray Profiles
	NM_001276251	(Get FASTA)	Search GEO for Microarray Profiles
	NM_004338	(Get FASTA)	Search GEO for Microarray Profiles
	NM_181481	(Get FASTA)	Search GEO for Microarray Profiles
	NM_181482	(Get FASTA)	Search GEO for Microarray Profiles
	NM_181483	(Get FASTA)	Search GEO for Microarray Profiles
GenBank Nucleotide	AA310737	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01074036	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01074037	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01074038	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01074039	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01074040	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01074041	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01074042	(Get FASTA)	Search GEO for Microarray Profiles
	AF009424	(Get FASTA)	Search GEO for Microarray Profiles
	AF009425	(Get FASTA)	Search GEO for Microarray Profiles
	AF009426	(Get FASTA)	Search GEO for Microarray Profiles
	AF009427	(Get FASTA)	Search GEO for Microarray Profiles
	AF009428	(Get FASTA)	Search GEO for Microarray Profiles
	AF009429	(Get FASTA)	Search GEO for Microarray Profiles
	AF009430	(Get FASTA)	Search GEO for Microarray Profiles
	AF009431	(Get FASTA)	Search GEO for Microarray Profiles
	AF009432	(Get FASTA)	Search GEO for Microarray Profiles
	AF009433	(Get FASTA)	Search GEO for Microarray Profiles
	AF009434	(Get FASTA)	Search GEO for Microarray Profiles
	AF009435	(Get FASTA)	Search GEO for Microarray Profiles
	AF009436	(Get FASTA)	Search GEO for Microarray Profiles
	AF009437	(Get FASTA)	Search GEO for Microarray Profiles
	AI668861	(Get FASTA)	Search GEO for Microarray Profiles
	AI878844	(Get FASTA)	Search GEO for Microarray Profiles
	AK023474	(Get FASTA)	Search GEO for Microarray Profiles
	AK055028	(Get FASTA)	Search GEO for Microarray Profiles
	AK291574	(Get FASTA)	Search GEO for Microarray Profiles
	AMYH01008845	(Get FASTA)	Search GEO for Microarray Profiles
	AMYH01008846	(Get FASTA)	Search GEO for Microarray Profiles
	AMYH01008847	(Get FASTA)	Search GEO for Microarray Profiles
	AMYH01008848	(Get FASTA)	Search GEO for Microarray Profiles
	AMYH01008849	(Get FASTA)	Search GEO for Microarray Profiles
	AP001010	(Get FASTA)	Search GEO for Microarray Profiles
	AP002439	(Get FASTA)	Search GEO for Microarray Profiles
	AP002505	(Get FASTA)	Search GEO for Microarray Profiles
	AP005131	(Get FASTA)	Search GEO for Microarray Profiles
	BC029958	(Get FASTA)	Search GEO for Microarray Profiles
	BC030199	(Get FASTA)	Search GEO for Microarray Profiles
	BC047093	(Get FASTA)	Search GEO for Microarray Profiles
	BC066971	(Get FASTA)	Search GEO for Microarray Profiles
	BM715555	(Get FASTA)	Search GEO for Microarray Profiles
	BM805426	(Get FASTA)	Search GEO for Microarray Profiles
	BM917439	(Get FASTA)	Search GEO for Microarray Profiles
	BM991627	(Get FASTA)	Search GEO for Microarray Profiles
	BX114947	(Get FASTA)	Search GEO for Microarray Profiles
	CH471113	(Get FASTA)	Search GEO for Microarray Profiles
	CR748400	(Get FASTA)	Search GEO for Microarray Profiles
	DA126127	(Get FASTA)	Search GEO for Microarray Profiles
	DA246476	(Get FASTA)	Search GEO for Microarray Profiles
	DA276009	(Get FASTA)	Search GEO for Microarray Profiles
	DA321390	(Get FASTA)	Search GEO for Microarray Profiles
	DA369876	(Get FASTA)	Search GEO for Microarray Profiles
	DA391326	(Get FASTA)	Search GEO for Microarray Profiles
	DA412541	(Get FASTA)	Search GEO for Microarray Profiles
	DA418068	(Get FASTA)	Search GEO for Microarray Profiles
	DB107684	(Get FASTA)	Search GEO for Microarray Profiles
	DB272592	(Get FASTA)	Search GEO for Microarray Profiles
	DC327672	(Get FASTA)	Search GEO for Microarray Profiles
	DC328561	(Get FASTA)	Search GEO for Microarray Profiles
	H04910	(Get FASTA)	Search GEO for Microarray Profiles
	HY115972	(Get FASTA)	Search GEO for Microarray Profiles
	HY309264	(Get FASTA)	Search GEO for Microarray Profiles
	JA738551	(Get FASTA)	Search GEO for Microarray Profiles
	JA738553	(Get FASTA)	Search GEO for Microarray Profiles
	JA738555	(Get FASTA)	Search GEO for Microarray Profiles
	JA738557	(Get FASTA)	Search GEO for Microarray Profiles
	JA738559	(Get FASTA)	Search GEO for Microarray Profiles
	JA738561	(Get FASTA)	Search GEO for Microarray Profiles
	N48737	(Get FASTA)	Search GEO for Microarray Profiles
	N63974	(Get FASTA)	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_181481

RefSeq Status:

Type:

CODING

Protein Acc Id:

NP_852146

Peptide Label:

isoform alpha 1

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	18	13,206,717 - 13,640,930	+	NCBI
Human Genome Assembly HuRef	18	13,172,372 - 13,607,009	+	RGD
Human Genome Assembly GRCh37	18	13,218,786 - 13,652,753	+	RGD
Human Celera Assembly	18	13,101,030 - 13,535,088	+	RGD
Human Genome Assembly Build 36	18	13,208,795 - 13,642,753	+	NCBI Archive

RefSeq Acc Id:

NM_181482

RefSeq Status:

VALIDATED

Type:

CODING

Protein Acc Id:

NP_852147

Peptide Label:

isoform alpha 2

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	18	13,206,717 - 13,640,930	+	NCBI
Human Genome Assembly HuRef	18	13,172,372 - 13,607,009	+	RGD
Human Genome Assembly GRCh37	18	13,218,786 - 13,652,753	+	RGD
Human Celera Assembly	18	13,101,030 - 13,535,088	+	RGD
Human Genome Assembly Build 36	18	13,208,795 - 13,642,748	+	NCBI Archive

RefSeq Acc Id:

NM_001003674

RefSeq Status:

VALIDATED

Type:

CODING

Protein Acc Id:

NP_001003674

Peptide Label:

isoform gamma 1

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	18	13,206,717 - 13,640,930	+	NCBI
Human Genome Assembly HuRef	18	13,172,372 - 13,607,009	+	RGD
Human Genome Assembly GRCh37	18	13,218,786 - 13,652,753	+	RGD
Human Celera Assembly	18	13,101,030 - 13,535,088	+	RGD
Human Genome Assembly Build 36	18	13,601,666 - 13,642,753	+	NCBI Archive

RefSeq Acc Id:

NM_001003675

RefSeq Status:

VALIDATED

Type:

CODING

Protein Acc Id:

NP_001003675

Peptide Label:

isoform gamma 2

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	18	13,206,717 - 13,640,930	+	NCBI
Human Genome Assembly HuRef	18	13,172,372 - 13,607,009	+	RGD
Human Genome Assembly GRCh37	18	13,218,786 - 13,652,753	+	RGD
Human Celera Assembly	18	13,101,030 - 13,535,088	+	RGD
Human Genome Assembly Build 36	18	13,601,666 - 13,642,753	+	NCBI Archive

RefSeq Acc Id:

NM_004338

RefSeq Status:

Type:

CODING

Protein Acc Id:

NP_004329

Peptide Label:

isoform beta 1

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	18	13,206,717 - 13,640,930	+	NCBI
Human Genome Assembly HuRef	18	13,172,372 - 13,607,009	+	RGD
Human Genome Assembly GRCh37	18	13,218,786 - 13,652,753	+	RGD
Human Celera Assembly	18	13,101,030 - 13,535,088	+	RGD
Human Genome Assembly Build 36	18	13,610,867 - 13,642,753	+	NCBI Archive

RefSeq Acc Id:

NM_181483

RefSeq Status:

Type:

CODING

Protein Acc Id:

NP_852148

Peptide Label:

isoform beta 2

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	18	13,206,717 - 13,640,930	+	NCBI
Human Genome Assembly HuRef	18	13,172,372 - 13,607,009	+	RGD
Human Genome Assembly GRCh37	18	13,218,786 - 13,652,753	+	RGD
Human Celera Assembly	18	13,101,030 - 13,535,088	+	RGD
Human Genome Assembly Build 36	18	13,610,867 - 13,642,753	+	NCBI Archive

Protein Sequences

Protein RefSeqs	NP_001003674	(Get FASTA)
	NP_001003675	(Get FASTA)
	NP_001263178	(Get FASTA)
	NP_001263180	(Get FASTA)
	NP_004329	(Get FASTA)
	NP_852146	(Get FASTA)
	NP_852147	(Get FASTA)
	NP_852148	(Get FASTA)
GenBank Protein	AAC52023	(Get FASTA)
	AAC52024	(Get FASTA)
	AAC52025	(Get FASTA)
	AAC52026	(Get FASTA)
	AAH30199	(Get FASTA)
	AAH66971	(Get FASTA)
	ADQ31925	(Get FASTA)
	BAF84263	(Get FASTA)
	BAG51451	(Get FASTA)
	CCF76928	(Get FASTA)
	CCF76929	(Get FASTA)
	CCF76930	(Get FASTA)
	CCF76931	(Get FASTA)
	CCF76932	(Get FASTA)
	CCF76933	(Get FASTA)
	EAX01511	(Get FASTA)
	EAX01512	(Get FASTA)
	EAX01513	(Get FASTA)
	EAX01514	(Get FASTA)
	O15165	(Get FASTA)

Promoters

RGD ID:

6811405

Promoter ID:

HG_ACW:37498

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell

Transcripts:

C18ORF1.JAPR07

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,207,426 - 13,207,926	+	MPROMDB

RGD ID:

6794784

Promoter ID:

HG_KWN:27685

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour

Transcripts:

NM_181481, NM_181482

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,207,931 - 13,208,431	+	MPROMDB

RGD ID:

7231877

Promoter ID:

EPDNEW_H21685

Type:

initiation region

Name:

C18orf1_1

Description:

chromosome 18 open reading frame 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,218,784 - 13,218,844		EPDNEW

RGD ID:

6811496

Promoter ID:

HG_ACW:37508

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour

Transcripts:

C18ORF1.UAPR07, SLOPLY.AAPR07-UNSPLICED, VYSU.AAPR07-UNSPLICED

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,372,446 - 13,372,946	-	MPROMDB

RGD ID:

6811408

Promoter ID:

HG_ACW:37512

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, Jurkat, K562, Lymphoblastoid

Transcripts:

C18ORF1.VAAPR07, C18ORF1.VCAPR07

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,454,894 - 13,455,394	+	MPROMDB

RGD ID:

7231879

Promoter ID:

EPDNEW_H21686

Type:

initiation region

Name:

C18orf1_2

Description:

chromosome 18 open reading frame 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,464,972 - 13,465,032		EPDNEW

RGD ID:

7231881

Promoter ID:

EPDNEW_H21687

Type:

initiation region

Name:

C18orf1_3

Description:

chromosome 18 open reading frame 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,542,330 - 13,542,390		EPDNEW

RGD ID:

6794782

Promoter ID:

HG_KWN:27689

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, Jurkat, K562, Lymphoblastoid

Transcripts:

NM_001003674, NM_001003675, UC002KSG.1

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,601,416 - 13,602,707	+	MPROMDB

RGD ID:

6815231

Promoter ID:

HG_MRA:7335

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

K562

Transcripts:

AK023474

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,603,616 - 13,604,116	+	MPROMDB

RGD ID:

6794783

Promoter ID:

HG_KWN:27690

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Lymphoblastoid

Transcripts:

NM_004338, NM_181483

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,609,966 - 13,611,067	+	MPROMDB

RGD ID:

7231883

Promoter ID:

EPDNEW_H21688

Type:

initiation region

Name:

C18orf1_4

Description:

chromosome 18 open reading frame 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,611,461 - 13,611,521		EPDNEW

RGD ID:

6811404

Promoter ID:

HG_ACW:37534

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Lymphoblastoid

Transcripts:

C18ORF1.HAPR07

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,631,336 - 13,631,836	+	MPROMDB

RGD ID:

6811407

Promoter ID:

HG_ACW:37535

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Lymphoblastoid

Transcripts:

C18ORF1.NAPR07-UNSPLICED

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	18	13,635,086 - 13,635,586	+	MPROMDB

RGD ID:

6869486

Promoter ID:

EPDNEW_H7908

Type:

initiation region

Name:

TMEM173_2

Description:

transmembrane protein 173

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	5	138,861,901 - 138,861,961		EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
COSMIC	LDLRAD4	COSMIC
Ensembl Genes	ENSG00000168675	ENTREZGENE
Ensembl Protein	ENSP00000382740	ENTREZGENE
	ENSP00000382741	ENTREZGENE
Ensembl Transcript	ENST00000399847	ENTREZGENE
	ENST00000399848	ENTREZGENE
Entrez Gene	753	ENTREZGENE
Gene3D-CATH	LDL_rcpt_classA_cys-rich	UniProtKB/Swiss-Prot
Germonline	ENSG00000168675
HGNC ID	1224	ENTREZGENE
HomoloGene Group ID	3202	ENTREZGENE
HPRD ID	07358	ENTREZGENE
InterPro	LDLR_class-A_CS	UniProtKB/Swiss-Prot
	LDrepeatLR_classA_rpt	UniProtKB/Swiss-Prot
IPI	IPI00218243	UniProtKB/Swiss-Prot
	IPI00218244	UniProtKB/Swiss-Prot
	IPI00220323	UniProtKB/Swiss-Prot
	IPI00413630	UniProtKB/Swiss-Prot
	IPI00455979	UniProtKB/Swiss-Prot
	IPI00455980	UniProtKB/Swiss-Prot
	IPI01017886	UniProtKB/Swiss-Prot
KEGG Report	hsa:753	ENTREZGENE, UniProtKB/Swiss-Prot
OMIM	606571	OMIM
Pfam	Ldl_recept_a	UniProtKB/Swiss-Prot
PharmGKB	PA25593	PharmGKB
PROSITE	LDLRA_1	UniProtKB/Swiss-Prot
	LDLRA_2	UniProtKB/Swiss-Prot
SMART	LDLa	UniProtKB/Swiss-Prot
Superfamily-SCOP	LDL_rcpt_classA_cys-rich	UniProtKB/Swiss-Prot
UniGene	Hs.731853	ENTREZGENE
UniProt	CR001_HUMAN	UniProtKB/Swiss-Prot
	K7EJM9_HUMAN	UniProtKB/TrEMBL
	K7EKD6_HUMAN	UniProtKB/TrEMBL
	K7EMG1_HUMAN	UniProtKB/TrEMBL
	K7EN38_HUMAN	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-30	LDLRAD4	low density lipoprotein receptor class A domain containing 4	C18orf1	chromosome 18 open reading frame 1	Symbol and/or name change	39860	APPROVED

More on LDLRAD4

Entrez Gene

Ensembl Gene

Genome Browser:

(hg18) (hg19)

RGD Object Information
RGD ID:	1313099
Created:	2005-01-12
Species:	Homo sapiens
Last Modified:	2013-03-06
Status:	ACTIVE