Gas1 (growth arrest-specific 1) - Rat Genome Database

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Gene: Gas1 (growth arrest-specific 1) Rattus norvegicus
Analyze
Symbol: Gas1
Name: growth arrest-specific 1
RGD ID: 1586820
Description: Predicted to enable oxysterol binding activity. Predicted to be involved in several processes, including negative regulation of protein processing; regulation of ER to Golgi vesicle-mediated transport; and regulation of smoothened signaling pathway. Predicted to act upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regulation of smoothened signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GAS1 (growth arrest specific 1); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: growth arrest specific 1; growth arrest-specific protein 1; LOC683470; similar to growth arrest specific 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,487,716 - 4,490,701 (+)NCBIGRCr8
mRatBN7.2174,482,168 - 4,485,153 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx174,501,253 - 4,504,238 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0176,042,584 - 6,045,570 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0174,497,694 - 4,500,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0174,846,116 - 4,849,350 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,846,789 - 4,847,940 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0177,072,776 - 7,075,999 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera174,606,730 - 4,609,964 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
desferrioxamine B  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dimercaprol  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
hemin  (ISO)
hydroquinone  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
lamivudine  (ISO)
lead(II) chloride  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8127893   PMID:10996315   PMID:10996316   PMID:11356029   PMID:11456441   PMID:11456442   PMID:11572986   PMID:11906213   PMID:15070677   PMID:16551639   PMID:17504940   PMID:17504941  
PMID:17525797   PMID:19211681   PMID:19478089   PMID:21357679   PMID:27225491   PMID:36272046  


Genomics

Comparative Map Data
Gas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,487,716 - 4,490,701 (+)NCBIGRCr8
mRatBN7.2174,482,168 - 4,485,153 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx174,501,253 - 4,504,238 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0176,042,584 - 6,045,570 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0174,497,694 - 4,500,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0174,846,116 - 4,849,350 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,846,789 - 4,847,940 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0177,072,776 - 7,075,999 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera174,606,730 - 4,609,964 (+)NCBICelera
Cytogenetic Map17p14NCBI
GAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38986,944,362 - 86,947,506 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl986,944,362 - 86,947,506 (-)EnsemblGRCh38hg38GRCh38
GRCh37989,559,277 - 89,562,421 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36988,749,098 - 88,751,924 (-)NCBINCBI36Build 36hg18NCBI36
Build 34986,788,831 - 86,791,658NCBI
Celera960,128,056 - 60,130,876 (-)NCBICelera
Cytogenetic Map9q21.33NCBI
HuRef959,383,451 - 59,386,172 (-)NCBIHuRef
CHM1_1989,705,737 - 89,708,564 (-)NCBICHM1_1
T2T-CHM13v2.0999,095,595 - 99,098,739 (-)NCBIT2T-CHM13v2.0
Gas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391360,322,219 - 60,325,179 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1360,322,219 - 60,325,179 (-)EnsemblGRCm39 Ensembl
GRCm381360,174,405 - 60,177,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1360,174,405 - 60,177,365 (-)EnsemblGRCm38mm10GRCm38
MGSCv371360,275,766 - 60,278,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361360,184,028 - 60,186,988 (-)NCBIMGSCv36mm8
Celera1361,235,218 - 61,238,431 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1331.92NCBI
Gas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955432727,784 - 729,096 (+)NCBIChiLan1.0ChiLan1.0
GAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21152,469,368 - 52,472,019 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1952,471,269 - 52,474,412 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0958,079,700 - 58,082,849 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1986,137,630 - 86,140,170 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl986,139,009 - 86,140,045 (-)Ensemblpanpan1.1panPan2
GAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1172,927,346 - 72,930,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl172,927,670 - 72,928,827 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha173,689,084 - 73,690,386 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0173,232,667 - 73,233,972 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1173,042,847 - 73,044,149 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0172,809,335 - 72,810,621 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0173,514,553 - 73,515,855 (+)NCBIUU_Cfam_GSD_1.0
GAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1028,509,261 - 28,510,301 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11028,509,168 - 28,511,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21032,610,336 - 32,613,309 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11297,590,381 - 97,593,209 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1297,591,762 - 97,592,805 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603885,913,252 - 85,916,646 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480910,415,592 - 10,416,596 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480910,414,935 - 10,417,838 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gas1
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:67
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000073271
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat

Markers in Region
Gas1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2174,483,495 - 4,484,506 (+)MAPPERmRatBN7.2
Rnor_6.0174,847,691 - 4,848,701NCBIRnor6.0
Rnor_5.0177,074,342 - 7,075,352UniSTSRnor5.0
Celera174,608,305 - 4,609,315UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 17 9 2 2 2 6 8 12 20 31 8 6
Low 3 26 46 37 16 37 2 3 62 15 10 3 2
Below cutoff 2 2 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073271   ⟹   ENSRNOP00000066915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl174,846,789 - 4,847,940 (+)Ensembl
RefSeq Acc Id: NM_001400814   ⟹   NP_001387743
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,487,716 - 4,490,701 (+)NCBI
mRatBN7.2174,482,168 - 4,485,153 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387743 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000066915   ⟸   ENSRNOT00000073271
RefSeq Acc Id: NP_001387743   ⟸   NM_001400814
- UniProtKB: A6KAG2 (UniProtKB/TrEMBL)
Protein Domains
GDNF/GAS1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RBH9-F1-model_v2 AlphaFold M0RBH9 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586820 AgrOrtholog
BioCyc Gene G2FUF-10453 BioCyc
Ensembl Genes ENSRNOG00000050485 Ensembl
InterPro GAS1 UniProtKB/TrEMBL
  GDNF/GAS1 UniProtKB/TrEMBL
NCBI Gene 683470 ENTREZGENE
PANTHER GROWTH ARREST-SPECIFIC PROTEIN 1 UniProtKB/TrEMBL
  GROWTH ARREST-SPECIFIC PROTEIN 1 UniProtKB/TrEMBL
Pfam GDNF UniProtKB/TrEMBL
PhenoGen Gas1 PhenoGen
RatGTEx ENSRNOG00000050485 RatGTEx
SMART GDNF UniProtKB/TrEMBL
UniProt A6KAG2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-13 Gas1  growth arrest-specific 1  LOC683470  similar to growth arrest specific 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC683470  similar to growth arrest specific 1      Symbol and Name status set to provisional 70820 PROVISIONAL