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Gene: Gas1 (growth arrest-specific 1) Rattus norvegicus

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Symbol:

Gas1

Name:

growth arrest-specific 1

RGD ID:

1586820

Description:

Orthologous to human GAS1 (growth arrest specific 1); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

growth arrest specific 1; growth arrest-specific protein 1; LOC683470; similar to growth arrest specific 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GAS1 (growth arrest specific 1)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Gas1 (growth arrest specific 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gas1 (growth arrest specific 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GAS1 (growth arrest specific 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GAS1 (growth arrest specific 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gas1 (growth arrest specific 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GAS1 (growth arrest specific 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GAS1 (growth arrest specific 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gas1 (growth arrest specific 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gas1 (growth arrest specific 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GAS1 (growth arrest specific 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GAS1 (growth arrest specific 1)	Alliance	DIOPT (HGNC)
Mus musculus (house mouse):	Gas1 (growth arrest specific 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gas1b (growth arrest-specific 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gas1a (growth arrest-specific 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	phg-1	Alliance	DIOPT (OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	4,487,716 - 4,490,701 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	4,484,283 - 4,497,657 (+)	Ensembl				GRCr8
mRatBN7.2	17	4,482,168 - 4,485,153 (+)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	17	4,501,253 - 4,504,238 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	6,042,584 - 6,045,570 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	4,497,694 - 4,500,679 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	17	4,497,002 - 4,499,987 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	17	4,480,603 - 4,483,588 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	17	4,485,405 - 4,488,390 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	17	4,863,373 - 4,866,358 (+)	NCBI		F344_StmMcwi
Rnor_6.0	17	4,846,116 - 4,849,350 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	4,846,789 - 4,847,940 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	7,072,776 - 7,075,999 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	17	4,606,730 - 4,609,964 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

holoprosencephaly (ISO)

holoprosencephaly 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1-nitropyrene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-methylcholine (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetaldehyde (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

crotonaldehyde (ISO)

cycloheximide (ISO)

desferrioxamine B (ISO)

diallyl disulfide (ISO)

diarsenic trioxide (ISO)

diclofenac (ISO)

diethylstilbestrol (ISO)

dimercaprol (ISO)

dioxygen (ISO)

divanadium pentaoxide (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

flusilazole (ISO)

folic acid (ISO)

formaldehyde (ISO)

gemcitabine (ISO)

gentamycin (EXP)

hemin (ISO)

hydroquinone (ISO)

iron atom (ISO)

iron(0) (ISO)

L-citrulline (ISO)

lamivudine (ISO)

lead(II) chloride (ISO)

melphalan (ISO)

mercury dibromide (ISO)

methylseleninic acid (ISO)

microcystin-LR (ISO)

Monobutylphthalate (ISO)

N-nitrosodiethylamine (ISO)

nickel dichloride (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

Triptolide (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon guidance (ISO)

camera-type eye development (ISO)

cell fate commitment (ISO)

cellular response to vascular endothelial growth factor stimulus (ISO)

cerebellum morphogenesis (ISO)

developmental growth (ISO)

dorsal/ventral neural tube patterning (ISO)

dorsal/ventral pattern formation (ISO)

embryonic cranial skeleton morphogenesis (ISO)

embryonic digit morphogenesis (ISO)

embryonic morphogenesis (ISO)

embryonic skeletal system development (ISO)

eye morphogenesis (ISO)

middle ear morphogenesis (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of cell growth (ISO)

negative regulation of epithelial cell proliferation (ISO)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (ISO)

negative regulation of mitotic cell cycle (ISO)

negative regulation of protein processing (ISO)

negative regulation of smoothened signaling pathway (ISO)

odontogenesis (ISO)

outer ear morphogenesis (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of epithelial cell proliferation (ISO)

positive regulation of mesenchymal cell proliferation (ISO)

positive regulation of smoothened signaling pathway (ISO)

programmed cell death (ISO)

regulation of cell cycle (IEA)

regulation of ER to Golgi vesicle-mediated transport (ISO)

regulation of smoothened signaling pathway (ISO)

roof of mouth development (ISO)

Cellular Component

membrane (ISO)

plasma membrane (IEA,ISO)

Molecular Function

oxysterol binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Hedgehog signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8127893	PMID:10996315	PMID:10996316	PMID:11356029	PMID:11456441	PMID:11456442	PMID:11572986	PMID:11906213	PMID:15070677	PMID:16551639	PMID:17504940	PMID:17504941
PMID:17525797	PMID:19211681	PMID:19478089	PMID:21357679	PMID:27225491	PMID:36272046

Genomics

Comparative Map Data

Gas1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	4,487,716 - 4,490,701 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	4,484,283 - 4,497,657 (+)	Ensembl				GRCr8
mRatBN7.2	17	4,482,168 - 4,485,153 (+)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	17	4,501,253 - 4,504,238 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	6,042,584 - 6,045,570 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	4,497,694 - 4,500,679 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	17	4,497,002 - 4,499,987 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	17	4,480,603 - 4,483,588 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	17	4,485,405 - 4,488,390 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	17	4,863,373 - 4,866,358 (+)	NCBI		F344_StmMcwi
Rnor_6.0	17	4,846,116 - 4,849,350 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	4,846,789 - 4,847,940 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	7,072,776 - 7,075,999 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	17	4,606,730 - 4,609,964 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

GAS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	86,944,362 - 86,947,506 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	86,944,362 - 86,947,506 (-)	Ensembl			hg38	GRCh38
GRCh37	9	89,559,277 - 89,562,421 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	88,749,098 - 88,751,924 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	86,788,831 - 86,791,658	NCBI
Celera	9	60,128,056 - 60,130,876 (-)	NCBI		Celera
Cytogenetic Map	9	q21.33	NCBI
HuRef	9	59,383,451 - 59,386,172 (-)	NCBI		HuRef
CHM1_1	9	89,705,737 - 89,708,564 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	99,095,595 - 99,098,739 (-)	NCBI		T2T-CHM13v2.0

Gas1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	60,322,219 - 60,325,179 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	60,322,219 - 60,325,179 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	60,174,405 - 60,177,535 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	60,174,405 - 60,177,365 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	60,275,766 - 60,278,896 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	60,184,028 - 60,186,988 (-)	NCBI		MGSCv36	mm8
Celera	13	61,235,218 - 61,238,431 (-)	NCBI		Celera
Cytogenetic Map	13	B2	NCBI
cM Map	13	31.92	NCBI

Gas1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955432	727,784 - 729,096 (+)	NCBI	ChiLan1.0	ChiLan1.0

GAS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	52,469,368 - 52,472,019 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	52,471,269 - 52,474,412 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	58,079,700 - 58,082,849 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	86,137,630 - 86,140,170 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	86,139,009 - 86,140,045 (-)	Ensembl			panPan2	panpan1.1

GAS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	72,927,346 - 72,930,119 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	72,927,670 - 72,928,827 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	73,689,084 - 73,690,386 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	73,232,667 - 73,233,972 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	1	73,042,847 - 73,044,149 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	72,809,335 - 72,810,621 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	73,514,553 - 73,515,855 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

No map positions available.

GAS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	28,509,261 - 28,510,301 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	28,509,168 - 28,511,554 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	32,610,336 - 32,613,309 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GAS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	97,590,381 - 97,593,209 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	97,591,762 - 97,592,805 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	85,913,252 - 85,916,646 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gas1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624809	10,415,592 - 10,416,596 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624809	10,414,935 - 10,417,838 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gas1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	77,944,781 - 77,947,897 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gas1
30 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	70
Count of miRNA genes:	67
Interacting mature miRNAs:	70
Transcripts:	ENSRNOT00000073271
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	1	21499218	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2120843	22087569	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	1	22181410	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22877318	Rat

Markers in Region

Gas1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	4,483,495 - 4,484,506 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	4,847,691 - 4,848,701	NCBI	Rnor6.0
Rnor_5.0	17	7,074,342 - 7,075,352	UniSTS	Rnor5.0
Celera	17	4,608,305 - 4,609,315	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	14	12	150	247	91	90	65	81	59	22	425	273	11	226	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001400814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001066058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000073271 ⟹ ENSRNOP00000066915

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	17	4,846,789 - 4,847,940 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095873 ⟹ ENSRNOP00000102413

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	4,487,246 - 4,497,657 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107272 ⟹ ENSRNOP00000110132

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	4,487,471 - 4,492,191 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000142188 ⟹ ENSRNOP00000111057

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	4,484,283 - 4,490,745 (+)	Ensembl

RefSeq Acc Id:

NM_001400814 ⟹ NP_001387743

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	4,487,716 - 4,490,701 (+)	NCBI
mRatBN7.2	17	4,482,168 - 4,485,153 (+)	NCBI
Dahl_SR_JrHsd	17	4,497,002 - 4,499,987 (+)	NCBI
Lyon_Normotensive	17	4,480,603 - 4,483,588 (+)	NCBI
Lyon_Hypertensive	17	4,485,405 - 4,488,390 (+)	NCBI
F344_StmMcwi	17	4,863,373 - 4,866,358 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001387743	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000102413
	ENSRNOP00000102413.1
	ENSRNOP00000110132.1
	ENSRNOP00000111057.1

Ensembl Acc Id:

ENSRNOP00000066915 ⟸ ENSRNOT00000073271

RefSeq Acc Id:	NP_001387743 ⟸ NM_001400814
- UniProtKB:	A6KAG2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000110132 ⟸ ENSRNOT00000107272

Ensembl Acc Id:

ENSRNOP00000102413 ⟸ ENSRNOT00000095873

Ensembl Acc Id:

ENSRNOP00000111057 ⟸ ENSRNOT00000142188

Protein Domains

GDNF/GAS1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0RBH9-F1-model_v2	AlphaFold	M0RBH9	1-383	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1586820	AgrOrtholog
BioCyc Gene	G2FUF-10453	BioCyc
Ensembl Genes	ENSRNOG00000050485	Ensembl
	ENSRNOG00000065398	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000095873	ENTREZGENE
	ENSRNOT00000095873.2	UniProtKB/TrEMBL
	ENSRNOT00000107272.2	UniProtKB/TrEMBL
	ENSRNOT00000142188.1	UniProtKB/TrEMBL
InterPro	GAS1	UniProtKB/TrEMBL
	GDNF/GAS1	UniProtKB/TrEMBL
NCBI Gene	683470	ENTREZGENE
PANTHER	GROWTH ARREST-SPECIFIC PROTEIN 1	UniProtKB/TrEMBL
	GROWTH ARREST-SPECIFIC PROTEIN 1	UniProtKB/TrEMBL
Pfam	GDNF	UniProtKB/TrEMBL
PhenoGen	Gas1	PhenoGen
RatGTEx	ENSRNOG00000050485	RatGTEx
	ENSRNOG00000065398	RatGTEx
SMART	GDNF	UniProtKB/TrEMBL
UniProt	A0ABK0LMW9_RAT	UniProtKB/TrEMBL
	A6KAG2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-13	Gas1	growth arrest-specific 1	LOC683470	similar to growth arrest specific 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC683470	similar to growth arrest specific 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)