C19h16orf46 (similar to human chromosome 16 open reading frame 46) - Rat Genome Database

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Pathways
Gene: C19h16orf46 (similar to human chromosome 16 open reading frame 46) Rattus norvegicus
Analyze
Symbol: C19h16orf46
Name: similar to human chromosome 16 open reading frame 46
RGD ID: 1586501
Description: Predicted to be located in cytosol and nucleoplasm. Orthologous to human C16orf46 (chromosome 16 open reading frame 46); INTERACTS WITH (+)-catechin (ortholog); 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid (ortholog); all-trans-retinoic acid (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC687399; LOC687399; uncharacterized protein C16orf46 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81961,931,114 - 61,941,517 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1961,931,116 - 61,941,517 (-)EnsemblGRCr8
mRatBN7.21945,017,499 - 45,033,453 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,022,280 - 45,032,683 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1951,832,036 - 51,842,452 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01952,485,051 - 52,495,466 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01954,729,290 - 54,739,705 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01949,508,321 - 49,518,721 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,508,288 - 49,518,721 (-)Ensemblrn6Rnor6.0
Rnor_5.01960,299,626 - 60,309,967 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1944,295,476 - 44,305,865 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
C19h16orf46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81961,931,114 - 61,941,517 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1961,931,116 - 61,941,517 (-)EnsemblGRCr8
mRatBN7.21945,017,499 - 45,033,453 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,022,280 - 45,032,683 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1951,832,036 - 51,842,452 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01952,485,051 - 52,495,466 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01954,729,290 - 54,739,705 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01949,508,321 - 49,518,721 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,508,288 - 49,518,721 (-)Ensemblrn6Rnor6.0
Rnor_5.01960,299,626 - 60,309,967 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1944,295,476 - 44,305,865 (-)NCBICelera
Cytogenetic Map19q12NCBI
C16orf46
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381681,053,497 - 81,077,238 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1681,053,497 - 81,077,267 (-)Ensemblhg38GRCh38
GRCh371681,087,102 - 81,110,843 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361679,644,603 - 79,668,373 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341679,652,092 - 79,668,305NCBI
Celera1665,385,500 - 65,409,274 (-)NCBICelera
Cytogenetic Map16q23.2NCBI
HuRef1666,843,908 - 66,867,687 (-)NCBIHuRef
CHM1_11682,498,474 - 82,522,234 (-)NCBICHM1_1
T2T-CHM13v2.01687,115,033 - 87,138,779 (-)NCBIT2T-CHM13v2.0
1700030J22Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398117,696,333 - 117,705,741 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8117,696,333 - 117,705,698 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388116,969,594 - 116,978,959 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8116,969,594 - 116,978,959 (-)Ensemblmm10GRCm38
MGSCv378119,493,499 - 119,502,843 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368119,855,576 - 119,864,920 (-)NCBIMGSCv36mm8
Celera8121,188,996 - 121,198,332 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map863.41NCBI
LOC102030116
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555223,845,029 - 3,853,167 (-)NCBIChiLan1.0ChiLan1.0
C18H16orf46
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21890,805,494 - 90,829,620 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11696,718,168 - 96,738,099 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01661,659,749 - 61,684,534 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11681,094,781 - 81,111,048 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1681,088,460 - 81,098,032 (-)EnsemblpanPan2panpan1.1
C5H16orf46
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1570,762,353 - 70,775,341 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl570,765,736 - 70,774,052 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha570,711,103 - 70,724,298 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0571,067,399 - 71,080,383 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl571,070,781 - 71,079,099 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1571,009,677 - 71,022,859 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0570,844,889 - 70,858,073 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0571,322,416 - 71,335,600 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CUNH16orf46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,844,331 - 30,877,268 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647528,710,792 - 28,744,811 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647528,712,249 - 28,744,784 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C6H16orf46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl67,189,556 - 7,207,357 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.167,189,026 - 7,208,669 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
C5H16orf46
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1566,509,242 - 66,531,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl566,509,298 - 66,519,426 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660479,304,104 - 9,326,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH16orf46
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247466,285,316 - 6,288,211 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247466,281,954 - 6,289,142 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
C17H16orf46
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11736,606,008 - 36,616,458 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:42
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000071332
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 66 164 91 90 59 88 59 6 350 186 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071332   ⟹   ENSRNOP00000067219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1961,931,116 - 61,941,517 (-)Ensembl
mRatBN7.2 Ensembl1945,022,280 - 45,032,683 (-)Ensembl
Rnor_6.0 Ensembl1949,508,594 - 49,518,721 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079969   ⟹   ENSRNOP00000074763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1949,508,288 - 49,510,937 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082929   ⟹   ENSRNOP00000075426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1949,508,353 - 49,510,901 (-)Ensembl
RefSeq Acc Id: NM_001101015   ⟹   NP_001094485
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81961,931,114 - 61,941,517 (-)NCBI
mRatBN7.21945,022,277 - 45,032,680 (-)NCBI
Rnor_6.01949,508,321 - 49,518,721 (-)NCBI
Rnor_5.01960,299,626 - 60,309,967 (-)NCBI
Celera1944,295,476 - 44,305,865 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094485 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79279 (Get FASTA)   NCBI Sequence Viewer  
  EDL92641 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067219
  ENSRNOP00000067219.3
GenBank Protein Q6AXX2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001094485   ⟸   NM_001101015
- UniProtKB: Q6AXX2 (UniProtKB/Swiss-Prot),   A6IZG3 (UniProtKB/TrEMBL),   M0RCA7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075426   ⟸   ENSRNOT00000082929
Ensembl Acc Id: ENSRNOP00000074763   ⟸   ENSRNOT00000079969
Ensembl Acc Id: ENSRNOP00000067219   ⟸   ENSRNOT00000071332

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXX2-F1-model_v2 AlphaFold Q6AXX2 1-406 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701175
Promoter ID:EPDNEW_R11691
Type:initiation region
Name:LOC687399_1
Description:hypothetical protein LOC687399
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01949,518,736 - 49,518,796EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586501 AgrOrtholog
BioCyc Gene G2FUF-5559 BioCyc
Ensembl Genes ENSRNOG00000045541 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071332 ENTREZGENE
  ENSRNOT00000071332.3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134186 IMAGE-MGC_LOAD
InterPro DUF4529 UniProtKB/Swiss-Prot
KEGG Report rno:687399 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94405 IMAGE-MGC_LOAD
NCBI Gene 687399 ENTREZGENE
PANTHER CHROMOSOME 16 OPEN READING FRAME 46 UniProtKB/Swiss-Prot
  PTHR36869 UniProtKB/Swiss-Prot
Pfam DUF4529 UniProtKB/Swiss-Prot
PhenoGen C19h16orf46 PhenoGen
RatGTEx ENSRNOG00000045541 RatGTEx
UniProt A6IZG3 ENTREZGENE, UniProtKB/TrEMBL
  CP046_RAT UniProtKB/Swiss-Prot
  M0RCA7 ENTREZGENE, UniProtKB/TrEMBL
  Q6AXX2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-28 C19h16orf46  similar to human chromosome 16 open reading frame 46  LOC687399  hypothetical protein LOC687399  Name and Symbol changed 629549 APPROVED
2006-11-19 LOC687399  hypothetical protein LOC687399      Symbol and Name status set to provisional 70820 PROVISIONAL