Il23r (interleukin 23 receptor) - Rat Genome Database

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Gene: Il23r (interleukin 23 receptor) Rattus norvegicus
Analyze
Symbol: Il23r
Name: interleukin 23 receptor
RGD ID: 1586368
Description: Predicted to enable cytokine binding activity; peptide hormone binding activity; and prolactin receptor activity. Predicted to contribute to interleukin-12 receptor binding activity; interleukin-23 binding activity; and interleukin-23 receptor activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; regulation of cytokine production; and response to type II interferon. Predicted to act upstream of or within interleukin-23-mediated signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; arthritis (multiple); autoimmune disease of the nervous system (multiple); inflammatory bowel disease (multiple); and psoriasis (multiple). Orthologous to human IL23R (interleukin 23 receptor); PARTICIPATES IN interleukin-23 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2-amino-2-deoxy-D-glucopyranose; 3,7-dihydropurine-6-thione; aldehydo-D-glucosamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interleukin 23 receptor-like; interleukin-23 receptor; interleukin-23 receptor-like; LOC103690079; LOC689932; similar to interleukin 23 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,910,230 - 98,003,759 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl497,909,972 - 98,004,110 (-)EnsemblGRCr8
mRatBN7.2496,580,568 - 96,672,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,580,714 - 96,674,021 (-)EnsemblmRatBN7.2
Rnor_6.0498,203,788 - 98,306,729 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,203,958 - 98,305,173 (-)Ensemblrn6Rnor6.0
Rnor_5.04163,191,096 - 163,200,531 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.04162,989,461 - 163,092,313 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4497,087,580 - 97,768,978 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera491,260,435 - 91,346,771 (-)NCBICelera
Cytogenetic Map4q31NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis. Agarwal SK, etal., J Rheumatol. 2009 Dec;36(12):2715-23. Epub 2009 Nov 16.
2. Blocking of IL-6 suppresses experimental autoimmune myasthenia gravis. Aricha R, etal., J Autoimmun. 2011 Mar;36(2):135-41. Epub 2010 Dec 30.
3. Association studies of the IL-23R gene in autoimmune thyroid disease in the Japanese population. Ban Y, etal., Autoimmunity. 2009 Feb;42(2):126-30. doi: 10.1080/08916930802422265.
4. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Capon F, etal., Hum Genet. 2007 Sep;122(2):201-6. Epub 2007 Jun 22.
5. Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population. Davidson SI, etal., Arthritis Rheum. 2009 Nov;60(11):3263-8. doi: 10.1002/art.24933.
6. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Duerr RH, etal., Science. 2006 Dec 1;314(5804):1461-3. Epub 2006 Oct 26.
7. IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. Einarsdottir E, etal., BMC Med Genet. 2009 Jan 28;10:8. doi: 10.1186/1471-2350-10-8.
8. Investigation of association of the IL12B and IL23R genes with psoriatic arthritis. Filer C, etal., Arthritis Rheum. 2008 Dec;58(12):3705-9. doi: 10.1002/art.24128.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Hollis-Moffatt JE, etal., Ann Rheum Dis. 2009 Aug;68(8):1340-4. doi: 10.1136/ard.2008.090142. Epub 2008 Jul 22.
11. Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. Hu D, etal., PLoS One. 2013 May 16;8(5):e63858. doi: 10.1371/journal.pone.0063858. Print 2013.
12. Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: the IL-23/T-helper 17 axis extends to thyroid autoimmunity. Huber AK, etal., J Clin Endocrinol Metab. 2008 Mar;93(3):1077-81. Epub 2007 Dec 11.
13. IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population. Jiang Z, etal., Ann Rheum Dis. 2010 Jul;69(7):1325-8. doi: 10.1136/ard.2009.119420. Epub 2010 Apr 7.
14. Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population. Kim ES, etal., Life Sci. 2012 May 22;90(19-20):740-6. doi: 10.1016/j.lfs.2012.03.017. Epub 2012 Mar 27.
15. Association of interleukin 23 receptor gene with sarcoidosis. Kim HS, etal., Dis Markers. 2011;31(1):17-24. doi: 10.3233/DMA-2011-0796.
16. Association of IL-23 and its receptor gene single-nucleotide polymorphisms with multiple sclerosis in Chinese southern population. Liu M, etal., Int J Neurosci. 2014 Mar 19.
17. Expression of IL-17, IL-23 and their receptors in minor salivary glands of patients with primary Sjogren's syndrome. Mieliauskaite D, etal., Clin Dev Immunol. 2012;2012:187258. doi: 10.1155/2012/187258. Epub 2012 Jan 3.
18. IL23R: a susceptibility locus for celiac disease and multiple sclerosis? Nunez C, etal., Genes Immun. 2008 Jun;9(4):289-93. doi: 10.1038/gene.2008.16. Epub 2008 Mar 27.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Peng J, etal., Cell Res. 2010 Jan;20(1):62-71. Epub 2009 Nov 24.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Increased interleukin-23 receptor(+) T cells in peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Puwipirom H, etal., Arthritis Res Ther. 2010;12(6):R215. doi: 10.1186/ar3194. Epub 2010 Nov 29.
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype. Rueda B, etal., Ann Rheum Dis. 2009 Feb;68(2):253-6. doi: 10.1136/ard.2008.096719. Epub 2008 Aug 19.
28. Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis. Safrany E, etal., Inflamm Res. 2013 Feb;62(2):195-200. doi: 10.1007/s00011-012-0566-z. Epub 2012 Oct 25.
29. Polymorphisms of the IL23R gene are associated with psoriasis but not with immunoglobulin A nephropathy in a Hungarian population. Safrany E, etal., Inflammation. 2011 Dec;34(6):603-8. doi: 10.1007/s10753-010-9268-2.
30. Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples. Safrany E, etal., Scand J Immunol. 2009 Jul;70(1):68-74. doi: 10.1111/j.1365-3083.2009.02265.x.
31. Combination analysis of NOS3, ABCB1 and IL23R polymorphisms with alcohol-induced osteonecrosis of the femoral head risk in Chinese males. Wang Y, etal., Oncotarget. 2017 May 16;8(20):33770-33778. doi: 10.18632/oncotarget.16809.
32. Genetic profiling in Graves' disease: further evidence for lack of a distinct genetic contribution to Graves' ophthalmopathy. Yin X, etal., Thyroid. 2012 Jul;22(7):730-6. doi: 10.1089/thy.2012.0007. Epub 2012 Jun 4.
Additional References at PubMed
PMID:11114383   PMID:12023369   PMID:12421946   PMID:15114670   PMID:16751425   PMID:20027291   PMID:23382219   PMID:25600958   PMID:33843019  


Genomics

Comparative Map Data
Il23r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,910,230 - 98,003,759 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl497,909,972 - 98,004,110 (-)EnsemblGRCr8
mRatBN7.2496,580,568 - 96,672,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,580,714 - 96,674,021 (-)EnsemblmRatBN7.2
Rnor_6.0498,203,788 - 98,306,729 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,203,958 - 98,305,173 (-)Ensemblrn6Rnor6.0
Rnor_5.04163,191,096 - 163,200,531 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.04162,989,461 - 163,092,313 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4497,087,580 - 97,768,978 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera491,260,435 - 91,346,771 (-)NCBICelera
Cytogenetic Map4q31NCBI
IL23R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38167,138,637 - 67,265,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl167,138,907 - 67,259,979 (+)Ensemblhg38GRCh38
GRCh37167,632,137 - 67,725,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36167,404,757 - 67,498,250 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34167,344,189 - 67,437,669NCBI
Celera165,922,104 - 66,015,428 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef165,740,552 - 65,835,548 (+)NCBIHuRef
CHM1_1167,747,479 - 67,841,006 (+)NCBICHM1_1
T2T-CHM13v2.0167,016,149 - 67,143,448 (+)NCBIT2T-CHM13v2.0
Il23r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39667,399,906 - 67,468,838 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl667,399,916 - 67,468,839 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38667,422,932 - 67,491,855 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl667,422,932 - 67,491,855 (-)Ensemblmm10GRCm38
MGSCv37667,372,926 - 67,441,849 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36667,352,510 - 67,421,433 (-)NCBIMGSCv36mm8
Celera669,541,500 - 69,610,484 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map630.85NCBI
Il23r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,842,475 - 23,884,904 (-)Ensembl
ChiLan1.0NW_00495542323,841,342 - 23,885,191 (-)NCBIChiLan1.0ChiLan1.0
IL23R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21159,561,801 - 159,727,876 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11158,721,629 - 158,887,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0166,408,839 - 66,502,535 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,293,514 - 68,386,815 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,293,514 - 68,386,815 (+)EnsemblpanPan2panpan1.1
IL23R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1543,307,422 - 43,369,806 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl543,308,982 - 43,368,474 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha543,492,672 - 43,558,098 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0543,489,715 - 43,555,184 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl543,494,316 - 43,555,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1543,455,682 - 43,521,106 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0543,402,563 - 43,468,018 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0543,641,801 - 43,707,245 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il23r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,065,633 - 80,123,951 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365914,365,762 - 4,425,005 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365914,365,598 - 4,425,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL23R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6145,335,741 - 145,401,510 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16145,337,765 - 145,401,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26134,219,683 - 134,283,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL23R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12065,853,379 - 65,946,000 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2065,854,349 - 65,938,024 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603351,655,750 - 51,751,460 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il23r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,901,071 - 27,941,109 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474227,899,934 - 27,954,145 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il23r
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1676,970,947 - 77,058,358 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il23r
2684 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:44
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000010151
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)489986808101226978Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
BI301678  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04166,754,352 - 166,754,517NCBIRnor5.0
Rnor_5.04166,745,460 - 166,745,622NCBIRnor5.0
Rnor_5.01119,929,467 - 119,929,629NCBIRnor5.0
Rnor_5.04166,762,264 - 166,762,429NCBIRnor5.0
RGSC_v3.4497,544,598 - 97,544,761UniSTSRGSC3.4
RGSC_v3.4497,479,951 - 97,480,112UniSTSRGSC3.4
RH 3.4 Map4593.4UniSTS
Cytogenetic Map4q31UniSTS
AU048125  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04166,498,717 - 166,498,876NCBIRnor5.0
Rnor_5.04166,239,430 - 166,239,589NCBIRnor5.0
Rnor_5.0X96,779,107 - 96,779,266NCBIRnor5.0
RGSC_v3.4497,251,868 - 97,252,026UniSTSRGSC3.4
Cytogenetic Map4q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 4 14 83 35 34 7 83 7 6 185 122 11 55 39 77 27 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000010151   ⟹   ENSRNOP00000010151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl497,909,972 - 98,004,110 (-)Ensembl
mRatBN7.2 Ensembl496,580,714 - 96,674,021 (-)Ensembl
Rnor_6.0 Ensembl498,203,958 - 98,305,173 (-)Ensembl
RefSeq Acc Id: XM_039108697   ⟹   XP_038964625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,910,230 - 98,003,759 (-)NCBI
mRatBN7.2496,580,568 - 96,672,540 (-)NCBI
RefSeq Acc Id: XM_063286966   ⟹   XP_063143036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,912,299 - 98,003,759 (-)NCBI
RefSeq Acc Id: XR_010066178
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,910,899 - 98,003,759 (-)NCBI
RefSeq Acc Id: XR_010066179
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,912,561 - 98,003,759 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001418851 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964625 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143036 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010151
  ENSRNOP00000010151.6
Ensembl Acc Id: ENSRNOP00000010151   ⟸   ENSRNOT00000010151
RefSeq Acc Id: XP_038964625   ⟸   XM_039108697
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063143036   ⟸   XM_063286966
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LX96-F1-model_v2 AlphaFold F1LX96 1-624 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586368 AgrOrtholog
BioCyc Gene G2FUF-44559 BioCyc
Ensembl Genes ENSRNOG00000007544 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010151 ENTREZGENE
  ENSRNOT00000010151.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Type1_Cytokine_Rcpt_Type2 UniProtKB/TrEMBL
NCBI Gene 689932 ENTREZGENE
PANTHER INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2 UniProtKB/TrEMBL
  INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA UniProtKB/TrEMBL
PhenoGen Il23r PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007544 RatGTEx
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt F1LX96 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Il23r  interleukin 23 receptor  LOC103690079  interleukin-23 receptor-like  Data merged from RGD:9432483 737654 PROVISIONAL
2014-08-25 LOC103690079  interleukin-23 receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-24 Il23r  interleukin 23 receptor  LOC100364993  interleukin 23 receptor-like  Data merged from RGD:2319973 1643240 APPROVED
2010-05-05 LOC100364993  interleukin 23 receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Il23r  interleukin 23 receptor  LOC689932  similar to interleukin 23 receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689932  similar to interleukin 23 receptor  LOC683816  similar to interleukin 23 receptor  Data merged from RGD:1597863 1643240 APPROVED
2006-11-20 LOC683816  similar to interleukin 23 receptor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC689932  similar to interleukin 23 receptor      Symbol and Name status set to provisional 70820 PROVISIONAL