Ercc5 (ERCC excision repair 5, endonuclease) - Rat Genome Database

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Gene: Ercc5 (ERCC excision repair 5, endonuclease) Rattus norvegicus
Analyze
Symbol: Ercc5
Name: ERCC excision repair 5, endonuclease
RGD ID: 1586176
Description: Predicted to enable several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Predicted to be involved in DNA repair; negative regulation of apoptotic process; and response to UV-C. Predicted to act upstream of or within UV protection; determination of adult lifespan; and nucleotide-excision repair. Predicted to be located in chromosome. Predicted to be part of DNA replication factor A complex and nucleotide-excision repair complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; melanoma; respiratory system cancer (multiple); stomach cancer; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; Ercc5_mapped; excision repair cross-complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped); Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum complementation group G (Cockayne syndrome)); excision repair cross-complementing rodent repair deficiency,complementation group 5; Xpg
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,801,471 - 53,846,611 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl953,801,714 - 53,875,084 (+)EnsemblGRCr8
mRatBN7.2946,309,477 - 46,354,478 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,309,389 - 46,354,472 (+)EnsemblmRatBN7.2
Rnor_6.0950,928,847 - 50,970,962 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,925,619 - 50,970,955 (+)Ensemblrn6Rnor6.0
Rnor_5.0950,591,955 - 50,637,694 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4943,248,023 - 43,293,196 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera944,012,579 - 44,057,619 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
daidzein  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichromium trioxide  (ISO)
dicyclanil  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
fenthion  (ISO)
fluvastatin  (ISO)
FR900359  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
imiquimod  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lovastatin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-nitrosodiethylamine  (ISO)
p-anisidine  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. Abbasi R, etal., Int J Cancer. 2009 Sep 15;125(6):1431-9. doi: 10.1002/ijc.24442.
2. ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease. Bai Z, etal., FEBS Open Bio. 2022 Oct;12(10):1814-1827. doi: 10.1002/2211-5463.13469. Epub 2022 Aug 7.
3. Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. Cheng L, etal., Carcinogenesis. 2000 Aug;21(8):1527-30.
4. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM and Coin F, DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Complementary DNA sequence and chromosomal localization of xpg, the mouse counterpart of human repair gene XPG/ERCC5. Harada YN, etal., Genomics 1995 Jul 1;28(1):59-65.
7. Nucleotide excision repair: new tricks with old bricks. Kamileri I, etal., Trends Genet. 2012 Nov;28(11):566-73. doi: 10.1016/j.tig.2012.06.004. Epub 2012 Jul 22.
8. Role of XRCC1 and ERCC5 polymorphisms on clinical outcomes in advanced non-small cell lung cancer. Liu D, etal., Genet Mol Res. 2014 Apr 17;13(2):3100-7. doi: 10.4238/2014.April.17.6.
9. Polymorphisms of multiple genes involved in NER pathway predict prognosis of gastric cancer. Liu J, etal., Oncotarget. 2016 Jul 26;7(30):48130-48142. doi: 10.18632/oncotarget.10173.
10. Polymorphisms in DNA repair genes and risk of glioma and meningioma. Luo KQ, etal., Asian Pac J Cancer Prev. 2013;14(1):449-52. doi: 10.7314/apjcp.2013.14.1.449.
11. Prognostic Value of Excision Repair Cross-Complementing mRNA Expression in Gastric Cancer. Luo SS, etal., Biomed Res Int. 2018 Oct 17;2018:6204684. doi: 10.1155/2018/6204684. eCollection 2018.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. The multi-replication protein A (RPA) system--a new perspective. Sakaguchi K, etal., FEBS J. 2009 Feb;276(4):943-63. doi: 10.1111/j.1742-4658.2008.06841.x. Epub 2009 Jan 12.
20. ERCC5 p.Asp1104His and ERCC2 p.Lys751Gln polymorphisms are independent prognostic factors for the clinical course of melanoma. Schrama D, etal., J Invest Dermatol. 2011 Jun;131(6):1280-90. doi: 10.1038/jid.2011.35. Epub 2011 Mar 10.
21. Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. Shiomi N, etal., Mol Cell Biol. 2004 May;24(9):3712-9.
22. Single nucleotide polymorphisms of nucleotide excision repair pathway are significantly associated with outcomes of platinum-based chemotherapy in lung cancer. Song X, etal., Sci Rep. 2017 Sep 18;7(1):11785. doi: 10.1038/s41598-017-08257-7.
23. Association between single nucleotide polymorphisms (SNPs) and toxicity of advanced non-small-cell lung cancer patients treated with chemotherapy. Zhang L, etal., PLoS One. 2012;7(10):e48350. doi: 10.1371/journal.pone.0048350. Epub 2012 Oct 31.
Additional References at PubMed
PMID:7510366   PMID:7657672   PMID:7700386   PMID:8090225   PMID:8652557   PMID:8703115   PMID:8710877   PMID:10022922   PMID:10026181   PMID:11259578   PMID:12644470   PMID:16167068  
PMID:16246722   PMID:17208056  


Genomics

Comparative Map Data
Ercc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,801,471 - 53,846,611 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl953,801,714 - 53,875,084 (+)EnsemblGRCr8
mRatBN7.2946,309,477 - 46,354,478 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,309,389 - 46,354,472 (+)EnsemblmRatBN7.2
Rnor_6.0950,928,847 - 50,970,962 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,925,619 - 50,970,955 (+)Ensemblrn6Rnor6.0
Rnor_5.0950,591,955 - 50,637,694 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4943,248,023 - 43,293,196 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera944,012,579 - 44,057,619 (+)NCBICelera
Cytogenetic Map9q22NCBI
ERCC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,846,032 - 102,875,995 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13102,845,831 - 102,875,995 (+)Ensemblhg38GRCh38
GRCh3713103,498,382 - 103,528,345 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,296,175 - 102,326,346 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3413102,296,174 - 102,326,346NCBI
Celera1384,342,654 - 84,372,832 (+)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1384,090,418 - 84,120,587 (+)NCBIHuRef
CHM1_113103,467,640 - 103,497,809 (+)NCBICHM1_1
T2T-CHM13v2.013102,064,228 - 102,094,203 (+)NCBIT2T-CHM13v2.0
Ercc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,184,084 - 44,220,399 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,186,904 - 44,220,420 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38144,146,948 - 44,181,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl144,147,744 - 44,181,260 (+)Ensemblmm10GRCm38
MGSCv37144,204,589 - 44,238,105 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36144,092,393 - 44,125,806 (+)NCBIMGSCv36mm8
Celera144,491,664 - 44,523,751 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.55NCBI
Ercc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554048,294,346 - 8,321,112 (-)Ensembl
ChiLan1.0NW_0049554048,294,506 - 8,321,505 (-)NCBIChiLan1.0ChiLan1.0
ERCC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214104,361,975 - 104,393,675 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113103,033,007 - 103,063,245 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01384,005,950 - 84,036,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113103,142,508 - 103,173,022 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13103,096,344 - 103,174,182 (+)EnsemblpanPan2panpan1.1
ERCC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,339,011 - 52,372,618 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2252,118,439 - 52,152,268 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02252,786,543 - 52,820,389 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2252,786,765 - 52,820,387 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12252,438,966 - 52,472,791 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,455,293 - 52,489,134 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,496,357 - 52,530,203 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ercc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,718,036 - 187,758,810 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364728,209,540 - 8,234,334 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364728,209,482 - 8,234,696 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERCC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1171,141,842 - 71,168,322 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11171,141,823 - 71,168,326 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ERCC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,406,103 - 81,441,422 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,405,872 - 81,436,040 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604637,942,886 - 37,972,889 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ercc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247938,632,471 - 8,657,346 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247938,632,581 - 8,657,514 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ercc5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14120,218,325 - 120,271,550 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ercc5
414 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:132
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000059349
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH135251  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2946,308,996 - 46,309,185 (+)MAPPERmRatBN7.2
Rnor_6.0950,925,092 - 50,925,280NCBIRnor6.0
Rnor_5.0950,592,053 - 50,592,241UniSTSRnor5.0
RGSC_v3.4943,247,706 - 43,247,894UniSTSRGSC3.4
Celera944,012,229 - 44,012,417UniSTS
RH 3.4 Map9391.99UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000059349   ⟹   ENSRNOP00000056107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl953,801,714 - 53,875,084 (+)Ensembl
mRatBN7.2 Ensembl946,309,389 - 46,354,472 (+)Ensembl
Rnor_6.0 Ensembl950,925,620 - 50,970,854 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076248   ⟹   ENSRNOP00000068529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,311,526 - 46,354,472 (+)Ensembl
Rnor_6.0 Ensembl950,925,619 - 50,955,882 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076636   ⟹   ENSRNOP00000067938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl950,966,766 - 50,970,955 (+)Ensembl
RefSeq Acc Id: NM_001426998   ⟹   NP_001413927
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,801,471 - 53,846,611 (+)NCBI
RefSeq Acc Id: XM_017596798   ⟹   XP_017452287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,801,561 - 53,842,499 (+)NCBI
mRatBN7.2946,309,477 - 46,350,420 (+)NCBI
Rnor_6.0950,928,847 - 50,967,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596799   ⟹   XP_017452288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,801,561 - 53,842,499 (+)NCBI
mRatBN7.2946,309,477 - 46,350,422 (+)NCBI
Rnor_6.0950,928,847 - 50,967,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596800   ⟹   XP_017452289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,801,561 - 53,842,482 (+)NCBI
mRatBN7.2946,309,477 - 46,350,405 (+)NCBI
Rnor_6.0950,928,847 - 50,967,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084555   ⟹   XP_038940483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,801,699 - 53,846,553 (+)NCBI
mRatBN7.2946,309,625 - 46,354,478 (+)NCBI
RefSeq Acc Id: XM_039084556   ⟹   XP_038940484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,801,561 - 53,842,151 (+)NCBI
mRatBN7.2946,309,477 - 46,349,995 (+)NCBI
RefSeq Acc Id: XM_063266934   ⟹   XP_063123004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,801,547 - 53,846,553 (+)NCBI
RefSeq Acc Id: XM_063266935   ⟹   XP_063123005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,801,561 - 53,830,122 (+)NCBI
RefSeq Acc Id: XP_017452289   ⟸   XM_017596800
- Peptide Label: isoform X5
- UniProtKB: A6INS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452287   ⟸   XM_017596798
- Peptide Label: isoform X4
- UniProtKB: A6INS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452288   ⟸   XM_017596799
- Peptide Label: isoform X4
- UniProtKB: A6INS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056107   ⟸   ENSRNOT00000059349
Ensembl Acc Id: ENSRNOP00000068529   ⟸   ENSRNOT00000076248
Ensembl Acc Id: ENSRNOP00000067938   ⟸   ENSRNOT00000076636
RefSeq Acc Id: XP_038940484   ⟸   XM_039084556
- Peptide Label: isoform X3
- UniProtKB: A6INS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940483   ⟸   XM_039084555
- Peptide Label: isoform X1
- UniProtKB: A0A096MKI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001413927   ⟸   NM_001426998
- UniProtKB: A0A096MKI6 (UniProtKB/TrEMBL),   D3ZTV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123004   ⟸   XM_063266934
- Peptide Label: isoform X2
- UniProtKB: A0A096MKI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123005   ⟸   XM_063266935
- Peptide Label: isoform X6
Protein Domains
XPG N-terminal   XPG-I

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTV2-F1-model_v2 AlphaFold D3ZTV2 1-1166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586176 AgrOrtholog
BioCyc Gene G2FUF-27650 BioCyc
Ensembl Genes ENSRNOG00000022812 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059349 ENTREZGENE
  ENSRNOT00000059349.6 UniProtKB/TrEMBL
Gene3D-CATH 5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
  5'-nuclease UniProtKB/TrEMBL
InterPro 5-3_exonuclease_C_sf UniProtKB/TrEMBL
  HhH2 UniProtKB/TrEMBL
  PIN_domain-like UniProtKB/TrEMBL
  XPG-I_dom UniProtKB/TrEMBL
  XPG/Rad2 UniProtKB/TrEMBL
  XPG_CS UniProtKB/TrEMBL
  XPG_DNA_repair_N UniProtKB/TrEMBL
  XPGC_DNA_repair UniProtKB/TrEMBL
NCBI Gene 301382 ENTREZGENE
PANTHER DNA EXCISION REPAIR PROTEIN ERCC-5 UniProtKB/TrEMBL
  DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED UniProtKB/TrEMBL
Pfam XPG_I UniProtKB/TrEMBL
  XPG_N UniProtKB/TrEMBL
PhenoGen Ercc5 PhenoGen
PRINTS XPGRADSUPER UniProtKB/TrEMBL
  XRODRMPGMNTG UniProtKB/TrEMBL
PROSITE XPG_1 UniProtKB/TrEMBL
  XPG_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022812 RatGTEx
SMART HhH2 UniProtKB/TrEMBL
  XPGI UniProtKB/TrEMBL
  XPGN UniProtKB/TrEMBL
Superfamily-SCOP SSF47807 UniProtKB/TrEMBL
  SSF88723 UniProtKB/TrEMBL
UniProt A0A096MKI6 ENTREZGENE
  A6INS6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTV2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Ercc5  ERCC excision repair 5, endonuclease  Ercc5  excision repair cross-complementation group 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-12 Ercc5  excision repair cross-complementation group 5  Ercc5  excision repair cross-complementing rodent repair deficiency, complementation group 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   excision repair cross-complementing rodent repair deficiency, complementation group 5  Ercc5  excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped)  Name updated 737654 APPROVED
2007-04-11 Ercc5  excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped)  Ercc5_mapped  excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped)  Data merged from RGD:2562 737654 APPROVED
2006-11-19 Ercc5  excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Ercc5_mapped  excision repair cross-complementing rodent repair deficiency,complementation group 5 (mapped)  Ercc5  excision repair cross-complementing rodent repair deficiency,complementation group 5  Symbol and Name updated 1556543 APPROVED
2002-11-06 Ercc5  excision repair cross-complementing rodent repair deficiency,complementation group 5    Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum complementation group G (Cockayne syndrome))  Name updated 625702 APPROVED
2002-06-10 Ercc5  Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum complementation group G (Cockayne syndrome))      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may be involved in DNA repair 1302205
gene_homology shares homology with mouse ercc5 located on mouse chromosome 1 1302205