Advanced Search (OLGA)

Gene: Bmp8a (bone morphogenetic protein 8a) Rattus norvegicus

Analyze

Symbol:

Bmp8a (Ensembl: Oxct2a)

Name:

bone morphogenetic protein 8a (Ensembl:3-oxoacid CoA transferase 2A)

RGD ID:

1585858

Description:

Predicted to enable cytokine activity. Predicted to be involved in several processes, including BMP signaling pathway; diet induced thermogenesis; and negative regulation of insulin secretion. Predicted to act upstream of or within germ cell development and spermatogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to several human genes including BMP8A (bone morphogenetic protein 8a); PARTICIPATES IN Hedgehog signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC680931; similar to Bone morphogenetic protein 8A precursor (BMP-8A) (Osteogenic protein 2) (OP-2)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BMP8A (bone morphogenetic protein 8a)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Bmp8a (bone morphogenetic protein 8a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100984543 (bone morphogenetic protein 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bmp8a (bone morphogenetic protein 8a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BMP8A (bone morphogenetic protein 8a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103225049 (bone morphogenetic protein 8B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	BMP8B (bone morphogenetic protein 8b)	HGNC	EggNOG, OrthoDB, Panther, PhylomeDB
Alliance orthologs ³
Homo sapiens (human):	BMP8A (bone morphogenetic protein 8a)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BMP8B (bone morphogenetic protein 8b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Bmp8a (bone morphogenetic protein 8a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	bmp8a (bone morphogenetic protein 8a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tig-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	tig-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	gbb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	scw	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	bmp8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	bmp8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	140,874,942 - 140,902,881 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	140,874,503 - 140,902,881 (-)	Ensembl				GRCr8
mRatBN7.2	5	135,589,839 - 135,617,785 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	135,591,716 - 135,617,785 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	138,297,599 - 138,323,720 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	140,067,563 - 140,093,682 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	140,074,710 - 140,100,831 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	141,007,462 - 141,033,511 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	141,007,462 - 141,033,511 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	144,797,125 - 144,823,640 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	142,627,733 - 142,653,782 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	134,130,213 - 134,156,308 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Otitis Media (ISO)

peripheral artery disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

folic acid (ISO)

irinotecan (ISO)

lipopolysaccharide (ISO)

N-methyl-4-phenylpyridinium (EXP)

paracetamol (EXP)

pirinixic acid (ISO)

propanal (ISO)

quercetin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

tunicamycin (ISO)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

BMP signaling pathway (IBA)

cartilage development (IEA)

cell differentiation (IEA,ISO)

diet induced thermogenesis (ISO)

energy homeostasis (ISO)

germ cell development (IEA,ISO)

ketone body catabolic process (IEA)

negative regulation of insulin secretion (ISO)

ossification (IEA)

osteoblast differentiation (ISO)

spermatogenesis (ISO)

transforming growth factor beta receptor signaling pathway (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IEA)

mitochondrion (IEA)

Molecular Function

CoA-transferase activity (IEA)

cytokine activity (IBA,IEA)

growth factor activity (IEA)

succinyl-CoA:3-oxo-acid CoA-transferase activity (IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Hedgehog signaling pathway (IEA)

transforming growth factor-beta superfamily mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Tissue remodeling in the acute otitis media mouse model.	Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.

Additional References at PubMed

PMID:9463357	PMID:10894154	PMID:12925636	PMID:22579288	PMID:31940275

Genomics

Comparative Map Data

Bmp8a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	140,874,942 - 140,902,881 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	140,874,503 - 140,902,881 (-)	Ensembl				GRCr8
mRatBN7.2	5	135,589,839 - 135,617,785 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	135,591,716 - 135,617,785 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	138,297,599 - 138,323,720 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	140,067,563 - 140,093,682 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	140,074,710 - 140,100,831 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	141,007,462 - 141,033,511 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	141,007,462 - 141,033,511 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	144,797,125 - 144,823,640 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	142,627,733 - 142,653,782 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	134,130,213 - 134,156,308 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

BMP8A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	39,491,636 - 39,529,869 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	39,491,069 - 39,529,869 (+)	Ensembl			hg38	GRCh38
GRCh37	1	39,957,308 - 39,995,541 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	39,729,905 - 39,768,128 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	39,626,410 - 39,660,700	NCBI
Celera	1	38,238,694 - 38,277,383 (+)	NCBI		Celera
Cytogenetic Map	1	p34.3	NCBI
HuRef	1	38,076,358 - 38,114,746 (+)	NCBI		HuRef
CHM1_1	1	40,073,204 - 40,111,431 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	39,359,546 - 39,398,241 (+)	NCBI		T2T-CHM13v2.0

Bmp8a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	123,206,438 - 123,237,045 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	123,206,438 - 123,237,045 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	123,312,645 - 123,343,252 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	123,312,645 - 123,343,252 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	122,989,888 - 123,020,046 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	122,814,948 - 122,845,106 (-)	NCBI		MGSCv36	mm8
Celera	4	121,645,017 - 121,675,333 (-)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	57.42	NCBI

LOC100984543
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	187,300,838 - 187,335,381 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	186,427,733 - 186,473,022 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	38,776,557 - 38,815,210 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	40,122,134 - 40,138,165 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

Bmp8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	55,579,406 - 55,597,786 (+)	NCBI		HiC_Itri_2

BMP8A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	95,322,454 - 95,366,546 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	88,407,104 - 88,449,938 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103225049
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	93,102,468 - 93,133,875 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	23,436,850 - 23,470,879 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Bmp8a
199 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	89
Count of miRNA genes:	75
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000045922
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
1300122	Wbc1	White blood cell count QTL 1	2.75		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	5	130678987	145274255	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
7411722	Strs6	Sensitivity to stroke QTL 6	3.9		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	5	140258140	143398122	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

BE115320

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	135,398,167 - 135,398,321 (-)	MAPPER	mRatBN7.2
mRatBN7.2	5	135,398,167 - 135,398,321 (+)	MAPPER	mRatBN7.2
mRatBN7.2	5	135,600,876 - 135,601,030 (-)	MAPPER	mRatBN7.2
mRatBN7.2	5	135,600,876 - 135,601,030 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	141,016,609 - 141,016,762	NCBI	Rnor6.0
Rnor_6.0	5	140,815,493 - 140,815,646	NCBI	Rnor6.0
Rnor_5.0	5	144,605,973 - 144,606,126	UniSTS	Rnor5.0
Rnor_5.0	5	144,806,613 - 144,806,766	UniSTS	Rnor5.0
RGSC_v3.4	5	142,433,795 - 142,433,948	UniSTS	RGSC3.4
RGSC_v3.4	5	142,636,880 - 142,637,033	UniSTS	RGSC3.4
Celera	5	134,139,315 - 134,139,468	UniSTS
Celera	5	133,936,889 - 133,937,042	UniSTS
RH 3.4 Map	5	890.2	UniSTS
Cytogenetic Map	5	q36	UniSTS

UniSTS:496645

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	135,595,728 - 135,596,753 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	141,011,474 - 141,012,498	NCBI	Rnor6.0
Rnor_5.0	5	144,801,456 - 144,802,480	UniSTS	Rnor5.0
RGSC_v3.4	5	142,631,745 - 142,632,769	UniSTS	RGSC3.4
Celera	5	134,134,190 - 134,135,214	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	2	32	124	51	53	29	27	29	6	162	86	11	99	31	85	24	8	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000045922 ⟹ ENSRNOP00000049643

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	135,591,716 - 135,617,785 (-)	Ensembl
Rnor_6.0 Ensembl	5	141,007,462 - 141,033,511 (-)	Ensembl

RefSeq Acc Id:

NM_001109432 ⟹ NP_001102902

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	140,876,819 - 140,902,881 (-)	NCBI
mRatBN7.2	5	135,591,716 - 135,617,785 (-)	NCBI
Rnor_6.0	5	141,007,462 - 141,033,511 (-)	NCBI
Rnor_5.0	5	144,797,125 - 144,823,640 (-)	NCBI
RGSC_v3.4	5	142,627,733 - 142,653,782 (-)	RGD
Celera	5	134,130,213 - 134,156,308 (-)	RGD

Sequence:

show sequence

ACCCGCGACAGGTGCGAACTCAAGGGATCCACTGCGCGGTCTGGTCCTCCCCATCGGGGCGTCG
CACCCGAGCCAGGCCAGCTACCGGTGGATGCGCATCTGCTGAAAGTCCGAGATGGCCGTACGTC
CCGGGCCACTCTGGCTATTGGGCCTGGCTCTGTGCGCGCTGGGAGGAGGCCACGGTCCGCGTCC
CCCGCACACCTGTCCCCAGCGTCGCCTGGGAGCGCGCGAGCGCCGCGACATGCAGCGCGAAATC
CTGGCAGTGCTCGGGCTACCCGGGAGACCCCGACCCCGTGCGCCACCCGCCGCTGCTCGGCAGC
CAGCATCCGCGCCCCTCTTCATGTTGGACCTGTATCACGCCATGACCGATGACGACGACGGCGG
GCCACCGCAGGCTCACTTGGGCCGTGCCGACCTGGTCATGAGCTTCGTCAACATGGTGGAGCGC
GACCGTACCCTGGGCTACCAGGAGCCGCACTGGAAGGAATTCCACTTTGACTTAACCCAGATCC
CTGCTGGTGAGGCTGTCACAGCCGCTGAGTTCCGGATATACAAAGAGCCCAGCACCCACCCGCC
CAACACAACCCTCCACATCAGCATGTTTGAAGTGGTCCAGGAGCGCTCCAACAGGGAGTCTGAC
TTGTTCTTTTTGGATCTTCAGACGCTCCGGTCTGGGGACGAGGGCTGGCTGGTGCTGGACATCA
CAGCAGCCAGTGACCGATGGCTGCTGAACCATAACAAGGACCTGGGACTCCGCCTCTATGTGGA
AACCGAGGATGGGCACAGCCTGGATCCTGGCCTGGCTGGTCTGCTTGGACAAACAGCACCACGC
TCCAGACAGCCTTTCATGGTCACCTTCTTCAGAGCCAGCTCGAGTCCTGTGCGGACCCCTCGGG
CAGTGAGACCGCTGAAGAGGAGGCAGCCAAAGAAAACAAACGAGCTTCCACATCCCAACAAACT
CCCAGGGATCTTTGATGATGGCCACGGTTCCCGAGGCAGAGAGGTTTGCCGCAGACACGAGCTG
TACGTCAGCTTCCGTGACCTCGGCTGGCTGGACTGGGTCATCGCCCCCCAGGGCTACTCCGCCT
ATTACTGTGAGGGAGAGTGTGCTTTCCCACTGGACTCCTGTATGAATGCCACCAACCATGCCAT
CTTGCAGTCTCTGGTGCACCTGATGAAACCAGATGTCGTCCCCAAGGCATGCTGTGCTCCCACC
AAACTGAGTGCCACCTCTGTGCTCTACTATGACAGCAGCAACAATGTCATCCTGCGGAAGCACC
GCAACATGGTGGTCAAGGCCTGCGGCTGCCACTGAGGCCCTGCCCGGCATCCTGCTTCTACGAC
GGTACCATCTGGTCAGGCCCCTCTCCAGAGGCAGGAAACCCTCTTATGTTATCATAGCTCAGAC
AGGGACAACGGGAGGCCATCACTTCCCCTGGCCACTTCCTGCTAAATTTTTGGTCCTTTCCCAG
TCCCCCTGTCCTCTTCATGGGGTTTGTGGGCTATCGCCCTCCCCTCTCCATCCCCCTACCCCAA
GCATAGACCGAATGCACACAGAATCCCAGAGCTGTGCTGACTGAGAGGTCTGGGGTCGGTGCTG
AAGACCCACATGAGGAAGACTCGTCCTTGGCCATCCTCAGTCCACAGTTGCAAACTCTGGACGG
TCTAAGAAGGCTCTGAAATTTGAAACTGGCTGATCTGGGCTCTGCACCACTCATTATGGTGGTC
AGGGCATTTGTAGGTATAACGGACACACACATCAGTGTATTGCTGTACTCCTTGAAATCAGAGC
AATCCTGTTATAAAAAGAATCAGAGCCAGGTATAACGGTGCATGACATTAATCCCAGCACTAGA
GAGATGGAGACAGGAGGATCTCTGTGAGTTCAAGGCCACATAGGAAGATCTTGTCTCAGGGGA

hide sequence

RefSeq Acc Id:

XM_039110766 ⟹ XP_038966694

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	140,874,942 - 140,885,772 (-)	NCBI
mRatBN7.2	5	135,589,839 - 135,600,688 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102902	(Get FASTA)	NCBI Sequence Viewer
	XP_038966694	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL80378	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000049643
	ENSRNOP00000049643.2
	ENSRNOP00000101349.1
	ENSRNOP00000103009.1
	ENSRNOP00000104482.1
	ENSRNOP00000109400.1

RefSeq Acc Id:	NP_001102902 ⟸ NM_001109432
- Peptide Label:	precursor
- UniProtKB:	D3ZTI5 (UniProtKB/TrEMBL), A6IS27 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVRPGPLWLLGLALCALGGGHGPRPPHTCPQRRLGARERRDMQREILAVLGLPGRPRPRAPPA AARQPASAPLFMLDLYHAMTDDDDGGPPQAHLGRADLVMSFVNMVERDRTLGYQEPHWKEFHFD LTQIPAGEAVTAAEFRIYKEPSTHPPNTTLHISMFEVVQERSNRESDLFFLDLQTLRSGDEGWL VLDITAASDRWLLNHNKDLGLRLYVETEDGHSLDPGLAGLLGQTAPRSRQPFMVTFFRASSSPV RTPRAVRPLKRRQPKKTNELPHPNKLPGIFDDGHGSRGREVCRRHELYVSFRDLGWLDWVIAPQ GYSAYYCEGECAFPLDSCMNATNHAILQSLVHLMKPDVVPKACCAPTKLSATSVLYYDSSNNVI LRKHRNMVVKACGCH hide sequence

Ensembl Acc Id:

ENSRNOP00000049643 ⟸ ENSRNOT00000045922

RefSeq Acc Id:	XP_038966694 ⟸ XM_039110766
- Peptide Label:	isoform X1

Protein Domains

TGF-beta family profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZTI5-F1-model_v2	AlphaFold	D3ZTI5	1-399	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1585858	AgrOrtholog
BioCyc Gene	G2FUF-40006	BioCyc
Ensembl Genes	ENSRNOG00000030155	Ensembl
	ENSRNOG00000079897	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000045922	ENTREZGENE
	ENSRNOT00000045922.4	UniProtKB/TrEMBL
	ENSRNOT00000140305.1	UniProtKB/TrEMBL
	ENSRNOT00000154874.1	UniProtKB/TrEMBL
	ENSRNOT00000160149.1	UniProtKB/TrEMBL
	ENSRNOT00000168542.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
	2.60.120.970	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-b_N	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
KEGG Report	rno:680931	UniProtKB/TrEMBL
NCBI Gene	680931	ENTREZGENE
PANTHER	BONE MORPHOGENETIC PROTEIN 8A	UniProtKB/TrEMBL
	TGFbeta	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TGFb_propeptide	UniProtKB/TrEMBL
PhenoGen	Bmp8a	PhenoGen
PRINTS	INHIBINA	UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000030155	RatGTEx
	ENSRNOG00000079897	RatGTEx
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0ABK0LE75_RAT	UniProtKB/TrEMBL
	A6IS27	ENTREZGENE, UniProtKB/TrEMBL
	D3ZTI5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-05	Bmp8a	bone morphogenetic protein 8a	LOC680931	similar to Bone morphogenetic protein 8A precursor (BMP-8A) (Osteogenic protein 2) (OP-2)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC680931	similar to Bone morphogenetic protein 8A precursor (BMP-8A) (Osteogenic protein 2) (OP-2)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)