Grpel2 (GrpE-like 2, mitochondrial) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Grpel2 (GrpE-like 2, mitochondrial) Rattus norvegicus
Analyze
Symbol: Grpel2
Name: GrpE-like 2, mitochondrial
RGD ID: 1585231
Description: Predicted to enable adenyl-nucleotide exchange factor activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial matrix. Predicted to be part of PAM complex, Tim23 associated import motor. Orthologous to human GRPEL2 (GrpE like 2, mitochondrial); PARTICIPATES IN presequence pathway of mitochondrial protein import; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin filament-associated protein 1-like 1; AFAP1-like protein 1; Afap1l1; grpE protein homolog 2, mitochondrial; LOC688777; similar to GrpE protein homolog 2, mitochondrial precursor (Mt-GrpE#2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,438,168 - 57,450,408 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1857,438,168 - 57,450,717 (-)EnsemblGRCr8
mRatBN7.21855,167,831 - 55,180,073 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,168,209 - 55,180,180 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1857,261,339 - 57,273,589 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,975,976 - 57,988,238 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,791,694 - 55,803,936 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01857,037,995 - 57,050,234 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1857,036,877 - 57,050,408 (-)Ensemblrn6Rnor6.0
Rnor_5.01856,266,330 - 56,278,569 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41857,691,610 - 57,703,850 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1853,316,882 - 53,329,122 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
Bufotalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
dichloroacetic acid  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
fenofibrate  (ISO)
flutamide  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
triticonazole  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
Additional References at PubMed
PMID:9694873   PMID:12865426   PMID:14651853   PMID:18614015  


Genomics

Comparative Map Data
Grpel2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,438,168 - 57,450,408 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1857,438,168 - 57,450,717 (-)EnsemblGRCr8
mRatBN7.21855,167,831 - 55,180,073 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,168,209 - 55,180,180 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1857,261,339 - 57,273,589 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,975,976 - 57,988,238 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,791,694 - 55,803,936 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01857,037,995 - 57,050,234 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1857,036,877 - 57,050,408 (-)Ensemblrn6Rnor6.0
Rnor_5.01856,266,330 - 56,278,569 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41857,691,610 - 57,703,850 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1853,316,882 - 53,329,122 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
GRPEL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,345,499 - 149,354,583 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,345,430 - 149,354,583 (+)Ensemblhg38GRCh38
GRCh375148,725,062 - 148,734,146 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,705,170 - 148,714,339 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345148,705,284 - 148,714,338NCBI
Celera5144,806,966 - 144,816,121 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5143,871,317 - 143,880,469 (+)NCBIHuRef
CHM1_15148,157,397 - 148,166,568 (+)NCBICHM1_1
T2T-CHM13v2.05149,880,331 - 149,889,398 (+)NCBIT2T-CHM13v2.0
Grpel2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,845,495 - 61,860,068 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,845,495 - 61,859,396 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381861,712,424 - 61,726,358 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,712,424 - 61,726,325 (-)Ensemblmm10GRCm38
MGSCv371861,872,078 - 61,885,985 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361861,837,793 - 61,851,700 (-)NCBIMGSCv36mm8
Celera1862,997,997 - 63,011,843 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.69NCBI
Grpel2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049558531,442 - 9,278 (+)Ensembl
ChiLan1.0NW_0049558531,443 - 9,278 (+)NCBIChiLan1.0ChiLan1.0
GRPEL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24144,575,752 - 144,585,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15142,715,494 - 142,724,786 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05144,771,261 - 144,780,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15150,781,671 - 150,791,377 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,781,671 - 150,791,377 (+)EnsemblpanPan2panpan1.1
GRPEL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,603,384 - 59,614,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,590,167 - 59,614,584 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha459,368,354 - 59,379,461 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0460,085,904 - 60,097,014 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl460,072,413 - 60,097,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,872,515 - 59,883,621 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,986,909 - 59,997,951 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,517,526 - 60,528,629 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grpel2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,937,230 - 143,948,617 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365045,511,186 - 5,522,614 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365045,511,203 - 5,522,553 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRPEL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,511,178 - 150,520,462 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12150,510,520 - 150,520,013 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,276,628 - 157,283,071 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRPEL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12351,963,532 - 51,970,251 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603425,773,516 - 25,782,645 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grpel2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247748,702,969 - 8,715,502 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247748,702,833 - 8,713,901 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Grpel2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11570,229,895 - 70,241,835 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grpel2
99 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:401
Count of miRNA genes:228
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000065046
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
RH144668  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81857,446,338 - 57,446,505 (+)Marker Load Pipeline
mRatBN7.21855,176,003 - 55,176,170 (+)MAPPERmRatBN7.2
Rnor_6.01857,046,165 - 57,046,331NCBIRnor6.0
Rnor_5.01856,274,500 - 56,274,666UniSTSRnor5.0
RGSC_v3.41857,699,781 - 57,699,947UniSTSRGSC3.4
Celera1853,325,053 - 53,325,219UniSTS
RH 3.4 Map18542.2UniSTS
Cytogenetic Map18q12.1UniSTS
RH139718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21855,168,501 - 55,168,692 (+)MAPPERmRatBN7.2
Rnor_6.01857,038,666 - 57,038,856NCBIRnor6.0
Rnor_5.01856,267,001 - 56,267,191UniSTSRnor5.0
RGSC_v3.41857,692,281 - 57,692,471UniSTSRGSC3.4
Celera1853,317,553 - 53,317,743UniSTS
RH 3.4 Map18540.09UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000065046   ⟹   ENSRNOP00000061858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1857,036,877 - 57,050,408 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099687   ⟹   ENSRNOP00000090396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,442,567 - 57,450,408 (-)Ensembl
mRatBN7.2 Ensembl1855,172,232 - 55,180,105 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113712   ⟹   ENSRNOP00000079308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,438,168 - 57,450,463 (-)Ensembl
mRatBN7.2 Ensembl1855,168,425 - 55,180,031 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114258   ⟹   ENSRNOP00000083372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,438,168 - 57,450,408 (-)Ensembl
mRatBN7.2 Ensembl1855,168,373 - 55,177,564 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117207   ⟹   ENSRNOP00000090880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,438,168 - 57,450,592 (-)Ensembl
mRatBN7.2 Ensembl1855,168,373 - 55,179,830 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118162   ⟹   ENSRNOP00000090798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,438,168 - 57,450,717 (-)Ensembl
mRatBN7.2 Ensembl1855,168,209 - 55,180,180 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152859   ⟹   ENSRNOP00000104251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,438,168 - 57,445,943 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167067   ⟹   ENSRNOP00000112018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,438,168 - 57,450,717 (-)Ensembl
RefSeq Acc Id: NM_001109513   ⟹   NP_001102983
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,438,168 - 57,450,408 (-)NCBI
mRatBN7.21855,167,831 - 55,180,073 (-)NCBI
Rnor_6.01857,037,995 - 57,050,234 (-)NCBI
Rnor_5.01856,266,330 - 56,278,569 (-)NCBI
RGSC_v3.41857,691,610 - 57,703,850 (-)RGD
Celera1853,316,882 - 53,329,122 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102983 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14618 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079308.2
  ENSRNOP00000083372
  ENSRNOP00000083372.2
  ENSRNOP00000090396.1
  ENSRNOP00000090798.2
  ENSRNOP00000090880.2
  ENSRNOP00000104251.1
  ENSRNOP00000112018.1
RefSeq Acc Id: NP_001102983   ⟸   NM_001109513
- UniProtKB: A6IXI7 (UniProtKB/TrEMBL),   A0A8I6ABV2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061858   ⟸   ENSRNOT00000065046
Ensembl Acc Id: ENSRNOP00000090396   ⟸   ENSRNOT00000099687
Ensembl Acc Id: ENSRNOP00000079308   ⟸   ENSRNOT00000113712
Ensembl Acc Id: ENSRNOP00000090798   ⟸   ENSRNOT00000118162
Ensembl Acc Id: ENSRNOP00000083372   ⟸   ENSRNOT00000114258
Ensembl Acc Id: ENSRNOP00000090880   ⟸   ENSRNOT00000117207
Ensembl Acc Id: ENSRNOP00000112018   ⟸   ENSRNOT00000167067
Ensembl Acc Id: ENSRNOP00000104251   ⟸   ENSRNOT00000152859

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A676-F1-model_v2 AlphaFold D4A676 1-224 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700821
Promoter ID:EPDNEW_R11344
Type:multiple initiation site
Name:Grpel2_1
Description:GrpE-like 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01857,050,232 - 57,050,292EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585231 AgrOrtholog
BioCyc Gene G2FUF-7304 BioCyc
Ensembl Genes ENSRNOG00000042682 Ensembl
  ENSRNOG00000064275 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000099687.2 UniProtKB/TrEMBL
  ENSRNOT00000113712.2 UniProtKB/TrEMBL
  ENSRNOT00000114258 ENTREZGENE
  ENSRNOT00000114258.2 UniProtKB/TrEMBL
  ENSRNOT00000117207.2 UniProtKB/TrEMBL
  ENSRNOT00000118162.2 UniProtKB/TrEMBL
  ENSRNOT00000152859.1 UniProtKB/TrEMBL
  ENSRNOT00000167067.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.22.10 UniProtKB/TrEMBL
  3.90.20.20 UniProtKB/TrEMBL
InterPro GrpE UniProtKB/TrEMBL
  GrpE_coiled_coil UniProtKB/TrEMBL
  GrpE_head UniProtKB/TrEMBL
KEGG Report rno:688777 UniProtKB/TrEMBL
NCBI Gene 688777 ENTREZGENE
PANTHER GRPE PROTEIN HOMOLOG 2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR21237 UniProtKB/TrEMBL
Pfam GrpE UniProtKB/TrEMBL
PhenoGen Grpel2 PhenoGen
PRINTS GRPEPROTEIN UniProtKB/TrEMBL
PROSITE GRPE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042682 RatGTEx
  ENSRNOG00000064275 RatGTEx
Superfamily-SCOP SSF51064 UniProtKB/TrEMBL
  SSF58014 UniProtKB/TrEMBL
UniProt A0A8I5ZMF8_RAT UniProtKB/TrEMBL
  A0A8I5ZVY3_RAT UniProtKB/TrEMBL
  A0A8I6ABV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACF5_RAT UniProtKB/TrEMBL
  A0A8I6ADA7_RAT UniProtKB/TrEMBL
  A0ABK0LM34_RAT UniProtKB/TrEMBL
  A0ABK0LRF3_RAT UniProtKB/TrEMBL
  A6IXI7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-08 Grpel2  GrpE-like 2, mitochondrial  LOC682303  similar to GrpE protein homolog 2, mitochondrial precursor (Mt-GrpE#2)  Data merged from RGD:1584642 1643240 APPROVED
2008-03-06 Grpel2  GrpE-like 2, mitochondrial  LOC688777  similar to GrpE protein homolog 2, mitochondrial precursor (Mt-GrpE#2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688777  similar to GrpE protein homolog 2, mitochondrial precursor (Mt-GrpE#2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682303  similar to GrpE protein homolog 2, mitochondrial precursor (Mt-GrpE#2)      Symbol and Name status set to provisional 70820 PROVISIONAL