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Gene: Trim8 (tripartite motif-containing 8) Rattus norvegicus

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Symbol:

Trim8

Name:

tripartite motif-containing 8

RGD ID:

1585223

Description:

Enables mitogen-activated protein kinase kinase kinase binding activity. Predicted to be involved in several processes, including host-mediated suppression of symbiont invasion; negative regulation of viral transcription; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within canonical NF-kappaB signal transduction; positive regulation of protein localization to nucleus; and stem cell population maintenance. Predicted to be located in PML body and cytosol. Predicted to be active in cytoplasm. Orthologous to human TRIM8 (tripartite motif containing 8); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase TRIM8; LOC308181; LOC688785; probable E3 ubiquitin-protein ligase TRIM8; similar to Tripartite motif protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein); tripartite motif protein 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRIM8 (tripartite motif containing 8)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Trim8 (tripartite motif-containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Trim8 (tripartite motif containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRIM8 (tripartite motif containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TRIM8 (tripartite motif containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Trim8 (tripartite motif containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRIM8 (tripartite motif containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRIM8 (tripartite motif containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Trim8 (tripartite motif containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Trim8 (tripartite motif containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RPS24 (ribosomal protein S24)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TRIM8 (tripartite motif containing 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Trim8 (tripartite motif-containing 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	trim8b (tripartite motif containing 8b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	trim8a (tripartite motif containing 8a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	trim8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	trim8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	255,311,039 - 255,325,937 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	255,310,457 - 255,325,937 (+)	Ensembl				GRCr8
mRatBN7.2	1	245,369,632 - 245,384,513 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	245,369,632 - 245,384,513 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	253,497,013 - 253,512,110 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	260,189,784 - 260,204,935 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	252,841,090 - 252,856,181 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	266,255,797 - 266,270,694 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	266,255,797 - 266,270,694 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	273,686,719 - 273,701,616 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	251,724,890 - 251,739,787 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	241,152,131 - 241,166,997 (+)	NCBI		Celera
RGSC_v3.1	1	251,988,330 - 252,002,878 (+)	NCBI
Cytogenetic Map	1	q54	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

electroclinical syndrome (ISO)

epilepsy (ISO)

Focal Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

5-aza-2'-deoxycytidine (ISO)

5-azacytidine (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

camptothecin (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

dexamethasone (ISO)

dimethylselenide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

gentamycin (EXP)

indometacin (ISO)

methapyrilene (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

nitrates (ISO)

Nutlin-3 (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

reactive oxygen species (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

WIN 55212-2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical NF-kappaB signal transduction (ISO)

host-mediated suppression of symbiont invasion (ISO)

immune system process (IEA)

innate immune response (IEA,ISO)

negative regulation of viral transcription (ISO)

positive regulation of autophagy (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of DNA-templated transcription (IEA)

positive regulation of protein localization to nucleus (ISO)

protein K63-linked ubiquitination (ISO)

stem cell population maintenance (ISO)

suppression of viral release by host (IEA,ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IEA,ISO)

nucleoplasm (ISO)

nucleus (IEA,ISO)

PML body (ISO)

Molecular Function

identical protein binding (ISO)

metal ion binding (IEA)

mitogen-activated protein kinase kinase kinase binding (IPI)

protein binding (ISO)

protein homodimerization activity (ISO)

transcription coactivator activity (ISO)

transferase activity (IEA)

ubiquitin protein ligase activity (IEA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor β-Activated Kinase 1-Dependent Signaling Pathways.	Chen L, etal., Hypertension. 2017 Feb;69(2):249-258. doi: 10.1161/HYPERTENSIONAHA.116.07741. Epub 2016 Dec 12.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11331580	PMID:18248090	PMID:21689689	PMID:22493164	PMID:22829933	PMID:23077300	PMID:26347139	PMID:32841049	PMID:35968584

Genomics

Comparative Map Data

Trim8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	255,311,039 - 255,325,937 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	255,310,457 - 255,325,937 (+)	Ensembl				GRCr8
mRatBN7.2	1	245,369,632 - 245,384,513 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	245,369,632 - 245,384,513 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	253,497,013 - 253,512,110 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	260,189,784 - 260,204,935 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	252,841,090 - 252,856,181 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	266,255,797 - 266,270,694 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	266,255,797 - 266,270,694 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	273,686,719 - 273,701,616 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	251,724,890 - 251,739,787 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	241,152,131 - 241,166,997 (+)	NCBI		Celera
RGSC_v3.1	1	251,988,330 - 252,002,878 (+)	NCBI
Cytogenetic Map	1	q54	NCBI

TRIM8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	102,644,479 - 102,658,319 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	102,642,503 - 102,662,789 (+)	Ensembl			hg38	GRCh38
GRCh37	10	104,404,236 - 104,418,076 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	104,394,242 - 104,408,066 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	104,394,355 - 104,408,064	NCBI
Celera	10	98,145,270 - 98,159,115 (+)	NCBI		Celera
Cytogenetic Map	10	q24.32	NCBI
HuRef	10	98,038,827 - 98,052,661 (+)	NCBI		HuRef
CHM1_1	10	104,688,022 - 104,701,849 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	103,530,264 - 103,544,111 (+)	NCBI		T2T-CHM13v2.0

Trim8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	46,490,087 - 46,504,894 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	46,490,141 - 46,505,287 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	46,501,648 - 46,516,805 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	46,501,702 - 46,516,848 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	46,576,138 - 46,590,945 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	46,555,610 - 46,569,672 (+)	NCBI		MGSCv36	mm8
Celera	19	47,265,345 - 47,280,149 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	38.92	NCBI

Trim8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955485	7,782,794 - 7,797,022 (-)	Ensembl
ChiLan1.0	NW_004955485	7,784,625 - 7,798,131 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRIM8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	114,525,712 - 114,540,343 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	114,531,491 - 114,545,666 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	99,242,187 - 99,256,342 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	102,707,203 - 102,720,565 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	102,707,199 - 102,720,565 (+)	Ensembl			panPan2	panpan1.1

TRIM8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	15,124,310 - 15,138,660 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	15,123,348 - 15,146,355 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	15,295,973 - 15,310,544 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	15,597,872 - 15,612,454 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	15,597,467 - 15,612,445 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	15,142,279 - 15,156,856 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	15,182,036 - 15,196,628 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	15,314,070 - 15,328,679 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Trim8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	31,641,667 - 31,655,616 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936600	3,244,405 - 3,259,218 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936600	3,244,888 - 3,259,042 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIM8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	113,636,832 - 113,652,372 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	113,637,437 - 113,652,577 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	123,491,837 - 123,506,692 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRIM8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	95,671,622 - 95,686,701 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	95,672,648 - 95,689,247 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	56,785,209 - 56,799,410 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trim8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624831	2,020,227 - 2,032,099 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624831	2,020,185 - 2,031,001 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Trim8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	45,969,119 - 45,983,898 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Trim8
68 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	83
Count of miRNA genes:	64
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000027047
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1578775	Iddm21	Insulin dependent diabetes mellitus QTL 21	4.13		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	245782829	270518180	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
631837	Niddm35	Non-insulin dependent diabetes mellitus QTL 35		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	248619887	269633915	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	5e-06	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	247133834	270518180	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	237995023	269633915	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	228180370	266453608	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	238398865	255849249	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228180243	255849249	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	241569529	269633915	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	243953669	270518180	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Markers in Region

AW124847

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	245,368,706 - 245,368,804 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	266,254,872 - 266,254,969	NCBI	Rnor6.0
Rnor_5.0	1	273,685,794 - 273,685,891	UniSTS	Rnor5.0
RGSC_v3.4	1	251,723,965 - 251,724,062	UniSTS	RGSC3.4
Celera	1	241,151,214 - 241,151,311	UniSTS
Cytogenetic Map	1	q54	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001128083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005492356	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO393559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027047 ⟹ ENSRNOP00000027047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	255,311,039 - 255,325,937 (+)	Ensembl
mRatBN7.2 Ensembl	1	245,369,632 - 245,384,513 (+)	Ensembl
Rnor_6.0 Ensembl	1	266,255,797 - 266,270,694 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000146874 ⟹ ENSRNOP00000110901

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	255,311,855 - 255,325,937 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000148661 ⟹ ENSRNOP00000108837

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	255,310,457 - 255,325,937 (+)	Ensembl

RefSeq Acc Id:

NM_001128083 ⟹ NP_001121555

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	255,311,039 - 255,325,937 (+)	NCBI
mRatBN7.2	1	245,369,632 - 245,384,513 (+)	NCBI
Rnor_6.0	1	266,255,797 - 266,270,694 (+)	NCBI
Rnor_5.0	1	273,686,719 - 273,701,616 (+)	NCBI
RGSC_v3.4	1	251,724,890 - 251,739,787 (+)	RGD
Celera	1	241,152,131 - 241,166,997 (+)	RGD

Sequence:

show sequence

GCCGAGCCTCCTGTTCATTAGCAGTTGAGAAAAATTCCTTTCTAGTTTGATCAATCCTTGTTTT
CCTCAGCGCAGGCGAGGCGCCCGCCCAGCGCGGGGACAGGGAGTGGGGTCTCTCCGCGGAGGGG
GCGCCCTGCGCGGGGCCTCCAGGGAGCGCAGAAGTAGCGACGAGGGGGTCAGGCCGGAGCACCT
CCCGGGCTTCTCCCTCCCTCCCTCTCTGGTTGCCTTTTTTTTTTTTTTTCCACTTCTCTCCCTC
CCCCTTCCGTTTCTATTTGTGAAGGGAGGAGGAAGGCAGAGGCGGGCTGGTGTCTCTGGCCGGG
GACTGGAATTTCATCTGAATGACTGCCCCAGCGCGCACGCAGCGCCCCGGAGTCGGCCCGCCCG
CGCCCTGCAACCCGCAGCCGGCCGGCCAGCTGGGGGACGCCCGCGCCACAGCCCGGGGACCGCC
GGCGCGCCTTGCTCGCCGGCTCCGGCTCCAGCCAGCCTCGGCGCGGCCGAACTAGATTTCCTGG
TCCCTCGGACCTCCGCCGGGATCCAGGCGAGGAAGGCGCGGCTCGCAGCAGCCAAGAGGGAGCC
ACCGTCACCGCCAAAGGAAGAGTGCGGCTCCCCAGCTCGGTGCGCCGCGGGGCGCGCCCCGATG
CCAGCTGCGGGGCCGAGCGCAGGCCTCGAGCCGCCGCTGCCCTAGCCGCGCTGACGGGAAGGCG
GCCTGTTATATGGAATTTGGACCACGGCGCTCCTCTCCAGGGCTGGTGCCCGGGCCGCGGCCCT
GGCGCAGCCCGCCGCCTCCCGCTAGGCTCTCGCCAGGAGGAGGAGACGCAGCCGGCGGCGCGCG
CGGCGCAAGGACCCAGGCTCCCTCCTCTGGGGGGCGGGCACGCGGAAGGCGCTGGTGACTGAGC
GACTGGCGCGGCCGGCGGGGACCGGAGCTCCGGGCTTGGTGGGTCCTCAGCTGCACCAGACTGA
TCCCCAGGGTTGGGGAGTTAGAGAGGTCTACCCGGGCCCCCTGCCCGCAGCCGCCATGGCGGAG
AATTGGAAGAACTGCTTTGAGGAGGAGCTCATCTGCCCCATCTGCCTGCACGTTTTCGTGGAAC
CGGTGCAGCTGCCGTGCAAACACAACTTCTGCCGGGGCTGCATCGGCGAGGCTTGGGCCAAGGA
CAGTGGCCTTGTGCGTTGCCCGGAGTGCAACCAGGCCTACAATCAGAAGCCGGGCCTGGAGAAG
AACCTGAAGCTCACCAACATCGTGGAGAAGTTCAACGCCCTGCACGTGGAGAAGCCCCCGACGG
CACTGCACTGCGTGTTCTGTCGCCGCGGCCCCCCGCTGCCGGCACAGAAGGTCTGCCTGCGCTG
CGAGGCTCCCTGCTGCCAGTCTCACGTGCAGACGCACCTGCAGCAGCCCTCCACCGCCCGCGGG
CACCTCCTGGTGGAGGCGGACGACGTGCGGGCCTGGAGCTGCCCGCAGCACAACGCCTACCGCC
TGTACCACTGCGAGGCCGAGCAGGTGGCGGTGTGCCAGTACTGCTGCTACTACAGCGGCGCGCA
TCAGGGACACTCGGTGTGTGACGTGGAGATACGGAGGAATGAGATACGGAAGATGCTAATGAAG
CAGCAGGAGCGACTGGAGGAGAGAGAGCAGGACATTGAGGACCAGTTGTACAAGCTTGAGTCAG
ACAAGCGCCTGGTGGAGGAGAAAGTGAGCCAACTGAAGGAGGAAGTGAGGCTGCAGTATGAAAA
GCTGCACCAGCTGCTGGACGAGGACCTGCGGCAGACAGTGGAGGTCCTAGACAAGGCGCAGGCC
AAGTTCTGCAGCGAGAACGCGGCGCAGGCGCTGCACCTCGGGGAGCGCATGCAAGAGGCTAAGA
AGCTGCTGGGCTCCCTGCAGCTCCTCTTTGACAAGACAGAGGACGTCAGCTTCATGAAGAATAC
CAAGTCTGTGAAAATCCTAATGGACAGGACCCAGACCTGCACAGGCAGCAGCCTTTCTCCCCCT
AAGATCGGCCACCTGAACTCCAAGCTCTTCCTGAACGAGGTGGCCAAGAAGGAGAAGCAGTTGC
GGAAGATGCTAGAAGGTCCCTTCAGCACGCCGGTGCCCTTCCTACAGAGCGTCCCCCTGTACCC
TTGTGGTGTGAACAGCTCTGGGGCAGAGAAGCGTAAGCACTCCACGGCCTTCCCAGAGGCTAGC
TTCCTGGAGACTTCATCAGGCCCGGTGGGCAGCCAGTACGGGGCAGCAGGCCCAGCCAGCAGCG
AGGGGCAGTCCGGGCAACCCCTGGGGCCCTGTAGCTCCACGCAGCACTTGGTTGCTTTGCCAGG
TGGTGCCCAGCCAGTACACTCGAGTCCTGTGTTTCCCCCATCACAGTACCCCAATGGCTCTGCC
ACTCAGCAGCCCATGCTACCCCAGTATGGCGGTCGCAAGATTCTCGTCTGTTCTGTGGACAACT
GTTATTGTTCTTCCGTGGCCAACCATGGTGGCCACCAGCCGTACCCCCGATCCGGCCACTTCCC
CTGGACAGTGCCCTCTCAAGAATACTCACACCCACTTCCACCCACACCCTCCGTCCCTCAGTCC
CTCTCTGGCCTGGCAGTCAGAGACTGGCTCGACGCTTCCCAGCAGCCTGGCCACCAAGATTTCT
ACAGGGTGTATGGGCAGCCATCCACCAAACACTATGTGACAAGCTAACGCCAAGCAGGCAATGG
ACGCTGGGGACCCTTCTCCCCAGCCCCGGTGGCTCGGGAATTATGCATTCAGAGACCGGCCCTC
TCCACCCTCCTCTCTCCTCCTTTCTTCTCCATTCCTCCAGGTCATTTCTTTTTGGATTATGTTT
TATTTAGGGTCTTGTTTTGATTTTTTTTTTTTTTTAATTATGCATCTCCTGGATGAGGAGGTGA
TGGTGGGAAGTGGCCTGGGCAGGGGCTGCAGGTGGCCCTGGAGCTGGGACAGTATCCTAACTCA
AGGCACTGGGCTCTTTATCGTTCCTTTTTTAAATAAAATCCTACCCCTTTCCCTTCAATCCCCC
CATGGCTGGAAGAAGCCTTGGGCGCCAACTCTCCCTGCTTACCCCGGGAGGCAGCCCAGTGCCC
GCTGGCCTATTTCTTCCCCCCCCTCCAATGTTTCTTCTGGGCAGTTTGATCACTGGTGGAGTAA
AGAATGACCTATAGATTGTGGAGGGTTTTATTTGTTTTGTTTTTTAATTTTTTAAAAACCAAGA
ATGATTTCTTCTACTCAACACCTTCCCAGCCGGATGGAGTTCAAGTCTCAAGCAGCCTTTGGCA
CCTTCAAGCCTGAGTGGAACCCTACAAAGCCAGGAGCCCCGTGTCCAGGAAAAGCTGAGAATAA
AAAAGAACTTTGCCAATGATAGTGACCACAGCAAAAGCAAATAATAATATTAATAATAATAAAG
AGAAATAAAAGAAATAATGAATAAAAAACAAGAGCCCA

hide sequence

RefSeq Acc Id:

XR_005492356

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	255,311,734 - 255,324,604 (+)	NCBI
mRatBN7.2	1	245,370,605 - 245,383,780 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001121555	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027047
	ENSRNOP00000027047.4
	ENSRNOP00000108837.1
	ENSRNOP00000110901.1

RefSeq Acc Id:

NP_001121555 ⟸ NM_001128083

- UniProtKB:

D3ZQE3 (UniProtKB/TrEMBL), A6JHM7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYNQKPG
LEKNLKLTNIVEKFNALHVEKPPTALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQTHLQQPST
ARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKM
LMKQQERLEEREQDIEDQLYKLESDKRLVEEKVSQLKEEVRLQYEKLHQLLDEDLRQTVEVLDK
AQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTGSSL
SPPKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVNSSGAEKRKHSTAFP
EASFLETSSGPVGSQYGAAGPASSEGQSGQPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPN
GSATQQPMLPQYGGRKILVCSVDNCYCSSVANHGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSV
PQSLSGLAVRDWLDASQQPGHQDFYRVYGQPSTKHYVTS

hide sequence

Ensembl Acc Id:

ENSRNOP00000027047 ⟸ ENSRNOT00000027047

Ensembl Acc Id:

ENSRNOP00000108837 ⟸ ENSRNOT00000148661

Ensembl Acc Id:

ENSRNOP00000110901 ⟸ ENSRNOT00000146874

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZQE3-F1-model_v2	AlphaFold	D3ZQE3	1-551	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690967

Promoter ID:

EPDNEW_R1491

Type:

initiation region

Name:

Trim8_1

Description:

tripartite motif-containing 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	266,256,129 - 266,256,189	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1585223	AgrOrtholog
BioCyc Gene	G2FUF-55507	BioCyc
Ensembl Genes	ENSRNOG00000019968	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027047	ENTREZGENE
	ENSRNOT00000027047.7	UniProtKB/TrEMBL
	ENSRNOT00000146874.1	UniProtKB/TrEMBL
	ENSRNOT00000148661.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
	4.10.830.40	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	E3_ubiq-ligase_TRIM/RNF	UniProtKB/TrEMBL
	Znf-RING_euk	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
KEGG Report	rno:688785	UniProtKB/TrEMBL
NCBI Gene	688785	ENTREZGENE
PANTHER	B-BOX DOMAIN CONTAINING	UniProtKB/TrEMBL
	E3 UBIQUITIN-PROTEIN LIGASE TRIM8	UniProtKB/TrEMBL
Pfam	TRIM_CC	UniProtKB/TrEMBL
	zf-RING_UBOX	UniProtKB/TrEMBL
PhenoGen	Trim8	PhenoGen
PROSITE	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019968	RatGTEx
SMART	RING	UniProtKB/TrEMBL
Superfamily-SCOP	B-box zinc-binding domain	UniProtKB/TrEMBL
	RING/U-box	UniProtKB/TrEMBL
UniProt	A0ABK0LWM5_RAT	UniProtKB/TrEMBL
	A0ABK0M4P2_RAT	UniProtKB/TrEMBL
	A6JHM7	ENTREZGENE, UniProtKB/TrEMBL
	D3ZQE3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-06-02	Trim8	tripartite motif-containing 8	Trim8_predicted	tripartite motif protein 8 (predicted)	Data merged from RGD:1309476	737654	APPROVED
2008-03-06	Trim8	tripartite motif-containing 8	LOC688785	similar to Tripartite motif protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC688785	similar to Tripartite motif protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Trim8_predicted	tripartite motif protein 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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