Enables mitogen-activated protein kinase kinase kinase binding activity. Predicted to be involved in several processes, including defense response to symbiont; negative regulation of viral transcription; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within positive regulation of protein localization to nucleus and stem cell population maintenance. Predicted to be located in PML body and cytosol. Predicted to be active in cytoplasm. Orthologous to human TRIM8 (tripartite motif containing 8); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
E3 ubiquitin-protein ligase TRIM8; LOC308181; LOC688785; probable E3 ubiquitin-protein ligase TRIM8; similar to Tripartite motif protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein); tripartite motif protein 8
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM8 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM8 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM8 mRNA
[[Reactive Oxygen Species results in increased oxidation of dimethylselenide] which results in increased expression of LINC01629 mRNA] which results in increased expression of TRIM8 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM8 mRNA
[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM8 mRNA
(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of TRIM8 mRNA] and panobinostat promotes the reaction [(+)-JQ1 compound affects the expression of TRIM8 mRNA]
[[Reactive Oxygen Species results in increased oxidation of dimethylselenide] which results in increased expression of LINC01629 mRNA] which results in increased expression of TRIM8 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM8 mRNA