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Gene: Rnf168 (ring finger protein 168) Rattus norvegicus

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Symbol:

Rnf168

Name:

ring finger protein 168

RGD ID:

1585168

Description:

Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; histone H2AK15 ubiquitin ligase activity; and histone binding activity. Predicted to be involved in several processes, including DNA metabolic process; chromatin remodeling; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within several processes, including DNA damage checkpoint signaling; cellular response to UV; and double-strand break repair via classical nonhomologous end joining. Predicted to be part of DNA repair complex and ubiquitin ligase complex. Predicted to be active in nucleus and site of double-strand break. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase RNF168; LOC690043; MGC188789; ring finger protein 168, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF168; similar to ring finger protein 168

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RNF168 (ring finger protein 168)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rnf168 (ring finger protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rnf168 (ring finger protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RNF168 (ring finger protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RNF168 (ring finger protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rnf168 (ring finger protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RNF168 (ring finger protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RNF168 (ring finger protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rnf168 (ring finger protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rnf168 (ring finger protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RNF168 (ring finger protein 168)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rnf168 (ring finger protein 168)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rnf168 (ring finger protein 168)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T02C1.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rnf168	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	81,991,352 - 82,013,306 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	81,991,360 - 82,013,306 (-)	Ensembl				GRCr8
mRatBN7.2	11	68,486,313 - 68,508,296 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	68,486,321 - 68,508,277 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	77,323,357 - 77,345,315 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	69,987,965 - 70,010,092 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	69,012,484 - 69,034,433 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	71,721,242 - 71,743,421 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	71,721,250 - 71,743,421 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	74,805,354 - 74,827,533 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	70,304,917 - 70,328,010 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	67,918,463 - 67,940,284 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Disease Progression (ISO)

genetic disease (ISO)

lung non-small cell carcinoma (ISO)

Riddle syndrome (ISO,ISS)

squamous cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

clobetasol (ISO)

coumarin (ISO)

cycloheximide (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylmercury chloride (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nitrofen (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

topotecan (EXP)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cellular response to UV (ISO)

chromatin organization (IEA)

DNA damage response (IEA,ISO,ISS)

DNA metabolic process (IEA)

DNA repair (IEA)

DNA repair-dependent chromatin remodeling (ISO,ISS)

double-strand break repair (IBA,IEA,ISO,ISS)

double-strand break repair via classical nonhomologous end joining (ISO)

double-strand break repair via nonhomologous end joining (ISO)

epigenetic regulation of gene expression (ISO)

isotype switching (ISO,ISS)

negative regulation of transcription elongation by RNA polymerase II (ISO,ISS)

positive regulation of DNA repair (IEA,ISO,ISS)

protein K63-linked ubiquitination (ISO,ISS)

protein ubiquitination (IEA,ISO,ISS)

regulation of protein localization (ISO)

response to ionizing radiation (IEA,ISO,ISS)

response to radiation (IEA)

ubiquitin-dependent protein catabolic process (ISO,ISS)

Cellular Component

catalytic complex (IEA)

DNA repair complex (ISO)

nuclear body (ISO)

nucleoplasm (ISO)

nucleus (IBA,IEA,ISO,ISS)

protein-containing complex (ISO)

site of double-strand break (IBA,ISO,ISS)

ubiquitin ligase complex (IEA,ISO,ISS)

Molecular Function

chromatin binding (IEA,ISO,ISS)

histone binding (IEA,ISO,ISS)

histone H2AK15 ubiquitin ligase activity (ISO)

histone ubiquitin ligase activity (ISO)

K63-linked polyubiquitin modification-dependent protein binding (ISO,ISS)

metal ion binding (IEA)

nucleosome binding (IBA,ISO)

protein binding (ISO)

transferase activity (IEA)

ubiquitin binding (IEA,ISO,ISS)

ubiquitin protein ligase activity (IEA)

ubiquitin-protein transferase activity (IBA,IEA,ISO,ISS)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ataxia telangiectasia-mutated (ATM) signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ATM protein kinase: the linchpin of cellular defenses to stress.	Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	Double-strand break repair: 53BP1 comes into focus.	Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:19203578	PMID:19203579	PMID:19500350	PMID:20080757	PMID:20550933	PMID:21041483	PMID:22266820	PMID:22373579	PMID:22508508	PMID:22742833	PMID:22980979
PMID:23760478	PMID:24217620

Genomics

Comparative Map Data

Rnf168
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	81,991,352 - 82,013,306 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	81,991,360 - 82,013,306 (-)	Ensembl				GRCr8
mRatBN7.2	11	68,486,313 - 68,508,296 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	68,486,321 - 68,508,277 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	77,323,357 - 77,345,315 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	69,987,965 - 70,010,092 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	69,012,484 - 69,034,433 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	71,721,242 - 71,743,421 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	71,721,250 - 71,743,421 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	74,805,354 - 74,827,533 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	70,304,917 - 70,328,010 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	67,918,463 - 67,940,284 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

RNF168
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	196,468,783 - 196,503,768 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	196,468,783 - 196,503,768 (-)	Ensembl			hg38	GRCh38
GRCh37	3	196,195,654 - 196,230,639 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	197,683,025 - 197,714,979 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	197,686,938 - 197,718,892	NCBI
Celera	3	194,777,591 - 194,812,751 (-)	NCBI		Celera
Cytogenetic Map	3	q29	NCBI
HuRef	3	193,493,420 - 193,527,598 (-)	NCBI		HuRef
CHM1_1	3	196,167,064 - 196,202,063 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	199,187,976 - 199,222,947 (-)	NCBI		T2T-CHM13v2.0

Rnf168
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	32,096,279 - 32,120,260 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	32,096,277 - 32,120,252 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	32,277,461 - 32,301,442 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	32,277,459 - 32,301,434 (+)	Ensembl			mm10	GRCm38
MGSCv37	16	32,277,547 - 32,301,528 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	32,197,236 - 32,220,653 (+)	NCBI		MGSCv36	mm8
Celera	16	32,762,446 - 32,786,422 (+)	NCBI		Celera
Cytogenetic Map	16	B2	NCBI
cM Map	16	22.51	NCBI

Rnf168
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	12,657,272 - 12,676,426 (-)	Ensembl
ChiLan1.0	NW_004955420	12,656,815 - 12,676,836 (-)	NCBI	ChiLan1.0	ChiLan1.0

RNF168
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	194,336,681 - 194,375,254 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	194,341,443 - 194,379,313 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	193,814,785 - 193,848,620 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	203,755,988 - 203,791,324 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	203,756,589 - 203,790,687 (-)	Ensembl			panPan2	panpan1.1

RNF168
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	29,542,209 - 29,575,127 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	29,539,182 - 29,628,248 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	29,566,807 - 29,599,487 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	29,784,005 - 29,817,553 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	29,783,909 - 29,817,527 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	29,563,108 - 29,596,234 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	29,618,089 - 29,651,643 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	30,240,484 - 30,273,553 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rnf168
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	124,790,716 - 124,813,795 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936784	1,073,236 - 1,094,575 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNF168
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	13	133,625,534 - 133,659,253 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RNF168
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	90,702,740 - 90,735,279 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	90,702,765 - 90,737,687 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	64,501,700 - 64,536,650 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rnf168
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	61,591,943 - 61,627,170 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	61,592,967 - 61,627,585 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rnf168
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	17,096,744 - 17,115,927 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rnf168
113 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	311
Count of miRNA genes:	190
Interacting mature miRNAs:	232
Transcripts:	ENSRNOT00000002395
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	22524746	82951192	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	46443168	91443168	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	73308487	96070872	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	58928336	99753367	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	32943067	89836615	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	79618519	99753367	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	73850894	99753367	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	54415391	96071021	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	58931822	92356038	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	57754837	96071021	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	67962184	99753367	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	68599321	96497754	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	69855943	99753367	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	73308315	99753367	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	51071021	96071021	Rat

Markers in Region

RH139965

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	68,487,369 - 68,487,579 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	71,722,299 - 71,722,508	NCBI	Rnor6.0
Rnor_5.0	11	74,806,411 - 74,806,620	UniSTS	Rnor5.0
RGSC_v3.4	11	70,305,421 - 70,305,630	UniSTS	RGSC3.4
Celera	11	67,919,520 - 67,919,729	UniSTS
RH 3.4 Map	11	392.9	UniSTS
Cytogenetic Map	11	q22	UniSTS

RH136967

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	68,486,899 - 68,487,084 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	71,721,829 - 71,722,013	NCBI	Rnor6.0
Rnor_5.0	11	74,805,941 - 74,806,125	UniSTS	Rnor5.0
RGSC_v3.4	11	70,304,951 - 70,305,135	UniSTS	RGSC3.4
Celera	11	67,919,050 - 67,919,234	UniSTS
RH 3.4 Map	11	403.0	UniSTS
Cytogenetic Map	11	q22	UniSTS

AU048786

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	68,490,453 - 68,490,702 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	71,725,608 - 71,725,856	NCBI	Rnor6.0
Rnor_5.0	11	74,809,720 - 74,809,968	UniSTS	Rnor5.0
RGSC_v3.4	11	70,308,505 - 70,308,753	UniSTS	RGSC3.4
Cytogenetic Map	11	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166869	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002395 ⟹ ENSRNOP00000002395

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	81,991,360 - 82,013,306 (-)	Ensembl
mRatBN7.2 Ensembl	11	68,486,321 - 68,508,277 (-)	Ensembl
Rnor_6.0 Ensembl	11	71,721,250 - 71,743,421 (-)	Ensembl

RefSeq Acc Id:

NM_001127597 ⟹ NP_001121069

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	81,991,352 - 82,013,306 (-)	NCBI
mRatBN7.2	11	68,486,313 - 68,508,277 (-)	NCBI
Rnor_6.0	11	71,721,242 - 71,743,421 (-)	NCBI
Rnor_5.0	11	74,805,354 - 74,827,533 (-)	NCBI
RGSC_v3.4	11	70,304,917 - 70,328,010 (-)	RGD
Celera	11	67,918,463 - 67,940,284 (-)	NCBI

Sequence:

show sequence

AGGCCACATTAGCATATGAAGATGGCTGCACCTAAAAACTCCATCCCTTCCTTAGCGGAATGTC
AGTGCGGGATCTGCATGGAAATCCTCGTAGAGCCTGTTACCCTACCTTGCAACCACACGCTCTG
TAACCCATGCTTCCAATCGACTGTTGAAAAGGCCAATTTATGCTGTCCCTTCTGTCGCCGCCGG
GTCTCTTCGTGGACTCGGTACCATACCCGAAGAAATTCTCTGGTCAATACAGACCTGTGGGAGA
TTATTCAAAAGCACTATGCAAAGGAATGCAAGCTTAGAATCTCTGGACAAGAATCAAAGGAAAT
CGTTGATGAGTACCAGCCAGTTCGTCTACTCAGTAAACCTGGGGAGTTGAGGCGAGAATATGAA
GAGGAGATAAGCAAGGTGGAGGCTGAGCGACAAGCCAGCAAGGAAGAGGAAAACAAAGCCAGTG
AGGAGTACATACAGAGACTGCTGGCCGAGGAGGAGGAGGAGGAGAAAAGGCGGACGGAGAGAAG
ACGAAGTGAGATGGAGGAGCAGCTGAGGGGCGATGAGGAGCTGGCGAGGAGGCTGAGCACCAGC
ATCAACAGTAACTACGAGAGAAATATCTTGGCATCTCCTTTGAGTTCCAGAAAATCAGATCCCG
TCACAAACAAGTCACAGAAGAAAAATACGAACAAACAAAAAAACTTTGGAGATATTCAAAGATA
CTTGTCACCTAAGTCAAAGCCTGGGACAGCATGGGCATGTAAAACTGAGCATGGAGAAGACATG
TGCAAGTCTAAGGAAACAGACAGTAGTGACACGAAGAGCCCTGTGTTGCAAGACACAGACGTTG
AAGAAAGCATGCCAACACATTCTCCTCAGACCTGCCCAGAAACTCAAGGGCAAGGTCCGGAGCC
TTTGACAGAGATGCCTGTGCCATGGCTATGTGCAAGGAATGCTGAACAGTGCCTTGAGGGAAAA
GCTGAAGCAGTGTCAACCAATCCTGATGATTCATGTATTGTAAATGATGGTGGACCTAGAGCCA
TAGTTTCTAACTCTAAGGAAGCTGCAGTTAAGCCTCCTACCAAGATAGAAAACGAAGAGTATTC
TGTGTCAGGTGTGACCCAGTTAACTGGGGGCAACGGAGTTCCAACAGAGAGCAGAGTGTACGAC
TTACTAGTCGGAAAAGAGATTTCCGAAAGAGAAAACCAGGAATCTGTGTTTGAAGAAGTCATGG
ATCCATGCTTTTCTGCAAAAAGAAGGAAAATATTCATCACATCCTCCTTAGATCAAGAAGAAAC
AGAAGTGAATTTTACACAAAAACTGATAGATTTGGAACATATGCTTTTCGAGAGACATAAGCAA
GAAGAACAGGACAGGTTGTTAGCATTACAACTTCAAAAAGAGGCAGATAAAGAAAAAATGGTGC
CAAACCGGCAGAAAGGATCCCCAGATCAGTACCAGCTGCGCACATCTTCACCCCCAGACGGGTT
GCTGAATGGACAGAGGAAGAATGTCAAAGATAGGAACTCCCCAAAGCAAACTGCAGATCGTTCA
AAATCTCAGAGGAGCAGGAAAGGTGAATACTGGGAGACCTTCGAAAGCACTTGGAAGGGTTCAG
TTAATGGAACGAAGATGCCAACTCCTAGGAAAGATAGTTGTAATGTATCTAAACGTGCCTGTCC
CCTACAGCACAGAAGTGCACAGAAAAGCATTCTTCAAATGTTTCAGAGGTAACCAAGCAAAGCA
CCGGGAGAGAGTTCTATAGTCCAGTAAAGCTATATTATAGCAAAGCTAGCTCTTCTCCCCTAAA
ATCCTGAGATGTGTCATTAGTTTCTGCTCAGCAAACACACTTCTTCTCTTTAAGCTGTGATTAC
AAAGGAAGAACTTACGAATGTGTTTCTGCAAAAGTCAGTGATGAGGAAATGTCCTTGAGAATTG
TTTCCCTTGTTAGCAGCTGCTGTGTTCTAAGTGTGACACCTTTACAGGTGTAAAACTCCTCGGT
CAGGACATCTTCAGGGCCACTCCCTTTTCCAAACTTTTTTTTATTTTTAATGAATGGGTAAGGA
GTCCACACAGGGATCTTCCGTAACACCAGTAAGTCCCCATCCCAGTTTTAACTCTAAGCATTTT
AGCATTTCCTTTGGTGGAAAGTGGGTTGGTGTCAACAGCAGCTAGTTACAAAGCTGCTAGATTG
TTAATGCAAGGGCTTTACGGTGGGCTGGGCTGAGTGCTGGAATGGGAGTGAGGGGAATCCCTGA
ACTGAATGGGTGATCAAAAACCGGGTCCAGCATGGGCACCAGATTTCCTGTGGCAGAACATTCT
CCTTAGTTCCTTTGTTAAATGACAGAAAATATTTGGAGTTTACAGCTTTTCACGCCATGGCATC
TTGGTGTGAAAGGGCAAATTGGTATAGTTTTACTTATCTCTTCTAGAAAAGAAATAAATTATTG
AAGGAAAATTATACTGTGCTCTGCTAGCATTATACTGAACACCCGGCATTACCGTCTTTATTGC
GTACTGGCTCAGACTCATGCCTGTTTGTGCACACAGGGACGTGGTGTGTGGGACTTGTCATGGA
TTGTCCTGGGTATGTGGGGCTTGACTTGGATTGTCCTGGGGTCCAGACTGAAGTCACCTCGTGA
AGCTGAGCCTCTGCTATTCACCTTCTGTTAAAACAGCTCAGCAGGCTGTAGTCTCAGTAGGATT
TCTCTGGTGTCTTGGCTCCACTTATGTCCTGCAAACATAATAAACCGTCCTAATGCACTGTTTG
CCTTTATCCACACTTTGGTCATTTGAATTTCTTCTTACAAGTTTTGAGACTTTTTTTTTTTTTA
TGTTTATCTTGGCAGAATTTTTCTCTAAAATCAATTTAACTTGATGCTTTAAGGAGACAGTGTT
GGAACTTCAAATTAGAAATTATCACATTGAGTCTTCGTGGAATAGTTCATGACCAAAAAGGGAA
TAAGAAAAACATTCTAGTATGATATAGTGGGAATTTATATATTCACCACTAGTTTGTCCATGGG
GAGTCATCCTGATTGAAGTTGTTTTCAGGTTTTTCGTTTCTCTGTTAGCCTTTCTGTTATTCTT
ATTGTTGGTGCCTTTGTGTTAGAAAACATTAGATTTTTTAAAATTGGTCATTAGTGAACTGCTT
TTTCCTCATTTTTGTTGGAAAATATTTAATATCTCAGTATTAAAGCTGTGCAGCTTTGAAAAAA
TAAAAGACGCCTAACATGGTGGCACGGCCTAATTAATCCCAGTACTTCAGAGACAGGGAGATCT
CTGTGAGTTCTTTTTAAAAAAAAAATTAAAAGAATGGTTAATAAAAA

hide sequence

RefSeq Acc Id:

XM_039088630 ⟹ XP_038944558

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	81,991,352 - 82,006,005 (-)	NCBI
mRatBN7.2	11	68,486,313 - 68,500,964 (-)	NCBI

RefSeq Acc Id:

XM_039088631 ⟹ XP_038944559

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	81,991,352 - 82,013,291 (-)	NCBI
mRatBN7.2	11	68,488,393 - 68,508,296 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001121069	(Get FASTA)	NCBI Sequence Viewer
	XP_038944558	(Get FASTA)	NCBI Sequence Viewer
	XP_038944559	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66869	(Get FASTA)	NCBI Sequence Viewer
	B2RYR0	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002395

RefSeq Acc Id:

NP_001121069 ⟸ NM_001127597

- UniProtKB:

B2RYR0 (UniProtKB/Swiss-Prot), A0A140TA93 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKMAAPKNSIPSLAECQCGICMEILVEPVTLPCNHTLCNPCFQSTVEKANLCCPFCRRRVSSWT
RYHTRRNSLVNTDLWEIIQKHYAKECKLRISGQESKEIVDEYQPVRLLSKPGELRREYEEEISK
VEAERQASKEEENKASEEYIQRLLAEEEEEEKRRTERRRSEMEEQLRGDEELARRLSTSINSNY
ERNILASPLSSRKSDPVTNKSQKKNTNKQKNFGDIQRYLSPKSKPGTAWACKTEHGEDMCKSKE
TDSSDTKSPVLQDTDVEESMPTHSPQTCPETQGQGPEPLTEMPVPWLCARNAEQCLEGKAEAVS
TNPDDSCIVNDGGPRAIVSNSKEAAVKPPTKIENEEYSVSGVTQLTGGNGVPTESRVYDLLVGK
EISERENQESVFEEVMDPCFSAKRRKIFITSSLDQEETEVNFTQKLIDLEHMLFERHKQEEQDR
LLALQLQKEADKEKMVPNRQKGSPDQYQLRTSSPPDGLLNGQRKNVKDRNSPKQTADRSKSQRS
RKGEYWETFESTWKGSVNGTKMPTPRKDSCNVSKRACPLQHRSAQKSILQMFQR

hide sequence

Ensembl Acc Id:

ENSRNOP00000002395 ⟸ ENSRNOT00000002395

RefSeq Acc Id:	XP_038944558 ⟸ XM_039088630
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038944559 ⟸ XM_039088631
- Peptide Label:	isoform X2

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2RYR0-F1-model_v2	AlphaFold	B2RYR0	1-564	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1585168	AgrOrtholog
BioCyc Gene	G2FUF-21090	BioCyc
Ensembl Genes	ENSRNOG00000043345	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000002395	ENTREZGENE
Gene3D-CATH	3.30.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:9030307	IMAGE-MGC_LOAD
InterPro	RNF168	UniProtKB/Swiss-Prot
	RNF168/RNF169_E3_ubiq-ligase	UniProtKB/Swiss-Prot
	Znf_C3HC4_RING-type	UniProtKB/Swiss-Prot
	Znf_RING	UniProtKB/Swiss-Prot
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot
KEGG Report	rno:690043	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:188789	IMAGE-MGC_LOAD
NCBI Gene	690043	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE RNF168	UniProtKB/Swiss-Prot
	UNCHARACTERIZED	UniProtKB/Swiss-Prot
Pfam	zf-C3HC4	UniProtKB/Swiss-Prot
PhenoGen	Rnf168	PhenoGen
PROSITE	ZF_RING_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000043345	RatGTEx
SMART	RING	UniProtKB/Swiss-Prot
Superfamily-SCOP	RING/U-box	UniProtKB/Swiss-Prot
UniProt	A0A140TA93	ENTREZGENE, UniProtKB/TrEMBL
	B2RYR0	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Rnf168	ring finger protein 168	Rnf168	ring finger protein 168, E3 ubiquitin protein ligase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-15	Rnf168	ring finger protein 168, E3 ubiquitin protein ligase	Rnf168	ring finger protein 168	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-22	Rnf168	ring finger protein 168	LOC690043	similar to ring finger protein 168	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC690043	similar to ring finger protein 168			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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