Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Septin6 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SEPTIN6 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SEPTIN6 mRNA | CTD | PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SEPTIN6 mRNA | CTD | PMID:32741896 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Septin6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SEPTIN6 mRNA | CTD | PMID:19465110 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Septin6 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SEPTIN6 mRNA | CTD | PMID:20188158 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of SEPTIN6 mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SEPTIN6 mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased oxidation of SEPT6 mRNA | CTD | PMID:32845096 | aflatoxin B1 | increases methylation | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SEPTIN6 gene | CTD | PMID:27153756 | aflatoxin B1 | decreases expression | ISO | Septin6 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of SEPTIN6 mRNA | CTD | PMID:19770486 | Aflatoxin B2 alpha | increases methylation | ISO | SEPTIN6 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of SEPTIN6 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SEPTIN6 mRNA | CTD | PMID:33167477 | antirheumatic drug | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of SEPTIN6 mRNA | CTD | PMID:24449571 | arsenous acid | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of SEPTIN6 mRNA | CTD | PMID:17258074 | belinostat | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | belinostat results in increased expression of SEPTIN6 mRNA | CTD | PMID:26272509 | belinostat | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEPTIN6 mRNA | CTD | PMID:27188386 | benzo[a]pyrene | increases expression | ISO | Septin6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SEPTIN6 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SEPTIN6 5' UTR more ... | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | Septin6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SEPTIN6 mRNA | CTD | PMID:21569818 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SEPTIN6 gene | CTD | PMID:28505145 | bisphenol A | increases expression | ISO | Septin6 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SEPTIN6 mRNA | CTD | PMID:26063408 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SEPTIN6 mRNA | CTD | PMID:25181051 | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of SEPTIN6 protein | CTD | PMID:28903499 | buta-1,3-diene | decreases expression | ISO | Septin6 (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of SEPTIN6 mRNA | CTD | PMID:29038090 | cadmium atom | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Cadmium results in decreased expression of SEPTIN6 mRNA | CTD | PMID:24376830 | carbon nanotube | decreases expression | ISO | Septin6 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chloroprene | decreases expression | ISO | Septin6 (Mus musculus) | 6480464 | Chloroprene results in decreased expression of SEPTIN6 mRNA | CTD | PMID:23125180 | copper atom | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SEPTIN6 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SEPTIN6 mRNA | CTD | PMID:20971185 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of SEPTIN6 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SEPTIN6 mRNA | CTD | PMID:20106945 more ... | diarsenic trioxide | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of SEPTIN6 mRNA | CTD | PMID:17258074 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of SEPTIN6 mRNA | CTD | PMID:21551480 | dorsomorphin | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | affects response to substance | ISO | SEPTIN6 (Homo sapiens) | 6480464 | SEPTIN6 protein affects the susceptibility to Doxorubicin | CTD | PMID:16217747 | doxorubicin | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SEPTIN6 mRNA | CTD | PMID:29803840 | entinostat | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | entinostat results in increased expression of SEPTIN6 mRNA | CTD | PMID:26272509 and PMID:27188386 | entinostat | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEPTIN6 mRNA | CTD | PMID:27188386 | ethanol | affects expression | ISO | Septin6 (Mus musculus) | 6480464 | Ethanol affects the expression of SEPTIN6 mRNA | CTD | PMID:30319688 | ethanol | affects splicing | ISO | Septin6 (Mus musculus) | 6480464 | Ethanol affects the splicing of SEPTIN6 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of SEPTIN6 mRNA | CTD | PMID:23649840 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of SEPTIN6 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Septin6 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SEPTIN6 mRNA | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of SEPTIN6 mRNA | CTD | PMID:23649840 | FR900359 | increases phosphorylation | ISO | SEPTIN6 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of SEPTIN6 protein | CTD | PMID:37730182 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SEPTIN6 mRNA | CTD | PMID:33387578 | hydroquinone | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | hydroquinone results in decreased expression of SEPTIN6 mRNA | CTD | PMID:31256213 | ivermectin | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SEPTIN6 protein | CTD | PMID:32959892 | methyl methanesulfonate | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of SEPTIN6 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of SEPTIN6 mRNA | CTD | PMID:28001369 | nickel atom | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Nickel results in increased expression of SEPTIN6 mRNA | CTD | PMID:24768652 and PMID:25583101 | ozone | multiple interactions | ISO | Septin6 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of SEPTIN6 mRNA | CTD | PMID:34911549 | ozone | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased oxidation of SEPT6 mRNA | CTD | PMID:32845096 | p-chloromercuribenzoic acid | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of SEPTIN6 mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEPTIN6 mRNA | CTD | PMID:27188386 | panobinostat | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEPTIN6 mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Panobinostat results in increased expression of SEPTIN6 mRNA | CTD | PMID:26272509 | paracetamol | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SEPTIN6 mRNA | CTD | PMID:29067470 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SEPTIN6 mRNA | CTD | PMID:33387578 | phenylmercury acetate | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of SEPTIN6 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEPTIN6 mRNA | CTD | PMID:27188386 | pirinixic acid | increases expression | ISO | Septin6 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SEPTIN6 mRNA | CTD | PMID:20813756 | poly(I:C) | multiple interactions | EXP | | 6480464 | [Poly I-C co-treated with HU 211] results in decreased expression of SEPTIN6 mRNA | CTD | PMID:26923065 | propanal | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of SEPTIN6 mRNA | CTD | PMID:26079696 | rimonabant | multiple interactions | ISO | Septin6 (Mus musculus) | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of SEPTIN6 mRNA] | CTD | PMID:19030233 | SB 431542 | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silver atom | decreases expression | ISO | Septin6 (Mus musculus) | 6480464 | Silver results in decreased expression of SEPTIN6 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Septin6 (Mus musculus) | 6480464 | Silver results in decreased expression of SEPTIN6 mRNA | CTD | PMID:27131904 | sodium arsenate | increases expression | ISO | Septin6 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of SEPTIN6 mRNA | CTD | PMID:30953684 | sodium fluoride | increases expression | EXP | | 6480464 | Sodium Fluoride results in increased expression of SEPTIN6 protein | CTD | PMID:29653260 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of SEPTIN6 mRNA | CTD | PMID:19281266 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of SEPTIN6 mRNA | CTD | PMID:19281266 | sulforaphane | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of SEPTIN6 mRNA | CTD | PMID:26833863 and PMID:31838189 | testosterone | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Testosterone results in increased expression of SEPTIN6 mRNA | CTD | PMID:33359661 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SEPTIN6 mRNA | CTD | PMID:32741896 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SEPTIN6 mRNA | CTD | PMID:23411599 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SEPTIN6 mRNA | CTD | PMID:34492290 | trichostatin A | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of SEPTIN6 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | affects expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | trichostatin A affects the expression of SEPTIN6 mRNA | CTD | PMID:28542535 | trichostatin A | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEPTIN6 mRNA | CTD | PMID:27188386 | troglitazone | decreases expression | ISO | Septin6 (Mus musculus) | 6480464 | Troglitazone results in decreased expression of SEPTIN6 mRNA | CTD | PMID:17569031 | valproic acid | increases methylation | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SEPTIN6 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SEPTIN6 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | SEPTIN6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEPTIN6 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SEPTIN6 mRNA | CTD | PMID:23179753 more ... | vincristine | decreases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Vincristine results in decreased expression of SEPTIN6 mRNA | CTD | PMID:23649840 | vitamin E | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of SEPTIN6 mRNA | CTD | PMID:19244175 | vorinostat | increases expression | ISO | SEPTIN6 (Homo sapiens) | 6480464 | Vorinostat results in increased expression of SEPTIN6 mRNA | CTD | PMID:27188386 | |