Mycn (MYCN proto-oncogene, bHLH transcription factor) - Rat Genome Database

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Gene: Mycn (MYCN proto-oncogene, bHLH transcription factor) Rattus norvegicus
Analyze
Symbol: Mycn
Name: MYCN proto-oncogene, bHLH transcription factor
RGD ID: 1584995
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and kinase binding activity. Predicted to be involved in negative regulation of reactive oxygen species metabolic process and regulation of gene expression. Predicted to act upstream of with a positive effect on autosome genomic imprinting. Predicted to act upstream of or within several processes, including negative regulation of astrocyte differentiation; positive regulation of cell population proliferation; and skeletal system morphogenesis. Predicted to be located in nucleolus and nucleoplasm. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc); Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc); Mycn_mapped; N-myc; N-myc proto-oncogene protein; Nmuc1; Nmyc; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian); v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (mapped)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8641,446,683 - 41,452,584 (-)NCBIGRCr8
mRatBN7.2635,717,764 - 35,723,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl635,717,764 - 35,723,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx636,030,195 - 36,036,011 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0636,344,835 - 36,350,651 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0635,812,708 - 35,818,534 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0638,222,554 - 38,228,419 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl638,222,555 - 38,228,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0651,348,169 - 51,354,719 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4636,508,262 - 36,514,071 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera635,082,308 - 35,088,132 (-)NCBICelera
Cytogenetic Map6q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-pantothenic acid  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
coumarin  (ISO)
crizotinib  (ISO)
crocin-1  (ISO)
Cuprizon  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emetine  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP)
genistein  (ISO)
glyphosate  (ISO)
Heptachlor epoxide  (ISO)
hydrogen cyanide  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
LY294002  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
PCB138  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
retinyl acetate  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sonidegib  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (EXP)
Testosterone propionate  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Tryptanthrine  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vismodegib  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1719466   PMID:10597290   PMID:15331636   PMID:15716345   PMID:17327229   PMID:17357786   PMID:17360777   PMID:18640244   PMID:19796622   PMID:21047779   PMID:21796614   PMID:23022312  
PMID:23308108   PMID:24391509   PMID:27837025   PMID:30221657   PMID:38407765  


Genomics

Comparative Map Data
Mycn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8641,446,683 - 41,452,584 (-)NCBIGRCr8
mRatBN7.2635,717,764 - 35,723,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl635,717,764 - 35,723,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx636,030,195 - 36,036,011 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0636,344,835 - 36,350,651 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0635,812,708 - 35,818,534 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0638,222,554 - 38,228,419 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl638,222,555 - 38,228,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0651,348,169 - 51,354,719 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4636,508,262 - 36,514,071 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera635,082,308 - 35,088,132 (-)NCBICelera
Cytogenetic Map6q15NCBI
MYCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38215,940,550 - 15,947,004 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl215,940,550 - 15,947,007 (+)EnsemblGRCh38hg38GRCh38
GRCh37216,080,672 - 16,087,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36215,998,134 - 16,004,580 (+)NCBINCBI36Build 36hg18NCBI36
Build 34216,032,643 - 16,037,721NCBI
Celera215,998,381 - 16,004,827 (+)NCBICelera
Cytogenetic Map2p24.3NCBI
HuRef215,934,021 - 15,938,396 (+)NCBIHuRef
CHM1_1216,010,469 - 16,016,915 (+)NCBICHM1_1
T2T-CHM13v2.0215,972,182 - 15,978,635 (+)NCBIT2T-CHM13v2.0
Mycn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391212,986,094 - 12,991,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1212,986,094 - 12,991,915 (-)EnsemblGRCm39 Ensembl
GRCm381212,936,093 - 12,941,836 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1212,936,093 - 12,941,914 (-)EnsemblGRCm38mm10GRCm38
MGSCv371212,942,899 - 12,948,642 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361212,962,079 - 12,967,694 (-)NCBIMGSCv36mm8
Celera1213,282,496 - 13,288,240 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map126.14NCBI
Mycn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554879,219,528 - 9,224,818 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554879,219,528 - 9,224,818 (+)NCBIChiLan1.0ChiLan1.0
MYCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212110,580,807 - 110,585,956 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A110,584,779 - 110,591,313 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A15,925,130 - 15,931,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A16,058,298 - 16,064,547 (+)NCBIpanpan1.1PanPan1.1panPan2
MYCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11711,720,857 - 11,724,308 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1711,663,228 - 11,669,338 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01711,848,344 - 11,854,451 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1711,848,002 - 11,854,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11711,707,661 - 11,713,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01711,718,338 - 11,724,418 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01711,742,671 - 11,748,783 (+)NCBIUU_Cfam_GSD_1.0
Mycn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629256,215,359 - 56,221,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649314,618,060 - 14,624,315 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649314,618,176 - 14,624,201 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3121,543,109 - 121,549,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13121,543,201 - 121,549,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23129,821,890 - 129,827,921 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11491,685,376 - 91,692,091 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604520,532,406 - 20,539,075 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mycn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624865780,163 - 785,776 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mycn
14 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir34arno-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI19167416

Predicted Target Of
Summary Value
Count of predictions:334
Count of miRNA genes:211
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000008643
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63432335751121479Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat

Markers in Region
MYCN  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2635,717,807 - 35,718,531 (+)MAPPERmRatBN7.2
Rnor_6.0638,222,599 - 38,223,322NCBIRnor6.0
Rnor_5.0651,348,214 - 51,348,937UniSTSRnor5.0
RGSC_v3.4636,508,306 - 36,509,029UniSTSRGSC3.4
Celera635,082,352 - 35,083,075UniSTS
Cytogenetic Map6q14UniSTS
MYCN  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2635,723,137 - 35,723,584 (+)MAPPERmRatBN7.2
Rnor_6.0638,227,928 - 38,228,373NCBIRnor6.0
Rnor_5.0651,353,543 - 51,353,988UniSTSRnor5.0
RGSC_v3.4636,513,620 - 36,514,065UniSTSRGSC3.4
Celera635,087,681 - 35,088,126UniSTS
Cytogenetic Map6q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 80 79 48 25 48 6 207 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000084924   ⟹   ENSRNOP00000068733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl635,717,764 - 35,723,590 (-)Ensembl
Rnor_6.0 Ensembl638,222,555 - 38,228,379 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117993   ⟹   ENSRNOP00000094796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl635,718,681 - 35,723,590 (-)Ensembl
RefSeq Acc Id: NM_001013096   ⟹   NP_001013114
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8641,446,684 - 41,452,508 (-)NCBI
mRatBN7.2635,717,764 - 35,723,590 (-)NCBI
Rnor_6.0638,222,555 - 38,228,379 (-)NCBI
Rnor_5.0651,348,169 - 51,354,719 (-)NCBI
RGSC_v3.4636,508,262 - 36,514,071 (-)RGD
Celera635,082,308 - 35,088,132 (-)RGD
Sequence:
RefSeq Acc Id: XM_063261653   ⟹   XP_063117723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8641,446,683 - 41,452,584 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001013114 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117723 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA44920 (Get FASTA)   NCBI Sequence Viewer  
  EDM03113 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068733.1
  ENSRNOP00000094796.1
GenBank Protein Q63379 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013114   ⟸   NM_001013096
- UniProtKB: G3V6T6 (UniProtKB/TrEMBL),   A6HAQ8 (UniProtKB/TrEMBL),   A0A8I6AMA1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068733   ⟸   ENSRNOT00000084924
Ensembl Acc Id: ENSRNOP00000094796   ⟸   ENSRNOT00000117993
RefSeq Acc Id: XP_063117723   ⟸   XM_063261653
- Peptide Label: isoform X1
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63379-F1-model_v2 AlphaFold Q63379 1-462 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694498
Promoter ID:EPDNEW_R5023
Type:single initiation site
Name:Mycn_1
Description:MYCN proto-oncogene, bHLH transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0638,228,376 - 38,228,436EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584995 AgrOrtholog
BioCyc Gene G2FUF-38126 BioCyc
Ensembl Genes ENSRNOG00000051372 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084924.2 UniProtKB/TrEMBL
  ENSRNOT00000117993.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myc_transcription_factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tscrpt_reg_Myc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tscrpt_reg_Myc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:298894 UniProtKB/Swiss-Prot
NCBI Gene 298894 ENTREZGENE
PANTHER MYC PROTO-ONCOGENE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  N-MYC PROTO-ONCOGENE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mycn PhenoGen
PIRSF Myc_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LEUZIPPRMYC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051372 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AMA1 ENTREZGENE, UniProtKB/TrEMBL
  A6HAQ8 ENTREZGENE, UniProtKB/TrEMBL
  G3V6T6 ENTREZGENE, UniProtKB/TrEMBL
  MYCN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Mycn  MYCN proto-oncogene, bHLH transcription factor  Mycn  v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Mycn  v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog  Mycn  v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)  Mycn  v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (mapped)  Name updated 737654 APPROVED
2007-04-11 Mycn  v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (mapped)  Mycn_mapped  v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (mapped)  Data merged from RGD:3132 737654 APPROVED
2006-11-19 Mycn  v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Mycn_mapped  v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (mapped)  Mycn  v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)  Symbol and Name updated 1556543 APPROVED
2002-11-06 Mycn  v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)    Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc)  Name updated 625702 APPROVED
2002-06-10 Mycn  Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology mouse neuroblastoma myc-related oncogene 1 (Nmyc1) possesses transcription factor activity that plays a role in cell cycle regulation 704405