Bmyc (brain expressed myelocytomatosis oncogene) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bmyc (brain expressed myelocytomatosis oncogene) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Bmyc
Name: brain expressed myelocytomatosis oncogene
RGD ID: 1584970
Description: Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus and spindle; INTERACTS WITH 4,4'-sulfonyldiphenol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: avian myelocytomatosis viral (v-myc) related oncogene; B-myc; Bmyc protein (AA 1-178); Bmyc_mapped; brain expressed myelocytomatosis oncogene (mapped); Mycb; transforming protein B-Myc
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,910,689 - 28,911,448 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,910,220 - 28,912,171 (+)EnsemblGRCr8
mRatBN7.238,512,569 - 8,513,328 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,512,325 - 8,513,623 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,618,220 - 11,618,979 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,204,454 - 20,205,213 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,394,296 - 18,395,055 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,916,662 - 2,917,421 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,916,662 - 2,917,421 (+)Ensemblrn6Rnor6.0
Rnor_5.032,898,075 - 2,898,834 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,864,740 - 3,865,499 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,337,166 - 3,337,926 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Structure and expression of B-myc, a new member of the myc gene family. Ingvarsson S, etal., Mol Cell Biol 1988 Aug;8(8):3168-74.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2687773   PMID:7478514   PMID:8423780  


Genomics

Variants

.
Variants in Bmyc
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:62
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000064358
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH129186  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,513,312 - 8,513,493 (+)MAPPERmRatBN7.2
Rnor_6.032,917,406 - 2,917,586NCBIRnor6.0
Rnor_5.032,898,819 - 2,898,999UniSTSRnor5.0
RGSC_v3.433,865,484 - 3,865,664UniSTSRGSC3.4
Celera33,337,911 - 3,338,091UniSTS
Cytogenetic Map3p13UniSTS
AW060705  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,513,034 - 8,513,133 (+)MAPPERmRatBN7.2
Rnor_6.032,917,128 - 2,917,226NCBIRnor6.0
Rnor_5.032,898,541 - 2,898,639UniSTSRnor5.0
RGSC_v3.433,865,206 - 3,865,304UniSTSRGSC3.4
Celera33,337,633 - 3,337,731UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 54 59 6 318 154 10 136 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064358   ⟹   ENSRNOP00000059721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,910,220 - 28,912,171 (+)Ensembl
mRatBN7.2 Ensembl38,512,325 - 8,513,623 (+)Ensembl
Rnor_6.0 Ensembl32,916,662 - 2,917,421 (+)Ensembl
RefSeq Acc Id: NM_001013163   ⟹   NP_001013181
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,910,689 - 28,911,448 (+)NCBI
mRatBN7.238,512,569 - 8,513,328 (+)NCBI
Rnor_6.032,916,662 - 2,917,421 (+)NCBI
Rnor_5.032,898,075 - 2,898,834 (+)NCBI
RGSC_v3.433,864,740 - 3,865,499 (+)RGD
Celera33,337,166 - 3,337,926 (+)RGD
Sequence:
RefSeq Acc Id: NP_001013181   ⟸   NM_001013163
- UniProtKB: Q3HVJ5 (UniProtKB/Swiss-Prot),   P15063 (UniProtKB/Swiss-Prot),   A6JTA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059721   ⟸   ENSRNOT00000064358
Protein Domains
Transcription regulator Myc N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15063-F1-model_v2 AlphaFold P15063 1-168 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584970 AgrOrtholog
BioCyc Gene G2FUF-50425 BioCyc
Ensembl Genes ENSRNOG00000042556 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000064358 ENTREZGENE
  ENSRNOT00000064358.2 UniProtKB/Swiss-Prot
InterPro Myc_transcription_factors UniProtKB/Swiss-Prot
  Tscrpt_reg_Myc UniProtKB/Swiss-Prot
  Tscrpt_reg_Myc_N UniProtKB/Swiss-Prot
KEGG Report rno:311807 UniProtKB/Swiss-Prot
NCBI Gene 311807 ENTREZGENE
PANTHER MYC PROTO-ONCOGENE UniProtKB/Swiss-Prot
Pfam Myc_N UniProtKB/Swiss-Prot
PhenoGen Bmyc PhenoGen
PRINTS LEUZIPPRMYC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000042556 RatGTEx
UniProt A6JTA3 ENTREZGENE, UniProtKB/TrEMBL
  MYCB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3HVJ5 ENTREZGENE
UniProt Secondary Q3HVJ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   brain expressed myelocytomatosis oncogene  Bmyc  brain expressed myelocytomatosis oncogene (mapped)  Name updated 737654 APPROVED
2007-04-10 Bmyc  brain expressed myelocytomatosis oncogene (mapped)  Bmyc_mapped  brain expressed myelocytomatosis oncogene (mapped)  Data merged from RGD:2215 737654 APPROVED
2006-11-19 Bmyc  brain expressed myelocytomatosis oncogene (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Bmyc_mapped  brain expressed myelocytomatosis oncogene (mapped)  Bmyc  brain expressed myelocytomatosis oncogene  Symbol and Name updated 1556543 APPROVED
2004-09-10 Bmyc  brain expressed myelocytomatosis oncogene    avian myelocytomatosis viral (v-myc) related oncogene  Name updated 1299863 APPROVED
2002-06-10 Bmyc  Avian myelocytomatosis viral (v-myc) related oncogene (Bmyc)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in several organs and tissues, with highest expression in the brain 1300398