Adam12 (ADAM metallopeptidase domain 12) - Rat Genome Database

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Gene: Adam12 (ADAM metallopeptidase domain 12) Rattus norvegicus
Analyze
Symbol: Adam12
Name: ADAM metallopeptidase domain 12
RGD ID: 1583652
Description: Predicted to enable SH3 domain binding activity and metalloendopeptidase activity. Predicted to be involved in positive regulation of angiogenesis and proteolysis. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human ADAM12 (ADAM metallopeptidase domain 12); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; Notch signaling pathway; syndecan signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 12; a disintegrin and metallopeptidase domain 12 (meltrin alpha); disintegrin and metalloproteinase domain-containing protein 12; LOC309072; LOC679837; meltrin alpha; similar to ADAM 12 precursor (A disintegrin and metalloproteinase domain 12) (Meltrin alpha)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,116,968 - 198,443,680 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1198,116,975 - 198,447,552 (-)EnsemblGRCr8
mRatBN7.21188,686,984 - 189,014,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1188,686,989 - 189,020,667 (-)EnsemblmRatBN7.2
Rnor_6.01205,951,840 - 206,286,294 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1205,956,342 - 206,282,575 (-)Ensemblrn6Rnor6.0
Rnor_5.01212,899,587 - 213,227,846 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41193,384,457 - 193,650,892 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1186,424,760 - 186,758,584 (-)NCBICelera
RGSC_v3.11193,533,921 - 193,999,142 (-)NCBI
Cytogenetic Map1q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
cortisol  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ADAMs: key components in EGFR signalling and development. Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. Canonical transforming growth factor-ß signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Ramdas V, etal., Am J Pathol. 2013 Dec;183(6):1885-1896. doi: 10.1016/j.ajpath.2013.08.027. Epub 2013 Oct 6.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Valdes AM, etal., Arthritis Rheum. 2004 Aug;50(8):2497-507.
Additional References at PubMed
PMID:12477932   PMID:15280379   PMID:15574885   PMID:15632090   PMID:15910695   PMID:19398663   PMID:19581512   PMID:24006456   PMID:28637396  


Genomics

Comparative Map Data
Adam12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,116,968 - 198,443,680 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1198,116,975 - 198,447,552 (-)EnsemblGRCr8
mRatBN7.21188,686,984 - 189,014,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1188,686,989 - 189,020,667 (-)EnsemblmRatBN7.2
Rnor_6.01205,951,840 - 206,286,294 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1205,956,342 - 206,282,575 (-)Ensemblrn6Rnor6.0
Rnor_5.01212,899,587 - 213,227,846 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41193,384,457 - 193,650,892 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1186,424,760 - 186,758,584 (-)NCBICelera
RGSC_v3.11193,533,921 - 193,999,142 (-)NCBI
Cytogenetic Map1q41NCBI
ADAM12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810126,012,391 - 126,388,477 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10126,012,381 - 126,388,477 (-)Ensemblhg38GRCh38
GRCh3710127,700,960 - 128,077,046 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610127,693,415 - 128,067,055 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410127,719,903 - 128,067,014NCBI
Celera10121,478,343 - 121,851,743 (-)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10121,392,073 - 121,764,737 (-)NCBIHuRef
CHM1_110127,984,707 - 128,358,883 (-)NCBICHM1_1
T2T-CHM13v2.010126,894,888 - 127,270,982 (-)NCBIT2T-CHM13v2.0
Adam12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397133,484,928 - 133,826,859 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7133,484,928 - 133,833,875 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387133,883,199 - 134,225,097 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7133,883,199 - 134,232,146 (-)Ensemblmm10GRCm38
MGSCv377141,074,882 - 141,416,780 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367133,722,315 - 134,063,440 (-)NCBIMGSCv36mm8
Celera7133,687,776 - 134,032,137 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map777.61NCBI
Adam12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554773,922,644 - 4,263,296 (-)Ensembl
ChiLan1.0NW_0049554773,917,637 - 4,263,529 (-)NCBIChiLan1.0ChiLan1.0
ADAM12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28137,873,308 - 138,248,641 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110137,878,657 - 138,253,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010122,583,989 - 122,958,895 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110126,847,555 - 127,165,887 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10126,852,441 - 127,165,048 (-)EnsemblpanPan2panpan1.1
ADAM12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12835,154,899 - 35,484,852 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2835,158,126 - 35,485,573 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2835,213,245 - 35,542,024 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02835,712,857 - 36,042,749 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2835,717,643 - 36,042,829 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12835,266,353 - 35,595,299 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02835,256,524 - 35,591,575 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02835,517,721 - 35,847,105 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adam12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721311,501,260 - 11,602,871 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648613,963,091 - 14,279,796 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648613,963,000 - 14,189,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14135,302,813 - 135,682,159 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114135,302,188 - 135,682,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214146,932,579 - 147,045,417 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19118,641,551 - 119,014,280 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9118,646,539 - 118,749,351 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604880,005,529 - 80,378,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473720,650,427 - 21,065,944 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473720,650,365 - 21,107,171 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Adam12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1267,801,189 - 67,991,232 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adam12
2189 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:86
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000024974
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
D1Rat365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21188,869,238 - 188,869,404 (+)MAPPERmRatBN7.2
Rnor_6.01206,133,967 - 206,134,132NCBIRnor6.0
Rnor_5.01213,081,714 - 213,081,879UniSTSRnor5.0
RGSC_v3.41193,562,635 - 193,562,800UniSTSRGSC3.4
Celera1186,607,194 - 186,607,359UniSTS
SHRSP x BN Map197.0799RGD
SHRSP x BN Map197.0799UniSTS
Cytogenetic Map1q41UniSTS
D1Got337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21188,849,265 - 188,849,381 (+)MAPPERmRatBN7.2
Rnor_6.01206,113,996 - 206,114,109NCBIRnor6.0
Rnor_5.01213,061,743 - 213,061,856UniSTSRnor5.0
RGSC_v3.41193,542,664 - 193,542,777UniSTSRGSC3.4
Celera1186,587,293 - 186,587,406UniSTS
Cytogenetic Map1q41UniSTS
AU049711  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21188,801,082 - 188,801,248 (+)MAPPERmRatBN7.2
Rnor_6.01206,065,817 - 206,065,982NCBIRnor6.0
Rnor_5.01213,013,564 - 213,013,729UniSTSRnor5.0
RGSC_v3.41193,494,488 - 193,494,653UniSTSRGSC3.4
Celera1186,538,826 - 186,538,985UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 158 89 88 57 87 57 6 344 185 11 137 78 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000024974   ⟹   ENSRNOP00000024974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1198,116,975 - 198,447,552 (-)Ensembl
mRatBN7.2 Ensembl1188,686,989 - 189,020,667 (-)Ensembl
Rnor_6.0 Ensembl1205,956,342 - 206,282,575 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105185   ⟹   ENSRNOP00000092528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1198,116,975 - 198,443,680 (-)Ensembl
mRatBN7.2 Ensembl1188,686,989 - 189,013,848 (-)Ensembl
RefSeq Acc Id: NM_001427293   ⟹   NP_001414222
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,116,968 - 198,443,680 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414222 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11775 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024974.5
  ENSRNOP00000092528
  ENSRNOP00000092528.1
Ensembl Acc Id: ENSRNOP00000024974   ⟸   ENSRNOT00000024974
Ensembl Acc Id: ENSRNOP00000092528   ⟸   ENSRNOT00000105185
RefSeq Acc Id: NP_001414222   ⟸   NM_001427293
- Peptide Label: precursor
- UniProtKB: F1M9Z9 (UniProtKB/TrEMBL),   A0A8I6AGQ6 (UniProtKB/TrEMBL),   A6HX44 (UniProtKB/TrEMBL)
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M9Z9-F1-model_v2 AlphaFold F1M9Z9 1-882 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583652 AgrOrtholog
BioCyc Gene G2FUF-57174 BioCyc
Ensembl Genes ENSRNOG00000018384 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024974.8 UniProtKB/TrEMBL
  ENSRNOT00000105185 ENTREZGENE
  ENSRNOT00000105185.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene 679837 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam12 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018384 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A8I6AGQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6HX44 ENTREZGENE, UniProtKB/TrEMBL
  F1M9Z9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adam12  ADAM metallopeptidase domain 12  Adam12  a disintegrin and metallopeptidase domain 12 (meltrin alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-14 Adam12  a disintegrin and metallopeptidase domain 12 (meltrin alpha)  Adam12_predicted  a disintegrin and metallopeptidase domain 12 (meltrin alpha) (predicted)  Data merged from RGD:1307837 737654 APPROVED
2008-03-05 Adam12  a disintegrin and metallopeptidase domain 12 (meltrin alpha)  LOC679837  similar to ADAM 12 precursor (A disintegrin and metalloproteinase domain 12) (Meltrin alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC679837  similar to ADAM 12 precursor (A disintegrin and metalloproteinase domain 12) (Meltrin alpha)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Adam12_predicted  a disintegrin and metallopeptidase domain 12 (meltrin alpha) (predicted)    a disintegrin and metalloproteinase domain 12 (meltrin alpha) (predicted)  Name updated 1299863 APPROVED
2005-01-12 Adam12_predicted  a disintegrin and metalloproteinase domain 12 (meltrin alpha) (predicted)      Symbol and Name status set to approved 70820 APPROVED