H2az2l1 (H2A.Z histone variant 2 like 1) - Rat Genome Database

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Gene: H2az2l1 (H2A.Z histone variant 2 like 1) Rattus norvegicus
Analyze
Symbol: H2az2l1 (Ensembl: H2az1-ps2)
Name: H2A.Z histone variant 2 like 1 (Ensembl:H2A.Z variant histone 1, pseudogene 2)
RGD ID: 1583233
Description: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone H2A.V-like; LOC685069; similar to H2A histone family, member V isoform 1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,825,302 - 152,825,956 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4152,825,521 - 152,825,907 (-)EnsemblGRCr8
mRatBN7.24151,152,904 - 151,153,567 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,153,132 - 151,153,518 (-)EnsemblmRatBN7.2
Rnor_6.04150,029,954 - 150,030,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04215,957,744 - 215,958,352 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44154,275,833 - 154,276,219 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4140,027,574 - 140,028,169 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
nucleosome  (IBA,IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Variants

.
Variants in H2az2l1
2 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4150095743159267220Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
D4Rat200  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84152,833,529 - 152,833,657 (+)Marker Load Pipeline
mRatBN7.24151,161,140 - 151,161,268 (+)MAPPERmRatBN7.2
Rnor_6.04150,038,157 - 150,038,284NCBIRnor6.0
Rnor_5.04215,965,957 - 215,966,084UniSTSRnor5.0
RGSC_v3.44154,283,841 - 154,283,969RGDRGSC3.4
RGSC_v3.44154,283,842 - 154,283,969UniSTSRGSC3.4
Celera4140,035,775 - 140,035,902UniSTS
RGSC_v3.14154,528,682 - 154,528,810RGD
SHRSP x BN Map473.6199RGD
SHRSP x BN Map473.6199UniSTS
Cytogenetic Map4q42UniSTS
D4Got152  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84152,838,793 - 152,838,968 (+)Marker Load Pipeline
mRatBN7.24151,166,404 - 151,166,579 (+)MAPPERmRatBN7.2
Rnor_6.04150,043,421 - 150,043,595NCBIRnor6.0
Rnor_5.04215,971,221 - 215,971,395UniSTSRnor5.0
RGSC_v3.44154,289,104 - 154,289,279RGDRGSC3.4
RGSC_v3.44154,289,105 - 154,289,279UniSTSRGSC3.4
RGSC_v3.14154,533,945 - 154,534,120RGD
RH 3.4 Map4989.83RGD
RH 3.4 Map4989.83UniSTS
RH 2.0 Map4968.7RGD
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
1 1 1 4 11 6 2 3 4

Sequence


Ensembl Acc Id: ENSRNOT00000117013   ⟹   ENSRNOP00000096932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,153,132 - 151,153,518 (-)Ensembl
RefSeq Acc Id: XM_006237209   ⟹   XP_006237271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84152,825,302 - 152,825,956 (-)NCBI
mRatBN7.24151,152,904 - 151,153,567 (-)NCBI
Rnor_6.04150,029,954 - 150,030,549 (-)NCBI
Rnor_5.04215,957,744 - 215,958,352 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006237271 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065187
  ENSRNOP00000065187.3
  ENSRNOP00000083173.2
RefSeq Acc Id: XP_006237271   ⟸   XM_006237209
- UniProtKB: A0A8I5ZYU7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000096932   ⟸   ENSRNOT00000117013

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-43244 BioCyc
Ensembl Genes ENSRNOG00000031564 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000052275 UniProtKB/TrEMBL
  ENSRNOG00000068631 Ensembl
Ensembl Transcript ENSRNOT00000052280 ENTREZGENE
  ENSRNOT00000052280.6 UniProtKB/TrEMBL
  ENSRNOT00000103545.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/TrEMBL
  Histone_H2A UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/TrEMBL
  Histone_H2A_CS UniProtKB/TrEMBL
NCBI Gene 685069 ENTREZGENE
PANTHER PTHR23430 UniProtKB/TrEMBL
Pfam Histone UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/TrEMBL
PhenoGen H2az2l1 PhenoGen
PRINTS HISTONEH2A UniProtKB/TrEMBL
PROSITE HISTONE_H2A UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031564 RatGTEx
  ENSRNOG00000052275 RatGTEx
  ENSRNOG00000068631 RatGTEx
SMART H2A UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/TrEMBL
UniProt A0A8I5ZYU7 ENTREZGENE, UniProtKB/TrEMBL
  M0R6X5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 H2az2l1  H2A.Z histone variant 2 like 1  LOC685069  similar to H2A histone family, member V isoform 1  Symbol and Name Changed 1299863 APPROVED
2008-01-09 LOC685069  similar to H2A histone family, member V isoform 1  LOC681425  similar to H2A histone family, member V isoform 1  Data merged from RGD:1595400 1643240 APPROVED
2006-11-20 LOC681425  similar to H2A histone family, member V isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC685069  similar to H2A histone family, member V isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL