Il17c (interleukin 17C) - Rat Genome Database

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Gene: Il17c (interleukin 17C) Rattus norvegicus
Analyze
Symbol: Il17c
Name: interleukin 17C
RGD ID: 1582798
Description: Predicted to enable cytokine activity. Predicted to be involved in inflammatory response. Predicted to act upstream of or within neutrophil differentiation; positive regulation of cytokine production involved in inflammatory response; and signal transduction. Predicted to be located in extracellular space. Orthologous to human IL17C (interleukin 17C); INTERACTS WITH trichloroethene; 17beta-estradiol (ortholog); 4,4'-diaminodiphenylmethane (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: interleukin-17C; LOC691516; similar to interleukin 17C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,393,435 - 67,394,714 (+)NCBIGRCr8
mRatBN7.21950,484,890 - 50,486,169 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,484,890 - 50,486,169 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,280,071 - 57,281,350 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,959,823 - 57,961,102 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,178,689 - 60,179,968 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,246,926 - 55,248,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,246,926 - 55,248,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,957,110 - 65,958,389 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,710,442 - 52,711,721 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1949,724,434 - 49,725,713 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12077275   PMID:17982105  


Genomics

Comparative Map Data
Il17c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,393,435 - 67,394,714 (+)NCBIGRCr8
mRatBN7.21950,484,890 - 50,486,169 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,484,890 - 50,486,169 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,280,071 - 57,281,350 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,959,823 - 57,961,102 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,178,689 - 60,179,968 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,246,926 - 55,248,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,246,926 - 55,248,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,957,110 - 65,958,389 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,710,442 - 52,711,721 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1949,724,434 - 49,725,713 (+)NCBICelera
Cytogenetic Map19q12NCBI
IL17C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,638,572 - 88,640,468 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,638,572 - 88,640,468 (+)EnsemblGRCh38hg38GRCh38
GRCh371688,704,980 - 88,706,876 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,232,502 - 87,234,383 (+)NCBINCBI36Build 36hg18NCBI36
Build 341687,232,501 - 87,234,382NCBI
Celera1673,774,673 - 73,776,554 (+)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1674,399,029 - 74,400,912 (+)NCBIHuRef
CHM1_11690,116,302 - 90,118,183 (+)NCBICHM1_1
T2T-CHM13v2.01694,706,451 - 94,708,347 (+)NCBIT2T-CHM13v2.0
Il17c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,147,912 - 123,150,820 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,148,759 - 123,150,378 (+)EnsemblGRCm39 Ensembl
GRCm388122,422,020 - 122,423,639 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,422,020 - 122,423,639 (+)EnsemblGRCm38mm10GRCm38
MGSCv378124,945,983 - 124,947,539 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368125,308,175 - 125,309,658 (+)NCBIMGSCv36mm8
Celera8126,651,194 - 126,652,750 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map871.03NCBI
Il17c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,568,941 - 2,570,440 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555412,568,941 - 2,570,440 (+)NCBIChiLan1.0ChiLan1.0
IL17C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21898,407,102 - 98,413,501 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116104,323,781 - 104,325,607 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,347,233 - 69,353,562 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,007,702 - 89,013,678 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,011,688 - 89,013,678 (+)Ensemblpanpan1.1panPan2
IL17C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,702,668 - 64,703,694 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,702,730 - 64,703,984 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,712,994 - 64,714,373 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,921,652 - 64,923,031 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,922,067 - 64,923,321 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,947,760 - 64,949,140 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,779,537 - 64,780,916 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,185,572 - 65,186,951 (-)NCBIUU_Cfam_GSD_1.0
Il17c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,292,580 - 25,294,020 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366411,046,380 - 1,047,567 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366411,045,636 - 1,047,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,022,937 - 1,025,161 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,023,330 - 1,025,173 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IL17C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,019,253 - 74,021,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,019,253 - 74,020,344 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660471,664,162 - 1,665,977 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il17c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746920,266 - 921,967 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746919,239 - 922,336 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il17c
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:66
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000017358
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 8 17 5 3 4
Below cutoff 2 8 13 6 2 6 5 5 11 3 5 7 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017358   ⟹   ENSRNOP00000017358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1950,484,890 - 50,486,169 (+)Ensembl
Rnor_6.0 Ensembl1955,246,926 - 55,248,205 (+)Ensembl
RefSeq Acc Id: NM_001191115   ⟹   NP_001178044
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,393,435 - 67,394,714 (+)NCBI
mRatBN7.21950,484,890 - 50,486,169 (+)NCBI
Rnor_6.01955,246,926 - 55,248,205 (+)NCBI
Rnor_5.01965,957,110 - 65,958,389 (+)NCBI
Celera1949,724,434 - 49,725,713 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178044 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017358
  ENSRNOP00000017358.3
Reference Protein Sequences
RefSeq Acc Id: NP_001178044   ⟸   NM_001191115
- Peptide Label: precursor
- UniProtKB: F1LTN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017358   ⟸   ENSRNOT00000017358

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTN0-F1-model_v2 AlphaFold F1LTN0 1-203 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1582798 AgrOrtholog
BioCyc Gene G2FUF-5399 BioCyc
Ensembl Genes ENSRNOG00000013007 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017358 ENTREZGENE
  ENSRNOT00000017358.5 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Interleukin-17_chordata UniProtKB/TrEMBL
  Interleukin-17_met UniProtKB/TrEMBL
KEGG Report rno:691516 UniProtKB/TrEMBL
NCBI Gene 691516 ENTREZGENE
Pfam IL17 UniProtKB/TrEMBL
PhenoGen Il17c PhenoGen
PRINTS INTRLEUKIN17 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013007 RatGTEx
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt F1LTN0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Il17c  interleukin 17C  LOC691516  similar to interleukin 17C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691516  similar to interleukin 17C  LOC687591  similar to interleukin 17C  Data merged from RGD:1584174 1643240 APPROVED
2006-11-19 LOC691516  similar to interleukin 17C      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687591  similar to interleukin 17C      Symbol and Name status set to provisional 70820 PROVISIONAL