Slc6a20b (solute carrier family 6 member 20b) - Rat Genome Database

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Gene: Slc6a20b (solute carrier family 6 member 20b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Slc6a20b
Name: solute carrier family 6 member 20b
RGD ID: 1566368
Description: Enables L-proline transmembrane transporter activity; amino-acid betaine transmembrane transporter activity; and proline:sodium symporter activity. Involved in L-proline import across plasma membrane and amino-acid betaine transport. Predicted to be located in brush border membrane.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC301083; RGD1566368; similar to Solute carrier family 6 (neurotransmitter transporter), member 20; sodium- and chloride-dependent transporter XTRP3; sodium- and chloride-dependent transporter XTRP3B
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,108,481 - 132,158,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8132,112,258 - 132,155,422 (-)EnsemblGRCr8
mRatBN7.28123,234,731 - 123,278,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,234,714 - 123,278,680 (-)EnsemblmRatBN7.2
Rnor_6.08132,663,281 - 132,709,485 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08131,815,415 - 131,862,081 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48128,362,272 - 128,408,149 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8122,342,351 - 122,386,695 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IBA,IEA,ISS)
membrane  (IEA)
plasma membrane  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Na+-dependent and Na+-independent betaine transport across the apical membrane of rat renal epithelium. Cano M, etal., Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2172-9. doi: 10.1016/j.bbamem.2015.05.020. Epub 2015 May 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino. Takanaga H, etal., J Biol Chem. 2005 Mar 11;280(10):8974-84. Epub 2005 Jan 4.

Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000008172
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat

Markers in Region
BI281911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,234,947 - 123,235,159 (+)MAPPERmRatBN7.2
Rnor_6.08132,666,041 - 132,666,252NCBIRnor6.0
Rnor_5.08131,818,741 - 131,818,952UniSTSRnor5.0
RGSC_v3.48128,362,489 - 128,362,700UniSTSRGSC3.4
Celera8122,345,111 - 122,345,322UniSTS
RH 3.4 Map81276.89UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
1 8 23 31 78 42 3 25 36 11 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000008172   ⟹   ENSRNOP00000008172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8132,112,258 - 132,155,422 (-)Ensembl
mRatBN7.2 Ensembl8123,234,714 - 123,266,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108032   ⟹   ENSRNOP00000093413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,234,714 - 123,278,680 (-)Ensembl
RefSeq Acc Id: XM_002729986   ⟹   XP_002730032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,108,481 - 132,156,039 (-)NCBI
mRatBN7.28123,234,731 - 123,278,306 (-)NCBI
Rnor_6.08132,663,281 - 132,709,243 (-)NCBI
Rnor_5.08131,815,415 - 131,862,081 (-)NCBI
RGSC_v3.48128,362,272 - 128,408,149 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266353   ⟹   XP_063122423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,108,481 - 132,158,422 (-)NCBI
Protein Sequences
Protein RefSeqs XP_002730032 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122423 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008172
  ENSRNOP00000008172.8
RefSeq Acc Id: XP_002730032   ⟸   XM_002729986
- Peptide Label: isoform X1
- UniProtKB: Q64093 (UniProtKB/Swiss-Prot),   A0A8I6AX01 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000093413   ⟸   ENSRNOT00000108032
Ensembl Acc Id: ENSRNOP00000008172   ⟸   ENSRNOT00000008172
RefSeq Acc Id: XP_063122423   ⟸   XM_063266353
- Peptide Label: isoform X2
- UniProtKB: F1LZT7 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-28611 BioCyc
Ensembl Genes ENSRNOG00000006010 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008172 ENTREZGENE
  ENSRNOT00000008172.9 UniProtKB/TrEMBL
InterPro Na/ntran_symport UniProtKB/TrEMBL
  Neutral_aa_SLC6 UniProtKB/TrEMBL
  SNS_sf UniProtKB/TrEMBL
NCBI Gene 301083 ENTREZGENE
PANTHER PTHR11616 UniProtKB/TrEMBL
  SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3 UniProtKB/TrEMBL
Pfam SNF UniProtKB/TrEMBL
PhenoGen Slc6a20b PhenoGen
PRINTS NANEUSMPORT UniProtKB/TrEMBL
  ORPHTRNSPORT UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006010 RatGTEx
Superfamily-SCOP SSF161070 UniProtKB/TrEMBL
UniProt A0A8I6AX01 ENTREZGENE
  F1LZT7 ENTREZGENE, UniProtKB/TrEMBL
  Q64093 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-03 Slc6a20b  solute carrier family 6 member 20b  RGD1566368  similar to Solute carrier family 6 (neurotransmitter transporter), member 20  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1566368  similar to Solute carrier family 6 (neurotransmitter transporter), member 20   RGD1566368_predicted  similar to Solute carrier family 6 (neurotransmitter transporter), member 20 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566368_predicted  similar to Solute carrier family 6 (neurotransmitter transporter), member 20 (predicted)  LOC301083  similar to Solute carrier family 6 (neurotransmitter transporter), member 20  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC301083  similar to Solute carrier family 6 (neurotransmitter transporter), member 20      Symbol and Name status set to provisional 70820 PROVISIONAL