Cd274 (CD274 molecule) - Rat Genome Database

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Gene: Cd274 (CD274 molecule) Rattus norvegicus
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Symbol: Cd274
Name: CD274 molecule
RGD ID: 1566211
Description: Predicted to enable receptor ligand activity and transcription coactivator activity. Involved in positive regulation of T cell proliferation and positive regulation of cell migration. Located in cell surface. Biomarker of periodontitis and pre-eclampsia. Orthologous to human CD274 (CD274 molecule); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD274 antigen; LOC499342; Pdcd1lg1; programmed cell death 1 ligand 1; RGD1566211; similar to PD-1-ligand precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,526,215 - 236,549,956 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,496,463 - 236,549,951 (+)EnsemblGRCr8
mRatBN7.21227,116,674 - 227,137,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,116,649 - 227,134,450 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,523,534 - 235,535,346 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,453,199 - 242,465,011 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,269,986 - 235,282,673 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,519,890 - 247,539,659 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,519,939 - 247,537,943 (+)Ensemblrn6Rnor6.0
Rnor_5.01254,768,528 - 254,788,292 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41233,053,607 - 233,065,384 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1224,273,306 - 224,285,083 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute myocarditis  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
allergic disease  (ISO)
alveolar echinococcosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
autoimmune hepatitis  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chlamydia pneumonia  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
colon cancer  (ISO)
Corneal Graft Rejection  (IMP)
Coxsackievirus Infections  (ISO)
cryptococcal meningitis  (ISO)
cutaneous leishmaniasis  (ISO)
Disease Progression  (ISO)
Experimental Mammary Neoplasms  (IDA)
Fungemia  (ISO)
Hepatic Echinococcosis  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
herpes simplex virus keratitis  (ISO)
histoplasmosis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
infantile onset multisystem autoimmune disease 5  (ISO)
influenza  (ISO)
invasive ductal carcinoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
lymphocytic choriomeningitis  (ISO)
lymphoma  (ISO)
melanoma  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Neoplasm Metastasis  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
papillomavirus infectious disease  (ISO)
periodontitis  (IEP)
pre-eclampsia  (IEP)
primary progressive multiple sclerosis  (ISO)
pulmonary tuberculosis  (ISO)
rabies  (ISO)
Radiation-Induced Neoplasms  (ISO)
Recurrence  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retroviridae Infections  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (IEP)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
substance-related disorder  (ISO)
Thymus Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
Viral Bronchiolitis  (ISO)
viral encephalitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
auranofin  (ISO)
Azoxymethane  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
daclatasvir  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
estriol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gardiquimod  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
indolin-2-one  (ISO)
isoeugenol  (ISO)
ketoconazole  (EXP)
kojic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mocetinostat  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
platycodin D  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tubastatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
cell surface receptor signaling pathway  (IBA,ISO)
cellular response to lipopolysaccharide  (IBA)
immune response  (IBA,ISO)
immune system process  (IEA)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
negative regulation of CD8-positive, alpha-beta T cell activation  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T cell mediated immune response to tumor cell  (ISO)
negative regulation of T cell proliferation  (IBA,IEA,ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor superfamily cytokine production  (ISO)
negative regulation of type II interferon production  (ISO)
positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of interleukin-10 production  (ISO)
positive regulation of T cell apoptotic process  (ISO)
positive regulation of T cell proliferation  (IBA,IMP)
regulation of activated CD4-positive, alpha-beta T cell apoptotic process  (ISO)
regulation of activated T cell proliferation  (ISO)
regulation of T cell apoptotic process  (ISO)
response to cytokine  (ISO)
signal transduction  (ISO)
T cell costimulation  (IBA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3. null
2. PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction. Abiko K, etal., Clin Cancer Res. 2013 Mar 15;19(6):1363-74. doi: 10.1158/1078-0432.CCR-12-2199. Epub 2013 Jan 22.
3. Expression of programmed death 1 and its ligands in the liver of autoimmune hepatitis C57BL/6 mice. Cao J, etal., Chin Med J (Engl). 2009 Aug 20;122(16):1941-6.
4. Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Chang KC, etal., Crit Care. 2013 May 11;17(3):R85. doi: 10.1186/cc12711.
5. In vitro and in vivo effect of PD-1/PD-L1 blockade on microglia/macrophage activation and T cell subset balance in cryptococcal meningitis. Che YM, etal., J Cell Biochem. 2018 Apr;119(4):3044-3057. doi: 10.1002/jcb.26432. Epub 2017 Dec 26.
6. CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion. Correa-Rocha R, etal., PLoS One. 2018 Aug 30;13(8):e0203419. doi: 10.1371/journal.pone.0203419. eCollection 2018.
7. CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease. Duncan DS and Miller SD, PLoS One. 2011 Apr 8;6(4):e18548.
8. Viral acute lower respiratory infections impair CD8+ T cells through PD-1. Erickson JJ, etal., J Clin Invest. 2012 Aug;122(8):2967-82. doi: 10.1172/JCI62860. Epub 2012 Jul 17.
9. Expression of PD-L1 on CD4+CD25+Foxp3+ Regulatory T Cells of Patients with Chronic HBV Infection and Its Correlation with Clinical Parameters. Feng C, etal., Viral Immunol. 2015 Oct;28(8):418-24. doi: 10.1089/vim.2015.0062. Epub 2015 Aug 12.
10. Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice. Frebel H, etal., J Exp Med. 2012 Dec 17;209(13):2485-99. doi: 10.1084/jem.20121015. Epub 2012 Dec 10.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Pre-treatment serum levels of soluble programmed cell death-ligand 1 predict prognosis in patients with hepatitis B-related hepatocellular carcinoma. Han X, etal., J Cancer Res Clin Oncol. 2019 Feb;145(2):303-312. doi: 10.1007/s00432-018-2758-6. Epub 2018 Sep 28.
13. Immune suppression in premalignant respiratory papillomas: enriched functional CD4+Foxp3+ regulatory T cells and PD-1/PD-L1/L2 expression. Hatam LJ, etal., Clin Cancer Res. 2012 Apr 1;18(7):1925-35. doi: 10.1158/1078-0432.CCR-11-2941. Epub 2012 Feb 9.
14. Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation through Upregulation of Programmed Cell Death Protein 1 in a Rat Spinal Cord Injury Model. He H, etal., J Neurotrauma. 2018 Nov 1;35(21):2591-2603. doi: 10.1089/neu.2017.5625. Epub 2018 Jun 7.
15. Prognostic Significance of PD-1, PD-L1 and CD8 Gene Expression Levels in Gastric Cancer. Ito S, etal., Oncology. 2020;98(7):501-511. doi: 10.1159/000506075. Epub 2020 May 7.
16. PD-L1/B7-H1 Inhibits Viral Clearance by Macrophages in HSV-1-Infected Corneas. Jeon S, etal., J Immunol. 2018 Jun 1;200(11):3711-3719. doi: 10.4049/jimmunol.1700417. Epub 2018 Apr 18.
17. Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection. Jeong HY, etal., J Leukoc Biol. 2008 Mar;83(3):755-64. doi: 10.1189/jlb.0307168. Epub 2007 Dec 17.
18. Combination of an oncolytic virus with PD-L1 blockade keeps cancer in check. Jonas BA, Sci Transl Med. 2017 Apr 19;9(386). pii: 9/386/eaan2781. doi: 10.1126/scitranslmed.aan2781.
19. B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK). Jun H, etal., FEBS Lett. 2005 Nov 7;579(27):6259-64. doi: 10.1016/j.febslet.2005.09.098. Epub 2005 Oct 19.
20. Expression of programmed cell death ligand 1 (PD-L1) in advanced stage EBV-associated extranodal NK/T cell lymphoma is associated with better prognosis. Kim WY, etal., Virchows Arch. 2016 Nov;469(5):581-590. doi: 10.1007/s00428-016-2011-0. Epub 2016 Sep 5.
21. Upregulation of PD-1 on CD4⁺CD25⁺ T cells is associated with immunosuppression in liver of mice infected with Echinococcus multilocularis. La X, etal., Int Immunopharmacol. 2015 Jun;26(2):357-66. doi: 10.1016/j.intimp.2015.04.013. Epub 2015 Apr 20.
22. Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis. Lafon M, etal., J Immunol. 2008 Jun 1;180(11):7506-15. doi: 10.4049/jimmunol.180.11.7506.
23. Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. Lee I, etal., J Immunol. 2003 Dec 15;171(12):6929-35.
24. Increased levels of soluble co-stimulatory molecule PD-L1 (B7-H1) in the plasma of viraemic HIV-1+ individuals. León-Flores A, etal., Immunol Lett. 2018 Nov;203:70-79. doi: 10.1016/j.imlet.2018.09.007. Epub 2018 Sep 17.
25. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Liang SC, etal., Eur J Immunol. 2006 Jan;36(1):58-64. doi: 10.1002/eji.200535458.
26. High PD-L1 expression in gastric cancer (GC) patients and correlation with molecular features. Liu X, etal., Pathol Res Pract. 2020 Apr;216(4):152881. doi: 10.1016/j.prp.2020.152881. Epub 2020 Feb 13.
27. The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Lázár-Molnár E, etal., Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2658-63. doi: 10.1073/pnas.0711918105. Epub 2008 Feb 11.
28. Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis. McNab FW, etal., Eur J Immunol. 2011 Jul;41(7):1941-7. doi: 10.1002/eji.201141421. Epub 2011 May 27.
29. PD-L1 expression on neoplastic or stromal cells is respectively a poor or good prognostic factor for adult T-cell leukemia/lymphoma. Miyoshi H, etal., Blood. 2016 Sep 8;128(10):1374-81. doi: 10.1182/blood-2016-02-698936. Epub 2016 Jul 14.
30. Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival. Nosov M, etal., Am J Transplant. 2012 May;12(5):1313-22. doi: 10.1111/j.1600-6143.2011.03948.x. Epub 2012 Feb 2.
31. Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Pan T, etal., Mediators Inflamm. 2015;2015:539841. doi: 10.1155/2015/539841. Epub 2015 Apr 30.
32. Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis. Phares TW, etal., J Immunol. 2010 Nov 1;185(9):5607-18. Epub 2010 Sep 27.
33. Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis. Reynolds J, etal., Nephrol Dial Transplant. 2012 Apr;27(4):1343-50. doi: 10.1093/ndt/gfr529. Epub 2011 Sep 29.
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Comprehensive gene review and curation RGD comprehensive gene curation
36. Monocyte programmed death ligand-1 expression after 3-4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study. Shao R, etal., Crit Care. 2016 May 9;20(1):124. doi: 10.1186/s13054-016-1301-x.
37. Increased PD-L1 expression and PD-L1/CD86 ratio on dendritic cells were associated with impaired dendritic cells function in HCV infection. Shen T, etal., J Med Virol. 2010 Jul;82(7):1152-9. doi: 10.1002/jmv.21809.
38. PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis. Shwetank, etal., Front Immunol. 2019 Apr 17;10:783. doi: 10.3389/fimmu.2019.00783. eCollection 2019.
39. Inhibiting the programmed death 1 pathway rescues Mycobacterium tuberculosis-specific interferon γ-producing T cells from apoptosis in patients with pulmonary tuberculosis. Singh A, etal., J Infect Dis. 2013 Aug 15;208(4):603-15. doi: 10.1093/infdis/jit206. Epub 2013 May 9.
40. Programmed Death Ligand 1 Promotes Early-Life Chlamydia Respiratory Infection-Induced Severe Allergic Airway Disease. Starkey MR, etal., Am J Respir Cell Mol Biol. 2016 Apr;54(4):493-503. doi: 10.1165/rcmb.2015-0204OC.
41. The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats. Tian M, etal., Sci Rep. 2016 Jun 9;6:27683. doi: 10.1038/srep27683.
42. PD-L1 expression induced by the 2009 pandemic influenza A(H1N1) virus impairs the human T cell response. Valero-Pacheco N, etal., Clin Dev Immunol. 2013;2013:989673. doi: 10.1155/2013/989673. Epub 2013 Sep 26.
43. Immunotherapy of alveolar echinococcosis via PD-1/PD-L1 immune checkpoint blockade in mice. Wang J, etal., Parasite Immunol. 2018 Dec;40(12):e12596. doi: 10.1111/pim.12596. Epub 2018 Nov 4.
44. Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection. Wang T, etal., Antiviral Res. 2019 Jun;166:1-10. doi: 10.1016/j.antiviral.2019.03.007. Epub 2019 Mar 20.
45. [Enhancement of antiviral immunity in HBV mouse model by blocking PD-1/PD-L1 signaling pathway]. Weng ZH, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Apr;18(4):263-6. doi: 10.3760/cma.j.issn.1007-3418.2010.04.007.
46. Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study. Wilson JK, etal., Crit Care. 2018 Apr 17;22(1):95. doi: 10.1186/s13054-018-2020-2.
47. Immune Checkpoint Receptors Tim-3 and PD-1 Regulate Monocyte and T Lymphocyte Function in Septic Patients. Xia Q, etal., Mediators Inflamm. 2018 Nov 22;2018:1632902. doi: 10.1155/2018/1632902. eCollection 2018.
48. Inhibition of T-cell responses by intratumoral hepatic stellate cells contribute to migration and invasion of hepatocellular carcinoma. Xia Y, etal., Clin Exp Metastasis. 2011 Oct;28(7):661-74. doi: 10.1007/s10585-011-9399-3. Epub 2011 Jun 30.
49. The Protective and Immunomodulatory Effects of Fucoidan Against 7,12-Dimethyl benz[a]anthracene-Induced Experimental Mammary Carcinogenesis Through the PD1/PDL1 Signaling Pathway in Rats. Xue M, etal., Nutr Cancer. 2017 Nov-Dec;69(8):1234-1244. doi: 10.1080/01635581.2017.1362446. Epub 2017 Oct 18.
50. Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia. Yang W, etal., Immunology. 2013 Aug;139(4):513-22. doi: 10.1111/imm.12101.
51. [Temporal expression of PD-1 and PD-L1 during the development of experimental periodontitis in rats and its implications]. Yang X, etal., Shanghai Kou Qiang Yi Xue. 2019 Dec;28(6):591-596.
52. Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection. Yao S, etal., Mucosal Immunol. 2015 Jul;8(4):746-59. doi: 10.1038/mi.2014.106. Epub 2014 Dec 3.
53. Upregulation of circulating PD-L1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma. Zeng Z, etal., PLoS One. 2011;6(9):e23621. doi: 10.1371/journal.pone.0023621. Epub 2011 Sep 1.
54. Predictive Value of Soluble Programmed Death-1 for Severe Sepsis and Septic Shock During the First Week in an Intensive Care Unit. Zhao Y, etal., Shock. 2019 Mar;51(3):289-297. doi: 10.1097/SHK.0000000000001171.
Additional References at PubMed
PMID:10581077   PMID:12538684   PMID:15568026   PMID:17016562   PMID:17076679   PMID:17489864   PMID:21855860   PMID:23716698   PMID:24691993   PMID:25310899   PMID:25902191   PMID:28196545  
PMID:28458101   PMID:28813410   PMID:28813417   PMID:30092337   PMID:31733200   PMID:32631356   PMID:38203304  


Genomics

Comparative Map Data
Cd274
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,526,215 - 236,549,956 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,496,463 - 236,549,951 (+)EnsemblGRCr8
mRatBN7.21227,116,674 - 227,137,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,116,649 - 227,134,450 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,523,534 - 235,535,346 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,453,199 - 242,465,011 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,269,986 - 235,282,673 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,519,890 - 247,539,659 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,519,939 - 247,537,943 (+)Ensemblrn6Rnor6.0
Rnor_5.01254,768,528 - 254,788,292 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41233,053,607 - 233,065,384 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1224,273,306 - 224,285,083 (+)NCBICelera
Cytogenetic Map1q52NCBI
CD274
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3895,450,542 - 5,470,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl95,450,503 - 5,470,566 (+)Ensemblhg38GRCh38
GRCh3795,450,542 - 5,470,554 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3695,440,559 - 5,458,477 (+)NCBIBuild 36Build 36hg18NCBI36
Celera95,376,139 - 5,396,204 (+)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef95,406,210 - 5,426,274 (+)NCBIHuRef
CHM1_195,450,664 - 5,470,759 (+)NCBICHM1_1
T2T-CHM13v2.095,455,669 - 5,475,674 (+)NCBIT2T-CHM13v2.0
Cd274
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,339,428 - 29,365,495 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,344,855 - 29,365,495 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381929,362,107 - 29,388,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,367,455 - 29,388,095 (+)Ensemblmm10GRCm38
MGSCv371929,441,928 - 29,462,585 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361929,433,452 - 29,454,092 (+)NCBIMGSCv36mm8
Celera1930,144,050 - 30,164,685 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.88NCBI
Cd274
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554349,487,315 - 9,505,904 (+)Ensembl
ChiLan1.0NW_0049554349,487,309 - 9,508,366 (+)NCBIChiLan1.0ChiLan1.0
CD274
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211119,102,245 - 119,122,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19119,108,194 - 119,128,540 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v095,269,270 - 5,289,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.195,454,391 - 5,474,452 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,454,391 - 5,474,402 (+)EnsemblpanPan2panpan1.1
CD274
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,461,735 - 93,605,772 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,585,518 - 93,603,522 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha193,993,732 - 94,011,736 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0194,015,405 - 94,159,596 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,139,343 - 94,159,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,771,527 - 93,789,533 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,496,313 - 93,514,317 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0194,260,510 - 94,278,519 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd274
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947141,675,278 - 141,693,582 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936539132,868 - 143,602 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936539132,870 - 145,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD274
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,660,041 - 216,792,724 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11216,646,378 - 216,792,731 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,395,402 - 242,416,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD274
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,038,844 - 74,060,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,041,767 - 74,056,806 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603862,428,363 - 62,448,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd274
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247369,996,156 - 10,013,814 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247369,991,851 - 10,017,047 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cd274
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1229,452,186 - 29,466,469 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd274
199 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:47
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000034421
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
6480786Bw97Body weight QTL 975.03body mass (VT:0001259)body weight (CMO:0000012)1234540191237018045Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 165 91 90 59 92 59 6 354 190 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000034421   ⟹   ENSRNOP00000029992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,530,215 - 236,548,576 (+)Ensembl
mRatBN7.2 Ensembl1227,116,649 - 227,134,450 (+)Ensembl
Rnor_6.0 Ensembl1247,519,939 - 247,537,943 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000127038   ⟹   ENSRNOP00000110570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,530,215 - 236,547,202 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157954   ⟹   ENSRNOP00000105704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,496,463 - 236,549,951 (+)Ensembl
RefSeq Acc Id: NM_001191954   ⟹   NP_001178883
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,530,232 - 236,549,956 (+)NCBI
mRatBN7.21227,116,674 - 227,136,399 (+)NCBI
Rnor_6.01247,525,151 - 247,536,928 (+)NCBI
Rnor_5.01254,768,528 - 254,788,292 (+)NCBI
Celera1224,273,306 - 224,285,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088029   ⟹   XP_038943957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,530,298 - 236,549,956 (+)NCBI
mRatBN7.21227,116,740 - 227,137,379 (+)NCBI
RefSeq Acc Id: XM_039088034   ⟹   XP_038943962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,530,236 - 236,549,956 (+)NCBI
mRatBN7.21227,116,689 - 227,137,379 (+)NCBI
RefSeq Acc Id: XM_063271728   ⟹   XP_063127798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,526,215 - 236,549,956 (+)NCBI
RefSeq Acc Id: NP_001178883   ⟸   NM_001191954
- Peptide Label: precursor
- UniProtKB: D4AE25 (UniProtKB/TrEMBL),   A6I0W4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029992   ⟸   ENSRNOT00000034421
RefSeq Acc Id: XP_038943962   ⟸   XM_039088034
- Peptide Label: isoform X1
- UniProtKB: D4AE25 (UniProtKB/TrEMBL),   A6I0W4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943957   ⟸   XM_039088029
- Peptide Label: isoform X1
- UniProtKB: D4AE25 (UniProtKB/TrEMBL),   A6I0W4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127798   ⟸   XM_063271728
- Peptide Label: isoform X1
- UniProtKB: A6I0W4 (UniProtKB/TrEMBL),   D4AE25 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110570   ⟸   ENSRNOT00000127038
Ensembl Acc Id: ENSRNOP00000105704   ⟸   ENSRNOT00000157954
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE25-F1-model_v2 AlphaFold D4AE25 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690846
Promoter ID:EPDNEW_R1371
Type:single initiation site
Name:Cd274_1
Description:CD274 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01247,519,934 - 247,519,994EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566211 AgrOrtholog
BioCyc Gene G2FUF-55968 BioCyc
Ensembl Genes ENSRNOG00000016112 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034421 ENTREZGENE
  ENSRNOT00000034421.8 UniProtKB/TrEMBL
  ENSRNOT00000127038.1 UniProtKB/TrEMBL
  ENSRNOT00000157954 ENTREZGENE
  ENSRNOT00000157954.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro BTN3A2-like_Ig-C UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  T-cell_Activation_Regulation UniProtKB/TrEMBL
KEGG Report rno:499342 UniProtKB/TrEMBL
NCBI Gene 499342 ENTREZGENE
PANTHER PROGRAMMED CELL DEATH 1 LIGAND 1 UniProtKB/TrEMBL
  T-LYMPHOCYTE ACTIVATION ANTIGEN UniProtKB/TrEMBL
Pfam C2-set_3 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Cd274 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016112 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0ABK0LPZ6_RAT UniProtKB/TrEMBL
  A0ABK0M0P1_RAT UniProtKB/TrEMBL
  A6I0W4 ENTREZGENE, UniProtKB/TrEMBL
  D4AE25 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27 Cd274  CD274 molecule  Cd274  CD274 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Cd274  CD274 antigen  RGD1566211_predicted  similar to PD-1-ligand precursor (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566211_predicted  similar to PD-1-ligand precursor (predicted)  LOC499342  similar to PD-1-ligand precursor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499342  similar to PD-1-ligand precursor      Symbol and Name status set to provisional 70820 PROVISIONAL