CD274 (CD274 molecule) - Rat Genome Database

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Gene: CD274 (CD274 molecule) Chlorocebus sabaeus
Analyze
Symbol: CD274
Name: CD274 molecule
RGD ID: 18676368
Description: ENCODES a protein that exhibits receptor ligand activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN negative regulation of activated T cell proliferation (ortholog); negative regulation of CD4-positive, alpha-beta T cell proliferation (ortholog); negative regulation of CD8-positive, alpha-beta T cell activation (ortholog); ASSOCIATED WITH acute myocarditis (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cell surface (ortholog); early endosome membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: programmed cell death 1 ligand 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,038,844 - 74,060,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,041,767 - 74,056,806 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603862,428,363 - 62,448,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myocarditis  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
allergic disease  (ISO)
alveolar echinococcosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
autoimmune hepatitis  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chlamydia pneumonia  (ISO)
chromosome 9p deletion syndrome  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
colon cancer  (ISO)
Corneal Graft Rejection  (ISO)
Coxsackievirus Infections  (ISO)
cryptococcal meningitis  (ISO)
cutaneous leishmaniasis  (ISO)
Disease Progression  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fungemia  (ISO)
Hepatic Echinococcosis  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
herpes simplex virus keratitis  (ISO)
histoplasmosis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
influenza  (ISO)
invasive ductal carcinoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
lymphocytic choriomeningitis  (ISO)
lymphoma  (ISO)
melanoma  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Neoplasm Metastasis  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
papillomavirus infectious disease  (ISO)
periodontitis  (ISO)
pre-eclampsia  (ISO)
primary progressive multiple sclerosis  (ISO)
pulmonary tuberculosis  (ISO)
rabies  (ISO)
Radiation-Induced Neoplasms  (ISO)
Recurrence  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retroviridae Infections  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
substance-related disorder  (ISO)
Thymus Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
Viral Bronchiolitis  (ISO)
viral encephalitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CD274
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,038,844 - 74,060,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,041,767 - 74,056,806 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603862,428,363 - 62,448,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CD274
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3895,450,542 - 5,470,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl95,450,503 - 5,470,566 (+)EnsemblGRCh38hg38GRCh38
GRCh3795,450,542 - 5,470,554 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3695,440,559 - 5,458,477 (+)NCBINCBI36Build 36hg18NCBI36
Celera95,376,139 - 5,396,204 (+)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef95,406,210 - 5,426,274 (+)NCBIHuRef
CHM1_195,450,664 - 5,470,759 (+)NCBICHM1_1
T2T-CHM13v2.095,455,669 - 5,475,674 (+)NCBIT2T-CHM13v2.0
Cd274
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,339,428 - 29,365,495 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,344,855 - 29,365,495 (+)EnsemblGRCm39 Ensembl
GRCm381929,362,107 - 29,388,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,367,455 - 29,388,095 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,441,928 - 29,462,585 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361929,433,452 - 29,454,092 (+)NCBIMGSCv36mm8
Celera1930,144,050 - 30,164,685 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.88NCBI
Cd274
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,526,215 - 236,549,956 (+)NCBIGRCr8
mRatBN7.21227,116,674 - 227,137,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,116,649 - 227,134,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,523,534 - 235,535,346 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,453,199 - 242,465,011 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,269,986 - 235,282,673 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,519,890 - 247,539,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,519,939 - 247,537,943 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,768,528 - 254,788,292 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,053,607 - 233,065,384 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1224,273,306 - 224,285,083 (+)NCBICelera
Cytogenetic Map1q52NCBI
Cd274
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554349,487,315 - 9,505,904 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554349,487,309 - 9,508,366 (+)NCBIChiLan1.0ChiLan1.0
CD274
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211119,102,245 - 119,122,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19119,108,194 - 119,128,540 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v095,269,270 - 5,289,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.195,454,391 - 5,474,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,454,391 - 5,474,402 (+)Ensemblpanpan1.1panPan2
CD274
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,461,735 - 93,605,772 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,585,518 - 93,603,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,993,732 - 94,011,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0194,015,405 - 94,159,596 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,139,343 - 94,159,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,771,527 - 93,789,533 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,496,313 - 93,514,317 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0194,260,510 - 94,278,519 (+)NCBIUU_Cfam_GSD_1.0
Cd274
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947141,675,278 - 141,693,582 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936539132,868 - 143,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936539132,870 - 145,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD274
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,660,041 - 216,792,724 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,646,378 - 216,792,731 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,395,402 - 242,416,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Cd274
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247369,996,156 - 10,013,814 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247369,991,851 - 10,017,047 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 14
Low 36 6 59
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000006943   ⟹   ENSCSAP00000005140
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1274,041,767 - 74,056,806 (-)Ensembl
RefSeq Acc Id: XM_007969332   ⟹   XP_007967523
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11274,039,590 - 74,058,401 (-)NCBI
Vero_WHO_p1.0NW_02366603862,431,059 - 62,448,555 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007969335   ⟹   XP_007967526
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11274,038,844 - 74,058,402 (-)NCBI
Vero_WHO_p1.0NW_02366603862,428,363 - 62,448,546 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007967523 (Get FASTA)   NCBI Sequence Viewer  
  XP_007967526 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005140
  ENSCSAP00000005140.1
Reference Protein Sequences
RefSeq Acc Id: XP_007967526   ⟸   XM_007969335
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R951 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007967523   ⟸   XM_007969332
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R951 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005140   ⟸   ENSCSAT00000006943


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008879 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006943.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CD80_C2-set UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
NCBI Gene CD274 ENTREZGENE
PANTHER PROGRAMMED CELL DEATH 1 LIGAND 1 UniProtKB/TrEMBL
  T-LYMPHOCYTE ACTIVATION ANTIGEN UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0D9R951 ENTREZGENE, UniProtKB/TrEMBL