Umodl1 (uromodulin-like 1) - Rat Genome Database

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Gene: Umodl1 (uromodulin-like 1) Rattus norvegicus
Analyze
Symbol: Umodl1
Name: uromodulin-like 1
RGD ID: 1566039
Description: Predicted to enable calcium ion binding activity and peptidase inhibitor activity. Predicted to act upstream of or within several processes, including cellular response to gonadotropin-releasing hormone; regulation of granulosa cell apoptotic process; and regulation of ovarian follicle development. Predicted to be located in external side of plasma membrane. Predicted to be active in cell surface and extracellular space. Orthologous to human UMODL1 (uromodulin like 1); INTERACTS WITH bisphenol A; glyphosate; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC365544; RGD1566039; similar to uromodulin-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,029,025 - 9,088,510 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl209,029,128 - 9,086,613 (+)EnsemblGRCr8
mRatBN7.2209,027,751 - 9,087,133 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,025,724 - 9,087,146 (+)EnsemblmRatBN7.2
Rnor_6.0209,643,509 - 9,703,091 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,643,612 - 9,701,170 (+)Ensemblrn6Rnor6.0
Rnor_5.02011,825,676 - 11,882,918 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4209,275,199 - 9,348,637 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2010,553,867 - 10,613,203 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16026467   PMID:23190605  


Genomics

Comparative Map Data
Umodl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,029,025 - 9,088,510 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl209,029,128 - 9,086,613 (+)EnsemblGRCr8
mRatBN7.2209,027,751 - 9,087,133 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,025,724 - 9,087,146 (+)EnsemblmRatBN7.2
Rnor_6.0209,643,509 - 9,703,091 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,643,612 - 9,701,170 (+)Ensemblrn6Rnor6.0
Rnor_5.02011,825,676 - 11,882,918 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4209,275,199 - 9,348,637 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2010,553,867 - 10,613,203 (+)NCBICelera
Cytogenetic Map20p12NCBI
UMODL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,062,877 - 42,142,996 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,062,959 - 42,143,453 (+)Ensemblhg38GRCh38
GRCh372143,482,986 - 43,563,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,364,495 - 42,436,174 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342142,356,136 - 42,436,174NCBI
Celera2128,638,970 - 28,710,624 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2128,900,578 - 28,980,340 (+)NCBIHuRef
CHM1_12143,043,890 - 43,123,429 (+)NCBICHM1_1
T2T-CHM13v2.02140,453,189 - 40,533,058 (+)NCBIT2T-CHM13v2.0
Umodl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,173,614 - 31,229,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,173,614 - 31,229,684 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381730,954,648 - 31,010,710 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1730,954,640 - 31,010,710 (+)Ensemblmm10GRCm38
MGSCv371731,091,628 - 31,147,655 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361730,681,691 - 30,737,722 (+)NCBIMGSCv36mm8
Celera1731,870,736 - 31,927,026 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Umodl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,508,471 - 39,548,147 (-)Ensembl
ChiLan1.0NW_00495540739,508,526 - 39,555,604 (-)NCBIChiLan1.0ChiLan1.0
UMODL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,141,949 - 38,209,953 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12132,996,103 - 33,064,340 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,394,457 - 28,462,082 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,717,761 - 41,788,042 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,717,761 - 41,783,172 (+)EnsemblpanPan2panpan1.1
UMODL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,452,008 - 36,510,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,449,660 - 36,510,683 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3135,603,646 - 35,662,326 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03135,969,003 - 36,027,563 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3135,966,430 - 36,024,345 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13135,862,342 - 35,920,200 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03135,842,287 - 35,901,010 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,336,781 - 36,394,825 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Umodl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,681,967 - 35,736,740 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365001,732,481 - 1,785,720 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365001,732,481 - 1,785,711 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UMODL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,425,454 - 205,491,629 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113205,425,338 - 205,494,492 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213215,759,707 - 215,829,154 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UMODL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,894,102 - 86,023,577 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,959,746 - 86,019,950 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605413,753,923 - 13,885,886 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Umodl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,238,299 - 28,282,699 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474528,236,121 - 28,282,696 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Umodl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1182,862,130 - 2,919,791 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Umodl1
627 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:94
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000042989, ENSRNOT00000050744
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
D20Mgh5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8209,041,099 - 9,041,205 (+)Marker Load Pipeline
mRatBN7.2209,039,719 - 9,039,825 (+)MAPPERmRatBN7.2
Rnor_6.0209,655,642 - 9,655,747NCBIRnor6.0
Rnor_5.02011,836,888 - 11,836,993UniSTSRnor5.0
RGSC_v3.4209,301,974 - 9,302,078RGDRGSC3.4
RGSC_v3.4209,301,974 - 9,302,079UniSTSRGSC3.4
Celera2010,565,531 - 10,565,636UniSTS
RGSC_v3.1209,302,201 - 9,302,305RGD
RH 3.4 Map20118.7RGD
RH 3.4 Map20118.7UniSTS
RH 2.0 Map20128.5RGD
SHRSP x BN Map208.03RGD
Cytogenetic Map20p12UniSTS
BE106532  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,086,902 - 9,087,064 (+)MAPPERmRatBN7.2
Rnor_6.0209,702,861 - 9,703,022NCBIRnor6.0
Rnor_5.02011,882,688 - 11,882,849UniSTSRnor5.0
RGSC_v3.4209,350,328 - 9,350,489UniSTSRGSC3.4
Celera2010,612,973 - 10,613,134UniSTS
RH 3.4 Map20118.5UniSTS
UniSTS:259168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,077,290 - 9,077,762 (+)MAPPERmRatBN7.2
Rnor_6.0209,693,178 - 9,693,649NCBIRnor6.0
Rnor_5.02011,873,005 - 11,873,476UniSTSRnor5.0
RGSC_v3.4209,340,716 - 9,341,187UniSTSRGSC3.4
Celera2010,603,361 - 10,603,832UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 1 15 100 42 39 17 55 17 6 179 86 9 86 62 88 22 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000050744   ⟹   ENSRNOP00000045256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,029,128 - 9,086,613 (+)Ensembl
mRatBN7.2 Ensembl209,025,724 - 9,087,146 (+)Ensembl
Rnor_6.0 Ensembl209,643,612 - 9,701,170 (+)Ensembl
RefSeq Acc Id: XM_039099227   ⟹   XP_038955155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,029,025 - 9,088,510 (+)NCBI
mRatBN7.2209,027,751 - 9,087,133 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001418964 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955155 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96994 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045256
  ENSRNOP00000045256.7
Ensembl Acc Id: ENSRNOP00000045256   ⟸   ENSRNOT00000050744
RefSeq Acc Id: XP_038955155   ⟸   XM_039099227

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7D3-F1-model_v2 AlphaFold F1M7D3 1-1325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566039 AgrOrtholog
BioCyc Gene G2FUF-4334 BioCyc
Ensembl Genes ENSRNOG00000001157 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050744 ENTREZGENE
  ENSRNOT00000050744.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.4100 UniProtKB/TrEMBL
  4.10.75.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/TrEMBL
InterPro EG-like_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Elafin-like_sf UniProtKB/TrEMBL
  EMI_domain UniProtKB/TrEMBL
  Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  Whey_acidic_protein_4-diS_core UniProtKB/TrEMBL
  ZP-C UniProtKB/TrEMBL
  ZP-C UniProtKB/TrEMBL
  ZP-N UniProtKB/TrEMBL
  ZP_chr UniProtKB/TrEMBL
  ZP_dom UniProtKB/TrEMBL
NCBI Gene 365544 ENTREZGENE
PANTHER ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/TrEMBL
  UROMODULIN-LIKE 1 UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
  Zona_pellucida UniProtKB/TrEMBL
  ZP-N UniProtKB/TrEMBL
PhenoGen Umodl1 PhenoGen
PRINTS ZPELLUCIDA UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  EMI UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
  ZP_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001157 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  SM00241 UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  FN_III-like UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
UniProt F1M7D3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Umodl1  uromodulin-like 1  RGD1566039_predicted  similar to uromodulin-like 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566039_predicted  similar to uromodulin-like 1 (predicted)  LOC365544  similar to uromodulin-like 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365544  similar to uromodulin-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL