Nkap (NFKB activating protein) - Rat Genome Database

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Gene: Nkap (NFKB activating protein) Rattus norvegicus
Analyze
Symbol: Nkap
Name: NFKB activating protein
RGD ID: 1565955
Description: Predicted to enable chromatin DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of alpha-beta T cell differentiation. Predicted to act upstream of or within hemopoiesis and somatic stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human NKAP (NFKB activating protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2610020o08rik; NF-kappa-B-activating protein; nuclear NF-kappaB activating protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,238,714 - 121,258,360 (+)NCBIGRCr8
mRatBN7.2X116,373,031 - 116,392,677 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,372,839 - 116,394,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX118,476,600 - 118,496,278 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,045,736 - 122,065,413 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,591,795 - 119,611,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,751,196 - 123,770,595 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,751,089 - 123,770,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X123,887,476 - 123,907,122 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,762,215 - 7,781,862 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX115,600,861 - 115,620,299 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NkapRatMarfanoid Mental Retardation Syndrome, Autosomal  ISONKAP (Homo sapiens)155641252DNA:missense mutations:exon 8-9:multiple (human)RGD 
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NkapRatautistic disorder  ISONKAP (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
NkapRatautosomal hemophilia A  ISONKAP (Homo sapiens)8554872ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA AClinVarPMID:31690835
NkapRatDanon disease  ISONKAP (Homo sapiens)8554872ClinVar Annotator: match by term: Danon diseaseClinVarPMID:28492532
NkapRatDEVELOPMENTAL DELAY, IMPAIRED GROWTH, DYSMORPHIC FACIES, AND AXONAL NEUROPATHY  ISONKAP (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental delay more ...ClinVarPMID:25741868
NkapRatDevelopmental Disabilities  ISONKAP (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVar 
NkapRatfactor VIII deficiency  ISONKAP (Homo sapiens)8554872ClinVar Annotator: match by term: Factor 8 deficiency and congenitalClinVarPMID:31690835
NkapRatgenetic disease  ISONKAP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:31587868
NkapRatINTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, HACKMANN-DI DONATO TYPE  ISONKAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
NkapRatsyndromic X-linked intellectual disability 14  ISONKAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17236139 more ...
NkapRatsyndromic X-linked intellectual disability Cabezas type  ISONKAP (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual developmental disorder more ...ClinVarPMID:17236139 more ...
NkapRatsyndromic X-linked intellectual disability Lubs type  ISONKAP (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NkapRatINTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, HACKMANN-DI DONATO TYPE  ISONKAP (Homo sapiens)7240710 OMIM 

1 to 20 of 39 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NkapRat(1->4)-beta-D-glucan multiple interactionsISONkap (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of NKAP mRNACTDPMID:36331819
NkapRat1,2-dichloroethane decreases expressionISONkap (Mus musculus)6480464ethylene dichloride results in decreased expression of NKAP mRNACTDPMID:28960355
NkapRat1,2-dimethylhydrazine decreases expressionISONkap (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of NKAP mRNACTDPMID:22206623
NkapRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of NKAP mRNACTDPMID:32109520
NkapRat2,3,7,8-Tetrachlorodibenzofuran increases expressionEXP 64804642 more ...CTDPMID:32109520
NkapRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of NKAP mRNACTDPMID:21346803
NkapRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of NKAP mRNACTDPMID:21346803
NkapRatacetamide decreases expressionEXP 6480464acetamide results in decreased expression of NKAP mRNACTDPMID:31881176
NkapRataflatoxin B1 increases expressionISONkap (Mus musculus)6480464Aflatoxin B1 results in increased expression of NKAP mRNACTDPMID:19770486
NkapRatarsenite(3-) multiple interactionsISONKAP (Homo sapiens)6480464arsenite promotes the reaction [G3BP1 protein binds to NKAP mRNA]CTDPMID:32406909
NkapRatbenzo[a]pyrene affects methylationISONKAP (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of NKAP exon and Benzo(a)pyrene affects the methylation of NKAP promoterCTDPMID:27901495
NkapRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of NKAP mRNACTDPMID:25181051
NkapRatbisphenol A affects expressionISONKAP (Homo sapiens)6480464bisphenol A affects the expression of NKAP mRNACTDPMID:30903817
NkapRatbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of NKAP geneCTDPMID:28505145
NkapRatbisphenol AF decreases expressionISONkap (Mus musculus)6480464bisphenol AF results in decreased expression of NKAP proteinCTDPMID:37216864
NkapRatchloroprene increases expressionEXP 6480464Chloroprene results in increased expression of NKAP mRNACTDPMID:23125180
NkapRatcopper(II) sulfate decreases expressionISONKAP (Homo sapiens)6480464Copper Sulfate results in decreased expression of NKAP mRNACTDPMID:19549813
NkapRatcoumarin affects phosphorylationISONKAP (Homo sapiens)6480464coumarin affects the phosphorylation of NKAP proteinCTDPMID:35688186
NkapRatcyclosporin A increases expressionISONKAP (Homo sapiens)6480464Cyclosporine results in increased expression of NKAP mRNACTDPMID:25562108 and PMID:27989131
NkapRatdicrotophos decreases expressionISONKAP (Homo sapiens)6480464dicrotophos results in decreased expression of NKAP mRNACTDPMID:28302478

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Biological Process
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NkapRatgranulocyte differentiation acts_upstream_of_or_withinISONkap (Mus musculus)1624291MGI:2176073 more ...RGDPMID:20610818
NkapRatgranulocyte differentiation acts_upstream_of_or_withinIEAUniProtKB:Q9D0F4 and ensembl:ENSMUSP000000165531600115GO_REF:0000107EnsemblGO_REF:0000107
NkapRathematopoietic stem cell proliferation acts_upstream_of_or_withinISONkap (Mus musculus)1624291MGI:2176073 more ...RGDPMID:20610818
NkapRathematopoietic stem cell proliferation acts_upstream_of_or_withinIEAUniProtKB:Q9D0F4 and ensembl:ENSMUSP000000165531600115GO_REF:0000107EnsemblGO_REF:0000107
NkapRathemopoiesis acts_upstream_of_or_withinISONkap (Mus musculus)1624291MGI:3765313 more ...RGDPMID:20610818
NkapRathemopoiesis acts_upstream_of_or_withinIEAUniProtKB:Q9D0F4 and ensembl:ENSMUSP000000165531600115GO_REF:0000107EnsemblGO_REF:0000107
NkapRatnegative regulation of DNA-templated transcription involved_inISONKAP (Homo sapiens)1624291 PMID:19409814RGDPMID:19409814
NkapRatnegative regulation of DNA-templated transcription involved_inIBAMGI:1914300 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
NkapRatnegative regulation of DNA-templated transcription involved_inISSUniProtKB:Q8N5F71600115GO_REF:0000024UniProtGO_REF:0000024
NkapRatnegative regulation of transcription by RNA polymerase II involved_inISSUniProtKB:Q8N5F71600115GO_REF:0000024UniProtGO_REF:0000024
NkapRatnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIEAUniProtKB:Q9D0F4 and ensembl:ENSMUSP000000165531600115GO_REF:0000107EnsemblGO_REF:0000107
NkapRatnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISONkap (Mus musculus)1624291MGI:2176073 more ...RGDPMID:20610818
NkapRatnegative regulation of transcription by RNA polymerase II involved_inISONKAP (Homo sapiens)1624291 PMID:31587868RGDPMID:31587868
NkapRatNotch signaling pathway involved_inIEAUniProtKB-KW:KW-09141600115GO_REF:0000043UniProtGO_REF:0000043
NkapRatpositive regulation of alpha-beta T cell differentiation involved_inISSUniProtKB:Q8N5F71600115GO_REF:0000024UniProtGO_REF:0000024
NkapRatpositive regulation of alpha-beta T cell differentiation involved_inISONKAP (Homo sapiens)1624291 PMID:19409814RGDPMID:19409814
NkapRatsomatic stem cell population maintenance acts_upstream_of_or_withinISONkap (Mus musculus)1624291MGI:3765313 more ...RGDPMID:20610818
NkapRatsomatic stem cell population maintenance acts_upstream_of_or_withinIEAUniProtKB:Q9D0F4 and ensembl:ENSMUSP000000165531600115GO_REF:0000107EnsemblGO_REF:0000107
NkapRatT cell differentiation in thymus acts_upstream_of_or_withinISONkap (Mus musculus)1624291MGI:3765313 more ...RGDPMID:20610818
NkapRatT cell differentiation in thymus acts_upstream_of_or_withinIEAUniProtKB:Q9D0F4 and ensembl:ENSMUSP000000165531600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 20 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NkapRatcytosol located_inISONKAP (Homo sapiens)1624291 RGDGO_REF:0000052
NkapRatnucleoplasm located_inISONKAP (Homo sapiens)1624291 RGDGO_REF:0000052
NkapRatnucleus is_active_inIBAFB:FBgn0039488 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
NkapRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
NkapRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  


#
Reference Title
Reference Citation
1. Missense Mutations in NKAP Cause a Disorder of Transcriptional Regulation Characterized by Marfanoid Habitus and Cognitive Impairment. Fiordaliso SK, etal., Am J Hum Genet. 2019 Nov 7;105(5):987-995. doi: 10.1016/j.ajhg.2019.09.009. Epub 2019 Oct 3.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
PMID:15489334   PMID:19409814   PMID:20610818   PMID:22681889   PMID:24270810  



Nkap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,238,714 - 121,258,360 (+)NCBIGRCr8
mRatBN7.2X116,373,031 - 116,392,677 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,372,839 - 116,394,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX118,476,600 - 118,496,278 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,045,736 - 122,065,413 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,591,795 - 119,611,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,751,196 - 123,770,595 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,751,089 - 123,770,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X123,887,476 - 123,907,122 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,762,215 - 7,781,862 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX115,600,861 - 115,620,299 (+)NCBICelera
Cytogenetic MapXq35NCBI
NKAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X119,920,672 - 119,943,751 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX119,920,672 - 119,943,751 (-)EnsemblGRCh38hg38GRCh38
GRCh37X119,054,635 - 119,077,714 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,943,051 - 118,961,763 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX119,513,642 - 119,532,364 (-)NCBICelera
Cytogenetic MapXq24NCBI
HuRefX108,555,462 - 108,574,439 (-)NCBIHuRef
CHM1_1X118,970,042 - 118,988,764 (-)NCBICHM1_1
T2T-CHM13v2.0X118,295,798 - 118,318,877 (-)NCBIT2T-CHM13v2.0
Nkap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X36,390,416 - 36,414,399 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX36,390,448 - 36,414,399 (+)EnsemblGRCm39 Ensembl
GRCm38X37,126,763 - 37,150,746 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX37,126,795 - 37,150,746 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X34,666,758 - 34,690,741 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X33,558,261 - 33,582,191 (+)NCBIMGSCv36mm8
CeleraX23,850,391 - 23,874,368 (+)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX21.54NCBI
Nkap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955534106,122 - 119,344 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955534106,122 - 119,508 (+)NCBIChiLan1.0ChiLan1.0
NKAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X119,332,833 - 119,351,220 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X119,336,438 - 119,354,814 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X108,988,561 - 109,006,946 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X119,384,489 - 119,402,943 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX119,384,655 - 119,402,775 (-)Ensemblpanpan1.1panPan2
NKAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X91,922,326 - 91,956,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX91,923,550 - 91,956,414 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX77,994,979 - 78,030,230 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X93,659,144 - 93,694,394 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX93,660,195 - 93,694,327 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X91,112,068 - 91,147,313 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X92,871,557 - 92,906,785 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X92,600,530 - 92,635,783 (-)NCBIUU_Cfam_GSD_1.0
Nkap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X90,945,876 - 90,962,816 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647910,024,705 - 10,041,590 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647910,024,674 - 10,041,738 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX98,256,632 - 98,276,773 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,233,504 - 98,276,839 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X113,335,166 - 113,355,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606532,710,929 - 32,731,311 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248953,840,846 - 3,849,390 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Nkap
68 total Variants

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000047912
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat

1 to 10 of 11 rows
D20S1001  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,392,481 - 116,392,581 (+)MAPPERmRatBN7.2
Rnor_6.0X123,770,400 - 123,770,499NCBIRnor6.0
Rnor_5.0X123,906,927 - 123,907,026UniSTSRnor5.0
RGSC_v3.4X7,762,311 - 7,762,410UniSTSRGSC3.4
CeleraX115,620,104 - 115,620,203UniSTS
Cytogenetic MapXq12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000089883   ⟹   ENSRNOP00000073123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,372,839 - 116,394,945 (+)Ensembl
Rnor_6.0 EnsemblX123,751,293 - 123,770,511 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092384   ⟹   ENSRNOP00000075780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,372,929 - 116,380,390 (+)Ensembl
Rnor_6.0 EnsemblX123,751,089 - 123,765,639 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092554   ⟹   ENSRNOP00000075909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,770,337 - 123,770,595 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,751,496 - 123,760,081 (+)Ensembl
RefSeq Acc Id: NM_001024872   ⟹   NP_001020043
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,238,714 - 121,258,360 (+)NCBI
mRatBN7.2X116,373,031 - 116,392,677 (+)NCBI
Rnor_6.0X123,751,196 - 123,770,595 (+)NCBI
Rnor_5.0X123,887,476 - 123,907,122 (+)NCBI
RGSC_v3.4X7,762,215 - 7,781,862 (-)RGD
CeleraX115,600,861 - 115,620,299 (+)RGD
Sequence:
Protein RefSeqs NP_001020043 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98011 (Get FASTA)   NCBI Sequence Viewer  
  EDM10839 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073123
GenBank Protein Q4V7C9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020043   ⟸   NM_001024872
- UniProtKB: Q4V7C9 (UniProtKB/Swiss-Prot),   A6JMH7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075780   ⟸   ENSRNOT00000092384
Ensembl Acc Id: ENSRNOP00000075909   ⟸   ENSRNOT00000092554
Ensembl Acc Id: ENSRNOP00000073123   ⟸   ENSRNOT00000089883
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7C9-F1-model_v2 AlphaFold Q4V7C9 1-415 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701988
Promoter ID:EPDNEW_R12512
Type:initiation region
Name:Nkap_1
Description:NFKB activating protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12513  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X123,751,119 - 123,751,179EPDNEW
RGD ID:13701994
Promoter ID:EPDNEW_R12513
Type:single initiation site
Name:Nkap_2
Description:NFKB activating protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12512  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X123,751,285 - 123,751,345EPDNEW


1 to 19 of 19 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-1295 BioCyc
Ensembl Genes ENSRNOG00000053813 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000089883 ENTREZGENE
IMAGE_CLONE IMAGE:7454308 IMAGE-MGC_LOAD
InterPro NKAP UniProtKB/Swiss-Prot
  NKAP_C UniProtKB/Swiss-Prot
KEGG Report rno:298342 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116158 IMAGE-MGC_LOAD
NCBI Gene 298342 ENTREZGENE
PANTHER NF-KAPPA-B-ACTIVATING PROTEIN UniProtKB/Swiss-Prot
  PTHR13087 UniProtKB/Swiss-Prot
Pfam NKAP UniProtKB/Swiss-Prot
  Nkap_C UniProtKB/Swiss-Prot
PhenoGen Nkap PhenoGen
RatGTEx ENSRNOG00000053813 RatGTEx
UniProt A0A0G2K4P5_RAT UniProtKB/TrEMBL
  A0A0U1RRR3_RAT UniProtKB/TrEMBL
  A6JMH7 ENTREZGENE, UniProtKB/TrEMBL
  NKAP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Nkap  NFKB activating protein  2610020o08rik  nuclear NF-kappaB activating protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 2610020o08rik  nuclear NF-kappaB activating protein      Symbol and Name status set to provisional 70820 PROVISIONAL