Nkap (NFKB activating protein) - Rat Genome Database

Name: Nkap
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Nkap (NFKB activating protein) Rattus norvegicus

Analyze

Symbol:

Nkap

Name:

NFKB activating protein

RGD ID:

1565955

Description:

Predicted to enable chromatin DNA binding activity; mRNA binding activity; and molecular adaptor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of alpha-beta T cell differentiation. Predicted to act upstream of or within hemopoiesis and somatic stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human NKAP (NFKB activating protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

2610020o08rik; NF-kappa-B-activating protein; nuclear NF-kappaB activating protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NKAP (NFKB activating protein)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Nkap (NFKB activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nkap (NFKB activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NKAP (NFKB activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NKAP (NFKB activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nkap (NFKB activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NKAP (NFKB activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NKAP (NFKB activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nkap (NFKB activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NKAPL (NFKB activating protein like)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Nkap (NFKB activating protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NKAP (NFKB activating protein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nkap (NFKB activating protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	let-504	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6066	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nkap	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	121,238,714 - 121,258,360 (+)	NCBI		GRCr8
mRatBN7.2	X	116,373,031 - 116,392,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	116,372,839 - 116,394,945 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	118,476,600 - 118,496,278 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	122,045,736 - 122,065,413 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	119,591,795 - 119,611,472 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	123,751,196 - 123,770,595 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	123,751,089 - 123,770,595 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	123,887,476 - 123,907,122 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	7,762,215 - 7,781,862 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	115,600,861 - 115,620,299 (+)	NCBI		Celera
Cytogenetic Map	X	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Danon disease (ISO)

DEVELOPMENTAL DELAY, IMPAIRED GROWTH, DYSMORPHIC FACIES, AND AXONAL NEUROPATHY (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, HACKMANN-DI DONATO TYPE (ISO)

Marfanoid Mental Retardation Syndrome, Autosomal (ISO)

syndromic X-linked intellectual disability 14 (ISO)

syndromic X-linked intellectual disability Cabezas type (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

chloroprene (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

dioxygen (EXP)

enzalutamide (ISO)

enzyme inhibitor (ISO)

furan (EXP)

methyl methanesulfonate (ISO)

nitrofen (EXP)

PCB138 (EXP)

perfluorooctane-1-sulfonic acid (ISO)

streptozocin (EXP)

titanium dioxide (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

granulocyte differentiation (IEA,ISO)

hematopoietic stem cell proliferation (IEA,ISO)

hemopoiesis (ISO)

negative regulation of DNA-templated transcription (IBA,IEA,ISO,ISS)

negative regulation of transcription by RNA polymerase II (IEA,ISO,ISS)

Notch signaling pathway (IEA)

positive regulation of alpha-beta T cell differentiation (ISO,ISS)

somatic stem cell population maintenance (IEA,ISO)

T cell differentiation in thymus (IEA,ISO)

Cellular Component

cytosol (ISO)

nucleoplasm (ISO)

nucleus (IBA,IEA)

Molecular Function

chromatin binding (IBA,IEA,ISO,ISS)

chromatin DNA binding (IEA,ISO)

molecular adaptor activity (ISO)

mRNA binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Missense Mutations in NKAP Cause a Disorder of Transcriptional Regulation Characterized by Marfanoid Habitus and Cognitive Impairment.	Fiordaliso SK, etal., Am J Hum Genet. 2019 Nov 7;105(5):987-995. doi: 10.1016/j.ajhg.2019.09.009. Epub 2019 Oct 3.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:19409814	PMID:20610818	PMID:22681889	PMID:24270810

Genomics

Comparative Map Data

Nkap
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	121,238,714 - 121,258,360 (+)	NCBI		GRCr8
mRatBN7.2	X	116,373,031 - 116,392,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	116,372,839 - 116,394,945 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	118,476,600 - 118,496,278 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	122,045,736 - 122,065,413 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	119,591,795 - 119,611,472 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	123,751,196 - 123,770,595 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	123,751,089 - 123,770,595 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	123,887,476 - 123,907,122 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	7,762,215 - 7,781,862 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	115,600,861 - 115,620,299 (+)	NCBI		Celera
Cytogenetic Map	X	q35	NCBI

NKAP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	119,920,672 - 119,943,751 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	119,920,672 - 119,943,751 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	119,054,635 - 119,077,714 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	118,943,051 - 118,961,763 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	119,513,642 - 119,532,364 (-)	NCBI		Celera
Cytogenetic Map	X	q24	NCBI
HuRef	X	108,555,462 - 108,574,439 (-)	NCBI		HuRef
CHM1_1	X	118,970,042 - 118,988,764 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	118,295,798 - 118,318,877 (-)	NCBI		T2T-CHM13v2.0

Nkap
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	36,390,416 - 36,414,399 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	36,390,448 - 36,414,399 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	37,126,763 - 37,150,746 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	37,126,795 - 37,150,746 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	34,666,758 - 34,690,741 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	33,558,261 - 33,582,191 (+)	NCBI		MGSCv36	mm8
Celera	X	23,850,391 - 23,874,368 (+)	NCBI		Celera
Cytogenetic Map	X	A3.3	NCBI
cM Map	X	21.54	NCBI

Nkap
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955534	106,122 - 119,344 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955534	106,122 - 119,508 (+)	NCBI	ChiLan1.0	ChiLan1.0

NKAP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	119,332,833 - 119,351,220 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	119,336,438 - 119,354,814 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	108,988,561 - 109,006,946 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	119,384,489 - 119,402,943 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	119,384,655 - 119,402,775 (-)	Ensembl	panpan1.1		panPan2

NKAP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	91,922,326 - 91,956,566 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	91,923,550 - 91,956,414 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	77,994,979 - 78,030,230 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	93,659,144 - 93,694,394 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	93,660,195 - 93,694,327 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	91,112,068 - 91,147,313 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	92,871,557 - 92,906,785 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	92,600,530 - 92,635,783 (-)	NCBI		UU_Cfam_GSD_1.0

Nkap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	90,945,876 - 90,962,816 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	10,024,705 - 10,041,590 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	10,024,674 - 10,041,738 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NKAP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	98,256,632 - 98,276,773 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	98,233,504 - 98,276,839 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	113,335,166 - 113,355,494 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NKAP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666065	32,710,929 - 32,731,311 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nkap
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624895	3,840,846 - 3,849,390 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nkap
68 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	22
Count of miRNA genes:	22
Interacting mature miRNAs:	22
Transcripts:	ENSRNOT00000047912
Prediction methods:	Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat
724551	Glom1	Glomerulus QTL 1	2.8	0.0004	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	X	75294106	120294106	Rat
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	93956491	138956491	Rat
738025	Stresp3	Stress response QTL 3	4.61	0.0066	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	100567703	150256146	Rat
1598809	Memor15	Memory QTL 15	4.4		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	103312877	148312877	Rat
1598856	Memor1	Memory QTL 1	1.9		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	X	103312877	148312877	Rat
738029	Stresp2	Stress response QTL 2	3.4	0.0004	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	112934952	138400867	Rat
5685004	Bss104	Bone structure and strength QTL 104	3.9		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	X	113805422	126975220	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat

Markers in Region

D20S1001

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	116,392,481 - 116,392,581 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	123,770,400 - 123,770,499	NCBI	Rnor6.0
Rnor_5.0	X	123,906,927 - 123,907,026	UniSTS	Rnor5.0
RGSC_v3.4	X	7,762,311 - 7,762,410	UniSTS	RGSC3.4
Celera	X	115,620,104 - 115,620,203	UniSTS
Cytogenetic Map	X	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	27	41	25	19	25	5	7	74	33	34	11	5
Low		16	16	16		16	3	4		2	7		3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232052	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000089883 ⟹ ENSRNOP00000073123

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	116,372,839 - 116,394,945 (+)	Ensembl
Rnor_6.0 Ensembl	X	123,751,293 - 123,770,511 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092384 ⟹ ENSRNOP00000075780

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	116,372,929 - 116,380,390 (+)	Ensembl
Rnor_6.0 Ensembl	X	123,751,089 - 123,765,639 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092554 ⟹ ENSRNOP00000075909

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	123,770,337 - 123,770,595 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092564

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	123,751,496 - 123,760,081 (+)	Ensembl

RefSeq Acc Id:

NM_001024872 ⟹ NP_001020043

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	121,238,714 - 121,258,360 (+)	NCBI
mRatBN7.2	X	116,373,031 - 116,392,677 (+)	NCBI
Rnor_6.0	X	123,751,196 - 123,770,595 (+)	NCBI
Rnor_5.0	X	123,887,476 - 123,907,122 (+)	NCBI
RGSC_v3.4	X	7,762,215 - 7,781,862 (-)	RGD
Celera	X	115,600,861 - 115,620,299 (+)	RGD

Sequence:

show sequence

CGCTGCAAGCTCTAAGACCCTAGGTATCCGAGAACCTTTAGGGGACAAGGAGAGCGCCTCCTTG
TCCCGCCCCTTAGCCGGTTCAGCTCACACCACCATGGCTCCTGTGTCGGGCTCGCGTAGCCCTG
TACGGGAGGCCTCCGGGGGAAAGCGTCGCAGTTCGTCGAGGAGCCCCAAATCCATCAAATCTTC
CCGCTCCCCGCGATGTCGCCGGTCTCGCTCGCGCTCTTGTTCTCGGTTCGGTGACCGGAATGGC
CTCAGCCATTCGCTGAGTGGCTTCAGCCAAAGCTCTCGAAACCAATCTTATCGCTCCCGCTCTC
GATCGCGTTCTCGAGAACGGCCTTCTGCACAGCGGAGTGCCCCGTTCGCGTCTTCATCCTCGTC
CGCCTATTATGGCGGCTACTCGCGTCCCTACGGGGGTGACAAGCCATGGCCTAGCCTGCTGGAC
AAGGAAAGGGAGGAGAGTCTGCGGCAGAAGAGATTAAGTGAAAGAGAGAGGATTGGAGAATTGG
GAGCTCCTGAAGTTTGGGGACTTTCCCCAAAGAATCCTGAACCAGACTCTGATGAACATACACC
AGTAGAGGATGAAGAACCAAAGAAAAGCACTACTTCAGCATCTAGTTCGGAAGATGATAAGAAG
AAGAAAAGGAAATCTAGTCGTTCAAAAGAAAGAGCCAAGAAAAAGAGAAAGAAAAAGTCATCTA
AAAGAAAACATAAGAAGTATTCTGAAGATAGCGACAGTGACTCAGAGTCTGACACCGACTCTAG
TGATGAAGATTCAAAAAGAAGAGCAAAGAAAGCTAAGAAAAAGGAAAAGAAGAAGAAACGAAGA
GGGAAGAAATACAAGAAAAAGAAGTCTAAGAAAAACAGAAAGGAGTCCAGTGATTCAAGCTCTA
AAGAGTCCCAAGAAGAATTTCTAGAGAATCCGTGGAAGGATCGATCAAAGACAGAAGAACCATC
AGATCTGATTGGCCCAGAGGCTCCCAAAACACTTGCCTCCCAAGATGATAAGCCCTTGAACTAT
GGCCACGCCCTGTTACCTGGTGAAGGTGCAGCTATGGCTGAATATGTAAAAGCTGGCAAGCGTA
TCCCGAGAAGAGGTGAAATCGGCTTAACAAGTGAAGAGATCGCATCATTCGAATGTTCCGGTTA
TGTAATGAGCGGCAGCAGGCATCGCCGAATGGAGGCTGTCCGACTTCGGAAAGAGAACCAGATC
TACAGTGCCGATGAGAAGAGAGCCCTTGCCTCCTTTAACCAAGAAGAAAGACGGAAGAGGGAGA
ACAAGATTCTGGCCAGCTTTCGCGAGATGGTGTACAGAAAGACCAAAGGGAAGGATGACAAGTG
AGGGCTCTCTGACTTTGCAAGTGGACATTTTAACATCAAAAAGGAAATGTGGGTTCTAGACATA
AATACAAAAAGCTTATTGTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020043	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98011	(Get FASTA)	NCBI Sequence Viewer
	EDM10839	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000073123
	ENSRNOP00000073123.2
	ENSRNOP00000075780.2
GenBank Protein	Q4V7C9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001020043 ⟸ NM_001024872

- UniProtKB:

Q4V7C9 (UniProtKB/Swiss-Prot), A6JMH7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAPVSGSRSPVREASGGKRRSSSRSPKSIKSSRSPRCRRSRSRSCSRFGDRNGLSHSLSGFSQS
SRNQSYRSRSRSRSRERPSAQRSAPFASSSSSAYYGGYSRPYGGDKPWPSLLDKEREESLRQKR
LSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTSASSSEDDKKKKRKSSRSKER
AKKKRKKKSSKRKHKKYSEDSDSDSESDTDSSDEDSKRRAKKAKKKEKKKKRRGKKYKKKKSKK
NRKESSDSSSKESQEEFLENPWKDRSKTEEPSDLIGPEAPKTLASQDDKPLNYGHALLPGEGAA
MAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALAS
FNQEERRKRENKILASFREMVYRKTKGKDDK

hide sequence

RefSeq Acc Id:

ENSRNOP00000075780 ⟸ ENSRNOT00000092384

RefSeq Acc Id:

ENSRNOP00000075909 ⟸ ENSRNOT00000092554

RefSeq Acc Id:

ENSRNOP00000073123 ⟸ ENSRNOT00000089883

Protein Domains

NF-kappa-B-activating protein C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V7C9-F1-model_v2	AlphaFold	Q4V7C9	1-415	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701988

Promoter ID:

EPDNEW_R12512

Type:

initiation region

Name:

Nkap_1

Description:

NFKB activating protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R12513

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	123,751,119 - 123,751,179	EPDNEW

RGD ID:

13701994

Promoter ID:

EPDNEW_R12513

Type:

single initiation site

Name:

Nkap_2

Description:

NFKB activating protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R12512

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	123,751,285 - 123,751,345	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565955	AgrOrtholog
BioCyc Gene	G2FUF-1295	BioCyc
Ensembl Genes	ENSRNOG00000053813	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000089883	ENTREZGENE
	ENSRNOT00000089883.2	UniProtKB/TrEMBL
	ENSRNOT00000092384.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7454308	IMAGE-MGC_LOAD
InterPro	NKAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NKAP_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:298342	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116158	IMAGE-MGC_LOAD
NCBI Gene	298342	ENTREZGENE
PANTHER	NF-KAPPA-B-ACTIVATING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR13087	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	NKAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nkap_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nkap	PhenoGen
RatGTEx	ENSRNOG00000053813	RatGTEx
UniProt	A0A0G2K4P5_RAT	UniProtKB/TrEMBL
	A0A0U1RRR3_RAT	UniProtKB/TrEMBL
	A6JMH7	ENTREZGENE, UniProtKB/TrEMBL
	NKAP_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-26	Nkap	NFKB activating protein	2610020o08rik	nuclear NF-kappaB activating protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	2610020o08rik	nuclear NF-kappaB activating protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM