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Gene: Slc8b1 (solute carrier family 8 member B1) Rattus norvegicus

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Symbol:

Slc8b1

Name:

solute carrier family 8 member B1

RGD ID:

1565818

Description:

Enables protein homodimerization activity. Predicted to be involved in several processes, including calcium export from the mitochondrion; intracellular calcium ion homeostasis; and regulation of cardiac muscle cell membrane potential. Predicted to act upstream of or within calcium ion transmembrane transport and sodium ion transmembrane transport. Located in mitochondrial crista and sarcolemma. Orthologous to human SLC8B1 (solute carrier family 8 member B1); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC498185; na(+)/K(+)/Ca(2+)-exchange protein 6; similar to sodium/calcium exchanger protein; Slc24a6; sodium/calcium exchanger protein, mitochondrial; sodium/potassium/calcium exchanger 6; sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 (sodium/lithium/calcium exchanger), member 6; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6; solute carrier family 24 member 6; solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC8B1 (solute carrier family 8 member B1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc8b1 (solute carrier family 8 (sodium/lithium/calcium exchanger), member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc8b1 (solute carrier family 8 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC8B1 (solute carrier family 8 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC8B1 (solute carrier family 8 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc8b1 (solute carrier family 8 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC8B1 (solute carrier family 8 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC8B1 (solute carrier family 8 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc8b1 (solute carrier family 8 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slc8b1 (solute carrier family 8 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RNF216 (ring finger protein 216)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLC8B1 (solute carrier family 8 member B1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc8b1 (solute carrier family 8 (sodium/lithium/calcium exchanger), member B1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc8b1 (solute carrier family 8 member B1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12376	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12376	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ECM27	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ECM27	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YDL206W	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	ncx-10	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ncx-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ncx-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ncx-8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ncx-9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG13223	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG13223	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ncx-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14743	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14743	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14744	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5348	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc8b1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	slc8b1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,690,333 - 41,713,657 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	41,690,334 - 41,713,601 (-)	Ensembl				GRCr8
mRatBN7.2	12	36,029,759 - 36,053,087 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	36,029,760 - 36,053,031 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	37,208,956 - 37,232,225 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,820,175 - 37,843,444 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,872,639 - 36,895,908 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,566,980 - 41,590,294 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,566,981 - 41,590,244 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	43,421,506 - 43,444,143 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	37,227,844 - 37,250,698 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	37,689,943 - 37,713,214 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cerebral Hemorrhage (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (EXP)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clofibrate (ISO)

dichloroacetic acid (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenthion (ISO)

fipronil (EXP)

flutamide (EXP)

glufosinate (ISO)

hydralazine (ISO)

methotrexate (ISO)

methoxyacetic acid (EXP)

methylmercury chloride (EXP)

mono(2-ethylhexyl) phthalate (ISO)

Monobutylphthalate (EXP)

N-ethyl-N-nitrosourea (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

calcium export from the mitochondrion (IBA,IDA,IEA,ISO,ISS)

calcium ion transmembrane transport (ISO)

calcium ion transport (IEA)

glucose homeostasis (IEA,ISO,ISS)

intracellular calcium ion homeostasis (IBA)

mitochondrial calcium ion homeostasis (IEA,ISO,ISS)

mitochondrial calcium ion transmembrane transport (IEA,ISO,ISS)

monoatomic ion transport (IEA)

regulation of cardiac muscle cell membrane potential (IEA,ISO)

regulation of cytosolic calcium ion concentration (IEA,ISO,ISS)

regulation of insulin secretion (IEA,ISO,ISS)

regulation of lymphocyte chemotaxis (IEA,ISO,ISS)

regulation of store-operated calcium entry (IEA,ISO,ISS)

sodium ion transmembrane transport (ISO)

sodium ion transport (IEA)

transmembrane transport (IEA)

Cellular Component

membrane (IBA,IEA)

mitochondrial crista (IDA,IEA,ISO)

mitochondrial inner membrane (IDA,IEA)

mitochondrial membrane (IEA,ISO,ISS)

mitochondrion (IDA,IEA,ISO)

plasma membrane (IEA,ISO)

sarcolemma (IDA)

Molecular Function

antiporter activity (IEA)

calcium:sodium antiporter activity (IBA,IEA,ISO,ISS)

calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential (IEA,ISO,ISS)

identical protein binding (IDA)

protein homodimerization activity (IEA,IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6.	Cai X and Lytton J, J Biol Chem. 2004 Feb 13;279(7):5867-76. Epub 2003 Nov 18.
2.	Structure and mechanism of the mitochondrial calcium transporter NCLX.	Fan M, etal., Nature. 2025 Oct;646(8087):1272-1280. doi: 10.1038/s41586-025-09491-0. Epub 2025 Sep 10.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.	Palty R, etal., Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):436-41. doi: 10.1073/pnas.0908099107. Epub 2009 Dec 15.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Mitochondria as sensors and regulators of calcium signalling.	Rizzuto R, etal., Nat Rev Mol Cell Biol. 2012 Sep;13(9):566-78. doi: 10.1038/nrm3412. Epub 2012 Aug 1.
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11.	Alteration of intracellular calcium and its modulator SLC24A6 after experimental intracerebral hemorrhage.	Zheng M, etal., Acta Neurochir Suppl. 2013;118:169-73. doi: 10.1007/978-3-7091-1434-6_31.

Additional References at PubMed

PMID:15060069	PMID:15489334	PMID:23056385	PMID:24067497	PMID:24898248	PMID:27328625	PMID:28219928	PMID:28445457	PMID:29223733

Genomics

Comparative Map Data

Slc8b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,690,333 - 41,713,657 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	41,690,334 - 41,713,601 (-)	Ensembl				GRCr8
mRatBN7.2	12	36,029,759 - 36,053,087 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	36,029,760 - 36,053,031 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	37,208,956 - 37,232,225 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,820,175 - 37,843,444 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,872,639 - 36,895,908 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,566,980 - 41,590,294 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,566,981 - 41,590,244 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	43,421,506 - 43,444,143 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	37,227,844 - 37,250,698 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	37,689,943 - 37,713,214 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

SLC8B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	113,298,771 - 113,335,109 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	113,298,759 - 113,359,502 (-)	Ensembl			hg38	GRCh38
GRCh37	12	113,736,576 - 113,772,914 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	112,220,954 - 112,257,308 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	112,199,291 - 112,235,645	NCBI
Celera	12	113,363,396 - 113,399,748 (-)	NCBI		Celera
Cytogenetic Map	12	q24.13	NCBI
HuRef	12	110,749,040 - 110,785,386 (-)	NCBI		HuRef
CHM1_1	12	113,704,819 - 113,741,134 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	113,275,399 - 113,311,727 (-)	NCBI		T2T-CHM13v2.0

Slc8b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	120,649,233 - 120,672,089 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	120,649,233 - 120,672,089 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	120,511,168 - 120,534,024 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	120,511,168 - 120,534,024 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	120,961,201 - 120,984,033 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	120,771,809 - 120,794,636 (+)	NCBI		MGSCv36	mm8
Celera	5	117,595,553 - 117,618,613 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	60.63	NCBI

Slc8b1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	9,595,604 - 9,605,271 (-)	Ensembl
ChiLan1.0	NW_004955482	9,594,872 - 9,617,136 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC8B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	121,387,323 - 121,421,061 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	121,384,127 - 121,417,927 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	110,903,215 - 110,936,908 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	114,286,624 - 114,319,683 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	114,286,624 - 114,319,683 (-)	Ensembl			panPan2	panpan1.1

SLC8B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	10,662,491 - 10,688,182 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	10,662,208 - 10,687,629 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	10,784,902 - 10,810,095 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	10,906,960 - 10,932,125 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	10,906,963 - 10,932,067 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	10,880,877 - 10,906,061 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	10,943,518 - 10,968,703 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	10,992,669 - 11,017,851 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc8b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	148,663,425 - 148,682,942 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936668	3,160,148 - 3,181,814 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC8B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	38,773,407 - 38,808,265 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	38,773,396 - 38,808,261 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	41,272,619 - 41,288,609 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC8B1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	108,553,545 - 108,590,017 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	108,553,794 - 108,589,533 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	136,502,914 - 136,538,476 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc8b1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	19,168,834 - 19,178,783 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	19,158,395 - 19,179,450 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc8b1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	33,294,119 - 33,317,525 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc8b1
235 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	349
Count of miRNA genes:	200
Interacting mature miRNAs:	241
Transcripts:	ENSRNOT00000038736
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

RH130280

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	36,029,809 - 36,029,992 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	41,567,031 - 41,567,213	NCBI	Rnor6.0
Rnor_5.0	12	43,421,557 - 43,421,739	UniSTS	Rnor5.0
RGSC_v3.4	12	37,227,895 - 37,228,077	UniSTS	RGSC3.4
Celera	12	37,689,994 - 37,690,176	UniSTS
RH 3.4 Map	12	646.1	UniSTS
Cytogenetic Map	12	q16	UniSTS

RH131571

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	36,029,358 - 36,029,551 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	41,566,580 - 41,566,772	NCBI	Rnor6.0
Rnor_5.0	12	43,421,106 - 43,421,298	UniSTS	Rnor5.0
RGSC_v3.4	12	37,227,444 - 37,227,636	UniSTS	RGSC3.4
Celera	12	37,689,543 - 37,689,735	UniSTS
RH 3.4 Map	12	646.8	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001017488	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000038736 ⟹ ENSRNOP00000034026

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,690,334 - 41,713,601 (-)	Ensembl
mRatBN7.2 Ensembl	12	36,029,760 - 36,053,031 (-)	Ensembl
Rnor_6.0 Ensembl	12	41,566,981 - 41,590,244 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094097 ⟹ ENSRNOP00000096132

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,691,113 - 41,713,601 (-)	Ensembl
mRatBN7.2 Ensembl	12	36,030,539 - 36,053,031 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094252 ⟹ ENSRNOP00000095205

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,691,113 - 41,713,601 (-)	Ensembl
mRatBN7.2 Ensembl	12	36,030,539 - 36,053,031 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095087 ⟹ ENSRNOP00000096275

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,691,063 - 41,713,601 (-)	Ensembl
mRatBN7.2 Ensembl	12	36,030,489 - 36,053,031 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095422 ⟹ ENSRNOP00000086798

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,691,113 - 41,713,601 (-)	Ensembl
mRatBN7.2 Ensembl	12	36,030,539 - 36,053,031 (-)	Ensembl

RefSeq Acc Id:

NM_001017488 ⟹ NP_001017488

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,690,333 - 41,713,601 (-)	NCBI
mRatBN7.2	12	36,029,759 - 36,053,031 (-)	NCBI
Rnor_6.0	12	41,566,980 - 41,590,244 (-)	NCBI
Rnor_5.0	12	43,421,506 - 43,444,143 (-)	NCBI
RGSC_v3.4	12	37,227,844 - 37,250,698 (-)	RGD
Celera	12	37,689,943 - 37,713,214 (-)	RGD

Sequence:

show sequence

GTTGTGGCGCTGGCTGTCCTAGCTAGAGGAAGACTCCAGGCTCTCGTACCCAGGCCCCACCCGA
GGCACTGGAGTGGCCAACCCGCGGAAACTCAAGTGAGCAGAGGGCGCTGGTCAGGCCCCAAGGG
GCCCATGGCAGGCAGATGGCTGGATCCGCTCTGGGCGCCTGGCTTCCTCTGTGTGGCTCTGATA
CTGGAGACGGCATCTGGGGCCGGAGATCTATCCACAAAAGCACATGGACACATCCAGTTTTCAG
CCAGAGGTGTCAACCAGACTGCCATGGCAGACTGCCGAGCTGTGTGTAGCCTGAACACATCTGA
CCGCTGTGACTTTGTCAAGAGGAATCCCGACTGCCACAGCGAGGGGGGCTACCTGGACTACCTC
AAGGGCATCTTCTGCTACTTCCCCCCCAACCTCCTCCCTCTGGCCATCACCCTCTATGTTTTCT
GGCTCCTTTACCTCTTTCTGATCCTCGGAGTCACCGCAGCCAAGTTCTTCTGCCCTAACTTGTC
AGCCATCTCCACCAGCCTCAAGCTCTCCCACAACGTGGCAGGTGTCACCTTCCTGGCCTTTGGA
AATGGCGCTCCAGACATTTTCAGTGCTCTCGTGGCTTTCTCAGACCCTCGTACTGCTGGCCTGG
CCATTGGGGCTCTGTTTGGTGCAGGGGTGCTGGTCACTACTGTGGTGGCTGGTGGCATCACCAT
CCTGCGTCCCTTCATGGCTGCCTCCAGGCCCTTCCTCAGGGACATCACTTTCTATATGGTGGCC
GTGTTCCTCACCTTCACCGCACTCTATCTCGGCAGGATCACACTGGTGTGGGCACTGGGTTACC
TGGGCCTCTATGTCTTCTATGTGGTCACGGTCATCATCTGCACTTGGGTCTACCAAAGGCAGCG
GAGCAGGTCTTTGGTCCACTCCATATCAGAGACACCAGAGCTACTGACTGATTCAGAAGAGGAT
CAGATGTCTTCCAACACCAACAGCTATGACTATGGAGAGGAGTACCGGCCTCTGCTGCTGGGTG
AGGAGACCACTGGGCAGATCCTGCTCCAAGCCCTGAATCCCTTGGACTACAGGAAGTGGAGAAC
TCAGTCGATATCCTGCAAGCTCCTGAAAGTGGCCAAGTTGCCTGTGGAGTTCTTGTTGCTGCTC
ACGGTACCCGTTGTGGACCCCGACAAGGATGATCGGAACTGGAAACGGCCACTCAACTGTCTGC
AGCTGGTCATCAGCCCCCTGGTCCTGGTCCTGACCCTGCAGTCGGGGGTCTATGGCATCTATGA
GATCGGTGGCCTCCTTCCTGTGTGGGCTGTAGTGGTGATCGTGGGCACAGCCCTGGCTTCAGTG
ACCTTCTTTGCCACATCTAACAGCGAACCCCCTAGACTGCACTGGCTCTTTGCTTTCCTGGGTT
TCCTGACCAGCGCCCTGTGGATCAATGCAGCTGCCACGGAGGTGGTGAACATCTTGCGGTCCCT
GGGCGTGGTCTTCCGTCTGAGCAACACCGTCCTAGGGCTGACCCTCCTGGCCTGGGGGAACAGC
ATTGGAGATGCGTTCTCAGATTTCACGCTGGCCCGCCAGGGATACCCTCGGATGGCCTTCTCTG
CCTGTTTTGGCGGCATCATCTTCAATATCCTGGTTGGTGTGGGACTGGGCTGCTTGCTACAAAT
TGTCCGGAGCCATGCTTCCGAGGTGAAGCTGGAACCAGACGGACTGCTGGTGTGGGTGCTGGCC
AGTGCGCTGGGCCTCAGCCTGGTCTTCTCCCTGGTCTCGGTTCCGCTCCAGTGTTTCCAGCTCA
GCAAGGCCTACGGCCTCTGCCTCCTCCTCTTCTATATATGTTTCATTGTGGTGGTCCTCCTCAC
GGAGTTCGGGGTGATTCACTTGAAGGCTGACTGAAGCTGCTTGGCCTGGAGGTTTAGGGGTGAT
TCTGCTAGCCTCCTGAGGAGAGAACAGGAGTGGGGTGGGGGAACCCCCTGTAGTTCCCATGTAG
CTCCTGAGAAGGTAGTCTCACTGCCGGAGCTCTGCACGGATGGGAAGGTCCTGGCTGCCGGCAC
CCAACAGCCTTAGCATGGGGATCTGGAGGCTGGTTTTGCTGGGGACAATCCCAAGTGGGAATGA
CAGATCTGAATGACAGCGGAGACTCTGGGGAGGGCAGCCCGTCAGCCCCCATCCCTGCTGGGCT
CTAGGCAGCCCTGTGGCTTCCTGGTAGGCTCTTCCACTCTCTGTGGTGTCAGCTGAGTCCCACG
CCAGCAGTGTTGGCTGAACAGACTCCGCCAGACTGGGTCTCTCAGCCTCTGTGTCAGGTCAGCC
AGAGGAAATAGGTCAAGTTGACAGCAGCAGCAGGCAGTAAGTACTGAGTGGGGTGCCTCAGAAG
CACCCAGGCTCTGCCCTTCCCAGTTGGTAGCTGCTGCATTGGACTGTGGGACTAAATCCTTCTA
GAACATTGTGTTCCAAACTCTGGCTCCCCGCATCTACAAGACAGGAGCCAGCTTGGGCCCTGTG
TCTACCTCAAGGGGAGCTGGGGAGTGGGATGACCCTCCCAGGGGTGTCTTGCAAGGGGTGTGAC
CAGCCTTTTAAAAATACCACTCATTCCCTGACCGCCTTCAGCTGTAACTAGGAGACTTGACTTG
TTGTTGTTGTTCAAAAATAAAAGACTCGTTAATTCAAGTGTAAAAAAAAAAAAAAAAAAAAAAA
AAAAA

hide sequence

RefSeq Acc Id:

XM_063271592 ⟹ XP_063127662

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,690,333 - 41,713,657 (-)	NCBI

RefSeq Acc Id:

XM_063271594 ⟹ XP_063127664

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,690,333 - 41,713,657 (-)	NCBI

RefSeq Acc Id:

XR_010056412

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,694,111 - 41,713,657 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001017488	(Get FASTA)	NCBI Sequence Viewer
	XP_063127662	(Get FASTA)	NCBI Sequence Viewer
	XP_063127664	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79350	(Get FASTA)	NCBI Sequence Viewer
	EDM13779	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000034026
	ENSRNOP00000034026.4
GenBank Protein	Q6AXS0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001017488 ⟸ NM_001017488
- Peptide Label:	precursor
- UniProtKB:	Q6AXS0 (UniProtKB/Swiss-Prot), A6J1J0 (UniProtKB/TrEMBL), A0A8I6A2Y3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGRWLDPLWAPGFLCVALILETASGAGDLSTKAHGHIQFSARGVNQTAMADCRAVCSLNTSDR CDFVKRNPDCHSEGGYLDYLKGIFCYFPPNLLPLAITLYVFWLLYLFLILGVTAAKFFCPNLSA ISTSLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPRTAGLAIGALFGAGVLVTTVVAGGITIL RPFMAASRPFLRDITFYMVAVFLTFTALYLGRITLVWALGYLGLYVFYVVTVIICTWVYQRQRS RSLVHSISETPELLTDSEEDQMSSNTNSYDYGEEYRPLLLGEETTGQILLQALNPLDYRKWRTQ SISCKLLKVAKLPVEFLLLLTVPVVDPDKDDRNWKRPLNCLQLVISPLVLVLTLQSGVYGIYEI GGLLPVWAVVVIVGTALASVTFFATSNSEPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLG VVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQIV RSHASEVKLEPDGLLVWVLASALGLSLVFSLVSVPLQCFQLSKAYGLCLLLFYICFIVVVLLTE FGVIHLKAD hide sequence

Ensembl Acc Id:

ENSRNOP00000034026 ⟸ ENSRNOT00000038736

Ensembl Acc Id:

ENSRNOP00000095205 ⟸ ENSRNOT00000094252

Ensembl Acc Id:

ENSRNOP00000086798 ⟸ ENSRNOT00000095422

Ensembl Acc Id:

ENSRNOP00000096275 ⟸ ENSRNOT00000095087

Ensembl Acc Id:

ENSRNOP00000096132 ⟸ ENSRNOT00000094097

RefSeq Acc Id:	XP_063127664 ⟸ XM_063271594
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063127662 ⟸ XM_063271592
- Peptide Label:	isoform X1
- UniProtKB:	Q6AXS0 (UniProtKB/Swiss-Prot), A0A8I6A2Y3 (UniProtKB/TrEMBL), A6J1J0 (UniProtKB/TrEMBL)

Protein Domains

Sodium/calcium exchanger membrane region

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AXS0-F1-model_v2	AlphaFold	Q6AXS0	1-585	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698665

Promoter ID:

EPDNEW_R9190

Type:

initiation region

Name:

Slc8b1_1

Description:

solute carrier family 8 member B1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	41,590,241 - 41,590,301	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565818	AgrOrtholog
BioCyc Gene	G2FUF-19173	BioCyc
Ensembl Genes	ENSRNOG00000001383	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000038736	ENTREZGENE
	ENSRNOT00000038736.5	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1420.30	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7107820	IMAGE-MGC_LOAD
InterPro	CaCA_antiporter	UniProtKB/Swiss-Prot
	NaCa_Exmemb	UniProtKB/Swiss-Prot
	NCX_ion-bd_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:498185	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94807	IMAGE-MGC_LOAD
NCBI Gene	498185	ENTREZGENE
PANTHER	MITOCHONDRIAL SODIUM/CALCIUM EXCHANGER PROTEIN	UniProtKB/Swiss-Prot
	NA+/CA2+ K+ INDEPENDENT EXCHANGER	UniProtKB/Swiss-Prot
Pfam	Na_Ca_ex	UniProtKB/Swiss-Prot
PhenoGen	Slc8b1	PhenoGen
RatGTEx	ENSRNOG00000001383	RatGTEx
UniProt	A0A8I6A2Y3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6APW6_RAT	UniProtKB/TrEMBL
	A0A8I6AQA3_RAT	UniProtKB/TrEMBL
	A0A8I6AUV1_RAT	UniProtKB/TrEMBL
	A6J1J0	ENTREZGENE, UniProtKB/TrEMBL
	NCLX_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc8b1	solute carrier family 8 member B1	Slc8b1	solute carrier family 8 (sodium/lithium/calcium exchanger), member B1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-12	Slc8b1	solute carrier family 8 (sodium/lithium/calcium exchanger), member B1	Slc24a6	solute carrier family 24 (sodium/lithium/calcium exchanger), member 6	Name and Symbol changed	629549	APPROVED
2012-10-16	Slc24a6	solute carrier family 24 (sodium/lithium/calcium exchanger), member 6	Slc24a6	solute carrier family 24 (sodium/potassium/calcium exchanger), member 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Slc24a6	solute carrier family 24 (sodium/potassium/calcium exchanger), member 6	LOC498185	similar to sodium/calcium exchanger protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC498185	similar to sodium/calcium exchanger protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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