Magea8 (MAGE family member A8) - Rat Genome Database

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Gene: Magea8 (MAGE family member A8) Rattus norvegicus
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Symbol: Magea8 (Ensembl: Magea10-ps3)
Name: MAGE family member A8 (Ensembl:MAGE family member A10, pseudogene 3)
RGD ID: 1565778
Description: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including MAGEA10 (MAGE family member A10); INTERACTS WITH 4,4'-sulfonyldiphenol (ortholog); bisphenol A (ortholog); chlorpyrifos (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC302638; melanoma antigen, family A, 8; melanoma-associated antigen 10-like; RGD1565778; similar to Magea5
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X43,686,835 - 43,695,013 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX44,216,453 - 44,226,182 (+)EnsemblGRCr8
mRatBN7.2X39,858,662 - 39,866,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX40,297,704 - 40,298,651 (+)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX40,373,522 - 40,374,469 (+)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX42,146,837 - 42,156,546 (-)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX39,865,466 - 39,866,428 (+)EnsemblmRatBN7.2
Rnor_6.0X43,172,001 - 43,184,700 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX43,183,381 - 43,184,313 (+)Ensemblrn6Rnor6.0
Rnor_5.0X43,475,445 - 43,487,279 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X61,298,619 - 61,299,581 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX40,472,078 - 40,475,325 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Magea8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X43,686,835 - 43,695,013 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX44,216,453 - 44,226,182 (+)EnsemblGRCr8
mRatBN7.2X39,858,662 - 39,866,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX40,297,704 - 40,298,651 (+)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX40,373,522 - 40,374,469 (+)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX42,146,837 - 42,156,546 (-)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX39,865,466 - 39,866,428 (+)EnsemblmRatBN7.2
Rnor_6.0X43,172,001 - 43,184,700 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX43,183,381 - 43,184,313 (+)Ensemblrn6Rnor6.0
Rnor_5.0X43,475,445 - 43,487,279 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X61,298,619 - 61,299,581 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX40,472,078 - 40,475,325 (+)NCBICelera
Cytogenetic MapXq21NCBI
Magea8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X153,768,771 - 153,778,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX153,768,771 - 153,778,846 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X154,985,775 - 154,995,850 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX154,985,775 - 154,995,850 (-)Ensemblmm10GRCm38
MGSCv37X151,420,318 - 151,430,393 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X150,326,489 - 150,336,566 (-)NCBIMGSCv36mm8
CeleraX138,309,077 - 138,319,152 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX72.38NCBI

Variants

.
Variants in Magea8
24 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:43
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000039874
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 5 8 66 17 13 5 2 5 6 86 23 2 52 47 68 8 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000039874   ⟹   ENSRNOP00000047124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX43,183,381 - 43,184,313 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087679   ⟹   ENSRNOP00000070549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX40,373,522 - 40,374,469 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098746   ⟹   ENSRNOP00000085604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX44,216,453 - 44,226,182 (+)Ensembl
mRatBN7.2 EnsemblX42,146,837 - 42,156,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111111   ⟹   ENSRNOP00000090679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX40,297,704 - 40,298,651 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112875   ⟹   ENSRNOP00000092782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX39,865,466 - 39,866,428 (+)Ensembl
RefSeq Acc Id: XM_228890   ⟹   XP_228890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X43,686,835 - 43,695,013 (+)NCBI
mRatBN7.2X39,858,662 - 39,866,791 (+)NCBI
Rnor_6.0X43,172,001 - 43,184,700 (+)NCBI
Rnor_5.0X43,475,445 - 43,487,279 (+)NCBI
RGSC_v3.4X61,298,619 - 61,299,581 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_228890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070549.2
  ENSRNOP00000085604.1
  ENSRNOP00000090679.1
  ENSRNOP00000092782.2
RefSeq Acc Id: XP_228890   ⟸   XM_228890
- UniProtKB: A0A8I6AI73 (UniProtKB/TrEMBL),   D3ZW04 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047124   ⟸   ENSRNOT00000039874
Ensembl Acc Id: ENSRNOP00000092782   ⟸   ENSRNOT00000112875
Ensembl Acc Id: ENSRNOP00000070549   ⟸   ENSRNOT00000087679
Ensembl Acc Id: ENSRNOP00000085604   ⟸   ENSRNOT00000098746
Ensembl Acc Id: ENSRNOP00000090679   ⟸   ENSRNOT00000111111
Protein Domains
MAGE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A727-F1-model_v2 AlphaFold D4A727 1-311 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565778 AgrOrtholog
BioCyc Gene G2FUF-2445 BioCyc
Ensembl Genes ENSRNOG00000048840 Ensembl
  ENSRNOG00000062420 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000064790 Ensembl
  ENSRNOG00000066349 Ensembl
  ENSRNOG00000066429 Ensembl
  ENSRNOG00000073163 UniProtKB/TrEMBL
  ENSRNOG00000075783 UniProtKB/TrEMBL
  ENSRNOG00000082604 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087679.3 UniProtKB/TrEMBL
  ENSRNOT00000098746.2 UniProtKB/TrEMBL
  ENSRNOT00000111111.2 UniProtKB/TrEMBL
  ENSRNOT00000112875.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1200 UniProtKB/TrEMBL
  1.10.10.1210 UniProtKB/TrEMBL
InterPro MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
  MAGE_WH1 UniProtKB/TrEMBL
  MAGE_WH2 UniProtKB/TrEMBL
  MHD_dom UniProtKB/TrEMBL
KEGG Report rno:302638 UniProtKB/TrEMBL
NCBI Gene 302638 ENTREZGENE
PANTHER MAGE FAMILY MEMBER A1-RELATED UniProtKB/TrEMBL
  PTHR11736 UniProtKB/TrEMBL
Pfam MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
PhenoGen Magea8 PhenoGen
PROSITE MAGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048840 RatGTEx
  ENSRNOG00000062420 RatGTEx
  ENSRNOG00000064790 RatGTEx
  ENSRNOG00000066349 RatGTEx
  ENSRNOG00000066429 RatGTEx
  ENSRNOG00000073163 RatGTEx
  ENSRNOG00000075783 RatGTEx
  ENSRNOG00000082604 RatGTEx
SMART MAGE UniProtKB/TrEMBL
UniProt A0A8I6AI73 ENTREZGENE, UniProtKB/TrEMBL
  D3ZW04 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-09-08 Magea8  MAGE family member A8  Magea8  melanoma antigen, family A, 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Magea8  melanoma antigen, family A, 8  RGD1565778_predicted  similar to Magea5 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565778_predicted  similar to Magea5 (predicted)  LOC302638  similar to Magea5  Symbol and Name status set to approved 1299863 APPROVED