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Gene: Mn1 (MN1 proto-oncogene, transcriptional regulator) Rattus norvegicus

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Symbol:

Mn1

Name:

MN1 proto-oncogene, transcriptional regulator

RGD ID:

1565571

Description:

Predicted to be involved in negative regulation of osteoblast proliferation; positive regulation of vitamin D receptor signaling pathway; and regulation of cell cycle G1/S phase transition. Predicted to act upstream of or within intramembranous ossification. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in familial meningioma; meningioma; and myeloid leukemia. Orthologous to human MN1 (MN1 proto-oncogene, transcriptional regulator); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC498194; meningioma 1; probable tumor suppressor protein MN1; RGD1565571; similar to meningioma 1; transcriptional activator MN1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	50,841,632 - 50,880,795 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	50,841,632 - 50,880,795 (-)	Ensembl				GRCr8
mRatBN7.2	12	45,181,794 - 45,220,959 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	45,183,085 - 45,221,651 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	46,357,662 - 46,393,868 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	46,963,905 - 47,000,113 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	46,024,420 - 46,060,627 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	51,214,192 - 51,250,230 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	51,214,192 - 51,250,230 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	52,955,948 - 52,991,986 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	45,318,155 - 45,355,115 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	46,751,609 - 46,787,208 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

atrial heart septal defect (ISO)

CEBALID Syndrome (ISO)

congenital diaphragmatic hernia (ISO)

familial meningioma (ISO)

genetic disease (ISO)

meningioma (ISO)

myeloid leukemia (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

diazinon (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

fonofos (ISO)

formaldehyde (ISO)

gentamycin (EXP)

Heptachlor epoxide (ISO)

inulin (ISO)

Licochalcone B (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methamphetamine (EXP)

methapyrilene (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

N-nitrosodiethylamine (ISO)

paracetamol (EXP)

parathion (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

quercetin (ISO)

raloxifene (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

terbufos (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

troglitazone (ISO)

valproic acid (ISO)

valsartan (ISO)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

intramembranous ossification (ISO)

negative regulation of osteoblast proliferation (IEA,ISO)

positive regulation of vitamin D receptor signaling pathway (IEA,ISO)

regulation of cell cycle G1/S phase transition (IEA,ISO)

regulation of DNA-templated transcription (IEA)

Cellular Component

nucleus (IEA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.	Buijs A, etal., Oncogene. 1995 Apr 20;10(8):1511-9.
2.	Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma.	Lekanne Deprez RH, etal., Oncogene. 1995 Apr 20;10(8):1521-8.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	Molecular genetics of meningiomas.	Ragel BT and Jensen RL, Neurosurg Focus. 2005 Nov 15;19(5):E9.
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:15870292

Genomics

Comparative Map Data

Mn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	50,841,632 - 50,880,795 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	50,841,632 - 50,880,795 (-)	Ensembl				GRCr8
mRatBN7.2	12	45,181,794 - 45,220,959 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	45,183,085 - 45,221,651 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	46,357,662 - 46,393,868 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	46,963,905 - 47,000,113 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	46,024,420 - 46,060,627 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	51,214,192 - 51,250,230 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	51,214,192 - 51,250,230 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	52,955,948 - 52,991,986 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	45,318,155 - 45,355,115 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	46,751,609 - 46,787,208 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

MN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	27,748,277 - 27,801,756 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	27,748,277 - 27,801,756 (-)	Ensembl			hg38	GRCh38
GRCh37	22	28,144,265 - 28,197,744 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	26,474,265 - 26,527,486 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	22	26,468,819 - 26,522,040	NCBI
Celera	22	11,944,239 - 11,997,449 (-)	NCBI		Celera
Cytogenetic Map	22	q12.1	ENTREZGENE
HuRef	22	11,108,458 - 11,161,677 (-)	NCBI		HuRef
CHM1_1	22	28,103,532 - 28,156,750 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	28,209,592 - 28,263,071 (-)	NCBI		T2T-CHM13v2.0

Mn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	111,565,145 - 111,604,890 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	111,565,228 - 111,604,899 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	111,417,300 - 111,457,030 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	111,417,362 - 111,457,033 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	111,847,186 - 111,886,045 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	111,657,665 - 111,697,328 (+)	NCBI		MGSCv36	mm8
Celera	5	108,545,721 - 108,584,945 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	53.86	NCBI

Mn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	2,127,377 - 2,171,850 (-)	Ensembl
ChiLan1.0	NW_004955455	2,130,104 - 2,171,868 (-)	NCBI	ChiLan1.0	ChiLan1.0

MN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	37,743,652 - 37,798,711 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	40,442,580 - 40,494,924 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	8,799,832 - 8,854,695 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	26,519,251 - 26,571,373 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

MN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	21,216,912 - 21,261,518 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	21,216,837 - 21,261,031 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	21,087,978 - 21,132,430 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	21,583,778 - 21,628,255 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	21,581,242 - 21,627,694 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	21,301,607 - 21,346,030 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	21,557,327 - 21,601,736 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	21,626,045 - 21,670,478 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	113,804,928 - 113,846,405 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936657	2,024,350 - 2,065,263 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936657	2,024,302 - 2,066,196 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	45,096,485 - 45,140,570 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	45,093,660 - 45,142,476 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	47,943,781 - 47,990,706 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	10,652,940 - 10,706,989 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	10,652,939 - 10,706,762 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	115,411,325 - 115,467,616 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	4,093,279 - 4,134,876 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	4,090,664 - 4,135,822 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mn1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	42,521,426 - 42,560,063 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	132
Count of miRNA genes:	105
Interacting mature miRNAs:	117
Transcripts:	ENSRNOT00000029508
Prediction methods:	Microtar, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	44139558	52308831	Rat

Markers in Region

D12Rat49

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	50,867,324 - 50,867,455 (+)	Marker Load Pipeline
mRatBN7.2	12	45,207,488 - 45,207,619 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	51,237,617 - 51,237,747	NCBI	Rnor6.0
Rnor_5.0	12	52,979,373 - 52,979,503	UniSTS	Rnor5.0
RGSC_v3.4	12	45,342,501 - 45,342,632	RGD	RGSC3.4
RGSC_v3.4	12	45,342,502 - 45,342,632	UniSTS	RGSC3.4
Celera	12	46,774,609 - 46,774,725	UniSTS
RGSC_v3.1	12	45,205,890 - 45,206,020	RGD
RH 3.4 Map	12	802.8	UniSTS
RH 3.4 Map	12	802.8	RGD
RH 2.0 Map	12	566.1	RGD
SHRSP x BN Map	12	54.0099	RGD
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	90	59	6	354	190	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000029508 ⟹ ENSRNOP00000029870

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	50,841,632 - 50,880,795 (-)	Ensembl
mRatBN7.2 Ensembl	12	45,183,085 - 45,221,651 (-)	Ensembl
Rnor_6.0 Ensembl	12	51,214,192 - 51,250,230 (-)	Ensembl

RefSeq Acc Id:

NM_001191928 ⟹ NP_001178857

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	50,841,632 - 50,880,795 (-)	NCBI
mRatBN7.2	12	45,181,794 - 45,220,959 (-)	NCBI
Rnor_6.0	12	51,214,192 - 51,250,230 (-)	NCBI
Rnor_5.0	12	52,955,948 - 52,991,986 (-)	NCBI
Celera	12	46,751,609 - 46,787,208 (-)	NCBI

Sequence:

show sequence

ATGTTTGGGCTGGACCAATTCGAGCCCCAGATCAACAGCCGGCACGCTGGTCAGGGCGAGGGGA
ACTTTAACGAAGCCGGACTGAGTATGAACGCTCACTTTAAGGCCCCTGCTTTCCACGCCGGGCC
TCCTCCTGGCCCCGTGGACCCTGCAATAAGCGCTCTGGGCGAACCCCCGATCTTGGGTTTGAAT
ATGGAGCCATACGGCTTCCATGCGCGCGGTCACTCCGAGCTGCACGCAGGGGGGTTGCAGGCAC
AGCCTGTGCACGGCTTCTTCGGTGGTCAGCAGCCTCACCACAGCCATCCTGGAGGCCATCACCC
GCACCAGCATCACCCACACTTTGGGGGCAACTTCGGTGGTCCGGACCCAGGTGCCTCATGTCTG
CACGGGGGCCGGCTGCTTGGCTATGGAGGTGCAGCGAGCGGCCTCGGCAGCCAGCCTCCCTTCG
CAGAGAGTTACGAGCACATGGCGGAGAGCCAGGGGCCGGAGGGCTTCGGCCCGCAGCGGCCAGG
AAACCTCCCGGACTTCCACAGTTCGGGCACTTCGGGCCACGCTGTGCCTGCCCCGTGCCTGCCG
CTGGACCAGAGCCCTAACCGGGCTGCCTCTTTCCATGGCCTGTCCGCCTCTAGCGGCTCGGATT
CTCACAGCTTGGAACCCCGGAGGGTGACGAACCAAGGAGCCGTAGATTCGCTGGAATACAATTA
CCCGAGCGAGCCGCCCTCAGGACATTTTGACATGTTTTCACCCTCTGACTCTGAAGGGCAGCTG
CCACATTATGCTGCGGGTCGCCAGGTTCCCGGGGGCGCTTTCCCGGGTGCTTCAGCCATGCCCA
GAGCCTCAGGCATGGTGGGTTTGTCCAAAATGCACGGTCAGCCACCGCAGCCACCACCACCCCA
GCAGCAACCGCAGCACGGAGTGTTCTTCGAGAGGTTTGGCGGGGCCCGGAAGATGCCTGTGGGT
CTGGAGCCTGCAGTGGGCTCCAGGCACCCGCTAATGCAGCCTCCCCAGCAGGCCCCACCACCCC
CGCAGCAGCAGCCCCAGCAGCAGCAGCCACCGCCACCACCTGGGCTTCTGGTCCGACAGAATTC
TTGCCCTCCTGCGCTCCCGCGGCCCCAGCAGGGTGAGGCTGGCACACCCAGTGGCGGCCTGCAG
GACGGGGGCCCCATGCTGCCCAGCCAACACGCGCAGTTTGAGTACCCTATCCATCGGCTAGAGA
ACCGGAGCATGCACCCATATTCTGAACCTGTTTTCAGCATGCAGCATCCCCCTCCTCAACAGGC
ACCCAACCAGAGGCTGCAGCATTTCGATGCGCCCCCCTACATGAACGTGGCCAAGAGGCCGCGT
TTTGACTTTCCGGGCAGCACAGGCGTGGACCGCTGCGCCTCGTGGAATGGCAGCATGCACAACG
GCACTCTGGACAACCAACTCTCTCCCTCCGCCTACCCAGGCCTCCCAGGCGAGTTCACGCCGCC
TGTGCCGGACAGTTTTCCTTCAGGACCGCCCTTGCAGCACCCGGGGCCGGACCACCAGTCCCTG
CAGCAGCAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAAC
AACAACAGCAGCAGCAGCAGCAGCAACGCCAGAACGCGGCCCTCATGATTAAACAGATGGCGTC
CCGGAACCAGCACCAACGGTTGCGACAGCCCAATCTGGCCCAGCTAGGCCACCCTGGGGACGTG
GGCCAGGGCGGCCTTGTCCACGGAGGTTCCGTGAGCGGCTTGGCCCAGACGAACTTTGAGCGCG
AAGGCGGCAGCACAGGTGCGGGGCGCCTGGGTGGCTTTGAGCAGCAGGCGCCCCACCTGGCGCA
GGAGAGCGCGTGGTTCCCGGGTCCACACCCTCCGGGAGACCTGCTGCCCCGGAGGATGGGCAGC
GCGGGGTTGCCGGCTGACTGCGGCCCGCACGACCCTGGTCTGGCGCCTCCCCCTGCTCCAGGTG
GTTCAGGGGTGCTATTCCGAGGCTCTCTGCAGGAGCCTCTGAGGATGCCTGGGGAAGGCCACGT
GCCCGCACTGGCCTCGCCTGGGCTGCAGTTTGGGAGCAGCTTGGCTGGCCTAGGCCAGTTGCAG
TCGCCCGGGGCCGGTGTGGGACTGCCCAACGCTCCGTCGGAGCGACGGCCTCCGCCTCCGGACT
TCCCCGCGCCAGCTCTCGGGGGCCAGCCTGGCTTTCCCTTTGGCTCAGGCAGCCGGCAGGCCAC
GCCGCACAGCGCTCCAGGCGTGAATTCGCCCCCGAGCGCGGGCGCGGGCAGCGGCAGTTCCGGT
GCTGCTGGGGGCGCTTACCCACCACAGCCGGATTTCCAATCCAGCCAGCGCAACTCGGCCAGTA
AACTGGGCGCGCTGTCCTTGGGGTCTTTCAACAAGCCCAGCTCTAAGGACAACCTGTTTGGCCA
GAGCTGCCTGGCTGCGCTCTCCACTGCTTGCCAGAACATGATCGCCAGCCTGGGTGCTCCTAAC
CTCAACGTGACTTTCAACAAGAAGAACCCACCCGAGGGGAAGAGGAAACTGAGCCAGAATGAGC
CCGACAGCGCGGTTGCAGCCGGTAACCCGGGCTCGGATTACTTCCCCGGAGGGACTACTCCTGG
GGCCCCTGGACCCGGAGGCCCTTCCGGGACCAGTGGTGGTGGCTCCAAAGCCTCAGGACCGCCC
AACCCTCCCATTCAGGGGGACAGCACCAGTCTTTCTCCCAATTACACCCTGGAATCAACATCGG
GTAGCGATGGCAAGCCTGTCCCTGGGGGTAGTGGCCGGGGAAGGGGACGCAGAAAACGGGACAG
TGGTCATGTGAGCCCCGGGACCTTTTTCGACAAATACTCCGCAGCTCCTGACAGTGGGGGCGCA
CCAGGGGTGAGCCCGGGGCAGCAGCAGGCTCCTGGTTCAGCCGCTGGGGGAAGCTCAGTAAACG
AAGCCCGAGGGCCCACACCCCATGAGAAGGCCCTCACATCACCATCGTGGGGAAAGGGAGCCGA
GTTGCTCCTTGGGGACCAGCCGGACCTCATGGCGTCCCTGGACAGCACCGCCAAATCAGATGGT
AGTTCCCCACACGTGGGTGAGTTCGCCTCTGATGAGGTGAGCACAAGTTATGCGAATGAGGACG
AAGTGTCCTCTAGTTCTGACAACACTACAGCCCTGGCCAAAGCCAGCCGAAGTCCCCTGGTGAC
CAGCTCACCCAAACTCCCTCCTCGAGGAGTGGGTGCTGGGGAACACACACCGAAGGCTTCTGCC
CTGGGCCTGGGCATCCTGTCTACCTCTACCTCGACCCCTGACAGCTATGGTGGGGGCGTGGGCA
CCGGACATCCCGGCACACCAGGCCTGGAACAGGTCCGGACCCCAACGAGCAGCAGCGGTGCGCC
GCCTCCTGACGAGATTCATCCCCTGGAGATCCTCCAAGCCCAGATCCAGCTGCAGAGACAGCAA
TTTAGCATCTCGGAGGACCAACCCCTGGGGCTCAAGGGTAGCAAAAAAACCGAGTGTGCTGTAG
GGGCCTCTGGGGCACAGAATGGTGACAGCGAGCTGGGTAGCTGCTGCTCAGAAGCAGTCAAGAG
CGCCATGAGCACCATCGACCTGGACTCCCTGATGGCAGAACACAGCACTACCTGGTACATGCCG
CCTGACAAGGCCCTGGTGGATGGTGGAGACGATGACAAGACGCTGGCGCCCTGGGAGAAGGCCA
AGTCCCAGAACCCCAACAACAAAGAAGTTCATGACCACCCCACCAACAAGGCCTCAGCCACCCA
GCCTGGCAGTCACCTGCAGTGTCTGACTGTCCACTGCACAGACGGCGACCCCAAGGCCCGCACC
TCCGTACCCACCTGGCGGTCTCTGCACTCTGACATCTCCAACCGATTCGGGACATTTGTGGCTG
CCCTGACTTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001178857	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000029870
	ENSRNOP00000029870.4

RefSeq Acc Id:

NP_001178857 ⟸ NM_001191928

- UniProtKB:

D4AAP6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFGLDQFEPQINSRHAGQGEGNFNEAGLSMNAHFKAPAFHAGPPPGPVDPAISALGEPPILGLN
MEPYGFHARGHSELHAGGLQAQPVHGFFGGQQPHHSHPGGHHPHQHHPHFGGNFGGPDPGASCL
HGGRLLGYGGAASGLGSQPPFAESYEHMAESQGPEGFGPQRPGNLPDFHSSGTSGHAVPAPCLP
LDQSPNRAASFHGLSASSGSDSHSLEPRRVTNQGAVDSLEYNYPSEPPSGHFDMFSPSDSEGQL
PHYAAGRQVPGGAFPGASAMPRASGMVGLSKMHGQPPQPPPPQQQPQHGVFFERFGGARKMPVG
LEPAVGSRHPLMQPPQQAPPPPQQQPQQQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQ
DGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPR
FDFPGSTGVDRCASWNGSMHNGTLDNQLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPGPDHQSL
QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQHQRLRQPNLAQLGHPGDV
GQGGLVHGGSVSGLAQTNFEREGGSTGAGRLGGFEQQAPHLAQESAWFPGPHPPGDLLPRRMGS
AGLPADCGPHDPGLAPPPAPGGSGVLFRGSLQEPLRMPGEGHVPALASPGLQFGSSLAGLGQLQ
SPGAGVGLPNAPSERRPPPPDFPAPALGGQPGFPFGSGSRQATPHSAPGVNSPPSAGAGSGSSG
AAGGAYPPQPDFQSSQRNSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPN
LNVTFNKKNPPEGKRKLSQNEPDSAVAAGNPGSDYFPGGTTPGAPGPGGPSGTSGGGSKASGPP
NPPIQGDSTSLSPNYTLESTSGSDGKPVPGGSGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGA
PGVSPGQQQAPGSAAGGSSVNEARGPTPHEKALTSPSWGKGAELLLGDQPDLMASLDSTAKSDG
SSPHVGEFASDEVSTSYANEDEVSSSSDNTTALAKASRSPLVTSSPKLPPRGVGAGEHTPKASA
LGLGILSTSTSTPDSYGGGVGTGHPGTPGLEQVRTPTSSSGAPPPDEIHPLEILQAQIQLQRQQ
FSISEDQPLGLKGSKKTECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSTTWYMP
PDKALVDGGDDDKTLAPWEKAKSQNPNNKEVHDHPTNKASATQPGSHLQCLTVHCTDGDPKART
SVPTWRSLHSDISNRFGTFVAALT

hide sequence

Ensembl Acc Id:

ENSRNOP00000029870 ⟸ ENSRNOT00000029508

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AAP6-F1-model_v2	AlphaFold	D4AAP6	1-1304	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565571	AgrOrtholog
BioCyc Gene	G2FUF-18840	BioCyc
Ensembl Genes	ENSRNOG00000027489	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000029508	ENTREZGENE
	ENSRNOT00000029508.6	UniProtKB/TrEMBL
InterPro	MN1	UniProtKB/TrEMBL
KEGG Report	rno:498194	UniProtKB/TrEMBL
NCBI Gene	498194	ENTREZGENE
PANTHER	PTHR15821	UniProtKB/TrEMBL
	TRANSCRIPTIONAL ACTIVATOR MN1	UniProtKB/TrEMBL
PhenoGen	Mn1	PhenoGen
RatGTEx	ENSRNOG00000027489	RatGTEx
UniProt	D4AAP6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-29	Mn1	MN1 proto-oncogene, transcriptional regulator	Mn1	meningioma 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Mn1	meningioma 1	RGD1565571_predicted	similar to meningioma 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565571_predicted	similar to meningioma 1 (predicted)	LOC498194	similar to meningioma 1	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498194	similar to meningioma 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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