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Gene: Prmt2 (protein arginine methyltransferase 2) Rattus norvegicus

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Symbol:

Prmt2

Name:

protein arginine methyltransferase 2

RGD ID:

1565519

Description:

Predicted to enable several functions, including beta-catenin binding activity; nuclear receptor binding activity; and protein methyltransferase activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; regulation of DNA-templated transcription; and regulation of intracellular signal transduction. Predicted to be located in cytosol. Predicted to be active in nucleus. Biomarker of asthma. Orthologous to human PRMT2 (protein arginine methyltransferase 2); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

HMT1 hnRNP methyltransferase-like 1; HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae); Hrmt1l1; LOC102549829; protein arginine N-methyltransferase 2; uncharacterized LOC102549829

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRMT2 (protein arginine methyltransferase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Prmt2 (protein arginine N-methyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prmt2 (protein arginine methyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRMT2 (protein arginine methyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRMT2 (protein arginine methyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prmt2 (protein arginine methyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRMT2 (protein arginine methyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRMT2 (protein arginine methyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prmt2 (protein arginine methyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Prmt2 (protein arginine methyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Prmt2 (protein arginine N-methyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PRMT2 (protein arginine methyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prmt2 (protein arginine methyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prmt2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prmt2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	12,391,388 - 12,420,096 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	12,394,268 - 12,420,108 (+)	Ensembl				GRCr8
mRatBN7.2	20	12,394,748 - 12,420,643 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	12,394,798 - 12,420,643 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	13,093,643 - 13,119,429 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	12,454,567 - 12,480,355 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	12,926,352 - 12,952,138 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	13,154,513 - 13,212,613 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	13,156,241 - 13,212,606 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	15,350,261 - 15,366,947 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	12,800,400 - 12,817,018 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	13,888,666 - 13,914,342 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (IEP)

Cocaine-Related Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

all-trans-retinoic acid (EXP,ISO)

amitrole (EXP)

avobenzone (ISO)

benzo[a]pyrene (ISO)

berberine (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

cocaine (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

DDE (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

geldanamycin (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

indometacin (ISO)

ketamine (EXP)

kojic acid (ISO)

L-methionine (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

obeticholic acid (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

ribavirin (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamibarotene (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin remodeling (IBA)

methylation (IEA)

negative regulation of canonical NF-kappaB signal transduction (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of G1/S transition of mitotic cell cycle (ISO)

negative regulation of inflammatory response (ISO)

obsolete negative regulation of DNA-binding transcription factor activity (ISO)

positive regulation of DNA-templated transcription (ISO)

regulation of androgen receptor signaling pathway (ISO)

regulation of DNA-templated transcription (IBA)

response to hypoxia (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

nucleoplasm (ISO)

nucleus (IBA,ISO)

Molecular Function

beta-catenin binding (ISO)

histone H3 methyltransferase activity (ISO)

histone methyltransferase activity (IBA,ISO)

methyltransferase activity (IEA)

nuclear androgen receptor binding (ISO)

nuclear estrogen receptor binding (ISO)

nuclear progesterone receptor binding (ISO)

nuclear retinoic acid receptor binding (ISO)

nuclear thyroid hormone receptor binding (ISO)

peroxisome proliferator activated receptor binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

protein-arginine N-methyltransferase activity (IBA,IEA,ISO)

protein-containing complex binding (ISO)

transcription coactivator activity (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

methionine cycle/metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Histone arginine methylation in cocaine action in the nucleus accumbens.	Damez-Werno DM, etal., Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9623-8. doi: 10.1073/pnas.1605045113. Epub 2016 Aug 9.
2.	Histone arginine methylation.	Di Lorenzo A and Bedford MT, FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Readers of histone methylarginine marks.	Gayatri S and Bedford MT, Biochim Biophys Acta. 2014 Aug;1839(8):702-710. doi: 10.1016/j.bbagrm.2014.02.015. Epub 2014 Feb 28.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9.	[Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma].	Sun QZ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):716-9.

Additional References at PubMed

PMID:11513728	PMID:12039952	PMID:16616919	PMID:16648481	PMID:16690984	PMID:17587566	PMID:19405910	PMID:20708585	PMID:20798359	PMID:38561150

Genomics

Comparative Map Data

Prmt2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	12,391,388 - 12,420,096 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	12,394,268 - 12,420,108 (+)	Ensembl				GRCr8
mRatBN7.2	20	12,394,748 - 12,420,643 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	12,394,798 - 12,420,643 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	13,093,643 - 13,119,429 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	12,454,567 - 12,480,355 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	12,926,352 - 12,952,138 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	13,154,513 - 13,212,613 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	13,156,241 - 13,212,606 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	15,350,261 - 15,366,947 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	12,800,400 - 12,817,018 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	13,888,666 - 13,914,342 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

PRMT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	46,635,674 - 46,665,124 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	46,635,595 - 46,665,698 (+)	Ensembl			hg38	GRCh38
GRCh37	21	48,055,586 - 48,085,036 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	46,879,955 - 46,909,291 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	21	33,168,696 - 33,198,017 (+)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	33,435,442 - 33,465,194 (+)	NCBI		HuRef
CHM1_1	21	47,616,361 - 47,646,003 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	45,021,936 - 45,051,495 (+)	NCBI		T2T-CHM13v2.0

Prmt2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	76,043,060 - 76,073,699 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	76,043,056 - 76,073,699 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	76,207,226 - 76,237,865 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	76,207,222 - 76,237,865 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	75,669,967 - 75,700,610 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	75,650,945 - 75,681,491 (-)	NCBI		MGSCv36	mm8
Celera	10	77,251,152 - 77,281,794 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	38.74	NCBI

Prmt2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	42,992,469 - 43,018,760 (+)	Ensembl
ChiLan1.0	NW_004955407	42,991,305 - 43,019,332 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRMT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	42,816,850 - 42,846,435 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	37,626,465 - 37,656,054 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	33,100,101 - 33,130,060 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	46,233,951 - 46,263,570 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	46,233,951 - 46,263,570 (+)	Ensembl			panPan2	panpan1.1

PRMT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	39,806,086 - 39,838,959 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	39,807,593 - 39,838,972 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	39,035,200 - 39,063,238 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	39,448,681 - 39,482,537 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	39,448,738 - 39,482,534 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	39,309,961 - 39,343,796 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	39,270,792 - 39,304,601 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	39,789,053 - 39,822,809 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Prmt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	39,098,966 - 39,117,221 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936778	12,967 - 29,077 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936778	12,988 - 31,217 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRMT2
(Sus scrofa - pig)

No map positions available.

PRMT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	90,225,051 - 90,256,541 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	90,225,346 - 90,256,558 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	18,648,120 - 18,679,648 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prmt2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	31,689,868 - 31,709,018 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	31,680,149 - 31,701,322 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Prmt2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	106,885,319 - 106,910,309 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Prmt2
360 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	67
Count of miRNA genes:	63
Interacting mature miRNAs:	65
Transcripts:	ENSRNOT00000050531
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8043920	29865039	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8043920	15089182	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	12243242	49189476	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Markers in Region

RH136932

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	20	12,395,279 - 12,395,692 (+)	Marker Load Pipeline
mRatBN7.2	20	12,395,821 - 12,396,234 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	13,157,206 - 13,157,618	NCBI	Rnor6.0
Rnor_5.0	20	15,310,043 - 15,310,455	UniSTS	Rnor5.0
Celera	20	13,889,631 - 13,890,043	UniSTS
RH 3.4 Map	20	179.27	UniSTS
Cytogenetic Map	20	p12	UniSTS

AA945753

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	12,420,339 - 12,420,435 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	13,212,310 - 13,212,405	NCBI	Rnor6.0
Rnor_5.0	20	15,366,644 - 15,366,739	UniSTS	Rnor5.0
RGSC_v3.4	20	12,816,715 - 12,816,810	UniSTS	RGSC3.4
Celera	20	13,914,039 - 13,914,134	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_597356	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000050531 ⟹ ENSRNOP00000039976

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	12,394,268 - 12,420,089 (+)	Ensembl
mRatBN7.2 Ensembl	20	12,394,798 - 12,420,643 (+)	Ensembl
Rnor_6.0 Ensembl	20	13,156,241 - 13,212,606 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000165280 ⟹ ENSRNOP00000102865

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	12,394,548 - 12,420,108 (+)	Ensembl

RefSeq Acc Id:

NM_001025144 ⟹ NP_001020315

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,315 - 12,420,096 (+)	NCBI
mRatBN7.2	20	12,394,857 - 12,420,643 (+)	NCBI
Rnor_6.0	20	13,156,241 - 13,212,613 (+)	NCBI
Rnor_5.0	20	15,350,261 - 15,366,947 (+)	NCBI
RGSC_v3.4	20	12,800,400 - 12,817,018 (+)	RGD
Celera	20	13,888,666 - 13,914,342 (+)	RGD

Sequence:

show sequence

CTGTTCCTTTCTGGGCTAGCCTAGAATTCAGCGGAGAAACGCGGCTGAGACGTGATGAGAAGAT
GAAGTGAGGCACCAGTTATGAGACATGAGCTTACTGAACTATGGAGGCACCAGCTGAAGATCCC
AGCCATGAGTCACAGGTCACCCCAGCTCCGGAGGAAGACCCTGTGGACTATGGCTGTGAGATGC
AGCTCCTTCAGGACGGGGCACAGTTGCAGCTGCAGCTGCAGCCCGAGGAGTTCGTAGCCATTGC
AGATTACACCGCCACCGACGAGACACAGCTCAGCTTTCTGAGAGGAGAAAAAATTCTGATCCTG
AGGCAAACCACGGCGGACTGGTGGTGGGGCGAACGTGCGGGCTGCTGCGGGTACATCCCCGCAA
ACCACCTTGGGAAGCAGGTGGAGGAGTACGACCCGGAGGACACCTGGCAAGATGAGGAGTACTT
CGACAGCTATGGGACTCTGAAACTTCACCTGGAAATGTTGGCTGACCAGCCTCGGACAACCAAG
TACCACAGTGTCATCCTGCAGAACAAGGAGTCTCTGAAGGACAAGGTCATACTGGATGTGGGCT
GCGGCACCGGCATCATCAGCCTTTTCTGCGCTCATCATGCCCGGCCCAAGGCAGTGTACGCGGT
AGAAGCCAGTGACATGGCCCAGCACACGGGCCAGCTGGTCCTGCAGAATGGCTTTGCTGACACA
ATCACTGTGTTTCAGCAGAAGGTGGAGGACGTGGTGTTGCCCGAGAAGGTGGACGTGCTGGTGT
CGGAGTGGATGGGGACCTGTCTCTTGTTTGAGTTCATGATCGAGTCCATCCTGTACGCCCGGGA
TGCCTGGTTAAAGGAAGATGGCATCATTTGGCCAACCACGGCGGCACTGCACTTGGTACCCTGC
AGCGCTGAGAAAGACTACCACAGCAAGGTGCTCTTCTGGGACAACGCGTACGAGTTCAACCTCA
GTGCACTCAAGTCGTTAGCAATCAAGGAGTTCTTTTCAAGGCCAAAGTCTAATCATATCTTGAA
GCCAGAAGACTGCCTCTCTGAGCCATGCACAATATTGCAGTTGGACATGAGAACTGTGCAGGTC
TCTGACCTGGAGACCATGCGTGGCGAGCTGCGATTTGACATCCAAAAGGCTGGGACCCTGCATG
GCTTCACAGCTTGGTTCAGTGTACATTTCCAGAGCCTGGAGGAGGGCCAGCCTCAGCAGGTTCT
CAGCACAGGACCGCTGCACCCCACCACACACTGGAAGCAGACCTTGTTTATGATGGACGACCCA
GTCCCAGTCCACACAGGAGACGTGGTCACGGGTTCGGTGGTGTTACAGAGAAATCCGGTGTGGA
GAAGGCACATGTCCGTCTGTCTGAGCTGGGTCGTCACTTCCGCAGTTGATCCCACGTCTCAAAG
GGCTGGAGAGAAAGTCTTTCCGATCTGGAGGTGACGGTTAAGCACCGCGTGGGAGTCACGGCCG
TGGTGTGCATCTTGGTGGAAGAAGATGCGTCTGGCCACCTTCTGTGACGTACACACTCACCCGT
CCCATGCTGACCCCTTCCCACCCAGCAGGTGACATCGGGCCCCTCACAGCTCACCCCCCAACCC
CCAGTGTCATTTCTCCCGTAGGCTGTGTATATATATAGGTGTTCATCCTGTGGTGCCCGTCGCT
GCCAGCCGTGTTCCCAGCCGGGAGTAGTTGTAGATCCCTCAGACACACATTTCAGCCTGTGTAC
CTGTGACTGTGATGTCCACACCTTGTGTCAGTGGTGTCCTTGATGCCCTCGACCAGCTGCTGCA
CCTGTGGACTGTGGCTTGCCGAGCCGTGCTCCGGTATGAGAGATGGCCGAGCACCCGTGTCTCG
GGGCAAGGACTGGAGGTGGCAGCGTGCGCAGTGGGCTCTGCATGGGTAGCCGCGTGTAACGTCT
TATGGGTAAATTATATGTGGGGCATAGTACATGCTCAATAAATATTTTTTAATGAACAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039099009 ⟹ XP_038954937

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,383 - 12,420,096 (+)	NCBI
mRatBN7.2	20	12,394,921 - 12,420,643 (+)	NCBI

RefSeq Acc Id:

XM_039099010 ⟹ XP_038954938

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,383 - 12,420,096 (+)	NCBI
mRatBN7.2	20	12,395,375 - 12,420,643 (+)	NCBI

RefSeq Acc Id:

XM_063279461 ⟹ XP_063135531

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,391,388 - 12,420,096 (+)	NCBI

RefSeq Acc Id:

XM_063279462 ⟹ XP_063135532

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,379 - 12,420,096 (+)	NCBI

RefSeq Acc Id:

XM_063279463 ⟹ XP_063135533

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,743 - 12,420,096 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020315	(Get FASTA)	NCBI Sequence Viewer
	XP_038954937	(Get FASTA)	NCBI Sequence Viewer
	XP_038954938	(Get FASTA)	NCBI Sequence Viewer
	XP_063135531	(Get FASTA)	NCBI Sequence Viewer
	XP_063135532	(Get FASTA)	NCBI Sequence Viewer
	XP_063135533	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79112	(Get FASTA)	NCBI Sequence Viewer
	EDL97157	(Get FASTA)	NCBI Sequence Viewer
	EDL97158	(Get FASTA)	NCBI Sequence Viewer
	EDL97159	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000039976
	ENSRNOP00000039976.4
	ENSRNOP00000102865
	ENSRNOP00000102865.1

RefSeq Acc Id:

NP_001020315 ⟸ NM_001025144

- UniProtKB:

Q6AYB9 (UniProtKB/TrEMBL), F1LMD8 (UniProtKB/TrEMBL), A0A9K3Y6N8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAPAEDPSHESQVTPAPEEDPVDYGCEMQLLQDGAQLQLQLQPEEFVAIADYTATDETQLSFL
RGEKILILRQTTADWWWGERAGCCGYIPANHLGKQVEEYDPEDTWQDEEYFDSYGTLKLHLEML
ADQPRTTKYHSVILQNKESLKDKVILDVGCGTGIISLFCAHHARPKAVYAVEASDMAQHTGQLV
LQNGFADTITVFQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGIIWPTT
AALHLVPCSAEKDYHSKVLFWDNAYEFNLSALKSLAIKEFFSRPKSNHILKPEDCLSEPCTILQ
LDMRTVQVSDLETMRGELRFDIQKAGTLHGFTAWFSVHFQSLEEGQPQQVLSTGPLHPTTHWKQ
TLFMMDDPVPVHTGDVVTGSVVLQRNPVWRRHMSVCLSWVVTSAVDPTSQRAGEKVFPIWR

hide sequence

Ensembl Acc Id:

ENSRNOP00000039976 ⟸ ENSRNOT00000050531

RefSeq Acc Id:	XP_038954937 ⟸ XM_039099009
- Peptide Label:	isoform X2
- UniProtKB:	F1LMD8 (UniProtKB/TrEMBL), Q6AYB9 (UniProtKB/TrEMBL), A0A9K3Y6N8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954938 ⟸ XM_039099010
- Peptide Label:	isoform X2
- UniProtKB:	F1LMD8 (UniProtKB/TrEMBL), Q6AYB9 (UniProtKB/TrEMBL), A0A9K3Y6N8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135531 ⟸ XM_063279461
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063135532 ⟸ XM_063279462
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063135533 ⟸ XM_063279463
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000102865 ⟸ ENSRNOT00000165280

Protein Domains

SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYB9-F1-model_v2	AlphaFold	Q6AYB9	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701521

Promoter ID:

EPDNEW_R12045

Type:

multiple initiation site

Name:

Prmt2_1

Description:

protein arginine methyltransferase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	13,156,202 - 13,156,262	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565519	AgrOrtholog
BioCyc Gene	G2FUF-4182	BioCyc
Ensembl Genes	ENSRNOG00000001297	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000050531	ENTREZGENE
	ENSRNOT00000050531.5	UniProtKB/TrEMBL
	ENSRNOT00000165280	ENTREZGENE
	ENSRNOT00000165280.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
	Hnrnp arginine n-methyltransferase1	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7125748	IMAGE-MGC_LOAD
InterPro	Arg_MeTrfase	UniProtKB/TrEMBL
	PRMT_dom	UniProtKB/TrEMBL
	SAM-dependent_MTases-like	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Small_mtfrase_dom	UniProtKB/TrEMBL
KEGG Report	rno:499420	UniProtKB/TrEMBL
MGC_CLONE	MGC:94107	IMAGE-MGC_LOAD
NCBI Gene	499420	ENTREZGENE
PANTHER	PROTEIN ARGININE N-METHYLTRANSFERASE 2	UniProtKB/TrEMBL
	PTHR11006	UniProtKB/TrEMBL
Pfam	MTS	UniProtKB/TrEMBL
	PRMT_C	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PhenoGen	Prmt2	PhenoGen
PRINTS	SH3DOMAIN	UniProtKB/TrEMBL
PROSITE	SAM_MT_PRMT	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001297	RatGTEx
SMART	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	SH3	UniProtKB/TrEMBL
	SSF53335	UniProtKB/TrEMBL
UniProt	A0A9K3Y6N8	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LBM2_RAT	UniProtKB/TrEMBL
	F1LMD8	ENTREZGENE
	Q6AYB9	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1LMD8	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Prmt2	protein arginine methyltransferase 2	LOC102549829	uncharacterized LOC102549829	Data merged from RGD:7748611	737654	PROVISIONAL
2013-12-18	LOC102549829	uncharacterized LOC102549829			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-10-24	Prmt2	protein arginine methyltransferase 2	Prmt2	protein arginine N-methyltransferase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Prmt2	protein arginine N-methyltransferase 2	Hrmt1l1	HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	Hrmt1l1	HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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