Izumo1 (izumo sperm-oocyte fusion 1) - Rat Genome Database

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Gene: Izumo1 (izumo sperm-oocyte fusion 1) Rattus norvegicus
Analyze
Symbol: Izumo1
Name: izumo sperm-oocyte fusion 1 (Ensembl:izumo sperm-egg fusion 1)
RGD ID: 1565454
Description: Enables protein homodimerization activity. Involved in binding activity of sperm to zona pellucida. Located in plasma membrane. Orthologous to human IZUMO1 (izumo sperm-oocyte fusion 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: izumo sperm-egg fusion 1; izumo sperm-egg fusion protein 1; LOC499152; OBF; oocyte binding/fusion factor; similar to hypothetical protein MGC34799; sperm-specific protein izumo
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Izumo1em1Osb
Genetic Models: W;WIAR-Izumo1em1Osb
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,227,603 - 105,233,357 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2196,090,817 - 96,096,893 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1101,476,573 - 101,482,331 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,949,270 - 109,955,032 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,239,647 - 103,245,402 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,603,222 - 101,608,977 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,603,222 - 101,608,976 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,682,002 - 102,687,757 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,090,118 - 96,095,872 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,344,795 - 90,350,549 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Ellerman DA, etal., Mol Reprod Dev. 2009 Dec;76(12):1188-99. doi: 10.1002/mrd.21092.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO. Lai X, etal., Theriogenology. 2024 Jan 15;214:286-297. doi: 10.1016/j.theriogenology.2023.10.031. Epub 2023 Nov 7.
4. Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Matsumura T, etal., Front Cell Dev Biol. 2022 Jan 12;9:810118. doi: 10.3389/fcell.2021.810118. eCollection 2021.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:15759005   PMID:19144954   PMID:20375058   PMID:20421979   PMID:22954305   PMID:24739963   PMID:27309808   PMID:27624483  


Genomics

Comparative Map Data
Izumo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,227,603 - 105,233,357 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2196,090,817 - 96,096,893 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1101,476,573 - 101,482,331 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,949,270 - 109,955,032 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,239,647 - 103,245,402 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,603,222 - 101,608,977 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,603,222 - 101,608,976 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,682,002 - 102,687,757 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,090,118 - 96,095,872 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,344,795 - 90,350,549 (+)NCBICelera
Cytogenetic Map1q22NCBI
IZUMO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,740,852 - 48,746,909 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,740,852 - 48,746,909 (-)Ensemblhg38GRCh38
GRCh371949,244,109 - 49,250,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,935,957 - 53,941,978 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1946,110,237 - 46,116,258 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,622,956 - 45,628,979 (-)NCBIHuRef
CHM1_11949,245,907 - 49,251,937 (-)NCBICHM1_1
T2T-CHM13v2.01951,735,271 - 51,741,330 (-)NCBIT2T-CHM13v2.0
Izumo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,270,251 - 45,276,653 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,271,235 - 45,278,247 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,621,811 - 45,627,242 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,621,811 - 45,628,823 (+)Ensemblmm10GRCm38
MGSCv37752,877,181 - 52,882,612 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,489,853 - 45,495,284 (+)NCBIMGSCv36mm8
Celera741,083,355 - 41,088,784 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.39NCBI
Izumo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555591,825,589 - 1,830,535 (+)NCBIChiLan1.0ChiLan1.0
IZUMO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,844,051 - 54,850,311 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,770,395 - 56,776,681 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,740,372 - 45,747,177 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,330,542 - 54,337,974 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,330,545 - 54,337,533 (-)EnsemblpanPan2panpan1.1
IZUMO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,579,073 - 107,583,163 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,101,516 - 107,105,593 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01108,103,745 - 108,107,828 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,103,552 - 108,108,135 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,770,586 - 107,774,666 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,417,509 - 107,421,583 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,253,081 - 108,257,163 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
IZUMO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,072,265 - 54,076,474 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,072,607 - 54,076,319 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,819,983 - 49,824,696 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IZUMO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366607321,860,467 - 21,867,228 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Izumo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,173,070 - 5,176,480 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248325,171,778 - 5,176,674 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Izumo1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12153,894,344 - 153,899,376 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Izumo1
95 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:126
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000033278
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat


Genetic Models
This gene Izumo1 is modified in the following models/strains:
W;WIAR-Izumo1em1Osb    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 12 62 162 79 78 47 77 47 6 325 174 14 146 73 114 31 24 24

Sequence


Ensembl Acc Id: ENSRNOT00000033278   ⟹   ENSRNOP00000035119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,603,222 - 101,608,976 (+)Ensembl
RefSeq Acc Id: NM_001017514   ⟹   NP_001017514
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,227,603 - 105,233,357 (+)NCBI
mRatBN7.2196,091,138 - 96,096,893 (+)NCBI
Rnor_6.01101,603,222 - 101,608,977 (+)NCBI
Rnor_5.01102,682,002 - 102,687,757 (+)NCBI
RGSC_v3.4196,090,118 - 96,095,872 (+)RGD
Celera190,344,795 - 90,350,549 (+)RGD
Sequence:
RefSeq Acc Id: XM_039087498   ⟹   XP_038943426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,230,300 - 105,233,357 (+)NCBI
mRatBN7.2196,093,836 - 96,096,893 (+)NCBI
RefSeq Acc Id: XM_039087504   ⟹   XP_038943432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,228,596 - 105,232,038 (+)NCBI
mRatBN7.2196,090,817 - 96,095,521 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001017514 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943426 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943432 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79244 (Get FASTA)   NCBI Sequence Viewer  
  BAD91013 (Get FASTA)   NCBI Sequence Viewer  
  EDM07324 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000107803
GenBank Protein Q6AY06 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001017514   ⟸   NM_001017514
- Peptide Label: precursor
- UniProtKB: Q6AY06 (UniProtKB/Swiss-Prot),   A6JB60 (UniProtKB/TrEMBL),   A0A455R7F4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035119   ⟸   ENSRNOT00000033278
RefSeq Acc Id: XP_038943432   ⟸   XM_039087504
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038943426   ⟸   XM_039087498
- Peptide Label: isoform X1
Protein Domains
Ig-like C2-type   Izumo protein immunoglobulin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY06-F1-model_v2 AlphaFold Q6AY06 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690048
Promoter ID:EPDNEW_R572
Type:initiation region
Name:Izumo1_1
Description:izumo sperm-egg fusion 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,603,170 - 101,603,230EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565454 AgrOrtholog
BioCyc Gene G2FUF-59664 BioCyc
Ensembl Genes ENSRNOG00000024678 Ensembl
  ENSRNOG00000089371 ENTREZGENE
Ensembl Transcript ENSRNOT00000160746 ENTREZGENE
IMAGE_CLONE IMAGE:7132791 IMAGE-MGC_LOAD
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot
  IZUMO UniProtKB/Swiss-Prot
  Izumo-Ig UniProtKB/Swiss-Prot
  IZUMO1 UniProtKB/Swiss-Prot
KEGG Report rno:499152 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94329 IMAGE-MGC_LOAD
NCBI Gene 499152 ENTREZGENE
PANTHER IZUMO SPERM-EGG FUSION PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR35540 UniProtKB/Swiss-Prot
Pfam IZUMO UniProtKB/Swiss-Prot
  Izumo-Ig UniProtKB/Swiss-Prot
PhenoGen Izumo1 PhenoGen
RatGTEx ENSRNOG00000024678 RatGTEx
  ENSRNOG00000089371 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A455R7F4 ENTREZGENE, UniProtKB/TrEMBL
  A6JB60 ENTREZGENE, UniProtKB/TrEMBL
  IZUM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Izumo1  izumo sperm-oocyte fusion 1  Izumo1  izumo sperm-egg fusion 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Izumo1  izumo sperm-egg fusion 1  LOC499152  similar to hypothetical protein MGC34799  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC499152  similar to hypothetical protein MGC34799      Symbol and Name status set to provisional 70820 PROVISIONAL