Mcemp1 (mast cell-expressed membrane protein 1) - Rat Genome Database

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Gene: Mcemp1 (mast cell-expressed membrane protein 1) Rattus norvegicus
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Symbol: Mcemp1
Name: mast cell-expressed membrane protein 1
RGD ID: 1565374
Description: Predicted to enable identical protein binding activity. Predicted to act upstream of or within Kit signaling pathway; inflammatory response; and mast cell proliferation. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in cell surface. Orthologous to human MCEMP1 (mast cell expressed membrane protein 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC498128; LOC498128; RGD1565374; similar to hypothetical protein LOC199675; uncharacterized protein LOC498128
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,519,709 - 6,523,880 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl126,517,854 - 6,523,880 (+)EnsemblGRCr8
mRatBN7.2121,721,781 - 1,727,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,718,730 - 1,725,986 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx122,388,866 - 2,392,478 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,012,436 - 3,016,048 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,783,441 - 1,787,053 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,211,970 - 2,217,005 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,213,471 - 2,217,433 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,372,176 - 4,379,103 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,486,267 - 2,489,878 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera123,578,197 - 3,581,808 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:31104315  


Genomics

Comparative Map Data
Mcemp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,519,709 - 6,523,880 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl126,517,854 - 6,523,880 (+)EnsemblGRCr8
mRatBN7.2121,721,781 - 1,727,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,718,730 - 1,725,986 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx122,388,866 - 2,392,478 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,012,436 - 3,016,048 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,783,441 - 1,787,053 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,211,970 - 2,217,005 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,213,471 - 2,217,433 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,372,176 - 4,379,103 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,486,267 - 2,489,878 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera123,578,197 - 3,581,808 (+)NCBICelera
Cytogenetic Map12p12NCBI
MCEMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,677,090 - 7,679,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,677,088 - 7,679,833 (+)Ensemblhg38GRCh38
GRCh37197,741,976 - 7,744,715 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,647,943 - 7,650,719 (+)NCBIBuild 36Build 36hg18NCBI36
Celera197,613,125 - 7,615,901 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,411,723 - 7,414,497 (+)NCBIHuRef
CHM1_1197,741,698 - 7,744,472 (+)NCBICHM1_1
T2T-CHM13v2.0197,677,976 - 7,680,714 (+)NCBIT2T-CHM13v2.0
Mcemp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,715,754 - 3,718,916 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,715,754 - 3,719,259 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3883,665,762 - 3,668,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,665,754 - 3,669,259 (+)Ensemblmm10GRCm38
MGSCv3783,665,762 - 3,668,905 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3683,665,754 - 3,669,259 (+)NCBIMGSCv36mm8
Celera83,896,091 - 3,899,234 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Mcemp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555631,602,193 - 1,604,836 (-)NCBIChiLan1.0ChiLan1.0
MCEMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,344,290 - 12,351,281 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,461,856 - 11,468,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,966,022 - 6,969,354 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,821,152 - 7,823,928 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,821,177 - 7,827,590 (+)EnsemblpanPan2panpan1.1
MCEMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,440,815 - 52,443,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,441,384 - 52,443,488 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2052,245,403 - 52,248,087 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02052,970,684 - 52,973,370 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,969,824 - 52,973,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,174,393 - 52,177,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,618,010 - 52,620,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,849,244 - 52,851,928 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mcemp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,121,876 - 213,124,406 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365884,710,910 - 4,714,691 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCEMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1271,473,384 - 71,476,126 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,880,712 - 71,883,444 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCEMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,163,068 - 7,166,861 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,163,591 - 7,166,561 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666081694,901 - 697,636 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcemp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624828740,146 - 742,922 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mcemp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1161,584,287 - 1,591,387 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mcemp1
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:64
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000031653
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat

Markers in Region
RH141039  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,725,654 - 1,725,871 (+)MAPPERmRatBN7.2
Rnor_6.0122,216,671 - 2,216,887NCBIRnor6.0
Rnor_5.0124,378,769 - 4,378,985UniSTSRnor5.0
RGSC_v3.4122,486,382 - 2,486,598UniSTSRGSC3.4
Celera123,581,477 - 3,581,693UniSTS
Cytogenetic Map12p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 55 92 91 90 59 91 59 6 335 177 11 65 75 81 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000031653   ⟹   ENSRNOP00000030516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl126,519,682 - 6,523,880 (+)Ensembl
mRatBN7.2 Ensembl121,718,730 - 1,725,986 (+)Ensembl
Rnor_6.0 Ensembl122,213,705 - 2,217,002 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084431   ⟹   ENSRNOP00000071318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl126,517,854 - 6,523,877 (+)Ensembl
mRatBN7.2 Ensembl121,718,730 - 1,725,986 (+)Ensembl
Rnor_6.0 Ensembl122,213,471 - 2,217,433 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139444   ⟹   ENSRNOP00000098741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl126,519,550 - 6,523,877 (+)Ensembl
RefSeq Acc Id: NM_001134602   ⟹   NP_001128074
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,520,267 - 6,523,880 (+)NCBI
mRatBN7.2121,722,376 - 1,725,989 (+)NCBI
Rnor_6.0122,213,705 - 2,217,002 (+)NCBI
Rnor_5.0124,372,176 - 4,379,103 (+)NCBI
RGSC_v3.4122,486,267 - 2,489,878 (-)RGD
Celera123,578,197 - 3,581,808 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598421   ⟹   XP_017453910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,519,709 - 6,523,878 (+)NCBI
mRatBN7.2121,721,781 - 1,727,350 (+)NCBI
Rnor_6.0122,213,177 - 2,217,005 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089664   ⟹   XP_038945592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,519,757 - 6,523,878 (+)NCBI
mRatBN7.2121,721,864 - 1,727,350 (+)NCBI
RefSeq Acc Id: XM_039089666   ⟹   XP_038945594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,519,762 - 6,523,878 (+)NCBI
mRatBN7.2121,721,868 - 1,727,350 (+)NCBI
RefSeq Acc Id: NP_001128074   ⟸   NM_001134602
- UniProtKB: A6KQ30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453910   ⟸   XM_017598421
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000030516   ⟸   ENSRNOT00000031653
Ensembl Acc Id: ENSRNOP00000071318   ⟸   ENSRNOT00000084431
RefSeq Acc Id: XP_038945592   ⟸   XM_039089664
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K062 (UniProtKB/TrEMBL),   A6KQ30 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945594   ⟸   XM_039089666
- Peptide Label: isoform X3
- UniProtKB: A6KQ30 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098741   ⟸   ENSRNOT00000139444

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K062-F1-model_v2 AlphaFold A0A0G2K062 1-213 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698375
Promoter ID:EPDNEW_R8900
Type:single initiation site
Name:Mcemp1_1
Description:mast cell-expressed membrane protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,213,706 - 2,213,766EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565374 AgrOrtholog
BioCyc Gene G2FUF-20384 BioCyc
Ensembl Genes ENSRNOG00000028259 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031653 ENTREZGENE
  ENSRNOT00000031653.6 UniProtKB/TrEMBL
  ENSRNOT00000084431.3 UniProtKB/TrEMBL
  ENSRNOT00000139444 ENTREZGENE
  ENSRNOT00000139444.1 UniProtKB/TrEMBL
Gene3D-CATH Designed four-helix bundle protein UniProtKB/TrEMBL
InterPro MCEMP1 UniProtKB/TrEMBL
KEGG Report rno:498128 UniProtKB/TrEMBL
NCBI Gene 498128 ENTREZGENE
PANTHER MAST CELL-EXPRESSED MEMBRANE PROTEIN 1 UniProtKB/TrEMBL
  PTHR37856 UniProtKB/TrEMBL
Pfam Lectin_N UniProtKB/TrEMBL
PhenoGen Mcemp1 PhenoGen
RatGTEx ENSRNOG00000028259 RatGTEx
UniProt A0A0G2K062 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDJ7_RAT UniProtKB/TrEMBL
  A6KQ30 ENTREZGENE, UniProtKB/TrEMBL
  D4A545_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-23 Mcemp1  mast cell-expressed membrane protein 1  RGD1565374  similar to hypothetical protein LOC199675  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565374  similar to hypothetical protein LOC199675   RGD1565374_predicted  similar to hypothetical protein LOC199675 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565374_predicted  similar to hypothetical protein LOC199675 (predicted)  LOC498128  similar to hypothetical protein LOC199675  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498128  similar to hypothetical protein LOC199675      Symbol and Name status set to provisional 70820 PROVISIONAL